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Evidence Summary
SAMe is a naturally occurring compound investigated primarily for its roles in mental health and liver function. Research suggests it may be effective as an adjuvant treatment for depression and may support liver health in chronic or alcoholic liver disease.
Evidence by Condition
SAMe is studied as an effective adjuvant therapy and standalone treatment for adults with depression.
Evidence suggests potential benefits for chronic and alcoholic liver disease, including impacts on hepatic glutathione levels.
Effective Doses
Not specified in the provided research.
Key Findings
- SAMe serves as an effective adjuvant therapy for patients with depression (PMID: 38199136)
- Meta-analyses support the use of SAMe for depression in adults (PMID: 27727432)
- Oral SAMe may affect hepatic glutathione levels in patients with liver disease (PMID: 2781235)
Limitations
Some high-level Cochrane reviews on alcoholic liver disease have been withdrawn, and much of the research focuses on specific subsets of liver disease.
Safety & Interactions
No specific interactions or contraindications were provided in the source text.
AI-generated summary from 12 peer-reviewed studies. Not medical advice. Always consult a healthcare provider.
Drug-Supplement Interactions
⚠️ This information is for educational purposes only and does not constitute medical advice. Always consult your healthcare provider before combining supplements with medications.
Claims vs. Evidence
| Claim Type | % of Products | Evidence Required | Status |
|---|---|---|---|
| All Other | 100% | Tier D (Unclassified) | ✅ Supported |
| Structure/Function | 83% | Tier C (DSHEA Structure/Function (no pre-approval)) | ✅ Supported |
| Nutrient | 6% | Tier D (Unknown) | ✅ Supported |
Research by Topic
Research Evidence (12)
**Rambaldi et al., 2006** | Cochrane Database Syst Rev | Meta Analysis Rambaldi A, Gluud C. S-adenosyl-L-methionine for alcoholic liver diseases. Cochrane Database Syst Rev. 2006-Apr-19(2):CD002235 BACKGROUND: Alcohol is a major cause of liver diseas...
**Galizia et al., 2016** | Cochrane Database Syst Rev | Meta Analysis Galizia Ilaria, Oldani Lucio, ... Young Allan H. S-adenosyl methionine (SAMe) for depression in adults. Cochrane Database Syst Rev. 2016-Oct-10;10(10):CD011286 BACKGROUND: Depressi...
**De et al., 2024** | Ann Rheum Dis | Meta Analysis De Matteis Arianna, Bindoli Sara, ... Mitrovic Stéphane. Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analys...
**Poonchuay et al., 2024** | Am J Cardiovasc Drugs | Meta Analysis Poonchuay Natnicha, Saokaew Surasak, Incomenoy Supatcha. SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic R...
**Peng et al., 2024** | Gen Hosp Psychiatry | Meta Analysis Peng Tzu-Rong, Cheng Han-Yu, Wu Ta-Wei. S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis. Gen Hosp Psychiatry. ...
**Rambaldi et al., 2001** | Cochrane Database Syst Rev | Systematic Review Rambaldi A, Gluud C. S-adenosyl-L-methionine for alcoholic liver diseases. Cochrane Database Syst Rev. 2001(4):CD002235 BACKGROUND: Alcohol is a major cause of liver disease i...
**Rambaldi et al., 2015** | Cochrane Database Syst Rev | Meta Analysis Rambaldi Andrea, Gluud Christian. WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases. Cochrane Database Syst Rev. 2015-Nov-11;2015(11):CD002235. doi:10.1002/14651858....
**Guo et al., 2015** | PLoS One | Meta Analysis Guo Tao, Chang Lei, ... Liu Quanyan. S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis. PLoS One. 2015;10(3):e0122124. doi:10.1371/journal.pone.01...
**Baden et al., 2024** | Nutrients | Systematic Review Baden Kyrie Eleyson R, McClain Halley, ... Chen Aleda M H. S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review. Nutrients. 2024-Oct-28;16(21). doi:10.3390/nu16213668 BACKGROUND/OBJE...
**Incomenoy et al., 2024** | Ann Pharmacother | Meta Analysis Incomenoy Supatcha, Saokaew Surasak, Poonchuay Natnicha. SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and...
**Williams et al., 2005** | Clin Invest Med | Systematic Review Williams Anna-leila, Girard Christine, ... Katz David L. S-adenosylmethionine (SAMe) as treatment for depression: a systematic review. Clin Invest Med. 2005-Jun;28(3):132-9 PURPOSE: To a...
**Vendemiale et al., 1989** | Scand J Gastroenterol | Rct Vendemiale G, Altomare E, ... Albano O. Effects of oral S-adenosyl-L-methionine on hepatic glutathione in patients with liver disease. Scand J Gastroenterol. 1989-May;24(4):407-15 S-Adenosyl-L...
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Frequently Asked Questions
What is SAMe and what is it used for?
SAMe is a naturally occurring compound found in the body. There is moderate evidence suggesting it may be used to support liver health and mental health.
Does SAMe work for depression?
Yes, there is moderate evidence that SAMe can be an effective standalone treatment or an added therapy for adults with depression. Research supports its use as an effective adjuvant therapy.
Can SAMe help with liver disease?
There is moderate evidence that SAMe may benefit people with chronic or alcoholic liver disease. It may work by affecting hepatic glutathione levels in the liver.
What is the effective dose of SAMe?
The provided research does not specify an effective or recommended dose for SAMe. You should consult a healthcare professional to determine an appropriate dosage for your needs.
Are there any drug interactions with SAMe?
There are currently no documented drug interactions for SAMe in the available research. However, you should always consult your doctor before starting a new supplement if you are taking medication.
Is SAMe safe to take?
No specific safety concerns or contraindications were identified in the provided research. As with any supplement, it is important to discuss use with a medical professional.
Who should avoid taking SAMe?
The available research does not list specific groups of people who should avoid SAMe. You should speak with a doctor to ensure it is safe for your specific health profile.
Answers generated from research evidence. Not medical advice.