Ginger is a widely studied supplement with significant evidence supporting its use for gastrointestinal and metabolic health. Research highlights its primary efficacy in managing various forms of nausea and its potential benefits for weight management and blood sugar regulation.

Evidence by Condition

Nausea and Vomiting (Pregnancy) Strong

Meta-analysis indicates ginger is effective for treating nausea and vomiting during pregnancy compared to placebo or Vitamin B6.

Postoperative Nausea and Vomiting (PONV) Strong

Multiple meta-analyses demonstrate that ginger is an effective preventative measure for postoperative nausea and vomiting.

Weight Management and Metabolism Moderate

Evidence suggests ginger intake can impact body weight, body composition, and metabolic profiles in overweight and obese individuals.

Type 2 Diabetes Moderate

Systematic reviews suggest dietary ginger may assist in blood sugar control for patients with Type 2 diabetes.

Non-alcoholic Fatty Liver Disease (NAFLD) Moderate

Meta-analysis of randomized controlled trials supports the use of ginger supplementation for treating NAFLD.

Neuroprotection Insufficient

Current research on Zingerone's neuroprotective effects is primarily limited to preclinical studies.

Effective Doses

Dose ranges are not specified in the provided research summaries.

Key Findings

Ginger is an effective alternative for the prevention of postoperative nausea and vomiting (PMID: 30466995).
Ginger intake is associated with weight loss and improved metabolic profiles in overweight and obese subjects (PMID: 29393665).
Zingerone, a component of ginger, shows potential as a neuroprotective agent against cognitive disorders in preclinical models (PMID: 40649889).
Ginger supplementation shows efficacy in the treatment of non-alcoholic fatty liver disease (PMID: 37545930).

Limitations

Much of the evidence regarding neuroprotective properties is currently limited to preclinical studies rather than human clinical trials.

Safety & Interactions

The provided research text does not contain specific information regarding contraindications or drug interactions.

AI-generated summary from 151 peer-reviewed studies. Not medical advice. Always consult a healthcare provider.

Drug-Supplement Interactions

Antiarrhythmics 🔴 Critical

Mechanism: Ginger is a weak inhibitor of CYP2C9, which decreases metabolism of CYP2C9 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of amiodarone (antiarrhythmics), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of amiodarone. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Anticonvulsants 🔴 Critical

Mechanism: Ginger is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of carbamazepine (anticonvulsants), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of carbamazepine. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

GI Prokinetics 🔴 Critical

Mechanism: Ginger is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of cisapride (gi-prokinetics), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of cisapride. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Theophylline 🔴 Critical

Mechanism: Ginger is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of theophylline (theophylline), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of theophylline. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

ARB 🟡 Moderate

Mechanism: Ginger is a weak inhibitor of CYP2C9, which decreases metabolism of CYP2C9 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of losartan (arb), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of losartan. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Abciximab 🟡 Moderate

Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Abciximab

Effect: See mechanism description

Management: Consult healthcare provider before combining.

Evidence: ddinter-verified

Acalabrutinib 🟡 Moderate

Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Acalabrutinib

Effect: See mechanism description

Management: Consult healthcare provider before combining.

Evidence: ddinter-verified

Alteplase 🟡 Moderate

Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Alteplase

Effect: See mechanism description

Management: Consult healthcare provider before combining.

Evidence: ddinter-verified

Anistreplase 🟡 Moderate

Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Anistreplase

Effect: See mechanism description

Management: Consult healthcare provider before combining.

Evidence: ddinter-verified

Antibiotics 🟡 Moderate

Mechanism: Ginger is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of clarithromycin (antibiotics), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of clarithromycin. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Antidiabetic Drugs 🟡 Moderate

Mechanism: Ginger is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of repaglinide (antidiabetic-drugs), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of repaglinide. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Antifungals 🟡 Moderate

Mechanism: Ginger is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of fluconazole (antifungals), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of fluconazole. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Antiplatelet Drugs 🟡 Moderate

Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Acetylsalicylic acid, Dipyridamole, Acetylsalicylic acid, Clopidogrel, Prasugrel, Ticagrelor, Ticlopidine, Vorapaxar

Effect: See mechanism description

Management: Consult healthcare provider before combining.

Evidence: ddinter-verified

Antipsychotics 🟡 Moderate

Mechanism: Ginger is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of haloperidol (antipsychotics), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of haloperidol. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Antithrombin III human 🟡 Moderate

Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Antithrombin III human

Effect: See mechanism description

Management: Consult healthcare provider before combining.

Evidence: ddinter-verified

Argatroban 🟡 Moderate

Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Argatroban

Effect: See mechanism description

Management: Consult healthcare provider before combining.

Evidence: ddinter-verified

Benzodiazepines 🟡 Moderate

Mechanism: Ginger is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of midazolam (benzodiazepines), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of midazolam. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Beta Blockers 🟡 Moderate

Mechanism: Ginger is a weak inhibitor of CYP2C19, which decreases metabolism of CYP2C19 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of propranolol (beta-blockers), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of propranolol. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Beta-2 Agonists 🟡 Moderate

Mechanism: Ginger is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of salmeterol (beta2-agonists), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of salmeterol. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Betrixaban 🟡 Moderate

Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Betrixaban

Effect: See mechanism description

Management: Consult healthcare provider before combining.

Evidence: ddinter-verified

Binimetinib 🟡 Moderate

Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Binimetinib

Effect: See mechanism description

Management: Consult healthcare provider before combining.

Evidence: ddinter-verified

Bivalirudin 🟡 Moderate

Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Bivalirudin

Effect: See mechanism description

Management: Consult healthcare provider before combining.

Evidence: ddinter-verified

CFTR Modulators 🟡 Moderate

Mechanism: Ginger is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of ivacaftor (cftr-modulators), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of ivacaftor. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Calcium Channel Blockers 🟡 Moderate

Mechanism: Ginger is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of nifedipine (calcium-channel-blockers), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of nifedipine. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Cangrelor 🟡 Moderate

Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Cangrelor

Effect: See mechanism description

Management: Consult healthcare provider before combining.

Evidence: ddinter-verified

Caplacizumab 🟡 Moderate

Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Caplacizumab

Effect: See mechanism description

Management: Consult healthcare provider before combining.

Evidence: ddinter-verified

Chemotherapy 🟡 Moderate

Mechanism: Ginger is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of doxorubicin (chemotherapy), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of doxorubicin. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Corticosteroids 🟡 Moderate

Mechanism: Ginger is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of prednisone (corticosteroids), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of prednisone. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Crizotinib 🟡 Moderate

Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Crizotinib

Effect: See mechanism description

Management: Consult healthcare provider before combining.

Evidence: ddinter-verified

Dalteparin 🟡 Moderate

Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Dalteparin

Effect: See mechanism description

Management: Consult healthcare provider before combining.

Evidence: ddinter-verified

Danaparoid 🟡 Moderate

Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Danaparoid

Effect: See mechanism description

Management: Consult healthcare provider before combining.

Evidence: ddinter-verified

Defibrotide 🟡 Moderate

Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Defibrotide

Effect: See mechanism description

Management: Consult healthcare provider before combining.

Evidence: ddinter-verified

Eptifibatide 🟡 Moderate

Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Eptifibatide

Effect: See mechanism description

Management: Consult healthcare provider before combining.

Evidence: ddinter-verified

Immunosuppressants 🟡 Moderate

Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Everolimus

Effect: See mechanism description

Management: Consult healthcare provider before combining.

Evidence: ddinter-verified

Lepirudin 🟡 Moderate

Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Lepirudin

Effect: See mechanism description

Management: Consult healthcare provider before combining.

Evidence: ddinter-verified

Leukotriene Antagonists 🟡 Moderate

Mechanism: Ginger is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of montelukast (leukotriene-antagonists), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of montelukast. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Lusutrombopag 🟡 Moderate

Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Lusutrombopag

Effect: See mechanism description

Management: Consult healthcare provider before combining.

Evidence: ddinter-verified

NSAIDs 🟡 Moderate

Mechanism: Ginger is a weak inhibitor of CYP2C9, which decreases metabolism of CYP2C9 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of ibuprofen (nsaids), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of ibuprofen. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Nitisinone 🟡 Moderate

Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Nitisinone

Effect: See mechanism description

Management: Consult healthcare provider before combining.

Evidence: ddinter-verified

Opioids 🟡 Moderate

Mechanism: Ginger is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of methadone (opioids), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of methadone. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Oral Contraceptives 🟡 Moderate

Mechanism: Ginger is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of ethinylestradiol (oral-contraceptives), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of ethinylestradiol. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Osilodrostat 🟡 Moderate

Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Osilodrostat

Effect: See mechanism description

Management: Consult healthcare provider before combining.

Evidence: ddinter-verified

PDE5 Inhibitors 🟡 Moderate

Mechanism: Ginger is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of sildenafil (pde5-inhibitors), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of sildenafil. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

PPIS 🟡 Moderate

Mechanism: Ginger is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of omeprazole (ppis), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of omeprazole. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Reteplase 🟡 Moderate

Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Reteplase

Effect: See mechanism description

Management: Consult healthcare provider before combining.

Evidence: ddinter-verified

SNRI 🟡 Moderate

Mechanism: Ginger is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of venlafaxine (snri), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of venlafaxine. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

SSRI 🟡 Moderate

Mechanism: Ginger is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of sertraline (ssri), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of sertraline. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Statins 🟡 Moderate

Mechanism: Ginger is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of simvastatin (statins), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of simvastatin. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Streptokinase 🟡 Moderate

Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Streptokinase

Effect: See mechanism description

Management: Consult healthcare provider before combining.

Evidence: ddinter-verified

Tenecteplase 🟡 Moderate

Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Tenecteplase

Effect: See mechanism description

Management: Consult healthcare provider before combining.

Evidence: ddinter-verified

Tinzaparin 🟡 Moderate

Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Tinzaparin

Effect: See mechanism description

Management: Consult healthcare provider before combining.

Evidence: ddinter-verified

Tirofiban 🟡 Moderate

Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Tirofiban

Effect: See mechanism description

Management: Consult healthcare provider before combining.

Evidence: ddinter-verified

Tricyclic Antidepressants 🟡 Moderate

Mechanism: Ginger is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of amitriptyline (tricyclic-antidepressants), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of amitriptyline. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Urokinase 🟡 Moderate

Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Urokinase

Effect: See mechanism description

Management: Consult healthcare provider before combining.

Evidence: ddinter-verified

Warfarin 🟡 Moderate

Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Warfarin

Effect: See mechanism description

Management: Consult healthcare provider before combining.

Evidence: ddinter-verified

Anticoagulants 🟢 Minor

Mechanism: Ginger may have mild antiplatelet properties at very high doses, theoretically additive with anticoagulants.

Effect: Possible minor increased bleeding risk at supplemental doses

Management: Culinary ginger is safe. Monitor INR with high-dose ginger supplements.

Evidence: possible

⚠️ This information is for educational purposes only and does not constitute medical advice. Always consult your healthcare provider before combining supplements with medications.

Claims vs. Evidence

100% Evidence-Backed

0% Unsupported

81% Structure/Function

Claim Type	% of Products	Evidence Required	Status
All Other	98%	Tier D (Unclassified)	✅ Supported
Structure/Function	81%	Tier C (DSHEA Structure/Function (no pre-approval))	✅ Supported
Nutrient	6%	Tier D (Unknown)	✅ Supported
No Claim	1%	Tier D (No claim on label)	✅ Supported

🏛️ NIH ODS Factsheet

Ginger

Research by Topic

Ginger 126 studies

SYS Antibiofilm Effects of Novel Compounds in Otitis Media Treat...

MET Interventions for treating urinary incontinence after stroke...

MET The effects of ginger intake on weight loss and metabolic pr...

+123 more

Ginger Nausea 21 studies

MET Ginger (Zingiber officinale): An alternative for the prevent...

MET Efficacy of Ginger in Preventing Postoperative Nausea and Vo...

MET The preventive and relieving effects of ginger on postoperat...

+18 more

Vitamin B6 Nausea 2 studies

MET Effect of ginger in the treatment of nausea and vomiting com...

RCT A comparison between the effects of ginger, pyridoxine (vita...

Dietary Supplement General 2 studies

CLI Ginger's Therapeutic Potential in Asthma

CLI Effect of Ginger Supplement on Non-alcoholic Fatty Liver

⚠️ FDA Safety Data

Adverse Event Profile: Ginger

Research Evidence (151)

Systematic Review: 69 Meta Analysis: 50 Rct: 24 Other: 2 Narrative Review: 2 Clinical Trial: 2 Openfda Safety: 1

A Antibiofilm Effects of Novel Compounds in Otitis Media Treatment: Systematic Review

Systematic Review International journal of molecular sciences 2024 n=100000

**Jotic et al., 2024** | Int J Mol Sci | Systematic Review Jotic Ana, Savic Vujovic Katarina, ... Cirkovic Ivana. Antibiofilm Effects of Novel Compounds in Otitis Media Treatment: Systematic Review. Int J Mol Sci. 2024-Nov-29;25(23). doi:10.3390/ijms...

PubMed DOI

B Interventions for treating urinary incontinence after stroke in adults

Meta Analysis The Cochrane database of systematic reviews 2019 n=1338

**Thomas et al., 2019** | Cochrane Database Syst Rev | Meta Analysis Thomas Lois H, Coupe Jacqueline, ... Watkins Caroline L. Interventions for treating urinary incontinence after stroke in adults. Cochrane Database Syst Rev. 2019-Feb-01;2(2):CD00446...

PubMed DOI

B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis

Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022 n=1174

INTRODUCTION: Nausea and vomiting (NV) affect up to 85% of pregnant women, which has multiple effects on pregnancy outcome. The truth etiology of nausea and vomiting in pregnancy (NVP) is still unknown. Considering the potential teratogenic effect in...

PubMed DOI

B The effects of ginger intake on weight loss and metabolic profiles among overweight and obese subjects: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Critical reviews in food science and nutrition 2019 n=473

**Maharlouei et al., 2019** | Crit Rev Food Sci Nutr | Meta Analysis Maharlouei Najmeh, Tabrizi Reza, ... Asemi Zatollah. The effects of ginger intake on weight loss and metabolic profiles among overweight and obese subjects: A systematic review and ...

PubMed DOI

B Ginger supplementation for the treatment of non-alcoholic fatty liver disease: a meta-analysis of randomized controlled trials

Meta Analysis African health sciences 2023 n=177

**Zhou et al., 2023** | Afr Health Sci | Meta Analysis Zhou Qun, Peng Ying, ... Dai Jianbo. Ginger supplementation for the treatment of non-alcoholic fatty liver disease: a meta-analysis of randomized controlled trials. Afr Health Sci. 2023-Mar;23(1)...

PubMed DOI

B Herbal medications for anxiety, depression, pain, nausea and vomiting related to preoperative surgical patients: a systematic review and meta-analysis of randomised controlled trials

Meta Analysis BMJ open 2019 n=693

**Arruda et al., 2019** | BMJ Open | Meta Analysis Arruda Ana Paula Nappi, Zhang Yuchen, ... El Dib Regina. Herbal medications for anxiety, depression, pain, nausea and vomiting related to preoperative surgical patients: a systematic review and meta-...

PubMed DOI

B The frontal association area: exercise-induced brain plasticity in children and adolescents and implications for cognitive intervention practice

Systematic Review Frontiers in human neuroscience 2024 n=425

**Zhang et al., 2024** | Front Hum Neurosci | Systematic Review Zhang Ziyun, Shi Peng, ... Feng Xiaosu. The frontal association area: exercise-induced brain plasticity in children and adolescents and implications for cognitive intervention practice. ...

PubMed DOI

B Zingerone as a Neuroprotective Agent Against Cognitive Disorders: A Systematic Review of Preclinical Studies

Systematic Review International journal of molecular sciences 2025 n=482

**Olasehinde et al., 2025** | Int J Mol Sci | Systematic Review Olasehinde Tosin A, Olaokun Oyinlola O. Zingerone as a Neuroprotective Agent Against Cognitive Disorders: A Systematic Review of Preclinical Studies. Int J Mol Sci. 2025-Jun-25;26(13). d...

PubMed DOI

B Ginger intervention on body weight and body composition in adults: a GRADE-assessed systematic review and dose-response meta-analysis of 27 randomized controlled trials

Meta Analysis Nutrition reviews 2024 n=1309

**Rafieipour et al., 2024** | Nutr Rev | Meta Analysis Rafieipour Nastaran, Gharbi Negin, ... Mohammadi-Sartang Mohsen. Ginger intervention on body weight and body composition in adults: a GRADE-assessed systematic review and dose-response meta-analy...

PubMed DOI

B Consistent Efficacy of Wendan Decoction for the Treatment of Digestive Reflux Disorders

Meta Analysis The American journal of Chinese medicine 2015 n=3253

**Ling et al., 2015** | Am J Chin Med | Meta Analysis Ling Wei, Huang Yi, ... Zhao Hai-Lu. Consistent Efficacy of Wendan Decoction for the Treatment of Digestive Reflux Disorders. Am J Chin Med. 2015;43(5):893-913. doi:10.1142/S0192415X15500524 Gastr...

PubMed DOI

B Ginger (Zingiber officinale): An alternative for the prevention of postoperative nausea and vomiting. A meta-analysis

Meta Analysis Phytomedicine : international journal of phytotherapy and phytopharmacology 2018 n=918

BACKGROUND: Postoperative nausea and vomiting (PONV) is a distressing outcome related to surgeries. Traditionally, ginger has been used in the treatment of nausea and vomiting for thousands of years. Recently, several randomized, placebo-controlled c...

PubMed DOI

B Dietary ginger as a traditional therapy for blood sugar control in patients with type 2 diabetes mellitus: A systematic review and meta-analysis

Meta Analysis Medicine 2019 n=454

**Huang et al., 2019** | Medicine (Baltimore) | Meta Analysis Huang Fang-Yan, Deng Ting, ... Ma Xin-Ling. Dietary ginger as a traditional therapy for blood sugar control in patients with type 2 diabetes mellitus: A systematic review and meta-analysis...

PubMed DOI

B Efficacy of Ginger in Preventing Postoperative Nausea and Vomiting: A Systematic Review and Meta-Analysis

Meta Analysis Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing 2021 n=1417

PURPOSE: We aimed to synthesize the published evidence to evaluate the preventive efficacy of ginger on postoperative nausea and vomiting (PONV). DESIGN: A systematic review and meta-analysis were conducted in this study. METHODS: PubMed, EMBASE, Coc...

PubMed DOI

B The preventive and relieving effects of ginger on postoperative nausea and vomiting: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis International journal of nursing studies 2022 n=1506

BACKGROUND: Postoperative nausea and vomiting are common uncomfortable symptoms experienced by patients. Besides drugs, non-pharmaceutical therapies such as herbal medicine therapy are available. Ginger has played a therapeutic role in patients under...

PubMed DOI

B Efficacy of acupoint-related therapies for nausea and vomiting in pregnancy: a Bayesian network meta-analysis

Systematic Review Frontiers in medicine 2025 n=1164

**Liu et al., 2025** | Front Med (Lausanne) | Systematic Review Liu Hejing, Liao Cai, ... Tang Chenglin. Efficacy of acupoint-related therapies for nausea and vomiting in pregnancy: a Bayesian network meta-analysis. Front Med (Lausanne). 2025;12:1589...

PubMed DOI

B Interventions for nausea and vomiting in early pregnancy

Meta Analysis The Cochrane database of systematic reviews 2015

**Matthews et al., 2015** | Cochrane Database Syst Rev | Meta Analysis Matthews Anne, Haas David M, ... Dowswell Therese. Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev. 2015-Sep-08;2015(9):CD007575. doi:10.1002/...

PubMed DOI

B The effect of ginger supplementation on lipid profile: A systematic review and meta-analysis of clinical trials

Meta Analysis Phytomedicine : international journal of phytotherapy and phytopharmacology 2018 n=586

**Pourmasoumi et al., 2018** | Phytomedicine | Meta Analysis Pourmasoumi Makan, Hadi Amir, ... Rouhani Mohammad Hossein. The effect of ginger supplementation on lipid profile: A systematic review and meta-analysis of clinical trials. Phytomedicine. 2...

PubMed DOI

B Interventions for nausea and vomiting in early pregnancy

Meta Analysis The Cochrane database of systematic reviews 2014

**Matthews et al., 2014** | Cochrane Database Syst Rev | Meta Analysis Matthews Anne, Haas David M, ... Doyle Mary. Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev. 2014-Mar-21(3):CD007575. doi:10.1002/14651858.CD...

PubMed DOI

B Safety classification of herbal medicines used among pregnant women in Asian countries: a systematic review

Systematic Review BMC complementary and alternative medicine 2017 n=2729

**Ahmed et al., 2017** | BMC Complement Altern Med | Systematic Review Ahmed Mansoor, Hwang Jung Hye, ... Han Dongwoon. Safety classification of herbal medicines used among pregnant women in Asian countries: a systematic review. BMC Complement Altern...

PubMed DOI

B Effect of ginger (Zingiber officinale) on inflammatory markers: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Cytokine 2020 n=1010

**Morvaridzadeh et al., 2020** | Cytokine | Meta Analysis Morvaridzadeh Mojgan, Fazelian Siavash, ... Heshmati Javad. Effect of ginger (Zingiber officinale) on inflammatory markers: A systematic review and meta-analysis of randomized controlled trial...

PubMed DOI

B Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section

Meta Analysis The Cochrane database of systematic reviews 2021 n=12

**Griffiths et al., 2021** | Cochrane Database Syst Rev | Meta Analysis Griffiths James D, Gyte Gillian Ml, ... Thomas Jane. Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section. Cochrane Dat...

PubMed DOI

B The effects of the ginger supplements on inflammatory parameters in type 2 diabetes patients: A systematic review and meta-analysis of randomised controlled trials

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B Interventions for nausea and vomiting in early pregnancy

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B Effects of ginger for nausea and vomiting in early pregnancy: a meta-analysis

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B A systematic review on the effect of Ginger (Zingiber officinale) on improvement of biological and fertility indices of sperm in laboratory animals, poultry and humans

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B Effects of ginger supplementation on biomarkers of oxidative stress: A systematic review and meta-analysis of randomized controlled trials

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B The effect of oral supplementation of ginger on glycemic control of patients with type 2 diabetes mellitus - A systematic review and meta-analysis

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B Ginger on Human Health: A Comprehensive Systematic Review of 109 Randomized Controlled Trials

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B The effect of ginger supplementation on metabolic profiles in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials

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B Clinical effects of Zingiber cassumunar (Plai): A systematic review

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B Does ginger supplementation lower blood pressure? A systematic review and meta-analysis of clinical trials

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B Treatments for breast engorgement during lactation

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C Effect of ginger (Zingiber officinale) supplementation on oxidative stress parameters: A systematic review and meta-analysis

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Frequently Asked Questions

What is ginger and what are its main health benefits?

Ginger is a widely studied supplement used primarily for gastrointestinal and metabolic health. There is strong evidence for its use in managing nausea and moderate evidence regarding its potential benefits for weight management and blood sugar regulation.

Can ginger help with morning sickness during pregnancy?

Yes, there is strong evidence from meta-analyses indicating that ginger is an effective treatment for nausea and vomiting during pregnancy compared to a placebo or Vitamin B6.

Does ginger help with weight loss and metabolism?

There is moderate evidence suggesting that ginger intake can impact body weight, body composition, and metabolic profiles in individuals who are overweight or obese.

Can ginger help manage blood sugar levels?

There is moderate evidence from systematic reviews suggesting that dietary ginger may assist in blood sugar control for patients living with Type 2 diabetes.

Is ginger effective for preventing nausea after surgery?

Yes, there is strong evidence from multiple meta-analyses demonstrating that ginger serves as an effective preventative measure for postoperative nausea and vomiting.

Can ginger supplementation treat fatty liver disease?

There is moderate evidence from meta-analyses of randomized controlled trials that supports the use of ginger supplementation for treating non-alcoholic fatty liver disease (NAFLD).

Is ginger safe to take and are there any drug interactions?

No specific drug interactions or contraindications were documented in the provided research. However, effective doses are not yet specified, and you should consult a healthcare professional before use.

Does ginger provide neuroprotection against cognitive disorders?

There is currently insufficient evidence to support this in humans, as research on the neuroprotective effects of Zingerone is primarily limited to preclinical studies.

Answers generated from research evidence. Not medical advice.