Olive Leaf
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Evidence Summary
Olive leaf extract is a botanical supplement being researched for its potential roles in cardiovascular health and athletic performance. Current evidence includes studies on lipid management and blood pressure reduction, though much of the research is currently in the clinical trial stage.
Evidence by Condition
A combination of Monacolin K, CoQ10, grape seed, and olive leaf extracts was shown to lower LDL cholesterol in patients with mild dyslipidemia.
Clinical trials have investigated the use of olive leaf extract as part of a healthy lifestyle to assist in blood pressure reduction.
Ongoing clinical trials are exploring the effects of olive leaf extract on the performance of elite cyclists and handball players.
Effective Doses
Specific dose ranges for olive leaf extract alone were not provided in the reviewed studies.
Key Findings
- A combination of Monacolin K, CoQ10, grape seed, and olive leaf extracts lowers LDL cholesterol in patients with mild dyslipidemia (PMID: 37375586).
- Research has investigated the bioavailability of oleuropein, a key component of olive leaf extract, following enzymatic digestion and probiotic use.
- Clinical trials are evaluating the impact of olive leaf extract and vitamins on the performance of elite male cyclists.
Limitations
The current research is limited by a small number of studies and a lack of large-scale, independent randomized controlled trials focusing solely on olive leaf extract.
Safety & Interactions
No specific interactions or contraindications were identified in the provided research.
AI-generated summary from 5 peer-reviewed studies. Not medical advice. Always consult a healthcare provider.
Claims vs. Evidence
| Claim Type | % of Products | Evidence Required | Status |
|---|---|---|---|
| All Other | 100% | Tier D (Unclassified) | ✅ Supported |
| Structure/Function | 86% | Tier C (DSHEA Structure/Function (no pre-approval)) | ⚠️ Unsupported |
| Nutrient | 7% | Tier D (Unknown) | ✅ Supported |
| Approved Health | 1% | Tier A (FDA Approved Health Claim (21 CFR 101.9)) | ⚠️ Unsupported |
| Qualified Health | 1% | Tier B (FDA Qualified Health Claim) | ⚠️ Unsupported |
| No Claim | 1% | Tier D (No claim on label) | ✅ Supported |
Research by Topic
Research Evidence (5)
**Angelopoulos et al., 2023** | Nutrients | Rct Angelopoulos Nicholas, Paparodis Rodis D, ... Livadas Sarantis. Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with Mild Dyslipid...
**NCT ID**: NCT06741163 **Phase**: NA **Status**: COMPLETED **Enrollment**: 28 **Completion**: 2025-01-14
**NCT ID**: NCT07371052 **Phase**: NA **Status**: COMPLETED **Enrollment**: 18 **Completion**: 2025-02-01
**NCT ID**: NCT04328571 **Phase**: NA **Status**: COMPLETED **Enrollment**: 104 **Completion**: 2021-09-15
**NCT ID**: NCT02421835 **Phase**: NA **Status**: COMPLETED **Enrollment**: 120 **Completion**: 2016-04
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Frequently Asked Questions
What is olive leaf extract and what is it used for?
Olive leaf extract is a botanical supplement derived from olive leaves. It is being researched for its potential benefits in supporting cardiovascular health and improving athletic performance.
Can olive leaf extract help lower cholesterol?
There is moderate evidence that a combination of olive leaf extract, Monacolin K, CoQ10, and grape seed extract can help lower LDL cholesterol in individuals with mild dyslipidemia. The benefits of olive leaf extract used alone are not yet fully established.
Does olive leaf extract help with high blood pressure?
There is currently insufficient evidence to confirm that olive leaf extract directly reduces blood pressure. Clinical trials are ongoing to see if it can assist in blood pressure management as part of a healthy lifestyle.
Can olive leaf extract improve athletic performance?
There is currently insufficient evidence regarding its impact on athletic performance. Ongoing clinical trials are specifically investigating its effects on elite athletes, such as handball players and cyclists.
What is the recommended dose of olive leaf extract?
Specific effective dose ranges for olive leaf extract alone have not been provided in the reviewed research. You should consult a healthcare professional to determine an appropriate dosage for your needs.
Is olive leaf extract safe to take and are there any side effects?
No specific contraindications or safety concerns were identified in the current research. However, you should always consult a doctor before use, especially if you have underlying health conditions.
Are there any known drug interactions with olive leaf extract?
There are no documented drug interactions for olive leaf extract in the available research. However, it is important to discuss all supplements with your physician to ensure they are safe with your current medications.
Answers generated from research evidence. Not medical advice.