L Arginine
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Evidence Summary
L-Arginine is an amino acid that serves as a precursor to nitric oxide, playing a critical role in vasodilation and various physiological processes. Research indicates potential benefits in managing acute stroke, preventing necrotising enterocolitis in preterm infants, and aiding wound healing.
Evidence by Condition
Nitric oxide donors, including L-arginine, may be beneficial in the management of acute stroke.
Arginine supplementation is studied as a preventative measure for necrotising enterocolitis in preterm infants.
Arginine and glutamine supplementation have demonstrated effects on the wound healing process.
Meta-analytic evidence suggests L-arginine supplementation may have a blood pressure-lowering effect.
Systematic reviews analyze the use of various dietary supplements, including arginine, for erectile dysfunction.
The combined ingestion of L-theanine and L-arginine may impact short-term psychological stress in young adults.
Small-scale trials are investigating the effects of L-arginine and Vitamin C on endothelial function in Long COVID patients.
Effective Doses
Dose ranges are not explicitly stated in the provided research summaries.
Key Findings
- Nitric oxide donors, such as L-arginine, may provide benefits in acute stroke management (PMID: 28429459).
- Arginine supplementation is a potential strategy for the prevention of necrotising enterocolitis in preterm infants (PMID: 28399330).
- Arginine and glutamine supplementation can influence wound healing (PMID: 34444657).
Limitations
Research quality varies significantly, with some findings based on small-scale randomized controlled trials or specific, limited populations.
Safety & Interactions
The provided research text does not explicitly detail specific contraindications or drug interactions.
AI-generated summary from 45 peer-reviewed studies. Not medical advice. Always consult a healthcare provider.
Claims vs. Evidence
| Claim Type | % of Products | Evidence Required | Status |
|---|---|---|---|
| All Other | 100% | Tier D (Unclassified) | ✅ Supported |
| Structure/Function | 91% | Tier C (DSHEA Structure/Function (no pre-approval)) | ⚠️ Unsupported |
| Nutrient | 35% | Tier D (Unknown) | ✅ Supported |
Research by Topic
Research Evidence (45)
BACKGROUND: Nitric oxide (NO) has multiple effects that may be beneficial in acute stroke, including lowering blood pressure, and promoting reperfusion and cytoprotection. Some forms of nitric oxide synthase inhibition (NOS-I) may also be beneficial....
BACKGROUND: Decreased concentration of nitric oxide has been proposed as one of the possible cellular mechanisms of necrotising enterocolitis (NEC). Arginine can act as a substrate for production of nitric oxide in the tissues, and arginine supplemen...
**Moore et al., 2020** | Cochrane Database Syst Rev | Meta Analysis Moore Zena Eh, Corcoran Meave A, Patton Declan. Nutritional interventions for treating foot ulcers in people with diabetes. Cochrane Database Syst Rev. 2020-Jul-17;7(7):CD011378. doi...
BACKGROUND: Nitric oxide has several effects that may be beneficial in ischaemic stroke and useful in the management of high blood pressure in acute stroke. Some forms of nitric oxide synthase inhibition may also be beneficial. However, high concentr...
BACKGROUND: Immaturity, ischemia, and disturbances in gut mucosal integrity due to infections or hyperosmolar feeds are some of the suspected mechanisms in the development of necrotising enterocolitis (NEC) in preterm infants. Decreased concentration...
**Arribas-López et al., 2021** | Nutrients | Meta Analysis Arribas-López Elena, Zand Nazanin, ... Kochhar Tony. The Effect of Amino Acids on Wound Healing: A Systematic Review and Meta-Analysis on Arginine and Glutamine. Nutrients. 2021-Jul-22;13(8)....
BACKGROUND: Nitric oxide has several effects that may be beneficial in ischaemic stroke and useful in the management of hypertension in acute stroke. Some forms of nitric oxide synthase inhibition may also be beneficial. However, high concentrations ...
**Petre et al., 2023** | Nutrients | Meta Analysis Petre Gabriel Cosmin, Francini-Pesenti Francesco, ... Garolla Andrea. Dietary Supplements for Erectile Dysfunction: Analysis of Marketed Products, Systematic Review, Meta-Analysis and Rational Use. N...
BACKGROUND: Immaturity, ischemia, and disturbances in gut mucosal integrity due to infections or hyperosmolar feeds are some of the suspected mechanisms in the development of necrotising enterocolitis (NEC) in preterm infants. Decreased concentration...
**Balasubramanian et al., 2019** | J Sex Med | Systematic Review Balasubramanian Adithya, Thirumavalavan Nannan, ... Pastuszak Alexander W. An Analysis of Popular Online Erectile Dysfunction Supplements. J Sex Med. 2019-Jun;16(6):843-852. doi:10.1016...
l-Theanine, the most abundant amino acid component in green tea, has anti-stress effects and refreshes the mental state. A recent study demonstrated that l-arginine, the second most abundant amino acid in green tea, might enhance the anti-stress effe...
There is increasing interest in the pathophysiological role of arginine metabolism in schizophrenia, particularly in relation to the modulation of the endogenous messenger nitric oxide (NO). The assessment of specific arginine metabolites that, unlik...
**Huang et al., 2024** | Nutrients | Systematic Review Huang Dongxiang, Wang Xiaobing, ... Huang Bo. Effects of Different Dietary Supplements on Swimming Performance: A Systematic Review and Network Meta-Analysis. Nutrients. 2024-Dec-26;17(1). doi:10...
A decade-old meta-analytic work indicated that l-arginine supplementation might have a blood pressure (BP)-lowering effect in different populations. However, several relevant investigations have emerged in the last 10 y, and an up-to-date systematic ...
Long COVID, a condition characterized by symptom and/or sign persistence following an acute COVID-19 episode, is associated with reduced physical performance and endothelial dysfunction. Supplementation of l-arginine may improve endothelial and muscl...
**d'Unienville et al., 2021** | J Int Soc Sports Nutr | Meta Analysis d'Unienville Noah M A, Blake Henry T, ... Buckley Jonathan D. Effect of food sources of nitrate, polyphenols, L-arginine and L-citrulline on endurance exercise performance: a syste...
**Zinellu et al., 2023** | Cells | Meta Analysis Zinellu Angelo, Mangoni Arduino A. Arginine, Transsulfuration, and Folic Acid Pathway Metabolomics in Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis. Cells. 2023-Aug-30;12...
**Luo et al., 2017** | Mod Rheumatol | Meta Analysis Luo Jing-Ying, Liu Xin, ... Zhao Jing-Jun. Oxidative stress markers in blood in systemic sclerosis: A meta-analysis. Mod Rheumatol. 2017-Mar;27(2):306-314. doi:10.1080/14397595.2016.1206510 OBJECTI...
BACKGROUND: L-arginine is a semi-essential amino acid involved in nitric oxide production. As nitric oxide is an important vasodilator, L-arginine supplementation would increase blood perfusion and, subsequently, muscle performance during exercises. ...
**Coughlin et al., 2021** | J Inherit Metab Dis | Systematic Review Coughlin Curtis R, Tseng Laura A, ... van Karnebeek Clara D M. Consensus guidelines for the diagnosis and management of pyridoxine-dependent epilepsy due to α-aminoadipic semialdehyd...
**Brooks et al., 2016** | Nutr Rev | Systematic Review Brooks James R, Oketch-Rabah Hellen, ... Sarma Nandakumara D. Safety and performance benefits of arginine supplements for military personnel: a systematic review. Nutr Rev. 2016-Nov;74(11):708-72...
To study the efficacy and safety of a new combination of perindopril arginine and amlodipine besylate, 837 subjects were enrolled in a three-arm, prospective, 59-center, randomized clinical trial. For 42 days, subjects (average seated blood pressure ...
Controlling blood pressure is a global health priority; single-pill antihypertensive combinations may improve adherence, persistence, and outcomes. Areas covered: A novel combination of perindopril arginine and amlodipine besylate was recently approv...
**Yan et al., 2013** | Quintessence Int | Meta Analysis Yan Boxi, Yi Jianru, ... Shi Zongdao. Arginine-containing toothpastes for dentin hypersensitivity: systematic review and meta-analysis. Quintessence Int. 2013-Oct;44(9):709-23. doi:10.3290/j.qi....
Endothelial dysfunction (ED), in particular cerebral ED, may be an essential biomarker for ischaemic cerebrovascular disease. However, there is no consensus on methods to best estimate cerebral ED. In this systematic review, we evaluate the use of l-...
**Rahnemaei et al., 2020** | Taiwan J Obstet Gynecol | Systematic Review Rahnemaei Fatemeh Alsadat, Fashami Mahta Abbasi, ... Abbasi Mahmoud. Factors effective in the prevention of Preeclampsia:A systematic review. Taiwan J Obstet Gynecol. 2020-Mar;5...
**Imani et al., 2015** | Nutrition | Rct Imani Hossein, Tabibi Hadi, ... Rahmani Leila. Effects of ginger on serum glucose, advanced glycation end products, and inflammation in peritoneal dialysis patients. Nutrition. 2015-May;31(5):703-7. doi:10.101...
BACKGROUND: We investigated the effects of oral L-arginine on endothelial function, intravascular oxidative stress, and circulating inflammatory markers in patients with stable coronary artery disease (CAD). METHODS: Thirty-one stable CAD patients we...
OBJECTIVE: Chronic Obstructive Pulmonary Disease (COPD) patients experience limitations in activities of daily living (ADL) despite optimal inhaled treatment. L-arginine depletion is associated with poor exercise performance. Our aim was to assess wh...
**NCT ID**: NCT06439875 **Phase**: NA **Status**: COMPLETED **Enrollment**: 101 **Completion**: 2026-03-09
**NCT ID**: NCT07020754 **Phase**: PHASE2 **Status**: COMPLETED **Enrollment**: 84 **Completion**: 2026-01-25
**NCT ID**: NCT04549662 **Phase**: NA **Status**: COMPLETED **Enrollment**: 45 **Completion**: 2024-02-12
**NCT ID**: NCT06004375 **Phase**: PHASE3 **Status**: COMPLETED **Enrollment**: 20 **Completion**: 2023-05-30
**NCT ID**: NCT07506187 **Phase**: NA **Status**: COMPLETED **Enrollment**: 44 **Completion**: 2025-07-31
Exposure to traffic-related air pollution (TRAP) increases blood pressure (BP) and cardiovascular morbidity and mortality. We aimed to evaluate the potential efficacy of L-arginine supplementation in mitigating the adverse cardiovascular effects of a...
BACKGROUND: In patients with type 2 diabetes (T2D) sodium-glucose cotransporter 2 (SGLT-2) inhibitors improve glycaemic control as well as cardiovascular and renal outcomes. Their effects on L-arginine (Arg) related risk markers asymmetric and symmet...
OBJECTIVES: Arginine is an amino-acid supplement and precursor for nitric-oxide synthesis, which affects various biologic processes. The objective of this study was to determine the effects of arginine supplementation on growth hormone (GH) and metab...
AIM: To study the effect of metformin on plasma levels of arginine, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), indicators of the nitric oxide pathway. MATERIALS AND METHODS: In this post hoc analysis of the HOME trial, ...
This study investigated the effects of combined L-arginine (Arg) and citrulline-malate (CM) supplementation on aerobic, anaerobic, and high-intensity interval training in healthy, trained men. Both Arg and CM are widely marketed for their potential e...
**NCT ID**: NCT03221686 **Phase**: NA **Status**: COMPLETED **Enrollment**: 20 **Completion**: 2017-12-10
**NCT ID**: NCT03433963 **Phase**: NA **Status**: COMPLETED **Enrollment**: 118 **Completion**: 2020-03-31
**NCT ID**: NCT03679780 **Phase**: PHASE1 **Status**: COMPLETED **Enrollment**: 19 **Completion**: 2023-07-26
**NCT ID**: NCT04079010 **Phase**: NA **Status**: COMPLETED **Enrollment**: 30 **Completion**: 2019-11-25
**NCT ID**: NCT05042024 **Phase**: PHASE3 **Status**: COMPLETED **Enrollment**: 75 **Completion**: 2018-11-01
**NCT ID**: NCT02392767 **Phase**: NA **Status**: COMPLETED **Enrollment**: 25 **Completion**: 2015-08
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Frequently Asked Questions
What is L-Arginine and how does it work?
L-Arginine is an amino acid that serves as a precursor to nitric oxide, which is essential for vasodilation. This process helps blood vessels relax and plays a critical role in various physiological functions.
Is there strong evidence for using L-Arginine for stroke or infant health?
Yes, there is strong evidence that L-arginine may be beneficial in managing acute stroke. Additionally, there is strong evidence supporting its use as a potential preventative measure for necrotising enterocolitis in preterm infants.
Can L-Arginine help lower blood pressure?
There is moderate evidence suggesting that L-arginine supplementation may have a blood pressure-lowering effect. This is based on meta-analytic evidence currently available.
Does L-Ararginine help with wound healing?
There is moderate evidence that supplementing with both L-arginine and glutamine can influence the wound healing process. This may be beneficial for supporting recovery.
Is L-Arginine effective for erectile dysfunction?
Systematic reviews provide moderate evidence regarding the use of various supplements, including L-arginine, for managing erectile dysfunction. More research is often analyzed to determine its specific efficacy.
Can L-Arginine help reduce stress?
There is moderate evidence that the combined ingestion of L-theanine and L-arginine may impact short-term psychological stress in young adults. This suggests a potential benefit when used in combination with other nutrients.
What is the recommended dose of L-Arginine?
The provided research does not explicitly state an effective dose range for L-arginine supplementation. You should consult a healthcare professional to determine an appropriate dosage for your needs.
Are there any side effects or drug interactions with L-Arginine?
There are currently no documented drug interactions or specific contraindications for L-arginine in the provided research. However, no specific groups are identified as needing to avoid it, and you should always consult a doctor before starting a new supplement.
Answers generated from research evidence. Not medical advice.