Phosphatidylserine
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Evidence Summary
Phosphatidylserine is a phospholipid essential for cell membrane structure. Research suggests it may support cognitive function, particularly in the context of stress management and mild cognitive impairment.
Evidence by Condition
Evidence indicates potential benefits for cognitive performance under stress and for older adults with mild cognitive impairment.
Preliminary research is investigating the use of phosphatidylserine enriched with n-3 fatty acids for ADHD in children with epilepsy.
Effective Doses
Dose ranges not specified in the provided studies.
Key Findings
- Phosphatidylserine may influence cognitive performance and cortical activity following induced stress (PMID: 18616866).
- A food supplement containing phosphatidylserine may improve cognitive function in Chinese older adults with mild cognitive impairment (PMID: 39317299).
- Standardized Ginkgo biloba extract complexed with phosphatidylserine has demonstrated acute cognitive effects (PMID: 17457961).
- Phosphatidylserine enriched with n-3 fatty acids is being studied for ADHD management in pediatric epilepsy populations (PMID: 38173190).
Limitations
Much of the research focuses on specific sub-populations, such as elderly individuals with MCI or children with epilepsy, and often evaluates phosphatidylserine as part of a multi-ingredient formula.
Safety & Interactions
No specific interactions or contraindications were mentioned in the provided research summaries.
AI-generated summary from 5 peer-reviewed studies. Not medical advice. Always consult a healthcare provider.
Claims vs. Evidence
| Claim Type | % of Products | Evidence Required | Status |
|---|---|---|---|
| All Other | 97% | Tier D (Unclassified) | ✅ Supported |
| Structure/Function | 89% | Tier C (DSHEA Structure/Function (no pre-approval)) | ⚠️ Unsupported |
| Nutrient | 29% | Tier D (Unknown) | ✅ Supported |
| No Claim | 2% | Tier D (No claim on label) | ✅ Supported |
| Qualified Health | 2% | Tier B (FDA Qualified Health Claim) | ⚠️ Unsupported |
Research by Topic
Research Evidence (5)
**Baumeister et al., 2008** | Nutr Neurosci | Rct Baumeister J, Barthel T, ... Weiss M. Influence of phosphatidylserine on cognitive performance and cortical activity after induced stress. Nutr Neurosci. 2008-Jun;11(3):103-10. doi:10.1179/147683008X3...
**Duan et al., 2025** | J Affect Disord | Rct Duan Huilian, Xu Ning, ... Huang Guowei. Effects of a food supplement containing phosphatidylserine on cognitive function in Chinese older adults with mild cognitive impairment: A randomized double-blind,...
Magnesium is one of the most abundant essential minerals in the body. Magnesium supplements mostly have low bioavailability, except magnesium L-threonate. In 2010, a novel magnesium compound, magnesium L-threonate (Magtein®) was identified and was sh...
BACKGROUND: Attention-deficit hyperactivity disorder (ADHD) is a frequent comorbidity in children with epilepsy, which management mostly relies on the usual treatments of ADHD, especially methylphenidate. Supplementation with polyunsaturated n-3 Fatt...
**Kennedy et al., 2007** | Hum Psychopharmacol | Rct Kennedy D O, Haskell C F, ... Scholey A B. Acute cognitive effects of standardised Ginkgo biloba extract complexed with phosphatidylserine. Hum Psychopharmacol. 2007-Jun;22(4):199-210 Recent data s...
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Frequently Asked Questions
What is Phosphatidylserine and how does it work?
Phosphatidylserine is a phospholipid that is essential for maintaining the structure of your cell membranes. There is moderate evidence suggesting it may support cognitive function, particularly during periods of stress.
Can Phosphatidylserine help with memory or cognitive decline?
There is moderate evidence that Phosphatidylserine may improve cognitive function in older adults experiencing mild cognitive impairment. It may also help maintain cognitive performance when you are under stress.
Does Phosphatidylserine help with ADHD?
There is currently insufficient evidence to confirm if Phosphatidylserine is effective for ADHD. Preliminary research is investigating versions enriched with n-3 fatty acids specifically in children with epilepsy, but more studies are needed.
What is the recommended dose of Phosphatidylserine?
The provided research does not specify a standard effective dose range for Phosphatidylserine. You should consult with a healthcare professional to determine an appropriate dose for your needs.
Is Phosphatidylserine safe to take?
There are no specific safety concerns or contraindications mentioned in the current research summaries. However, you should always speak with a doctor before starting a new supplement.
Are there any drug interactions with Phosphatidylserine?
There are currently no documented drug interactions for Phosphatidylserine. However, it is always best to check with your physician if you are taking any prescription medications.
Who should avoid taking Phosphatidylserine?
The available research does not identify any specific groups of people who should avoid this supplement. As with any supplement, individuals with underlying health conditions should consult a medical professional first.
Answers generated from research evidence. Not medical advice.