Rhodiola
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Evidence Summary
Rhodiola rosea is an adaptogenic herb primarily researched for its ability to mitigate the effects of stress and fatigue. Research indicates potential benefits for physical and mental fatigue, cardiovascular health, and athletic performance.
Evidence by Condition
Evidence supports its use for reducing stress-related fatigue and maintaining strength performance during mental fatigue.
Meta-analyses suggest efficacy in treating ischemic heart disease and unstable angina when used in specific herbal formulations.
Studies indicate impacts on strength and performance in athletes, particularly under fatigue conditions.
Effective Doses
Dose ranges are not explicitly provided in the source text.
Key Findings
- Rhodiola rosea extract impacts strength performance in bench-press exercises under mental fatigue (PMID: 40289957)
- A combination of Rhodiola, green tea, magnesium, and B vitamins modulates brain activity to protect against social stress (PMID: 33896388)
- Standardized Rhodiola rosea injection may assist in left ventricular remodeling and inflammation in HFrEF patients (PMID: 40098619)
- Short-term supplementation may affect basketball performance and perceived fatigue (PMID: 41373984)
Limitations
Much of the cardiovascular research focuses on complex herbal formulations or injections rather than pure Rhodiola rosea extracts, and there is a lack of standardized dosing data.
Safety & Interactions
No specific contraindications or drug interactions were explicitly detailed in the provided research summaries.
AI-generated summary from 39 peer-reviewed studies. Not medical advice. Always consult a healthcare provider.
Claims vs. Evidence
| Claim Type | % of Products | Evidence Required | Status |
|---|---|---|---|
| All Other | 98% | Tier D (Unclassified) | ✅ Supported |
| Structure/Function | 80% | Tier C (DSHEA Structure/Function (no pre-approval)) | ✅ Supported |
| Nutrient | 3% | Tier D (Unknown) | ✅ Supported |
| No Claim | 0% | Tier D (No claim on label) | ✅ Supported |
Research by Topic
Research Evidence (39)
**Yu et al., 2014** | Complement Ther Med | Meta Analysis Yu Lei, Qin Yongjie, ... Xiong Hongyan. The efficacy and safety of Chinese herbal medicine, Rhodiola formulation in treating ischemic heart disease: a systematic review and meta-analysis of ra...
**Łuszczak et al., 2026** | Ann Agric Environ Med | Systematic Review Łuszczak Joanna, Kocki Janusz. Clinical evidence for the adaptogenic effects of Withania somnifera and Rhodiola rosea - A systematic review with molecular interpretation of psychom...
**Gao et al., 2025** | Front Pharmacol | Systematic Review Gao Zixuan, Liu Yaoyuan, ... Pang Wentai. Efficacy and safety of Rhodiola crenulata extract in the treatment of acute high altitude disease, based on studies involving populations in China: A...
Objectives: This study aimed to explore the effects of four days of Rhodiola Rosea (RR) supplementation on bench-press and bench-pull exercises under resting or mental fatigue conditions in young healthy individuals. Methods: Eighteen participants (s...
**Cheng et al., 2020** | Sci Rep | Meta Analysis Cheng Jin-Quan, Shi Qing-Ping, ... Wang Can. Liver function monitoring: a prospective nested case-control study of Salvia miltiorrhiza polyphenol injection. Sci Rep. 2020-Feb-26;10(1):3538. doi:10.1038...
**Boyle et al., 2022** | Nutr Neurosci | Rct Boyle Neil Bernard, Billington Jac, ... Dye Louise. A combination of green tea, rhodiola, magnesium and B vitamins modulates brain activity and protects against the effects of induced social stress in heal...
**Du et al., 2025** | Front Pharmacol | Systematic Review Du Xuqin, Wang Xiaorong, ... Ren Yi. Standardized Rhodiola rosea injection for left ventricular remodeling and inflammation in patients with HFrEF: a systematic review and meta-analysis. Front...
BACKGROUND: Rhodiola rosea (R. rosea) is grown at high altitudes and northern latitudes. Due to its purported adaptogenic properties, it has been studied for its performance-enhancing capabilities in healthy populations and its therapeutic properties...
**Man et al., 2020** | Front Pharmacol | Systematic Review Man Changfeng, Dai Zhe, Fan Yu. Dazhu Hongjingtian Preparation as Adjuvant Therapy for Unstable Angina Pectoris: A Meta-Analysis of Randomized Controlled Trials. Front Pharmacol. 2020;11:213....
**Frost et al., 2025** | Front Pharmacol | Systematic Review Frost Rachael, Zamri Aiman, ... Walters Kate. Understanding the research landscape of over-the-counter herbal products, dietary supplements, and medications evaluated for depressive symptom...
**Sanz-Barrio et al., 2023** | Phytother Res | Systematic Review Sanz-Barrio Patricia M, Noreen Eric E, ... Pareja-Galeano Helios. Rhodiola rosea supplementation on sports performance: A systematic review of randomized controlled trials. Phytother Re...
Objectives: This study aims to evaluate the effects of short-term Rhodiola rosea supplementation on simulated game performance, perceived fatigue, and aerobic capacity in basketball players. Methods: A total of 48 professional male basketball players...
The aim of the study was to assess the efficacy of the standardised extract SHR-5 of roots of Rhodiola Rosea L. in the treatment of individuals suffering from stress-related fatigue. The phase III clinical trial took the form of a randomised, double-...
**Chu et al., 2014** | Zhongguo Zhong Xi Yi Jie He Za Zhi | Meta Analysis Chu Jian-Feng, Wu Guang-Wen, ... Hong Zhen-Feng. [A system review of randomized controlled trials on treating chronic stable angina by rhodiola]. Zhongguo Zhong Xi Yi Jie He Za...
**Gan et al., 2024** | Int J Biol Macromol | Systematic Review Gan Zhengkun, Fang Xiao, ... Tao Aien. Extraction, purification, structural characterization, and bioactivities of the genus Rhodiola L. polysaccharides: A review. Int J Biol Macromol. 20...
**Hung et al., 2011** | Phytomedicine | Systematic Review Hung Shao Kang, Perry Rachel, Ernst Edzard. The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials. Phytomedicine. 2011-Feb-15;18(4):235-44. doi...
**Lu et al., 2022** | Front Nutr | Systematic Review Lu Yao, Deng Bin, ... Lin Fengxia. Effects of Rhodiola Rosea Supplementation on Exercise and Sport: A Systematic Review. Front Nutr. 2022;9:856287. doi:10.3389/fnut.2022.856287 Rhodiola rosea (Gold...
**Zhang et al., 2023** | J Agric Food Chem | Meta Analysis Zhang Nan, Nao Jianfei, Dong Xiaoyu. Neuroprotective Mechanisms of Salidroside in Alzheimer's Disease: A Systematic Review and Meta-analysis of Preclinical Studies. J Agric Food Chem. 2023-No...
The effect of a combination of magnesium, vitamins B6, B9, B12, rhodiola and green tea/L-theanine (Mg-Teadiola) on stress was evaluated in chronically stressed, otherwise healthy individuals. Effects on stress-related quality-of-life parameters (slee...
BACKGROUND: This study investigated the effects of combined Rhodiola rosea (RHO) and caffeine (CAF) supplementation on lower limb explosive power and fatigue recovery in volleyball players, aiming to validate their potential synergistic effects. METH...
Objectives: To determine whether four weeks of Rhodiola rosea (RHO) supplementation improves intermittent exercise performance, post-exercise blood lactate concentrations, and decision-making under fatigue in competitive football players. Methods: Tw...
**Dwyer et al., 2011** | Altern Med Rev | Systematic Review Dwyer Anna V, Whitten Dawn L, Hawrelak Jason A. Herbal medicines, other than St. John's Wort, in the treatment of depression: a systematic review. Altern Med Rev. 2011-Mar;16(1):40-9 OBJECTI...
INTRODUCTION: Supplementation with Rhodiola Rosea (RR) and Cordyceps Sinensis (CS) has been shown to improve aerobic performance, but their influence on concurrent training (resistance training plus high intensity interval training) outcomes has not ...
**Yu et al., 2023** | Front Pharmacol | Systematic Review Yu Haichuan, Lei Ting, ... Liu Jian. Efficacy and safety of three species of Rhodiola L. in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis. Front Ph...
**Wang et al., 2025** | Front Nutr | Systematic Review Wang Xiaolin, Yang Xuezhen, ... Liu Yutong. The effect of Rhodiola rosea supplementation on endurance performance and related biomarkers: a systematic review and meta-analysis. Front Nutr. 2025;1...
This trial evaluated the impact of a Rhodiola rosea L. extract on self-reported anxiety, stress, cognition, and other mood symptoms. Eighty mildly anxious participants were randomized into two different groups of either Rhodiola rosea L (2 × 200 mg d...
Objective:The aim of this study is to investigate the effects of rhodiola rosea on oxidative stress, anxiety and depression in patients with OSA. Method:Ninety patients with moderate and severe OSA patients with negative emotions diagnosed by PSG, se...
Yu Liu, Zhengyang Zhang, Yongting Luo, Peng An, Jingyi Qi, Xu Zhang, Shuaishuai Zhou, Yongzhi Li, Chong Xu, Junjie Luo, and Jiaping Wang. Product of traditional Chinese medicine longgui yangxinwan protects the human body from altitude sickness damage...
**NCT ID**: NCT06853600 **Phase**: NA **Status**: COMPLETED **Enrollment**: 25 **Completion**: 2024-09-15
**NCT ID**: NCT07239960 **Phase**: NA **Status**: COMPLETED **Enrollment**: 48 **Completion**: 2024-12-20
**NCT ID**: NCT07366320 **Phase**: NA **Status**: COMPLETED **Enrollment**: 24 **Completion**: 2025-10-04
**NCT ID**: NCT07461402 **Phase**: NA **Status**: COMPLETED **Enrollment**: 100 **Completion**: 2025-12-04
**Sarris et al., 2007** | Phytother Res | Systematic Review Sarris Jerome. Herbal medicines in the treatment of psychiatric disorders: a systematic review. Phytother Res. 2007-Aug;21(8):703-16 This paper reports a critical review of 27 herbal medicin...
**NCT ID**: NCT07225413 **Phase**: NA **Status**: COMPLETED **Enrollment**: 27 **Completion**: 2022-12-31
**Punja et al., 2014** | PLoS One | Rct Punja Salima, Shamseer Larissa, ... Vohra Sunita. Rhodiola rosea for mental and physical fatigue in nursing students: a randomized controlled trial. PLoS One. 2014;9(9):e108416. doi:10.1371/journal.pone.0108416...
The purpose of the present study was to examine the acute effects of an herbal supplement containing a 70:30 blend of Rhaponticum carthamoides extract and Rhodiola rosea extract, respectively, on performance fatigability and the affective responses p...
BACKGROUND: Rhodiola rosea extract is purported to improve physical performance and support resilience to stress. Salidroside is considered to be one of the main constituents responsible for the ergogenic actions of R. rosea. However, R. rosea extrac...
**Spasov et al., 2000** | Phytomedicine | Rct Spasov A A, Wikman G K, ... Neumoin V V. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stres...
**Darbinyan et al., 2000** | Phytomedicine | Rct Darbinyan V, Kteyan A, ... Wagner H. Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance...
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Frequently Asked Questions
What is Rhodiola rosea and what does it do?
Rhodiola rosea is an adaptogenic herb used primarily to help the body manage the effects of stress and fatigue. There is moderate evidence suggesting it can help reduce stress-related fatigue and support physical and mental performance.
Can Rhodiola rosea help with fatigue and burnout?
Yes, there is moderate evidence that Rhodiola rosea can help reduce fatigue caused by stress. It may also help maintain strength and physical performance when you are experiencing mental fatigue.
Does Rhodiola rosea improve athletic performance?
There is moderate evidence that Rhodiola rosea can impact strength and performance in athletes, particularly under fatigue conditions. Some studies have specifically noted its potential effects on basketball performance.
Can Rhodiola rosea help with heart disease?
There is moderate evidence suggesting that specific herbal formulations containing Rhodiola may be effective in treating ischemic heart disease and unstable angina. However, these benefits are noted when used in specific, targeted formulations.
What is the recommended dose of Rhodiola rosea?
The available research does not provide an explicitly defined effective dose range for Rhodiola rosea. You should consult with a healthcare professional to determine an appropriate dose for your needs.
Are there any side effects or safety concerns with Rhodiola rosea?
No specific contraindications or side effects were explicitly detailed in the provided research. However, you should always consult a doctor before starting a new supplement to ensure it is safe for your specific health profile.
Does Rhodiola rosea interact with any medications?
There are currently no documented drug interactions for Rhodiola rosea in the available research. Despite this, it is important to speak with a physician before use if you are taking any prescription medications.
Answers generated from research evidence. Not medical advice.