Black Cumin Seed (Nigella sativa) is being researched for its potential therapeutic effects on metabolic and endocrine health. Current studies focus on its impact on lipid profiles, glucose regulation, and polycystic ovarian syndrome (PCOS).

Evidence by Condition

Hyperlipidemia Insufficient

Clinical trials are investigating the efficacy of Nigella sativa supplementation in the treatment of high lipid levels.

Dysglycemia Insufficient

Research is exploring the impact of Nigella sativa oil and Vitamin E on glyco-lipid parameters in perimenopausal women.

Polycystic Ovarian Syndrome (PCOS) Insufficient

A randomized controlled trial investigated the short-term management of PCOS in adolescents using Nigella sativa.

Effective Doses

Dose ranges are not specified in the provided research.

Key Findings

Nigella sativa oil combined with Vitamin E is being studied for its effect on glyco-lipid parameters in perimenopausal women (NCT06901076).
Nigella sativa supplementation is being evaluated as a treatment for hyperlipidemia (NCT06890546).
Nigella sativa has been investigated for its potential role in the management of adolescent PCOS (PMID:38997723).

Limitations

The current body of evidence is limited to a small number of clinical trials and an RCT, with much of the research focused on trial registration and preliminary investigation.

Safety & Interactions

No specific interactions or contraindications were provided in the source text.

AI-generated summary from 3 peer-reviewed studies. Not medical advice. Always consult a healthcare provider.

Claims vs. Evidence

67% Evidence-Backed

33% Unsupported

75% Structure/Function

Claim Type	% of Products	Evidence Required	Status
All Other	99%	Tier D (Unclassified)	✅ Supported
Structure/Function	75%	Tier C (DSHEA Structure/Function (no pre-approval))	⚠️ Unsupported
Nutrient	55%	Tier D (Unknown)	✅ Supported

Research by Topic

Dietary Supplement General 2 studies

CLI Effect of a Food Supplement Based on Nigella Sativa Seeds Oi...

CLI Nigella Sativa Supplementation in Hyperlipidemia Treatment

Dhea 1 studies

RCT The possible short-term of Nigella sativa - L in the managem...

Research Evidence (3)

Clinical Trial: 2 Rct: 1

C Effect of a Food Supplement Based on Nigella Sativa Seeds Oil and Vitamin E on Glyco-lipid Parameters in Dysglycemic and Dyslipidemic Perimenopausal Women

Clinical Trial ClinicalTrials.gov 2024

**NCT ID**: NCT06901076 **Phase**: NA **Status**: COMPLETED **Enrollment**: 120 **Completion**: 2025-02-11

ClinicalTrials.gov

C Nigella Sativa Supplementation in Hyperlipidemia Treatment

Clinical Trial ClinicalTrials.gov 2023

**NCT ID**: NCT06890546 **Phase**: NA **Status**: COMPLETED **Enrollment**: 64 **Completion**: 2025-02-28

ClinicalTrials.gov

C The possible short-term of Nigella sativa - L in the management of adolescent polycystic ovarian syndrome: results of a randomized controlled trial.

Rct Journal of ovarian research

BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive age and the most common cause of infertility due to anovulation. PCOS in adolescents is concerning. Nigella sativa is effective in improving gonadotrop...

PubMed DOI

Related Supplements

Vitamin E 1 shared sources Dhea 1 shared sources

Frequently Asked Questions

What is Black Cumin Seed and what is it used for?

Black Cumin Seed, also known as Nigella sativa, is a supplement being researched for its potential impact on metabolic and endocrine health. Current evidence for its specific health benefits is considered weak as more clinical research is needed.

Can Black Cumin Seed help lower cholesterol?

There is currently insufficient evidence to confirm if Black Cumin Seed effectively treats hyperlipidemia (high lipid levels). Clinical trials are still investigating its efficacy for this purpose.

Does Black Cumin Seed help with PCOS?

Research has investigated the use of Black Cumin Seed for the short-term management of Polycystic Ovarian Syndrome (PCOS) in adolescents. However, the current evidence for this use is considered weak.

Can Black Cumin Seed help regulate blood sugar?

Studies are exploring the impact of Black Cumin Seed oil and Vitamin E on glucose and lipid parameters in perimenopausal women. At this time, there is insufficient evidence to support its use for dysglycemia.

What is the recommended dose of Black Cumin Seed?

There are currently no specific effective dose ranges established in the available research. You should consult a healthcare professional to determine an appropriate dosage for your needs.

Is Black Cumin Seed safe to take and are there any side effects?

No specific safety concerns, contraindications, or upper limits were identified in the provided research. However, you should always consult a doctor before starting a new supplement.

Are there any drug interactions with Black Cumin Seed?

There are currently no documented drug interactions for Black Cumin Seed. However, it is important to speak with your physician if you are taking any prescription medications.

Answers generated from research evidence. Not medical advice.