Quercetin
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Evidence Summary
Quercetin is a flavonoid polyphenol with diverse antioxidant and anti-inflammatory properties. Research indicates potential benefits for metabolic health, lipid profiles, and skin conditions, although its clinical efficacy is often hindered by low bioavailability.
Evidence by Condition
Meta-analyses suggest quercetin supplementation can positively impact lipid profiles, glucose levels, and inflammatory markers.
Evidence indicates potential for quercetin to influence plasma blood pressure levels.
Meta-analysis supports its use as a therapeutic agent for inflammation, wound healing, and hyperpigmentation.
Systematic reviews have found inconclusive results regarding quercetin's impact on endurance performance.
Current evidence for the prevention of periodontal disease is limited to animal models.
Effective Doses
Dose ranges are not explicitly provided in the provided research abstracts.
Key Findings
- Quercetin supplementation affects lipid profiles and inflammatory markers in patients with metabolic syndrome (PMID: 31017459).
- Quercetin may influence plasma lipid profiles, blood pressure, and glucose levels (PMID: 31940027).
- Quercetin shows therapeutic potential for various skin problems, including inflammation and wound healing (PMID: 39738831).
- A significant limitation to the health benefits of quercetin is its low bioavailability (PMID: 39596162).
Limitations
The primary limitation in quercetin research is its low bioavailability. Furthermore, much of the evidence for specific conditions like periodontal disease is currently restricted to animal models.
Safety & Interactions
No specific contraindications or drug interactions were detailed in the provided research summaries.
AI-generated summary from 184 peer-reviewed studies. Not medical advice. Always consult a healthcare provider.
Claims vs. Evidence
| Claim Type | % of Products | Evidence Required | Status |
|---|---|---|---|
| All Other | 99% | Tier D (Unclassified) | ✅ Supported |
| Structure/Function | 84% | Tier C (DSHEA Structure/Function (no pre-approval)) | ✅ Supported |
| Nutrient | 23% | Tier D (Unknown) | ✅ Supported |
| Qualified Health | 1% | Tier B (FDA Qualified Health Claim) | ✅ Supported |
| No Claim | 1% | Tier D (No claim on label) | ✅ Supported |
🏛️ NIH ODS Factsheet
Research by Topic
⚠️ FDA Safety Data
Research Evidence (184)
**Qu et al., 2024** | Medicine (Baltimore) | Meta Analysis Qu Pengda, Du Shiyu, ... Tang Xiaohu. Treatment of gouty arthritis with traditional Chinese medicine decoction: Meta-analysis, network pharmacology analysis, and molecular docking. Medicine (...
**Sahebkar et al., 2017** | Crit Rev Food Sci Nutr | Meta Analysis Sahebkar Amirhossein. Effects of quercetin supplementation on lipid profile: A systematic review and meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2017-Mar-04...
**Ramaiah et al., 2024** | BMC Endocr Disord | Meta Analysis Ramaiah Pushpamala, Baljon Kamilya Jamel, ... Garousi Nazila. Dietary polyphenols and the risk of metabolic syndrome: a systematic review and meta-analysis. BMC Endocr Disord. 2024-Mar-01;2...
**Kressler et al., 2011** | Med Sci Sports Exerc | Meta Analysis Kressler Jochen, Millard-Stafford Melinda, Warren Gordon L. Quercetin and endurance exercise capacity: a systematic review and meta-analysis. Med Sci Sports Exerc. 2011-Dec;43(12):2396-...
**Woo et al., 2013** | PLoS One | Meta Analysis Woo Hae Dong, Kim Jeongseon. Dietary flavonoid intake and smoking-related cancer risk: a meta-analysis. PLoS One. 2013;8(9):e75604. doi:10.1371/journal.pone.0075604 PURPOSE: To systematically investigat...
**Qu et al., 2023** | Medicine (Baltimore) | Meta Analysis Qu Pengda, Wang Haiyang, ... Tang Xiaohu. Clinical efficacy evaluation and potential mechanism prediction on Guizhi-Shaoyao-Zhimu decoction in the treatment of gouty arthritis based on meta-a...
**Frenț et al., 2024** | Int J Mol Sci | Systematic Review Frenț Olimpia-Daniela, Stefan Liana, ... Manole Felicia. A Systematic Review: Quercetin-Secondary Metabolite of the Flavonol Class, with Multiple Health Benefits and Low Bioavailability. Int ...
BACKGROUND: Flavonoids are polyphenolic compounds that are distributed widely in the plant kingdom; they are especially abundant in fruits and vegetables. More than 5,000 individual flavonoids have been identified and classified into more than 10 sub...
BACKGROUND: Venous leg ulcers are a major health burden: annually, in the UK alone, they contribute an estimated cost to the NHS of GBP 400 million. Flavonoids are a diverse group of naturally-occurring venotonic compounds that address certain microc...
**Tabrizi et al., 2020** | Crit Rev Food Sci Nutr | Meta Analysis Tabrizi Reza, Tamtaji Omid Reza, ... Asemi Zatollah. The effects of quercetin supplementation on lipid profiles and inflammatory markers among patients with metabolic syndrome and rela...
**Huang et al., 2020** | Nutr Rev | Meta Analysis Huang Haohai, Liao Dan, ... Pu Rong. Effect of quercetin supplementation on plasma lipid profiles, blood pressure, and glucose levels: a systematic review and meta-analysis. Nutr Rev. 2020-Aug-01;78(8...
**Kaul et al., 2021** | Int J Mol Sci | Systematic Review Kaul Ridhima, Paul Pradipta, ... Chaari Ali. Promising Antiviral Activities of Natural Flavonoids against SARS-CoV-2 Targets: Systematic Review. Int J Mol Sci. 2021-Oct-14;22(20). doi:10.3390/...
**Weng et al., 2023** | Ann Med | Systematic Review Weng Jiao, Wu Xiu-Fang, ... Wang Cai-Xia. Medicine for chronic atrophic gastritis: a systematic review, meta- and network pharmacology analysis. Ann Med. 2023;55(2):2299352. doi:10.1080/07853890.202...
**Laky et al., 2024** | Nutrients | Meta Analysis Laky Markus, Arslan Muazzez, ... Eick Sigrun. Quercetin in the Prevention of Induced Periodontal Disease in Animal Models: A Systematic Review and Meta-Analysis. Nutrients. 2024-Mar-04;16(5). doi:10.3...
**Okselni et al., 2025** | Naunyn Schmiedebergs Arch Pharmacol | Meta Analysis Okselni Tia, Septama Abdi Wira, ... Saputri Ariyanti. Quercetin as a therapeutic agent for skin problems: a systematic review and meta-analysis on antioxidant effects, oxi...
**Memarpour et al., 2025** | Clin Exp Dent Res | Meta Analysis Memarpour Mahtab, Afzali Baghdadabadi Neda, ... Bardideh Erfan. Preventive and Therapeutic Effects of Plant-Derived Compounds on Tooth Erosion: A Systematic Review and Meta-Analysis of In...
**Tan et al., 2025** | Front Biosci (Landmark Ed) | Meta Analysis Tan Zhiguo, Chen Yu, ... Chen Xu. Integration of Meta-Analysis and Network Pharmacology to Investigate the Pharmacological Mechanisms of Quercetin on Hepatocellular Carcinoma. Front Bi...
**Zhang et al., 2026** | Phytomedicine | Systematic Review Zhang Le-Le, Wang Jiao-Jiao, ... Sheng Feiya. A comprehensive systematic review on polyphenols acting against major chronic ocular diseases and their mechanisms of action. Phytomedicine. 2026...
**Peluso et al., 2015** | Crit Rev Food Sci Nutr | Systematic Review Peluso Ilaria, Miglio Cristiana, ... Serafini Mauro. Flavonoids and immune function in human: a systematic review. Crit Rev Food Sci Nutr. 2015;55(3):383-95. doi:10.1080/10408398.20...
**Ou et al., 2020** | Int J Food Sci Nutr | Meta Analysis Ou Qiaowen, Zheng Zhifen, ... Lin Weiqun. Impact of quercetin on systemic levels of inflammation: a meta-analysis of randomised controlled human trials. Int J Food Sci Nutr. 2020-Mar;71(2):152...
**Micek et al., 2021** | Mol Nutr Food Res | Meta Analysis Micek Agnieszka, Godos Justyna, ... Grosso Giuseppe. Dietary Flavonoids and Cardiovascular Disease: A Comprehensive Dose-Response Meta-Analysis. Mol Nutr Food Res. 2021-Mar;65(6):e2001019. do...
**Zhang et al., 2022** | J Ethnopharmacol | Meta Analysis Zhang Chi, Guo Wei, ... Lin Lizhu. Database mining and animal experiment-based validation of the efficacy and mechanism of Radix Astragali (Huangqi) and Rhizoma Atractylodis Macrocephalae (Bai...
**Schnarr et al., 2022** | Sci Total Environ | Systematic Review Schnarr Lena, Segatto Mateus L, ... Kümmerer Klaus. Flavonoids as biopesticides - Systematic assessment of sources, structures, activities and environmental fate. Sci Total Environ. 202...
**Wu et al., 2024** | Medicine (Baltimore) | Meta Analysis Wu Xiaozheng, Li Wen, ... Chen Yunzhi. Exploring the efficacy and molecular mechanism of Danhong injection comprehensively in the treatment of idiopathic pulmonary fibrosis by combining meta-...
**Gonfa et al., 2025** | Z Naturforsch C J Biosci | Systematic Review Gonfa Yilma Hunde, Bachheti Archana, ... Bachheti Rakesh Kumar. Hepatoprotective activity of medicinal plants, their phytochemistry, and safety concerns: a systematic review. Z Nat...
**Menezes et al., 2017** | Nutrients | Meta Analysis Menezes Regina, Rodriguez-Mateos Ana, ... Pinto Paula. Impact of Flavonols on Cardiometabolic Biomarkers: A Meta-Analysis of Randomized Controlled Human Trials to Explore the Role of Inter-Indivi...
**Micek et al., 2021** | Int J Food Sci Nutr | Meta Analysis Micek Agnieszka, Raźny Urszula, Paweł Kawalec. Association between health risk factors and dietary flavonoid intake in cohort studies. Int J Food Sci Nutr. 2021-Dec;72(8):1019-1034. doi:10....
**Zhu et al., 2024** | Nutr Neurosci | Systematic Review Zhu Ke, Zheng Zhong, ... Cui Xue-Jun. A comprehensive and systematic review of the potential neuroprotective effect of quercetin in rat models of spinal cord injury. Nutr Neurosci. 2024-Aug;27(...
**Liang et al., 2025** | Ren Fail | Meta Analysis Liang Huiyu, Chen Zedong, ... Xiao Ya. Efficacy and potential pharmacological mechanism of Astragalus-Salvia miltiorrhiza combination in diabetic nephropathy: integrating meta-analysis, network pharma...
**Ji et al., 2025** | Front Cardiovasc Med | Systematic Review Ji Kangshou, Han Meizi, ... Zhang Yan. Integrated meta-analysis and network pharmacology analysis: evaluation of Zhigancao decoction as treatment for diabetic cardiomyopathy. Front Cardio...
**Zhong et al., 2025** | BMC Pregnancy Childbirth | Meta Analysis Zhong Ting, Sun Jihan, ... Sun Guiju. The mechanism of probiotics in pregnancy outcomes in overweight or obese pregnant women based on meta-analysis, network pharmacology and molecular...
**Chen et al., 2026** | Int J Mol Sci | Meta Analysis Chen Daiqian, Wang Jiawei, ... Zou Wenjun. Evidence Synthesis and Mechanism Analysis of Quercetin Treatment for Atherosclerosis: A Preclinical Systematic Review and Meta-Analysis. Int J Mol Sci. 2...
**Serban et al., 2016** | J Am Heart Assoc | Meta Analysis Serban Maria-Corina, Sahebkar Amirhossein, ... Banach Maciej. Effects of Quercetin on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc. ...
**Mohammadi-Sartang et al., 2017** | Eur J Clin Nutr | Meta Analysis Mohammadi-Sartang M, Mazloom Z, ... Firoozi Donya. Effects of supplementation with quercetin on plasma C-reactive protein concentrations: a systematic review and meta-analysis of ra...
**Fernández-Palanca et al., 2019** | Nutrients | Systematic Review Fernández-Palanca Paula, Fondevila Flavia, ... Mauriz José L. Antitumor Effects of Quercetin in Hepatocarcinoma In Vitro and In Vivo Models: A Systematic Review. Nutrients. 2019-Nov-2...
**Lacerda et al., 2022** | Nutr Neurosci | Systematic Review Lacerda D C, Urquiza-Martínez M V, ... Guzmán-Quevedo O. Metabolic and neurological consequences of the treatment with polyphenols: a systematic review in rodent models of noncommunicable d...
**Popiolek-Kalisz et al., 2022** | Curr Probl Cardiol | Meta Analysis Popiolek-Kalisz Joanna, Fornal Emilia. The Effects of Quercetin Supplementation on Blood Pressure - Meta-Analysis. Curr Probl Cardiol. 2022-Nov;47(11):101350. doi:10.1016/j.cpcardi...
**Inchingolo et al., 2022** | Nutrients | Systematic Review Inchingolo Alessio Danilo, Inchingolo Angelo Michele, ... Dipalma Gianna. Effects of Resveratrol, Curcumin and Quercetin Supplementation on Bone Metabolism-A Systematic Review. Nutrients. 20...
**Bai et al., 2024** | Front Pharmacol | Systematic Review Bai Chen, Wang Junyi, ... Guo Rongjuan. Exploration of the mechanism of Traditional Chinese Medicine for anxiety and depression in patients with diarrheal irritable bowel syndrome based on ne...
**Monici et al., 2024** | Eur J Oral Sci | Systematic Review Monici Silva Isabela, Barbosa Cecília de Brito, ... Dame-Teixeira Naile. Effects of cross-linking agents on hydroxyproline release and root caries lesion size: Systematic review and network...
**Wang et al., 2025** | Front Aging Neurosci | Systematic Review Wang Xiaofang, Li Zhenyu, ... Jia Qianfang. Research progress on microglial pyroptosis and inflammasomes: a comprehensive analysis. Front Aging Neurosci. 2025;17:1582579. doi:10.3389/fn...
**Lai et al., 2025** | J Allergy Clin Immunol Pract | Meta Analysis Lai Yun-Ru, Liao Yi-Hsueh, ... Chen Yang-Ching. Clinical Effects of Polyphenolic Compounds on Allergic Rhinitis: A Systematic Review and Meta-Analysis. J Allergy Clin Immunol Pract. ...
**Peluso et al., 2013** | Mol Nutr Food Res | Meta Analysis Peluso Ilaria, Raguzzini Anna, Serafini Mauro. Effect of flavonoids on circulating levels of TNF-α and IL-6 in humans: a systematic review and meta-analysis. Mol Nutr Food Res. 2013-May;57(5...
**Chang et al., 2018** | Nutrients | Meta Analysis Chang Hui, Lei Lin, ... Zhao Guohua. Dietary Flavonoids and the Risk of Colorectal Cancer: An Updated Meta-Analysis of Epidemiological Studies. Nutrients. 2018-Jul-23;10(7). doi:10.3390/nu10070950 Ai...
**Zhang et al., 2020** | Int J Mol Sci | Systematic Review Zhang Xiao-Wen, Chen Jia-Yue, ... Lu Jia-Hong. Quercetin in Animal Models of Alzheimer's Disease: A Systematic Review of Preclinical Studies. Int J Mol Sci. 2020-Jan-13;21(2). doi:10.3390/ijm...
**Gandhi et al., 2020** | Nutrients | Systematic Review Gandhi Gopalsamy Rajiv, Vasconcelos Alan Bruno Silva, ... Gan Ren-You. Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro...
**Kubina et al., 2021** | Nutrients | Systematic Review Kubina Robert, Iriti Marcello, Kabała-Dzik Agata. Anticancer Potential of Selected Flavonols: Fisetin, Kaempferol, and Quercetin on Head and Neck Cancers. Nutrients. 2021-Mar-05;13(3). doi:10.33...
**Zhu et al., 2021** | Am J Chin Med | Meta Analysis Zhu Ying, Yu Jieru, ... Ruan Shanming. Network Pharmacology Analysis to Explore the Pharmacological Mechanism of Effective Chinese Medicines in Treating Metastatic Colorectal Cancer using Meta-Anal...
**Cassotta et al., 2025** | Nutrients | Systematic Review Cassotta Manuela, Cao Qingwei, ... Giampieri Francesca. Yerba Mate (Ilex paraguariensis) and Rheumatoid Arthritis: A Systematic Review of Mechanistic and Clinical Evidence. Nutrients. 2025-Dec...
**Aziz et al., 2015** | J Clin Pharm Ther | Meta Analysis Aziz Z, Tang W L, ... Tho L Y. A systematic review of the efficacy and tolerability of hydroxyethylrutosides for improvement of the signs and symptoms of chronic venous insufficiency. J Clin P...
Showing top 50 of 184 sources, sorted by quality score.
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Frequently Asked Questions
What is Quercetin and how does it work?
Quercetin is a flavonoid polyphenol that possesses antioxidant and anti-inflammatory properties. It is primarily studied for its potential to support metabolic health, blood pressure, and skin conditions.
Can Quercetin help lower blood pressure and improve cholesterol?
There is moderate evidence suggesting that quercetin may positively impact lipid profiles, glucose levels, and blood pressure. However, its effectiveness may be limited by the supplement's low bioavailability in the body.
Is Quercetin good for skin health?
Yes, there is moderate evidence supporting the use of quercetin as a therapeutic agent for skin inflammation, wound healing, and hyperpigmentation. It works through its natural anti-inflammatory properties.
Does Quercetin improve athletic performance?
The evidence regarding quercetin's impact on endurance exercise capacity is currently weak. Systematic reviews have found the results regarding its impact on performance to be inconclusive.
Are there any known drug interactions or safety concerns with Quercetin?
No specific drug interactions or contraindications were documented in the available research. However, because its bioavailability is low, you should consult a healthcare provider before use.
What is the recommended dose of Quercetin?
Specific effective dose ranges are not explicitly provided in the current research summaries. You should consult a medical professional to determine an appropriate dose for your needs.
Can Quercetin prevent periodontal disease?
There is currently insufficient evidence to support the use of quercetin for preventing periodontal disease in humans. Current research in this area has been limited to animal models.
Answers generated from research evidence. Not medical advice.