Quercetin
Also known as flavonoid, quercetin, quercetin glycoside
Key takeaways
- Quercetin supplementation significantly affects lipid profiles in patients with metabolic syndrome (PMID: 31017459).
- Dietary flavonoids are associated with a reduced risk of metabolic syndrome (PMID: 38429765).
- Quercetin shows potential as a therapeutic agent for skin problems, specifically regarding antioxidant effects and wound healing (PMID: 39738831).
What the research shows
AI-synthesized from 184 peer-reviewed sources · Updated 2025
Quercetin is a flavonoid polyphenol found in various plants with known antioxidant and anti-inflammatory properties. Research suggests it may provide benefits for lipid profiles, metabolic syndrome, and inflammatory conditions, though bioavailability remains a significant challenge.
By condition
Lipid Profile/Metabolic Syndrome
Moderate
Meta-analyses indicate that quercetin supplementation can positively influence plasma lipid profiles and markers of metabolic syndrome.
Gouty Arthritis
Moderate
Evidence from network pharmacology and meta-analyses suggests efficacy when used as part of traditional Chinese medicine decoctions.
Skin Health
Moderate
Research indicates potential therapeutic benefits for wound healing, oxidative stress, and inflammation in skin conditions.
Endurance Exercise Capacity
Weak
Systematic reviews show limited or inconsistent evidence regarding its ability to improve endurance capacity.
Periodontal Disease
Weak
Preventative effects have been observed primarily in animal models rather than human clinical trials.
Effective doses
Specific dose ranges were not detailed in the provided abstracts; however, it is typically administered as a supplement or within herbal decoctions.
Safety & interactions
Generally considered safe, but users should consult a provider regarding potential interactions with medications for blood pressure or glucose levels.
Limitations
Many findings are based on meta-analyses of small sample sizes or animal models, and the low bioavailability of quercetin limits its clinical efficacy.
Top-rated Quercetin products
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How it's sold
Data aggregated from 426 product labels
Research evidence
Showing top 10 of 184 sources, sorted by quality
**Qu et al., 2024** | Medicine (Baltimore) | Meta Analysis Qu Pengda, Du Shiyu, ... Tang Xiaohu. Treatment of gouty arthritis with traditional Chinese medicine decoction: Meta-analysis, network pharmacology analysis, and molecular docking. …
**Sahebkar et al., 2017** | Crit Rev Food Sci Nutr | Meta Analysis Sahebkar Amirhossein. Effects of quercetin supplementation on lipid profile: A systematic review and meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2…
**Ramaiah et al., 2024** | BMC Endocr Disord | Meta Analysis Ramaiah Pushpamala, Baljon Kamilya Jamel, ... Garousi Nazila. Dietary polyphenols and the risk of metabolic syndrome: a systematic review and meta-analysis. BMC Endocr Disord. 202…
**Kressler et al., 2011** | Med Sci Sports Exerc | Meta Analysis Kressler Jochen, Millard-Stafford Melinda, Warren Gordon L. Quercetin and endurance exercise capacity: a systematic review and meta-analysis. Med Sci Sports Exerc. 2011-Dec;43…
**Woo et al., 2013** | PLoS One | Meta Analysis Woo Hae Dong, Kim Jeongseon. Dietary flavonoid intake and smoking-related cancer risk: a meta-analysis. PLoS One. 2013;8(9):e75604. doi:10.1371/journal.pone.0075604 PURPOSE: To systematically …
**Qu et al., 2023** | Medicine (Baltimore) | Meta Analysis Qu Pengda, Wang Haiyang, ... Tang Xiaohu. Clinical efficacy evaluation and potential mechanism prediction on Guizhi-Shaoyao-Zhimu decoction in the treatment of gouty arthritis based…
**Frenț et al., 2024** | Int J Mol Sci | Systematic Review Frenț Olimpia-Daniela, Stefan Liana, ... Manole Felicia. A Systematic Review: Quercetin-Secondary Metabolite of the Flavonol Class, with Multiple Health Benefits and Low Bioavailabi…
BACKGROUND: Flavonoids are polyphenolic compounds that are distributed widely in the plant kingdom; they are especially abundant in fruits and vegetables. More than 5,000 individual flavonoids have been identified and classified into more t…
BACKGROUND: Venous leg ulcers are a major health burden: annually, in the UK alone, they contribute an estimated cost to the NHS of GBP 400 million. Flavonoids are a diverse group of naturally-occurring venotonic compounds that address cert…
**Tabrizi et al., 2020** | Crit Rev Food Sci Nutr | Meta Analysis Tabrizi Reza, Tamtaji Omid Reza, ... Asemi Zatollah. The effects of quercetin supplementation on lipid profiles and inflammatory markers among patients with metabolic syndrom…
Frequently asked questions
What is quercetin and what is it used for?
Quercetin is a flavonoid polyphenol found in various plants, known for its antioxidant and anti-inflammatory properties. It is commonly used to support lipid profiles, manage metabolic syndrome, and address inflammatory conditions like gouty arthritis and skin health issues.
Does quercetin help with cholesterol or metabolic syndrome?
Yes, there is moderate evidence suggesting quercetin supplementation can positively influence plasma lipid profiles and markers of metabolic syndrome. Research indicates it may help improve these health markers, though it should not replace prescribed medications.
Is quercetin effective for gouty arthritis?
There is moderate evidence supporting its efficacy, particularly when used as part of traditional Chinese medicine decoctions. Network pharmacology and meta-analyses suggest it can be a helpful component in treating gouty arthritis.
Can quercetin improve skin health or wound healing?
Research indicates moderate evidence for potential therapeutic benefits in skin health, specifically regarding oxidative stress, inflammation, and wound healing. Its antioxidant effects may support skin recovery, but it is not a standalone cure for skin diseases.
Does quercetin improve endurance exercise capacity?
The evidence for this is weak, as systematic reviews show limited or inconsistent results regarding its ability to improve endurance capacity. Consumers should not rely on quercetin as a proven performance enhancer for exercise.
Is quercetin safe to take with other medications?
While generally considered safe, users should consult a healthcare provider regarding potential interactions with medications for blood pressure or glucose levels. Although no specific drug interactions are documented in the summary, caution is advised for those on prescription drugs.
Who should avoid taking quercetin supplements?
Individuals taking medications for blood pressure or glucose levels should consult a provider before use due to potential interactions. Additionally, because specific safety data for pregnant or breastfeeding individuals is not detailed, they should seek medical advice before supplementation.