Dandelion
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Evidence Summary
Dandelion (Taraxacum species) is being researched primarily for its potential antitumor properties across various cancer cell lines. Current evidence focuses on its ability to induce cytotoxicity and disrupt tumor-associated pathways in vitro.
Evidence by Condition
In vitro studies suggest dandelion extracts may exhibit antitumor effects and induce cell death in breast, lung, and colorectal cancer cells.
Effective Doses
Not available from the provided research
Key Findings
- Taraxacum officinale extract shows antitumor effects on pediatric cancer cells and enhances mistletoe therapy (PMID: 30219442)
- Taraxacum mongolicum extract disrupts the interaction between triple-negative breast cancer cells and tumor-associated macrophages (PMID: 40199407)
- Combined dandelion extract and all-trans retinoic acid induces cytotoxicity in human breast cancer cells (PMID: 37700002)
- Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signaling pathways (PMID: 27564258)
Limitations
All provided studies are in vitro (cell-based) research, meaning the findings have not yet been established in human clinical trials.
Safety & Interactions
No specific safety or interaction data was provided in the research summaries.
AI-generated summary from 5 peer-reviewed studies. Not medical advice. Always consult a healthcare provider.
Claims vs. Evidence
| Claim Type | % of Products | Evidence Required | Status |
|---|---|---|---|
| All Other | 98% | Tier D (Unclassified) | ✅ Supported |
| Structure/Function | 80% | Tier C (DSHEA Structure/Function (no pre-approval)) | ⚠️ Unsupported |
| Nutrient | 6% | Tier D (Unknown) | ✅ Supported |
| No Claim | 2% | Tier D (No claim on label) | ✅ Supported |
Research by Topic
Research Evidence (5)
**Menke et al., 2018** | Complement Ther Med | Other Menke K, Schwermer M, ... Zuzak T J. Taraxacum officinale extract shows antitumor effects on pediatric cancer cells and enhance mistletoe therapy. Complement Ther Med. 2018-Oct;40:158-164. doi:10.1...
**Li et al., 2025** | J Ethnopharmacol | Other Li Xinrui, Guo Yang, ... Han Shuyan. Taraxacum mongolicum Hand.-Mazz. extract disrupts the interaction between triple-negative breast cancer cells and tumor-associated macrophages by inhibiting RAC2/NF-κ...
**Man et al., 2022** | Biomed Chromatogr | Other Man Jin, Wu Longjie, ... Tian Yongmei. Revealing the metabolic mechanism of dandelion extract against A549 cells using UPLC-QTOF MS. Biomed Chromatogr. 2022-Mar;36(3):e5272. doi:10.1002/bmc.5272 Dandel...
**Rezaie et al., 2023** | Sci Rep | Other Rezaie Hamed, Alipanah-Moghadam Reza, ... Nemati Ali. Combined dandelion extract and all-trans retinoic acid induces cytotoxicity in human breast cancer cells. Sci Rep. 2023-Sep-12;13(1):15074. doi:10.1038/s4...
**Ovadje et al., 2016** | Oncotarget | Other Ovadje Pamela, Ammar Saleem, ... Pandey Siyaram. Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways. Oncotarget. 2016-N...
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Frequently Asked Questions
What is dandelion supplement and what is it used for?
Dandelion (Taraxacum species) is a plant being researched for its potential antitumor properties. Current evidence is weak, as most studies focus on how the extract affects cancer cell lines in a laboratory setting.
Does dandelion work for cancer?
There is insufficient evidence to determine if dandelion works for cancer in humans. While laboratory studies suggest it may induce cell death in breast, lung, and colorectal cancer cells, these results have not been proven in clinical trials.
What are the potential benefits of dandelion extract?
Research indicates that dandelion extract may disrupt tumor-associated pathways and induce cytotoxicity in certain cancer cells. However, the strength of this evidence is weak because it is currently limited to in vitro studies.
What is the effective dose of dandelion for health benefits?
There is currently no available information regarding an effective dose of dandelion for the conditions being researched. Clinical dosing standards have not yet been established in the provided research.
Is dandelion safe to take?
No specific safety or toxicity data was provided in the current research summaries. You should consult a healthcare professional to determine if it is safe for your individual health needs.
Are there any drug interactions with dandelion?
No drug interactions have been documented for dandelion in the provided research. However, you should always consult a doctor before starting a new supplement, especially if you are taking prescription medications.
Who should avoid dandelion supplements?
There is no specific information regarding who should avoid dandelion. Because research is limited to laboratory settings, anyone with underlying health conditions or those undergoing medical treatments should consult a physician before use.
Answers generated from research evidence. Not medical advice.