Paba
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Evidence Summary
Para-aminobenzoic acid (PABA) is a compound historically investigated for its potential use in treating dermatological conditions and as a biochemical marker. Current research evidence is limited, focusing primarily on its utility in diagnostic testing and historical case studies rather than modern therapeutic applications.
Evidence by Condition
Historical studies explored the use of PABA in treating specific skin diseases, but modern clinical evidence is lacking.
Research has investigated the diagnostic value of serum PABA levels in relation to pancreatic disease.
Effective Doses
No therapeutic dose ranges for health conditions were reported in the provided research.
Key Findings
- PABA can be used as a marker to assess the completeness of 24-hour urine collections (PMID: 12548308)
- Serum PABA determination may have diagnostic value in pancreatic disease (PMID: 2698170)
- Historical studies investigated PABA therapy for lymphoblastoma cutis and mycosis fungoides (PMID: 13126914)
Limitations
The available research is largely historical or focused on diagnostic utility, with a significant lack of recent randomized controlled trials for therapeutic use.
Safety & Interactions
No specific interactions or contraindications were identified in the provided study abstracts.
AI-generated summary from 7 peer-reviewed studies. Not medical advice. Always consult a healthcare provider.
Claims vs. Evidence
| Claim Type | % of Products | Evidence Required | Status |
|---|---|---|---|
| All Other | 100% | Tier D (Unclassified) | ✅ Supported |
| Structure/Function | 92% | Tier C (DSHEA Structure/Function (no pre-approval)) | ⚠️ Unsupported |
| Nutrient | 35% | Tier D (Unknown) | ✅ Supported |
Research by Topic
Research Evidence (7)
**Jakobsen et al., 2003** | Eur J Clin Nutr | Rct Jakobsen J, Pedersen A N, Ovesen L. Para-aminobenzoic acid (PABA) used as a marker for completeness of 24 hour urine: effects of age and dosage scheduling. Eur J Clin Nutr. 2003-Jan;57(1):138-42 OBJEC...
**von et al., 1989** | Gastroenterol J | Rct von Kleist D, Rössler W, ... Hampel K E. [The diagnostic value of serum PABA determination in pancreatic disease and in relation to anticholinergic medication]. Gastroenterol J. 1989;49(3):108-12 PABA-seru...
**ZARAFONETIS et al., 1948** | J Lab Clin Med | Other ZARAFONETIS C J D. Para-aminobenzoic acid therapy in scleroderma and lymphoblastoma cutis. J Lab Clin Med. 1948-Nov;33(11):1462 *No abstract available* *Requires manual extraction from full text* ...
**Mackie et al., 1999** | Australas J Dermatol | Other Mackie B S, Mackie L E. The PABA story. Australas J Dermatol. 1999-Feb;40(1):51-3 The qualities of para-aminobenzoic acid (PABA) are discussed and an account is given of how it came to be the fav...
**GRAYSON et al., 1952** | J Invest Dermatol | Other GRAYSON L D, STEINER K. Sodium para-aminobenzoate PABA in the treatment of dermatoses. J Invest Dermatol. 1952-Dec;19(6):463-6 *No abstract available* *Requires manual extraction from full text* - ...
**ZARAFONETIS et al., 1954** | Cancer | Other ZARAFONETIS C J, CURTIS A C, KIRKMAN L W. Para-aminobenzoic acid therapy in lymphoblastoma cutis and mycosis fungoides. Cancer. 1954-Jan;7(1):190-201 *No abstract available* *Requires manual extraction fr...
**Allen et al., 1996** | J Photochem Photobiol B | Other Allen J M, Gossett C J, Allen S F. Photochemical formation of singlet molecular oxygen (1O2) in illuminated aqueous solutions of p-aminobenzoic acid (PABA). J Photochem Photobiol B. 1996-Jan;32...
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Frequently Asked Questions
What is PABA and what is it used for?
PABA, or para-aminobenzoic acid, is a compound used primarily as a biochemical marker in medical testing. While it has been studied for its role in diagnostic testing, its historical use was focused on certain skin conditions.
Does PABA help with skin conditions like scleroderma?
There is weak evidence regarding the use of PABA for dermatological conditions such as scleroderma or mycosis fungoides. Most research in this area is historical, and modern clinical evidence for its effectiveness is currently lacking.
Can PABA be used to diagnose pancreatic disease?
There is insufficient evidence to confirm PABA's effectiveness for treating pancreatic disease. However, some research suggests that measuring serum PABA levels may have diagnostic value in identifying pancreatic issues.
What is the recommended dose of PABA for health benefits?
There are currently no established therapeutic dose ranges for using PABA to treat specific health conditions. Research has not provided a recommended effective dose for health improvements.
Are there any safety concerns or side effects from taking PABA?
No specific safety concerns, contraindications, or upper limits (UL) were identified in the available research. However, because therapeutic doses are not established, you should consult a healthcare professional before use.
Does PABA interact with any medications?
There are currently no documented drug interactions for PABA in the provided research. It is still important to discuss any new supplements with your doctor to ensure they are safe for your specific needs.
Who should avoid taking PABA?
The provided research does not identify any specific groups of people who should avoid PABA. However, due to the lack of modern clinical evidence for its therapeutic use, medical guidance is recommended.
Answers generated from research evidence. Not medical advice.