Grape Seed
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Evidence Summary
Grape seed extract is a polyphenol-rich supplement primarily studied for its cardiovascular and metabolic benefits. Research indicates it may play a role in managing blood pressure, cholesterol levels, and metabolic health markers.
Evidence by Condition
Multiple meta-analyses and randomized controlled trials demonstrate that grape seed extract can reduce blood pressure and attenuate blood pressure responses to exercise.
Evidence suggests that grape seed extract, particularly when combined with other extracts like Monacolin K, can help lower LDL cholesterol levels.
Studies indicate improvements in metabolic indices and cardiovascular risk factors in individuals with metabolic syndrome or obesity, especially when paired with dietary interventions.
While research is emerging regarding its effect on liver enzymes and hepatic steatosis, studies in this area remain limited.
Effective Doses
Specific dose ranges for grape seed extract were not explicitly provided in the source text.
Key Findings
- A meta-analysis of 16 RCTs indicates that grape seed extract treatment impacts blood pressure changes (PMID: 27537554).
- Low-dose Monacolin K combined with CoQ10, grape seed, and olive leaf extracts lowers LDL cholesterol in patients with mild dyslipidemia (PMID: 37375586).
- Grape seed extract supplementation attenuates the blood pressure response to exercise in prehypertensive men (PMID: 29683391).
Limitations
There is a lack of large-scale, long-term research regarding the efficacy of grape seed extract for treating non-alcoholic fatty liver disease (NAFLD).
Safety & Interactions
No specific interactions or contraindications were identified in the provided research summaries.
AI-generated summary from 14 peer-reviewed studies. Not medical advice. Always consult a healthcare provider.
Claims vs. Evidence
| Claim Type | % of Products | Evidence Required | Status |
|---|---|---|---|
| All Other | 99% | Tier D (Unclassified) | ✅ Supported |
| Structure/Function | 85% | Tier C (DSHEA Structure/Function (no pre-approval)) | ✅ Supported |
| Nutrient | 9% | Tier D (Unknown) | ✅ Supported |
| No Claim | 1% | Tier D (No claim on label) | ✅ Supported |
| Qualified Health | 0% | Tier B (FDA Qualified Health Claim) | ✅ Supported |
Research by Topic
Research Evidence (14)
**Angelopoulos et al., 2023** | Nutrients | Rct Angelopoulos Nicholas, Paparodis Rodis D, ... Livadas Sarantis. Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with Mild Dyslipid...
**Grohmann et al., 2021** | Nutrients | Systematic Review Grohmann Teresa, Litts Caroline, ... de Roos Baukje. Efficacy of Bilberry and Grape Seed Extract Supplement Interventions to Improve Glucose and Cholesterol Metabolism and Blood Pressure in Di...
**Feringa et al., 2011** | J Am Diet Assoc | Meta Analysis Feringa Harm H H, Laskey Dayne A, ... Coleman Craig I. The effect of grape seed extract on cardiovascular risk markers: a meta-analysis of randomized controlled trials. J Am Diet Assoc. 2011-...
**Zhang et al., 2016** | Medicine (Baltimore) | Meta Analysis Zhang Haili, Liu Shuang, ... Tian Geng. The impact of grape seed extract treatment on blood pressure changes: A meta-analysis of 16 randomized controlled trials. Medicine (Baltimore). 2016...
**Schön et al., 2021** | Nutrients | Rct Schön Christiane, Allegrini Pietro, ... Petrangolini Giovanna. Grape Seed Extract Positively Modulates Blood Pressure and Perceived Stress: A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Volun...
**Park et al., 2016** | Br J Nutr | Rct Park Eunyoung, Edirisinghe Indika, ... Burton-Freeman Britt. Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a randomised, double-blinded, tw...
**Sivaprakasapillai et al., 2009** | Metabolism | Rct Sivaprakasapillai Brahmesh, Edirisinghe Indika, ... Kappagoda Tissa. Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome. Metabolism. 2009-Dec;58(12):1743-6. doi...
**Yousefi et al., 2021** | Phytother Res | Rct Yousefi Reyhaneh, Parandoosh Maryam, ... Ghorbani Arman. Grape seed extract supplementation along with a restricted-calorie diet improves cardiovascular risk factors in obese or overweight adult individu...
OBJECTIVE: Peripheral endothelial dysfunction (PED) is associated with major adverse cardiovascular events. Similar to cardio-protective Mediterranean diet, Chardonnay seeds are rich in polyphenols, fibers, and grape seed oil. In this randomized doub...
BACKGROUND: Despite the high antioxidant potential of grape seed extract (GSE), very limited studies have investigated its effect on non-alcoholic fatty liver disease (NAFLD). Therefore, this study was conducted with the aim of investigating the effe...
**Kim et al., 2018** | J Med Food | Rct Kim Jong-Kyung, Kim Kyung-Ae, ... Stebbins Charles L. Grape Seed Extract Supplementation Attenuates the Blood Pressure Response to Exercise in Prehypertensive Men. J Med Food. 2018-May;21(5):445-453. doi:10.108...
PURPOSE: Our objective was to assess the efficacy of a high dose cranberry proanthocyanidin extract for the prevention of recurrent urinary tract infection. MATERIAL AND METHODS: We recruited 145 healthy, adult women with a history of recurrent urina...
**NCT ID**: NCT04465110 **Phase**: NA **Status**: COMPLETED **Enrollment**: 10 **Completion**: 2020-04-22
**NCT ID**: NCT00979732 **Phase**: NA **Status**: COMPLETED **Enrollment**: 33 **Completion**: 2014-10-15
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Frequently Asked Questions
What is grape seed extract and what is it used for?
Grape seed extract is a supplement rich in polyphenols. It is primarily studied for its potential benefits in managing blood pressure, cholesterol levels, and overall metabolic health.
Does grape seed extract help lower blood pressure?
Yes, there is strong evidence that grape seed extract can help reduce blood pressure and manage pre-hypertension. Research also indicates it may help moderate blood pressure responses during exercise.
Can grape seed extract help with high cholesterol?
There is moderate evidence suggesting that grape seed extract may help lower LDL cholesterol levels. This effect is particularly noted when the extract is combined with other supplements like Monacolin K.
Is grape seed extract effective for metabolic syndrome or obesity?
There is moderate evidence that grape seed extract can improve metabolic health markers and cardiovascular risk factors in people with obesity or metabolic syndrome. These benefits are most effective when paired with dietary interventions.
Does grape seed extract help with fatty liver disease?
There is currently insufficient evidence to determine if grape seed extract is effective for Non-Alcoholic Fatty Liver Disease (NAFLD). While research is emerging regarding its effect on liver enzymes, more studies are needed.
Are there any side effects or drug interactions with grape seed extract?
No specific drug interactions or contraindications have been identified in the current research summaries. However, you should always consult a healthcare provider before starting a new supplement to ensure it is safe for your specific situation.
What is the recommended dose of grape seed extract?
Specific effective dose ranges for grape seed extract were not explicitly provided in the available research. You should consult a medical professional to determine the appropriate dosage for your needs.
Answers generated from research evidence. Not medical advice.