Biotin
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Evidence Summary
Biotin (Vitamin B7) is a water-soluble vitamin essential for energy production and metabolic regulation. Research indicates potential benefits for glycemic control in diabetes and improved health in dairy livestock, but also highlights significant risks regarding laboratory test interference.
Evidence by Condition
Biotin may influence blood glucose and lipid profiles, particularly when combined with chromium picroinate (PMID: 36386951, 17496732).
High-dose biotin has been investigated for its efficacy in treating multiple sclerosis (PMID: 34332461).
Biotin (B7) has been studied as part of a combined probiotic and vitamin treatment for depression (PMID: 33171595).
Biotin supplementation is linked to improved milk production and hoof health in lactating cows (PMID: 21338811).
Research focuses on the radiologic diagnosis of this biotin-related metabolic disorder (PMID: 26754537).
Effective Doses
Specific dose ranges are not explicitly provided in the studies, though 'high-dose' is mentioned in the context of multiple sclerosis research.
Key Findings
- Biotin intervention may influence glycemic control and lipid profiles in patients with type 2 diabetes (PMID: 36386951).
- The combination of chromium picolinate and biotin reduces the atherogenic index of plasma in patients with type 2 diabetes (PMID: 17496732).
- Biotin can cause significant interference in immunoassay results, potentially leading to factitious Graves' disease (PMID: 27362288).
Limitations
Research is fragmented across different species and specific clinical outcomes, with a notable lack of standardized human dosing data.
Safety & Interactions
High doses of biotin can interfere with laboratory immunoassays, potentially causing clinically significant errors in diagnostic results, such as thyroid function tests (PMID: 27362288).
AI-generated summary from 31 peer-reviewed studies. Not medical advice. Always consult a healthcare provider.
Dietary Reference Intakes
Source: IOM/NAM Dietary Reference Intakes · Dietary Reference Intakes: Biotin (Vitamin B7)
Claims vs. Evidence
| Claim Type | % of Products | Evidence Required | Status |
|---|---|---|---|
| All Other | 100% | Tier D (Unclassified) | ✅ Supported |
| Structure/Function | 91% | Tier C (DSHEA Structure/Function (no pre-approval)) | ✅ Supported |
| Nutrient | 57% | Tier D (Unknown) | ✅ Supported |
| No Claim | 0% | Tier D (No claim on label) | ✅ Supported |
🏛️ NIH ODS Factsheet
Research by Topic
⚠️ FDA Safety Data
Research Evidence (31)
**Brandao et al., 2017** | Cochrane Database Syst Rev | Meta Analysis Brandao Gustavo Ms, Junqueira Daniela R, ... Sobreira Marcone L. Pentasaccharides for the treatment of deep vein thrombosis. Cochrane Database Syst Rev. 2017-Dec-02;12(12):CD011782...
**Sui et al., 2023** | J Clin Neurosci | Meta Analysis Sui Zichao, Zhu Haoxiang, ... Zheng Qingshan. Quantitative comparison of the efficacy of clinical drug treatments for primary progressive multiple sclerosis. J Clin Neurosci. 2023-Jul;113:45-53. ...
**Parks et al., 2020** | Cochrane Database Syst Rev | Meta Analysis Parks Natalie E, Jackson-Tarlton Caitlin S, ... Johnston Bradley C. Dietary interventions for multiple sclerosis-related outcomes. Cochrane Database Syst Rev. 2020-May-19;5(5):CD0041...
**Victoire et al., 2019** | Cochrane Database Syst Rev | Meta Analysis Victoire Anousha, Magin Parker, ... van Driel Mieke L. Interventions for infantile seborrhoeic dermatitis (including cradle cap). Cochrane Database Syst Rev. 2019-Mar-04;3(3):CD01...
**Lira et al., 2021** | Fertil Steril | Meta Analysis Lira Neto Filipe Tenório, Roque Matheus, Esteves Sandro C. Effect of varicocelectomy on sperm deoxyribonucleic acid fragmentation rates in infertile men with clinical varicocele: a systematic revi...
**Lean et al., 2011** | J Dairy Sci | Meta Analysis Lean I J, Rabiee A R. Effect of feeding biotin on milk production and hoof health in lactating dairy cows: a quantitative assessment. J Dairy Sci. 2011-Mar;94(3):1465-76. doi:10.3168/jds.2010-3682 O...
**Elston et al., 2016** | J Clin Endocrinol Metab | Systematic Review Elston Marianne S, Sehgal Shekhar, ... Conaglen John V. Factitious Graves' Disease Due to Biotin Immunoassay Interference-A Case and Review of the Literature. J Clin Endocrinol Met...
**Chen et al., 2011** | J Dairy Sci | Meta Analysis Chen B, Wang C, ... Liu J X. Effect of biotin on milk performance of dairy cattle: a meta-analysis. J Dairy Sci. 2011-Jul;94(7):3537-46. doi:10.3168/jds.2010-3764 A meta-analysis of the effect of bi...
Gut microbiota are suspected to affect brain functions and behavior as well as lowering inflammation status. Therefore, an effect on depression has already been suggested by recent research. The aim of this randomized double-blind controlled trial wa...
**Espiritu et al., 2021** | Mult Scler Relat Disord | Meta Analysis Espiritu Adrian I, Remalante-Rayco Patricia Pauline M. High-dose biotin for multiple sclerosis: A systematic review and meta-analyses of randomized controlled trials. Mult Scler Rela...
BACKGROUND: Biotin is a water-soluble vitamin acting as a covalently bound coenzyme in regulating energy production. Previous studies have reported that biotin supplementation may influence blood glucose and lipid level in patients with type 2 diabet...
**Chai et al., 2025** | Asia Pac J Clin Nutr | Systematic Review Chai Yi, Chen Chengyu, ... Wang Qiuzhen. Effects of water-soluble vitamins on glycemic control and insulin resistance in adult type 2 diabetes: an umbrella review of meta-analyses. Asia...
**Bandaralage et al., 2016** | Pediatr Radiol | Meta Analysis Bandaralage Sahan P Semasinghe, Farnaghi Soheil, ... Kothari Alka. Antenatal and postnatal radiologic diagnosis of holocarboxylase synthetase deficiency: a systematic review. Pediatr Radio...
BACKGROUND: The atherogenic index of plasma (AIP), defined as logarithm [log] of the ratio of plasma concentration of triglycerides to high-density lipoprotein (HDL) cholesterol, has recently been proposed as a predictive marker for plasma atherogeni...
**Favresse et al., 2021** | Clin Chem Lab Med | Systematic Review Favresse Julien, Bayart Jean-Louis, ... Perrone Marco. The underestimated issue of non-reproducible cardiac troponin I and T results: case series and systematic review of the literatur...
**Wang et al., 2022** | Water Res | Meta Analysis Wang Depeng, Meng Yabing, Meng Fangang. Genome-centric metagenomics insights into functional divergence and horizontal gene transfer of denitrifying bacteria in anammox consortia. Water Res. 2022-Oct-...
**Prat-Duran et al., 2021** | Pharmacol Ther | Systematic Review Prat-Duran Judit, Pinilla Estéfano, ... Buus Niels Henrik. Transglutaminase 2 as a novel target in chronic kidney disease - Methods, mechanisms and pharmacological inhibition. Pharmacol...
**Huang et al., 2021** | Front Psychiatry | Systematic Review Huang Zhi-Xiong, Chen Yanhui, ... Chen Guo-Feng. Systematic Review and Bioinformatic Analysis of microRNA Expression in Autism Spectrum Disorder Identifies Pathways Associated With Cancer,...
**Hassan et al., 2023** | Tremor Other Hyperkinet Mov (N Y) | Systematic Review Hassan Anhar. Episodic Ataxias: Primary and Secondary Etiologies, Treatment, and Classification Approaches. Tremor Other Hyperkinet Mov (N Y). 2023;13:9. doi:10.5334/tohm...
**He et al., 2025** | Brain Res | Systematic Review He Jinghu, Gao Zhiyuan, ... Gao Biao. Systematic review of optimizing brain-targeted vitamin D delivery: Novel approaches to enhance mental illness therapeutics. Brain Res. 2025-Jul-01;1858:149656. ...
Dyslipidemia, often found in type 2 diabetes mellitus (T2DM) patients, plays an important role in the progression of cardiometabolic syndrome. Two essential nutrients, chromium and biotin, may maintain optimal glycemic control. The authors report her...
**Marx et al., 2020** | Mult Scler Relat Disord | Systematic Review Marx Wolfgang, Hockey Meghan, ... Ponsonby Anne-Louise. The effect of emerging nutraceutical interventions for clinical and biological outcomes in multiple sclerosis: A systematic re...
**Collins et al., 2008** | Fertil Steril | Meta Analysis Collins John A, Barnhart Kurt T, Schlegel Peter N. Do sperm DNA integrity tests predict pregnancy with in vitro fertilization?. Fertil Steril. 2008-Apr;89(4):823-31 OBJECTIVE: To evaluate the p...
**Source**: IOM 1998 Dietary Reference Intakes for Biotin **Unit**: mcg/day | Population | AI | |---|---| | Adult | 30 mcg/day |
**Gnepp et al., 1990** | Cancer | Meta Analysis Gnepp D R, Wick M R. Small cell carcinoma of the major salivary glands. An immunohistochemical study. Cancer. 1990-Jul-01;66(1):185-92 Small cell carcinomas of the major salivary glands are rare tumors,...
**NCT ID**: NCT05450900 **Phase**: EARLY_PHASE1 **Status**: COMPLETED **Enrollment**: 10 **Completion**: 2023-02-02
Combination therapy with biotin and dexpanthenol is a well-known practice in preventing and treating hair loss, however, it is not well studied. In this study, we compared the efficacy of the 6-week treatment with two brands of biotin and dexpantheno...
**NCT ID**: NCT01903304 **Phase**: NA **Status**: COMPLETED **Enrollment**: 41 **Completion**: 2014-05
**Source:** [Office of Dietary Supplements, NIH](https://ods.od.nih.gov:443/factsheets/Biotin-HealthProfessional/) **Reading Level:** Health Professional This fact sheet from the NIH Office of Dietary Supplements provides evidence-based information a...
**Source**: FDA Center for Food Safety and Applied Nutrition (CFSAN) Adverse Event Reporting System **Total Events**: 76 **Serious Events**: 17 **Date Range**: 20080325 to 20250519 - **Alopecia**: 7
Details
Biotin
Overview
Biotin is a essential nutrient tracked in the biomedical knowledge base.
Also known as: vitamin b7, vitamin h, d-biotin
Role in Health
Detailed overview pending — this entity has sources compiled across multiple verticals.
Related Verticals
See sources-index for all verified sources referencing Biotin.
Safety Considerations
Safety data extraction pending.
Sources
See linked source pages for full provenance.
Related Supplements
Frequently Asked Questions
What is Biotin and what does it do?
Biotin, also known as Vitamin B7, is a water-soluble vitamin that is essential for energy production and metabolic regulation. It plays a key role in helping your body process nutrients and maintain metabolic health.
Can Biotin help with Type 2 Diabetes?
There is moderate evidence suggesting that Biotin may influence blood glucose and lipid profiles in people with Type 2 Diabetes. This effect is particularly noted when Biotin is combined with chromium picolinate.
Is Biotin effective for treating Multiple Sclerosis or depression?
There is currently insufficient evidence to support the use of Biotin for treating Multiple Sclerosis or depression. While high doses have been studied for MS and combined treatments have been studied for depression, the research is not conclusive.
How much Biotin should I take daily?
The recommended dietary intake for adults is 30 mcg per day. While specific therapeutic dose ranges are not explicitly defined in the research, 'high-dose' supplementation has been used in certain clinical studies.
Are there any safety risks with Biotin supplements?
A significant safety concern is that high doses of Biotin can interfere with laboratory tests, such as thyroid function tests. This interference can lead to serious errors in medical diagnoses, such as a false indication of Graves' disease.
Does Biotin interact with any medications?
There are no documented drug-to-drug interactions for Biotin. However, you should be aware that high doses can interfere with the accuracy of medical laboratory assays.
Who should avoid taking Biotin supplements?
While no specific groups are strictly prohibited from taking Biotin, individuals undergoing medical testing should be cautious. High doses can cause clinically significant errors in diagnostic blood results.
Answers generated from research evidence. Not medical advice.