Nattokinase
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Evidence Summary
Nattokinase is an enzyme derived from fermented soybeans that has been studied for its impact on cardiovascular health. Research suggests it may play a role in managing blood pressure, fibrinolytic activity, and various cardiovascular risk factors.
Evidence by Condition
A systematic review and meta-analysis indicates that nattokinase supplementation impacts various cardiovascular risk markers.
Randomized controlled trials have demonstrated that nattokinase supplementation can affect blood pressure levels.
A single oral dose of nattokinase has been shown to potentiate thrombolytic and anti-coagulant profiles.
Preliminary clinical studies have investigated the effects of nattokinase on carotid artery atherosclerosis and lipid levels.
Effective Doses
Dose ranges are not specified in the provided research.
Key Findings
- Nattokinase supplementation is associated with changes in cardiovascular risk factors (PMID: 39076715)
- Nattokinase supplementation has measurable effects on blood pressure (PMID: 18971533)
- A single dose of oral nattokinase can potentiate thrombolysis and anti-coagulation profiles (PMID: 26109079)
Limitations
The current evidence is limited by small sample sizes in individual studies and a lack of large-scale, long-term clinical trials.
Safety & Interactions
Because nattokinase can potentiate anti-coagulation profiles, caution may be required regarding potential interactions with anticoagulant medications.
AI-generated summary from 4 peer-reviewed studies. Not medical advice. Always consult a healthcare provider.
Claims vs. Evidence
| Claim Type | % of Products | Evidence Required | Status |
|---|---|---|---|
| All Other | 99% | Tier D (Unclassified) | ✅ Supported |
| Structure/Function | 81% | Tier C (DSHEA Structure/Function (no pre-approval)) | ⚠️ Unsupported |
| Nutrient | 6% | Tier D (Unknown) | ✅ Supported |
Research by Topic
Research Evidence (4)
**Li et al., 2023** | Rev Cardiovasc Med | Systematic Review Li Xinmin, Long Junzi, ... Zhang Yasu. Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Rev Cardiovasc Med...
**Kim et al., 2008** | Hypertens Res | Rct Kim Ji Young, Gum Si Nae, ... Lee Jong Ho. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens Res. 2008-Aug;31(8):1583-8. doi:10.1291/hypres.31.1583 The objective of this stu...
**Kurosawa et al., 2015** | Sci Rep | Rct Kurosawa Yuko, Nirengi Shinsuke, ... Hamaoka Takafumi. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep. 2015-Jun-25;5:11601. doi:10.1038/srep11601 Our aim was...
**Ren et al., 2017** | Zhonghua Yi Xue Za Zhi | Other Ren N N, Chen H J, ... Lin Y G. [A clinical study on the effect of nattokinase on carotid artery atherosclerosis and hyperlipidaemia]. Zhonghua Yi Xue Za Zhi. 2017-Jul-11;97(26):2038-2042. doi:10....
Frequently Asked Questions
What is Nattokinase and what is it used for?
Nattokinase is an enzyme derived from fermented soybeans. It is primarily studied for its potential impact on cardiovascular health, including its role in managing blood pressure and various cardiovascular risk factors.
Does Nattokinase help lower blood pressure?
There is moderate evidence from randomized controlled trials suggesting that Nattokinase supplementation can affect blood pressure levels. This indicates it may play a role in managing hypertension.
Can Nattokinase reduce cardiovascular risk?
There is moderate evidence from systematic reviews and meta-analyses indicating that Nattokinase supplementation can impact various cardiovascular risk markers. This suggests potential benefits for overall heart health.
Does Nattokinase help prevent blood clots?
There is moderate evidence that a single oral dose of Nattokinase can enhance thrombolytic and anti-coagulant activity. This means it may assist in the breakdown of blood clots.
What is the recommended dose of Nattokinase?
Currently, there are no specific effective dose ranges established in the available research. You should consult with a healthcare provider to determine an appropriate dosage for your specific needs.
Are there any safety concerns or drug interactions with Nattokinase?
Because Nattokinase can increase anti-coagulant activity, there is a potential for interactions with anticoagulant medications. Caution is required if you are already taking blood-thinning drugs.
Who should avoid taking Nattokinase?
Individuals taking anticoagulant (blood-thinning) medications should exercise caution or avoid use unless directed by a doctor. This is due to the supplement's potential to enhance the effects of these medications.
Does Nattokinase help with high cholesterol or clogged arteries?
There is currently insufficient evidence to confirm if Nattokinase helps with hyperlipidemia (high cholesterol) or carotid artery atherosclerosis. While preliminary studies have investigated these areas, more research is needed.
Answers generated from research evidence. Not medical advice.