Garlic

142 research sources Also known as: allium sativum allicin aged garlic extract kyolic
534 Products on Market
500.0 mg Median Dose
🟢 92/100 Market Safety Score
142 Research Sources
Browse 534 products →

Product Forms

Capsule 34% Softgel Capsule 28% Tablet or Pill 19% Liquid 8% Powder 7% Other (e.g. tea bag) 3% Gummy or Jelly 0%

Dose Distribution

1-5 mg 31 10-25 mg 30 100-250 mg 25 25-50 mg 1 250-500 mg 70 5-10 mg 12 50-100 mg 19 500-1000 mg 214 <1 mg 6 >1000 mg 89

Top Brands

Kyolic 58 TerraVita Premium Collection 26 DC 22 Wonder Laboratories 21 BulkSupplements.com 19 Nature's Way 16 NOW 11 Puritan's Pride 11 Douglas Laboratories 10 The Vitamin Shoppe 8 Herbal Terra 8 Nature's Bounty 7

Claims on Labels

All Other 99% Structure/Function 77% Nutrient 8% No Claim 0% Approved Health 0%

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Evidence Summary

Garlic is a widely studied botanical with significant evidence supporting its role in cardiovascular and metabolic health. Research indicates potential benefits for blood pressure regulation, glucose management, and lipid profiles.

Evidence by Condition

Cardiovascular Strong

Evidence supports its use for lowering blood pressure in hypertensive patients and managing cardiovascular risk factors (PMID: 22895963, 40580481).

Metabolic Moderate

Studies show impacts on fasting blood glucose, lipid profiles, and metabolic syndrome components (PMID: 26693740, 38892625, 37481521).

Liver Disease Moderate

Meta-analyses suggest potential benefits for treating chronic liver disease and MAFLD (PMID: 38223588, 41695987).

Gastric Cancer Moderate

High consumption of Allium vegetables is associated with a reduced risk of gastric cancer (PMID: 21473867).

Common Cold Weak

Systematic reviews indicate insufficient evidence for the prevention or treatment of the common cold (PMID: 25386977).

Effective Doses

Dose ranges were not specified in the provided research summaries.

Key Findings

  • Garlic supplementation can lower blood pressure in hypertensive patients (PMID: 22895963)
  • Garlic intake is linked to lower fasting blood glucose levels (PMID: 26693740)
  • Large amounts of Allium vegetables may reduce the risk of gastric cancer (PMID: 21473867)
  • Garlic shows potential in managing components of metabolic syndrome (PMID: 37481521)

Limitations

The provided research does not specify standardized dosing protocols across the various studies.

Safety & Interactions

No specific safety interactions or contraindications were provided in the source text.

AI-generated summary from 142 peer-reviewed studies. Not medical advice. Always consult a healthcare provider.

Drug-Supplement Interactions

Antiarrhythmics 🔴 Critical
Mechanism: Garlic is a weak inhibitor of CYP2C9, which decreases metabolism of CYP2C9 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of amiodarone (antiarrhythmics), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of amiodarone. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Anticonvulsants 🔴 Critical
Mechanism: Garlic is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of carbamazepine (anticonvulsants), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of carbamazepine. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Digoxin 🔴 Critical
Mechanism: Garlic is a moderate inhibitor of P-gp, which decreases metabolism of P-gp substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of digoxin (digoxin), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of digoxin. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
GI Prokinetics 🔴 Critical
Mechanism: Garlic is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of cisapride (gi-prokinetics), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of cisapride. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Immunosuppressants 🔴 Critical
Mechanism: Garlic is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of cyclosporine (immunosuppressants), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of cyclosporine. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Theophylline 🔴 Critical
Mechanism: Garlic is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of theophylline (theophylline), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of theophylline. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
ARB 🟡 Moderate
Mechanism: Garlic is a weak inhibitor of CYP2C9, which decreases metabolism of CYP2C9 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of losartan (arb), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of losartan. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Abciximab 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Abciximab
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Alteplase 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Alteplase
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Anistreplase 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Anistreplase
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Antibiotics 🟡 Moderate
Mechanism: Garlic is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of clarithromycin (antibiotics), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of clarithromycin. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Anticoagulants 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Apixaban, Edoxaban, Rivaroxaban, Enoxaparin, Fondaparinux, Dicoumarol, Heparin
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Antidiabetic Drugs 🟡 Moderate
Mechanism: Garlic is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of repaglinide (antidiabetic-drugs), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of repaglinide. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Antidiarrheals 🟡 Moderate
Mechanism: Garlic is a moderate inhibitor of P-gp, which decreases metabolism of P-gp substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of loperamide (antidiarrheals), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of loperamide. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Antifungals 🟡 Moderate
Mechanism: Garlic is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of fluconazole (antifungals), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of fluconazole. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Antihistamines 🟡 Moderate
Mechanism: Garlic is a moderate inhibitor of P-gp, which decreases metabolism of P-gp substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of fexofenadine (antihistamines), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of fexofenadine. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Antiplatelet Drugs 🟡 Moderate
Mechanism: Garlic has antiplatelet properties that may add to antiplatelet drug effects.
Effect: Increased bleeding risk
Management: Avoid high-dose garlic supplements with antiplatelet drugs (aspirin, clopidogrel). Stop 7 days before surgery.
Evidence: probable
Antipsychotics 🟡 Moderate
Mechanism: Garlic is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of haloperidol (antipsychotics), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of haloperidol. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Antiretrovirals 🟡 Moderate
Mechanism: Garlic is a moderate inhibitor of P-gp, which decreases metabolism of P-gp substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of saquinavir (antiretrovirals), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of saquinavir. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Antithrombin III human 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Antithrombin III human
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Argatroban 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Argatroban
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Benzodiazepines 🟡 Moderate
Mechanism: Garlic is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of midazolam (benzodiazepines), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of midazolam. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Beta Blockers 🟡 Moderate
Mechanism: Garlic is a weak inhibitor of CYP2C19, which decreases metabolism of CYP2C19 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of propranolol (beta-blockers), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of propranolol. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Beta-2 Agonists 🟡 Moderate
Mechanism: Garlic is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of salmeterol (beta2-agonists), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of salmeterol. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Betrixaban 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Betrixaban
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Bivalirudin 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Bivalirudin
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
CFTR Modulators 🟡 Moderate
Mechanism: Garlic is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of ivacaftor (cftr-modulators), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of ivacaftor. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Calcium Channel Blockers 🟡 Moderate
Mechanism: Garlic is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of nifedipine (calcium-channel-blockers), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of nifedipine. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Cangrelor 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Cangrelor
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Caplacizumab 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Caplacizumab
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Chemotherapy 🟡 Moderate
Mechanism: Garlic is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of doxorubicin (chemotherapy), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of doxorubicin. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Corticosteroids 🟡 Moderate
Mechanism: Garlic is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of prednisone (corticosteroids), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of prednisone. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Dalteparin 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Dalteparin
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Danaparoid 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Danaparoid
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Defibrotide 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Defibrotide
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Eptifibatide 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Eptifibatide
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Lepirudin 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Lepirudin
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Leukotriene Antagonists 🟡 Moderate
Mechanism: Garlic is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of montelukast (leukotriene-antagonists), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of montelukast. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
NSAIDs 🟡 Moderate
Mechanism: Garlic is a weak inhibitor of CYP2C9, which decreases metabolism of CYP2C9 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of ibuprofen (nsaids), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of ibuprofen. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Opioids 🟡 Moderate
Mechanism: Garlic is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of methadone (opioids), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of methadone. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Oral Contraceptives 🟡 Moderate
Mechanism: Garlic is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of ethinylestradiol (oral-contraceptives), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of ethinylestradiol. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
PDE5 Inhibitors 🟡 Moderate
Mechanism: Garlic is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of sildenafil (pde5-inhibitors), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of sildenafil. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
PPIS 🟡 Moderate
Mechanism: Garlic is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of omeprazole (ppis), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of omeprazole. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Reteplase 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Reteplase
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
SNRI 🟡 Moderate
Mechanism: Garlic is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of venlafaxine (snri), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of venlafaxine. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
SSRI 🟡 Moderate
Mechanism: Garlic is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of sertraline (ssri), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of sertraline. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Saquinavir 🟡 Moderate
Mechanism: Garlic supplements decrease saquinavir plasma concentrations via CYP3A4 induction.
Effect: Reduced antiretroviral efficacy
Management: Avoid garlic supplements with protease inhibitors. Dietary garlic is safe.
Evidence: probable
Statins 🟡 Moderate
Mechanism: Garlic is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of simvastatin (statins), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of simvastatin. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Streptokinase 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Streptokinase
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Tenecteplase 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Tenecteplase
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Tinzaparin 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Tinzaparin
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Tirofiban 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Tirofiban
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Tricyclic Antidepressants 🟡 Moderate
Mechanism: Garlic is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of amitriptyline (tricyclic-antidepressants), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of amitriptyline. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Urokinase 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Urokinase
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Warfarin 🟡 Moderate
Mechanism: Garlic may have antiplatelet properties that add to warfarin's anticoagulant effect.
Effect: Increased bleeding risk
Management: Monitor INR and bleeding signs. Avoid high-dose garlic supplements.
Evidence: probable
Chlorzoxazone 🟢 Minor
Mechanism: Garlic may induce CYP2E1, increasing metabolism of chlorzoxazone.
Effect: Reduced muscle relaxant effect
Management: Monitor for reduced efficacy. Minor clinical concern.
Evidence: possible

⚠️ This information is for educational purposes only and does not constitute medical advice. Always consult your healthcare provider before combining supplements with medications.

Claims vs. Evidence

80% Evidence-Backed
20% Unsupported
77% Structure/Function
Claim Type% of ProductsEvidence RequiredStatus
All Other 99% Tier D (Unclassified) ✅ Supported
Structure/Function 77% Tier C (DSHEA Structure/Function (no pre-approval)) ✅ Supported
Nutrient 8% Tier D (Unknown) ✅ Supported
No Claim 0% Tier D (No claim on label) ✅ Supported
Approved Health 0% Tier A (FDA Approved Health Claim (21 CFR 101.9)) ⚠️ Unsupported

🏛️ NIH ODS Factsheet

Garlic

Research by Topic

Garlic 123 studies
MET Garlic supplementation for the treatment of chronic liver di...
MET Consumption of large amounts of Allium vegetables reduces ri...
SYS Garlic for the common cold
+120 more
Garlic Cardiovascular 17 studies
SYS Garlic for the prevention of cardiovascular morbidity and mo...
SYS Garlic: A systematic review of the effects on cardiovascular...
MET Effects of aged garlic extract on blood pressure in hyperten...
+14 more
Berberine 1 studies
SYS Clinical evidence of herbal drugs as perpetrators of pharmac...
Dhea 1 studies
RCT Efficacy of garlic (Allium sativum) on metabolic syndrome co...

⚠️ FDA Safety Data

Adverse Event Profile: Garlic

Research Evidence (142)

Meta Analysis: 70 Systematic Review: 56 Rct: 12 Regulatory Source: 2 Openfda Safety: 1
B Garlic for the prevention of cardiovascular morbidity and mortality in hypertensive patients
Systematic Review The Cochrane database of systematic reviews 2012 n=47

BACKGROUND: Garlic is widely used by patients for its blood pressure lowering effects. A meta-analysis published in 2008 concluded that garlic consumption lowers blood pressure in hypertensive and normotensive patients. Therefore, it is important to ...

PubMed DOI Cochrane
B Garlic supplementation for the treatment of chronic liver disease: a meta-analysis of randomized controlled trials
Meta Analysis African health sciences 2023 n=212

**Xiaohui et al., 2023** | Afr Health Sci | Meta Analysis Xiaohui Liu, Jinqi Li, ... Renxiu Niu. Garlic supplementation for the treatment of chronic liver disease: a meta-analysis of randomized controlled trials. Afr Health Sci. 2023-Jun;23(2):409-41...

PubMed DOI
B Consumption of large amounts of Allium vegetables reduces risk for gastric cancer in a meta-analysis
Meta Analysis Gastroenterology 2011 n=543220

**Zhou et al., 2011** | Gastroenterology | Meta Analysis Zhou Yong, Zhuang Wen, ... Wu Xiao-Ting. Consumption of large amounts of Allium vegetables reduces risk for gastric cancer in a meta-analysis. Gastroenterology. 2011-Jul;141(1):80-9. doi:10.105...

PubMed DOI
B Garlic for the common cold
Systematic Review The Cochrane database of systematic reviews 2014 n=146

**Lissiman et al., 2014** | Cochrane Database Syst Rev | Systematic Review Lissiman Elizabeth, Bhasale Alice L, Cohen Marc. Garlic for the common cold. Cochrane Database Syst Rev. 2014-Nov-11;2014(11):CD006206. doi:10.1002/14651858.CD006206.pub4 Back...

PubMed DOI
B Effects of Garlic Supplementation on Cardiovascular Risk Factors in Adults: A Comprehensive Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrition reviews 2026 n=7137

**Behrouz et al., 2026** | Nutr Rev | Meta Analysis Behrouz Vahideh, Zahroodi Mehrnaz, ... Rivaz Raha. Effects of Garlic Supplementation on Cardiovascular Risk Factors in Adults: A Comprehensive Updated Systematic Review and Meta-Analysis of Randomiz...

PubMed DOI
B Effects of seasoning on the formation of heterocyclic amines and polycyclic aromatic hydrocarbons in meats: A meta-analysis
Meta Analysis Comprehensive reviews in food science and food safety 2021

**Neves et al., 2021** | Compr Rev Food Sci Food Saf | Meta Analysis Neves Thaís de Moura, da Cunha Diogo Thimoteo, ... Domene Semíramis Martins Álvares. Effects of seasoning on the formation of heterocyclic amines and polycyclic aromatic hydrocarbon...

PubMed DOI
B A Systematic Review and Meta-Analysis of Ayurvedic Herbal Preparations for Hypercholesterolemia
Meta Analysis Medicina (Kaunas, Lithuania) 2021 n=1386

**Gyawali et al., 2021** | Medicina (Kaunas) | Meta Analysis Gyawali Dinesh, Vohra Rini, ... Schneider Robert H. A Systematic Review and Meta-Analysis of Ayurvedic Herbal Preparations for Hypercholesterolemia. Medicina (Kaunas). 2021-May-28;57(6). do...

PubMed DOI
B Garlic: A systematic review of the effects on cardiovascular diseases
Systematic Review Critical reviews in food science and nutrition 2023

Allium sativum (garlic) certainly is one of the oldest horticultural crops in the world and presents bioactive compounds that are related to the garlic's effects on human health. Several authors have shown beneficial effects on diabetes, hypertension...

PubMed DOI
B Garlic intake lowers fasting blood glucose: meta-analysis of randomized controlled trials
Meta Analysis Asia Pacific journal of clinical nutrition 2015 n=513

**Hou et al., 2015** | Asia Pac J Clin Nutr | Meta Analysis Hou Li-qiong, Liu Yun-hui, Zhang Yi-yi. Garlic intake lowers fasting blood glucose: meta-analysis of randomized controlled trials. Asia Pac J Clin Nutr. 2015;24(4):575-82. doi:10.6133/apjcn....

PubMed DOI
B Garlic for the common cold
Systematic Review The Cochrane database of systematic reviews 2012 n=146

**Lissiman et al., 2012** | Cochrane Database Syst Rev | Systematic Review Lissiman Elizabeth, Bhasale Alice L, Cohen Marc. Garlic for the common cold. Cochrane Database Syst Rev. 2012-Mar-14(3):CD006206. doi:10.1002/14651858.CD006206.pub3 BACKGROUND...

PubMed DOI
B Garlic for peripheral arterial occlusive disease
Systematic Review The Cochrane database of systematic reviews 2013 n=78

**Jepson et al., 2013** | Cochrane Database Syst Rev | Systematic Review Jepson Ruth G, Kleijnen Jos, Leng Gillian C. Garlic for peripheral arterial occlusive disease. Cochrane Database Syst Rev. 2013-Apr-30;2013(4):CD000095. doi:10.1002/14651858.CD0...

PubMed DOI
B The association of garlic intake and cardiovascular risk factors: A systematic review and meta-analysis
Meta Analysis Critical reviews in food science and nutrition 2023 n=22

**Li et al., 2023** | Crit Rev Food Sci Nutr | Meta Analysis Li Sha, Guo Wei, ... Wang Hui. The association of garlic intake and cardiovascular risk factors: A systematic review and meta-analysis. Crit Rev Food Sci Nutr. 2023;63(26):8013-8031. doi:10...

PubMed DOI
B Effects of garlic supplementation on components of metabolic syndrome: a systematic review, meta-analysis, and meta-regression of randomized controlled trials
Meta Analysis BMC complementary medicine and therapies 2023 n=999

**Fu et al., 2023** | BMC Complement Med Ther | Meta Analysis Fu Zhenyue, Lv Jiayu, ... Song Qingqiao. Effects of garlic supplementation on components of metabolic syndrome: a systematic review, meta-analysis, and meta-regression of randomized contro...

PubMed DOI
B Effects of Garlic on Glucose Parameters and Lipid Profile: A Systematic Review and Meta-Analysis on Randomized Controlled Trials
Meta Analysis Nutrients 2024

**Zhao et al., 2024** | Nutrients | Meta Analysis Zhao Xinyu, Cheng Tao, ... Wang Shaokang. Effects of Garlic on Glucose Parameters and Lipid Profile: A Systematic Review and Meta-Analysis on Randomized Controlled Trials. Nutrients. 2024-May-29;16(11...

PubMed DOI
B Efficacy of selected dietary supplements and pharmacological agents on metabolic and oxidative stress outcomes in metabolic dysfunction-associated fatty liver disease (MAFLD): a Bayesian network meta-analysis
Systematic Review Frontiers in pharmacology 2025 n=7273

**Yang et al., 2025** | Front Pharmacol | Systematic Review Yang Yunyi, He Xiaoli, ... Yang Hongjie. Efficacy of selected dietary supplements and pharmacological agents on metabolic and oxidative stress outcomes in metabolic dysfunction-associated fa...

PubMed DOI
B Allium vegetables and garlic supplements do not reduce risk of colorectal cancer, based on meta-analysis of prospective studies
Meta Analysis Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2014 n=5458

**Zhu et al., 2014** | Clin Gastroenterol Hepatol | Meta Analysis Zhu Beibei, Zou Li, ... Miao Xiaoping. Allium vegetables and garlic supplements do not reduce risk of colorectal cancer, based on meta-analysis of prospective studies. Clin Gastroenter...

PubMed DOI
B The effect of garlic on lipid profile and glucose parameters in diabetic patients: A systematic review and meta-analysis
Meta Analysis Primary care diabetes 2019 n=1273

**Shabani et al., 2019** | Prim Care Diabetes | Meta Analysis Shabani Ehsan, Sayemiri Korosh, Mohammadpour Mohammadtaghi. The effect of garlic on lipid profile and glucose parameters in diabetic patients: A systematic review and meta-analysis. Prim C...

PubMed DOI
B The effects of garlic supplementation on oxidative stress markers: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2020 n=317

**Moosavian et al., 2020** | Complement Ther Med | Meta Analysis Moosavian Seyedeh Parisa, Arab Arman, ... Moradi Sajjad. The effects of garlic supplementation on oxidative stress markers: A systematic review and meta-analysis of randomized controlle...

PubMed DOI
B Platelet Aggregation Inhibition: An Evidence-Based Systematic Review on the Role of Herbs for Primary Prevention Based on Randomized Controlled Trials
Systematic Review Iranian journal of medical sciences 2022

**Nouruzi et al., 2022** | Iran J Med Sci | Systematic Review Nouruzi Samane, Vasheghani Farahani Ali, ... Omidi Negar. Platelet Aggregation Inhibition: An Evidence-Based Systematic Review on the Role of Herbs for Primary Prevention Based on Randomiz...

PubMed DOI
B Effect of polyphenol compounds on Helicobacter pylori eradication: a systematic review with meta-analysis
Meta Analysis BMJ open 2023 n=12

**Wang et al., 2023** | BMJ Open | Meta Analysis Wang Qiuxiang, Yao Chengjiao, ... Feng Peimin. Effect of polyphenol compounds on Helicobacter pylori eradication: a systematic review with meta-analysis. BMJ Open. 2023-Jan-05;13(1):e062932. doi:10.113...

PubMed DOI
B Effects of aged garlic extract on blood pressure in hypertensive patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Prostaglandins & other lipid mediators 2024 n=584

BACKGROUND: There is no consensus based on the existing literature regarding the effect of aged garlic extract (AGE) on blood pressure. The present systematic review and meta-analysis was conducted to synthesize existing data from randomized clinical...

PubMed DOI
B Meta-analysis of selenium accumulation and expression of antioxidant enzymes in chicken tissues
Meta Analysis Animal : an international journal of animal bioscience 2014

**Zoidis et al., 2014** | Animal | Meta Analysis Zoidis E, Demiris N, ... Pappas A C. Meta-analysis of selenium accumulation and expression of antioxidant enzymes in chicken tissues. Animal. 2014-Apr;8(4):542-54. doi:10.1017/S1751731113002395 A meta-...

PubMed DOI
B Garlic Lowers Blood Pressure in Hypertensive Individuals, Regulates Serum Cholesterol, and Stimulates Immunity: An Updated Meta-analysis and Review
Meta Analysis The Journal of nutrition 2016 n=10

BACKGROUND: Garlic has been shown to have cardiovascular protective and immunomodulatory properties. OBJECTIVES: We updated a previous meta-analysis on the effect of garlic on blood pressure and reviewed the effect of garlic on cholesterol and immuni...

PubMed DOI
B The effect of garlic on vascular function: A systematic review of randomized clinical trials
Systematic Review Clinical nutrition (Edinburgh, Scotland) 2020 n=45

**Emamat et al., 2020** | Clin Nutr | Systematic Review Emamat Hadi, Tangestani Hadith, ... Nasrollahzadeh Javad. The effect of garlic on vascular function: A systematic review of randomized clinical trials. Clin Nutr. 2020-Dec;39(12):3563-3570. doi:...

PubMed DOI
B Garlic supplementation and serum cholesterol: a meta-analysis
Meta Analysis Journal of clinical pharmacy and therapeutics 2009 n=1056

**Khoo et al., 2009** | J Clin Pharm Ther | Meta Analysis Khoo Y S K, Aziz Z. Garlic supplementation and serum cholesterol: a meta-analysis. J Clin Pharm Ther. 2009-Apr;34(2):133-45. doi:10.1111/j.1365-2710.2008.00998.x BACKGROUND: Prevention of card...

PubMed DOI
B A meta-analysis of randomized, double-blind, placebo-controlled trials for the effects of garlic on serum lipid profiles
Meta Analysis Journal of the science of food and agriculture 2012 n=26

**Zeng et al., 2012** | J Sci Food Agric | Meta Analysis Zeng Tao, Guo Fang-Fang, ... Xie Ke-Qin. A meta-analysis of randomized, double-blind, placebo-controlled trials for the effects of garlic on serum lipid profiles. J Sci Food Agric. 2012-Jul;92(...

PubMed DOI
B LDL-Cholesterol-Lowering Effects of a Dietary Supplement Containing Onion and Garlic Extract Used in Healthy Volunteers
Rct Nutrients 2024

Hypercholesterolemia plays a pivotal role in the development and progression of cardiovascular diseases, and its prevention seems to be a crucial healthcare strategy to ameliorate these conditions. Subjects with mild hypercholesterolemia are frequent...

PubMed DOI
B Potential Effects of Bioactive Compounds of Plant-Based Foods and Medicinal Plants in Chronic Kidney Disease and Dialysis: A Systematic Review
Systematic Review Nutrients 2024

**Josa et al., 2024** | Nutrients | Systematic Review Josa Esmeralda, Barril Guillermina, Ruperto Mar. Potential Effects of Bioactive Compounds of Plant-Based Foods and Medicinal Plants in Chronic Kidney Disease and Dialysis: A Systematic Review. Nut...

PubMed DOI
B Systematic Review of the Effects of Plant-Based Foods on Metabolic Outcomes in Adults with MASLD and Comorbidities Such as Obesity, Metabolic Syndrome, and Type 2 Diabetes
Systematic Review Nutrients 2025

**Jurek et al., 2025** | Nutrients | Systematic Review Jurek Joanna Michalina, Zablocka-Slowinska Katarzyna, ... Auguet Teresa. Systematic Review of the Effects of Plant-Based Foods on Metabolic Outcomes in Adults with MASLD and Comorbidities Such as...

PubMed DOI
B The roles of garlic on the lipid parameters: a systematic review of the literature
Systematic Review Critical reviews in food science and nutrition 2013

**Zeng et al., 2013** | Crit Rev Food Sci Nutr | Systematic Review Zeng Tao, Zhang Cui-Li, ... Xie Ke-Qin. The roles of garlic on the lipid parameters: a systematic review of the literature. Crit Rev Food Sci Nutr. 2013;53(3):215-30. doi:10.1080/1040...

PubMed DOI
B Garlic for hypertension: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Phytomedicine : international journal of phytotherapy and phytopharmacology 2015

BACKGROUND: In the past decade, garlic has become one of the most popular complementary therapies for blood pressure (BP) control used by hypertensive patients. Numerous clinical studies have focused on the BP-lowering effect of garlic, but results h...

PubMed DOI
B Influence of maternal diet on flavor transfer to amniotic fluid and breast milk and children's responses: a systematic review
Systematic Review The American journal of clinical nutrition 2019

**Spahn et al., 2019** | Am J Clin Nutr | Systematic Review Spahn Joanne M, Callahan Emily H, ... Casavale Kellie O. Influence of maternal diet on flavor transfer to amniotic fluid and breast milk and children's responses: a systematic review. Am J C...

PubMed DOI
B Effect of garlic intake on inflammatory mediators: a systematic review and meta-analysis of randomised controlled trials
Meta Analysis Postgraduate medical journal 2021 n=530

**Koushki et al., 2021** | Postgrad Med J | Meta Analysis Koushki Mehdi, Amiri-Dashatan Nasrin, ... Doustimotlagh Amir Hossein. Effect of garlic intake on inflammatory mediators: a systematic review and meta-analysis of randomised controlled trials. ...

PubMed DOI
B Can an anti-inflammatory diet be effective in preventing or treating viral respiratory diseases? A systematic narrative review
Systematic Review Clinical nutrition ESPEN 2021

**Vahid et al., 2021** | Clin Nutr ESPEN | Systematic Review Vahid Farhad, Rahmani Diana. Can an anti-inflammatory diet be effective in preventing or treating viral respiratory diseases? A systematic narrative review. Clin Nutr ESPEN. 2021-Jun;43:9-1...

PubMed DOI
B Systematic review and meta-analysis of the effect of garlic in patients with non-alcoholic fatty liver disease
Meta Analysis Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology 2022 n=186

**Rastkar et al., 2022** | Indian J Gastroenterol | Meta Analysis Rastkar Mohsen, Nikniaz Leila, ... Nikniaz Zeinab. Systematic review and meta-analysis of the effect of garlic in patients with non-alcoholic fatty liver disease. Indian J Gastroentero...

PubMed DOI
B Effect of garlic on serum lipids: an updated meta-analysis
Meta Analysis Nutrition reviews 2013

**Ried et al., 2013** | Nutr Rev | Meta Analysis Ried Karin, Toben Catherine, Fakler Peter. Effect of garlic on serum lipids: an updated meta-analysis. Nutr Rev. 2013-May;71(5):282-99. doi:10.1111/nure.12012 Hypercholesterolemia is associated with an...

PubMed DOI
B The association of garlic with Helicobacter pylori infection and gastric cancer risk: A systematic review and meta-analysis
Meta Analysis Helicobacter 2018 n=921

**Li et al., 2018** | Helicobacter | Meta Analysis Li Ziyu, Ying Xiangji, ... Ji Jiafu. The association of garlic with Helicobacter pylori infection and gastric cancer risk: A systematic review and meta-analysis. Helicobacter. 2018-Oct;23(5):e12532. ...

PubMed DOI
B Allicin as add-on therapy for Helicobacter pylori infection: A systematic review and meta-analysis
Meta Analysis World journal of gastroenterology 2019 n=867

**Si et al., 2019** | World J Gastroenterol | Meta Analysis Si Xiao-Bei, Zhang Xu-Min, ... Huo Lin-Yu. Allicin as add-on therapy for Helicobacter pylori infection: A systematic review and meta-analysis. World J Gastroenterol. 2019-Oct-21;25(39):6025-...

PubMed DOI
B Garlic burn injuries- a systematic review of reported cases
Systematic Review The American journal of emergency medicine 2021 n=39

**Hitl et al., 2021** | Am J Emerg Med | Systematic Review Hitl Maja, Kladar Nebojša, ... Božin Biljana. Garlic burn injuries- a systematic review of reported cases. Am J Emerg Med. 2021-Jun;44:5-10. doi:10.1016/j.ajem.2021.01.039 Medicinal plants ha...

PubMed DOI
B Antihypertensive Effects of an Optimized Aged Garlic Extract in Subjects with Grade I Hypertension and Antihypertensive Drug Therapy: A Randomized, Triple-Blind Controlled Trial
Rct Nutrients 2023

The use of garlic (Allium sativum) for treating arterial hypertension has been recognized as effective for several decades. However, tolerance to treatment is low, and several technological modifications have been developed to improve its tolerabilit...

PubMed DOI
C Garlic for the common cold
Systematic Review The Cochrane database of systematic reviews 2009

**Lissiman et al., 2009** | Cochrane Database Syst Rev | Systematic Review Lissiman Elizabeth, Bhasale Alice L, Cohen Marc. Garlic for the common cold. Cochrane Database Syst Rev. 2009-Jul-08(3):CD006206. doi:10.1002/14651858.CD006206.pub2 BACKGROUND...

PubMed DOI
C A systematic review and metaanalysis on the effects of garlic preparations on blood pressure in individuals with hypertension
Meta Analysis American journal of hypertension 2015 n=482

**Rohner et al., 2015** | Am J Hypertens | Meta Analysis Rohner Andres, Ried Karin, ... Nordmann Alain J. A systematic review and metaanalysis on the effects of garlic preparations on blood pressure in individuals with hypertension. Am J Hypertens. 2...

PubMed DOI
C Anti-hyperlipidemia of garlic by reducing the level of total cholesterol and low-density lipoprotein: A meta-analysis
Meta Analysis Medicine 2018

**Sun et al., 2018** | Medicine (Baltimore) | Meta Analysis Sun Yue-E, Wang Weidong, Qin Jie. Anti-hyperlipidemia of garlic by reducing the level of total cholesterol and low-density lipoprotein: A meta-analysis. Medicine (Baltimore). 2018-May;97(18)...

PubMed DOI
C Effects of garlic supplementation on liver enzymes: A systematic review and meta-analysis of randomized controlled trials
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**Panjeshahin et al., 2020** | Phytother Res | Meta Analysis Panjeshahin Asieh, Mollahosseini Mehdi, ... Hosseinzadeh Mahdieh. Effects of garlic supplementation on liver enzymes: A systematic review and meta-analysis of randomized controlled trials. ...

PubMed DOI
C In Vivo and In Vitro Anti-schistosomiasis Effect of Garlic: A Systematic Review
Systematic Review Current drug discovery technologies 2022 n=2600

**Shakib et al., 2022** | Curr Drug Discov Technol | Systematic Review Shakib Pegah, Kalani Hamed, ... Cheraghipour Kourosh. In Vivo and In Vitro Anti-schistosomiasis Effect of Garlic: A Systematic Review. Curr Drug Discov Technol. 2022;19(4):e280222...

PubMed DOI
C Pooled analysis of epigenome-wide association studies of food consumption in KORA, TwinsUK and LLS
Meta Analysis European journal of nutrition 2023

**Hellbach et al., 2023** | Eur J Nutr | Meta Analysis Hellbach Fabian, Sinke Lucy, ... Linseisen Jakob. Pooled analysis of epigenome-wide association studies of food consumption in KORA, TwinsUK and LLS. Eur J Nutr. 2023-Apr;62(3):1357-1375. doi:10....

PubMed DOI
C Can natural irrigants replace sodium hypochlorite? A systematic review
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PubMed DOI
C The Effect of Aged Garlic Supplementation on Blood Pressure and Lipid Profile: A Dose-Response Grade-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Phytotherapy research : PTR 2025

Numerous clinical trials have examined the effects of aged garlic (AG) on metabolic factors, yielding inconsistent results. This systematic review and meta-analysis aimed to evaluate the impact of aged garlic on blood pressure (BP) and lipid profiles...

PubMed DOI
C Garlic for peripheral arterial occlusive disease
Systematic Review The Cochrane database of systematic reviews 2000 n=78

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PubMed
C Effect of garlic on the components of metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials
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PubMed DOI

Showing top 50 of 142 sources, sorted by quality score.

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Frequently Asked Questions

What is garlic supplement and what are its main benefits?

Garlic is a widely studied botanical used primarily to support cardiovascular and metabolic health. There is strong evidence for its role in blood pressure regulation and moderate evidence for its benefits in managing glucose and lipid profiles.

Can garlic help lower blood pressure?

Yes, there is strong evidence that garlic supplementation can help lower blood pressure in patients with hypertension. It is also useful for managing other cardiovascular risk factors.

Does garlic help with blood sugar and metabolic syndrome?

There is moderate evidence suggesting that garlic can impact fasting blood glucose levels and components of metabolic syndrome. It may also help in managing lipid profiles.

Can garlic help prevent cancer?

There is moderate evidence that high consumption of Allium vegetables, such as garlic, is associated with a reduced risk of gastric cancer. However, more research is needed to confirm these long-term benefits.

Does garlic help prevent the common cold?

Currently, there is only weak evidence regarding garlic's ability to prevent or treat the common cold. Systematic reviews indicate that there is insufficient evidence to support this use.

Are there any dangerous interactions with garlic?

Yes, garlic may interact with antiplatelet drugs and Warfarin, which could increase your risk of bleeding. If you are taking these medications, you should consult a healthcare professional before using garlic supplements.

What is the recommended dose of garlic?

The provided research does not specify an effective or recommended dose for garlic supplementation. You should consult a doctor to determine the appropriate amount for your specific health needs.

Answers generated from research evidence. Not medical advice.