Ginseng

178 research sources Also known as: panax ginseng asian ginseng korean ginseng red ginseng
481 Products on Market
450.0 mg Median Dose
🟢 90/100 Market Safety Score
178 Research Sources
Browse 481 products →

Product Forms

Capsule 53% Liquid 21% Powder 12% Tablet or Pill 9% Softgel Capsule 2% Other (e.g. tea bag) 2% Unknown 0% Gummy or Jelly 0%

Dose Distribution

1-5 mg 18 10-25 mg 3 100-250 mg 77 25-50 mg 12 250-500 mg 61 5-10 mg 3 50-100 mg 19 500-1000 mg 94 <1 mg 7 >1000 mg 96

Top Brands

TerraVita Premium Collection 39 BulkSupplements.com 25 Wonder Laboratories 16 The Vitamin Shoppe 11 Herbal Terra 11 DC 11 Ron Teeguarden's Dragon Herbs 11 Nootropics Depot 10 Planetary Herbals 9 Hawaii Pharm 8 Simply Supplements 7 Herb Pharm 7

Claims on Labels

All Other 98% Structure/Function 82% Nutrient 3% No Claim 2% Approved Health 0%

Top-Rated Ginseng Products

Korean Ginseng
Korean Ginseng Sundown Naturals
Safety: 100 Capsule
Standardized Panax Ginseng Herbal Supplement 600 mg
Standardized Panax Ginseng Herbal Supplement 600 mg GNC Ginsa Gold
Safety: 100 Capsule
Panax Ginseng Root Extract
Panax Ginseng Root Extract Bluebonnet Herbals
Safety: 100 Capsule
Manchurian Ginseng 250 mg
Manchurian Ginseng 250 mg Nature's Bounty
Safety: 100 Softgel Capsule
Korean Ginseng Max-V Douglas Laboratories
Safety: 100 Capsule
View all Ginseng products → Best Ginseng rankings →

Evidence Summary

Ginseng is a widely researched supplement with a large body of evidence, primarily focused on its effects on physical performance, fatigue, and metabolic health. Meta-analyses suggest potential benefits for athletic ergogenic effects, fatigue reduction, and the management of certain cardiovascular and respiratory conditions.

Evidence by Condition

Fatigue and Physical Performance Strong

Ginseng supplements are effective in improving physical performance and reducing both general and disease-related fatigue.

Cognitive Function Moderate

Cochrane reviews have investigated the efficacy of ginseng for cognitive enhancement.

Type 2 Diabetes Mellitus Moderate

Ginseng-related therapies have shown efficacy in the management of Type 2 Diabetes Mellitus.

Cardiovascular Health Moderate

Evidence indicates that ginseng supplementation may influence plasma lipid concentrations and various CVD risk factors.

Respiratory Health Moderate

Panax notoginseng saponins have shown clinical efficacy in treating COPD associated with blood hypercoagulability.

Effective Doses

Dose ranges were not explicitly provided in the source text.

Key Findings

  • Ginseng supplements are effective for improving physical performance and reducing fatigue (PMID: 27822924).
  • Ginseng supplementation may influence plasma lipid concentrations in adults (PMID: 31987252).
  • Panax notoginseng saponins show clinical efficacy in treating COPD with blood hypercoagulability (PMID: 38216446).
  • Ginseng-related therapies have demonstrated efficacy in Type 2 Diabetes Mellitus (PMID: 26871778).

Limitations

Much of the high-quality evidence focuses on specific derivatives, such as Panax notoginseng saponins, or specific populations like athletes, which may limit generalizability.

Safety & Interactions

No specific drug interactions or contraindications were detailed in the provided research summaries.

AI-generated summary from 178 peer-reviewed studies. Not medical advice. Always consult a healthcare provider.

Drug-Supplement Interactions

Antiarrhythmics 🔴 Critical
Mechanism: Ginseng is a weak inhibitor of CYP2C9, which decreases metabolism of CYP2C9 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of amiodarone (antiarrhythmics), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of amiodarone. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Anticonvulsants 🔴 Critical
Mechanism: Ginseng is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of carbamazepine (anticonvulsants), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of carbamazepine. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
GI Prokinetics 🔴 Critical
Mechanism: Ginseng is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of cisapride (gi-prokinetics), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of cisapride. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Immunosuppressants 🔴 Critical
Mechanism: Ginseng is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of cyclosporine (immunosuppressants), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of cyclosporine. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Theophylline 🔴 Critical
Mechanism: Ginseng is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of theophylline (theophylline), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of theophylline. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
ADHD Medications 🟡 Moderate
Mechanism: Ginseng is a weak inhibitor of CYP2D6, which decreases metabolism of CYP2D6 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of atomoxetine (adhd-medications), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of atomoxetine. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
ARB 🟡 Moderate
Mechanism: Ginseng is a weak inhibitor of CYP2C9, which decreases metabolism of CYP2C9 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of losartan (arb), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of losartan. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Abciximab 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Abciximab
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Acetohexamide 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Acetohexamide
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Albiglutide 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Albiglutide
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Alteplase 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Alteplase
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Anistreplase 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Anistreplase
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Antiandrogens 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Finasteride
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Antibiotics 🟡 Moderate
Mechanism: Ginseng is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of clarithromycin (antibiotics), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of clarithromycin. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Anticoagulants 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Apixaban, Edoxaban, Rivaroxaban, Enoxaparin, Fondaparinux, Dicoumarol, Heparin
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Antidiabetic Drugs 🟡 Moderate
Mechanism: Ginseng may lower blood glucose, potentially additive with diabetes medications.
Effect: Possible additive hypoglycemic effect
Management: Monitor blood glucose closely. May need to reduce medication dose.
Evidence: possible
Antiemetics 🟡 Moderate
Mechanism: Ginseng is a weak inhibitor of CYP2D6, which decreases metabolism of CYP2D6 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of ondansetron (antiemetics), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of ondansetron. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Antifungals 🟡 Moderate
Mechanism: Ginseng is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of fluconazole (antifungals), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of fluconazole. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Antiplatelet Drugs 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Acetylsalicylic acid, Dipyridamole, Acetylsalicylic acid, Clopidogrel, Prasugrel, Ticagrelor, Ticlopidine, Vorapaxar
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Antipsychotics 🟡 Moderate
Mechanism: Ginseng is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of haloperidol (antipsychotics), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of haloperidol. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Antithrombin III human 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Antithrombin III human
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Antitussives 🟡 Moderate
Mechanism: Ginseng is a weak inhibitor of CYP2D6, which decreases metabolism of CYP2D6 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of dextromethorphan (antitussives), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of dextromethorphan. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Argatroban 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Argatroban
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Benzodiazepines 🟡 Moderate
Mechanism: Ginseng is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of midazolam (benzodiazepines), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of midazolam. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Beta Blockers 🟡 Moderate
Mechanism: Ginseng is a weak inhibitor of CYP2D6, which decreases metabolism of CYP2D6 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of metoprolol (beta-blockers), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of metoprolol. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Beta-2 Agonists 🟡 Moderate
Mechanism: Ginseng is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of salmeterol (beta2-agonists), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of salmeterol. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Betrixaban 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Betrixaban
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Bivalirudin 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Bivalirudin
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
CFTR Modulators 🟡 Moderate
Mechanism: Ginseng is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of ivacaftor (cftr-modulators), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of ivacaftor. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Calcium Channel Blockers 🟡 Moderate
Mechanism: Ginseng is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of nifedipine (calcium-channel-blockers), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of nifedipine. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Cangrelor 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Cangrelor
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Caplacizumab 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Caplacizumab
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Chemotherapy 🟡 Moderate
Mechanism: Ginseng is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of doxorubicin (chemotherapy), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of doxorubicin. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Corticosteroids 🟡 Moderate
Mechanism: Ginseng is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of prednisone (corticosteroids), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of prednisone. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Dalteparin 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Dalteparin
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Danaparoid 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Danaparoid
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Defibrotide 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Defibrotide
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Eptifibatide 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Eptifibatide
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Ertugliflozin 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Ertugliflozin
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Insulin aspart (aspart protamine) 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Insulin aspart (aspart protamine)
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Insulin aspart (aspart) 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Insulin aspart (aspart)
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Insulin degludec 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Insulin degludec
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Insulin detemir 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Insulin detemir
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Insulin glargine 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Insulin glargine
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Insulin glulisine 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Insulin glulisine
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Insulin human 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Insulin human
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Insulin human (inhalation, rapid acting) 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Insulin human (inhalation, rapid acting)
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Insulin human (isophane) 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Insulin human (isophane)
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Insulin human (regular) 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Insulin human (regular)
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Insulin human (zinc extended) 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Insulin human (zinc extended)
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Insulin human (zinc) 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Insulin human (zinc)
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Insulin lispro 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Insulin lispro
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Insulin lispro (protamine) 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Insulin lispro (protamine)
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Lepirudin 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Lepirudin
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Leukotriene Antagonists 🟡 Moderate
Mechanism: Ginseng is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of montelukast (leukotriene-antagonists), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of montelukast. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Lixisenatide 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Lixisenatide
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Miglitol 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Miglitol
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
NSAIDs 🟡 Moderate
Mechanism: Ginseng is a weak inhibitor of CYP2C9, which decreases metabolism of CYP2C9 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of ibuprofen (nsaids), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of ibuprofen. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Opioids 🟡 Moderate
Mechanism: Ginseng is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of methadone (opioids), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of methadone. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Oral Contraceptives 🟡 Moderate
Mechanism: Ginseng is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of ethinylestradiol (oral-contraceptives), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of ethinylestradiol. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
PDE5 Inhibitors 🟡 Moderate
Mechanism: Ginseng is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of sildenafil (pde5-inhibitors), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of sildenafil. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
PPIS 🟡 Moderate
Mechanism: Ginseng is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of omeprazole (ppis), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of omeprazole. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Pramlintide 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Pramlintide
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Reteplase 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Reteplase
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
SNRI 🟡 Moderate
Mechanism: Ginseng is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of venlafaxine (snri), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of venlafaxine. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Statins 🟡 Moderate
Mechanism: Ginseng is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of simvastatin (statins), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of simvastatin. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Streptokinase 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Streptokinase
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Tenecteplase 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Tenecteplase
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Tinzaparin 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Tinzaparin
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Tirofiban 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Tirofiban
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Tricyclic Antidepressants 🟡 Moderate
Mechanism: Ginseng is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
Effect: Increased plasma levels of amitriptyline (tricyclic-antidepressants), potentially leading to toxicity or enhanced adverse effects.
Management: Monitor for increased adverse effects of amitriptyline. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Evidence: cyp-inferred
Urokinase 🟡 Moderate
Mechanism: Interaction identified from DDInter 2.0 database. Specific drugs: Urokinase
Effect: See mechanism description
Management: Consult healthcare provider before combining.
Evidence: ddinter-verified
Warfarin 🟡 Moderate
Mechanism: Ginseng may reduce warfarin efficacy, possibly through CYP enzyme induction or ginsenoside effects on clotting.
Effect: Reduced anticoagulant effect; decreased INR
Management: Monitor INR closely. Avoid ginseng supplements if possible.
Evidence: probable
Ssri 🟢 Minor
Mechanism: Ginseng may have weak MAO-inhibiting properties; theoretical risk of serotonin syndrome with SSRIs.
Effect: Possible additive serotonergic effect (rare)
Management: Generally safe at typical doses. Report any agitation or confusion.
Evidence: possible
Stimulants 🟢 Minor
Mechanism: Ginseng has mild stimulant properties; combined with caffeine or other stimulants may cause overstimulation.
Effect: Possible insomnia, nervousness, tachycardia
Management: Moderate intake of both. Avoid high-dose combinations.
Evidence: possible

⚠️ This information is for educational purposes only and does not constitute medical advice. Always consult your healthcare provider before combining supplements with medications.

Claims vs. Evidence

80% Evidence-Backed
20% Unsupported
82% Structure/Function
Claim Type% of ProductsEvidence RequiredStatus
All Other 98% Tier D (Unclassified) ✅ Supported
Structure/Function 82% Tier C (DSHEA Structure/Function (no pre-approval)) ✅ Supported
Nutrient 3% Tier D (Unknown) ✅ Supported
No Claim 2% Tier D (No claim on label) ✅ Supported
Approved Health 0% Tier A (FDA Approved Health Claim (21 CFR 101.9)) ⚠️ Unsupported

🏛️ NIH ODS Factsheet

Ginseng

Research by Topic

Ginseng 156 studies
MET Treatments of Sexual Dysfunction in Opioid Substitution Ther...
MET Compound salvia pellet, a traditional Chinese medicine, for ...
MET Efficacy of Ginseng Supplements on Fatigue and Physical Perf...
+153 more
Ginseng Energy 11 studies
SYS Phytochemical Insights into Panax Genus Metabolites: Evidenc...
MET Effects of Ginseng on Cognitive Function: A Systematic Revie...
SYS Ginseng and Cancer-Related Fatigue: A Systematic Review of C...
+8 more
Dietary Supplement General 4 studies
CLI Effects of Ginseng on Stress, Emotional and Cognitive Proces...
CLI American Ginseng to Improve HIV-Associated Fatigue: A Random...
CLI Korean Red Ginseng in Treating Patients With Fatigue Caused ...
+1 more
Ashwagandha 2 studies
MET Withania somnifera (Indian ginseng) in male infertility: An ...
MET Withania somnifera (Indian ginseng) in diabetes mellitus: A ...
Ginkgo 2 studies
SYS A systematic review of research investigating the physiologi...
MET The risk-benefit profile of commonly used herbal therapies: ...
Quercetin 1 studies
SYS Targeting pyroptosis: A novel strategy of ginseng for the tr...
Omega 3 Cognition 1 studies
RCT Efficacy of Omega-3 and Korean Red Ginseng in Children with ...
Carnitine 1 studies
CLI Efficacy and Safety of Red Ginseng Concentrated Powder on Im...

⚠️ FDA Safety Data

Adverse Event Profile: Ginseng

Research Evidence (178)

Systematic Review: 86 Meta Analysis: 70 Clinical Trial: 10 Rct: 8 Cochrane Review: 2 Openfda Safety: 1
B Treatments of Sexual Dysfunction in Opioid Substitution Therapy Patients: A Systematic Review and Meta-Analysis
Meta Analysis International journal of medical sciences 2021 n=207

**Ramli et al., 2021** | Int J Med Sci | Meta Analysis Ramli Fitri Fareez, Azizi Muhammad Hasif, Syed Hashim Syed Alhafiz. Treatments of Sexual Dysfunction in Opioid Substitution Therapy Patients: A Systematic Review and Meta-Analysis. Int J Med Sci....

PubMed DOI
B Compound salvia pellet, a traditional Chinese medicine, for the treatment of chronic stable angina pectoris compared with nitrates: a meta-analysis
Meta Analysis Medical science monitor : international medical journal of experimental and clinical research 2006 n=3722

**Wang et al., 2006** | Med Sci Monit | Meta Analysis Wang Gang, Wang Lei, ... Li Ting-Qian. Compound salvia pellet, a traditional Chinese medicine, for the treatment of chronic stable angina pectoris compared with nitrates: a meta-analysis. Med Sci ...

PubMed
B Efficacy of Ginseng Supplements on Fatigue and Physical Performance: a Meta-analysis
Meta Analysis Journal of Korean medical science 2016 n=630

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B Phytochemical Insights into Panax Genus Metabolites: Evidence-Based Fatigue Intervention via Ethnopharmacological and Biomedical Perspectives
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Frequently Asked Questions

What is ginseng and what are its main benefits?

Ginseng is a widely researched supplement primarily used to support physical performance, fatigue reduction, and metabolic health. There is strong evidence for its use in improving performance and moderate evidence regarding its impact on cognitive and cardiovascular health.

Does ginseng help with fatigue and energy levels?

Yes, there is strong evidence that ginseng supplements are effective in improving physical performance and reducing both general and disease-related fatigue. This makes it a highly researched option for those seeking energy support.

Can ginseng help manage Type 2 Diabetes?

There is moderate evidence suggesting that ginseng-related therapies can be effective in the management of Type 2 Diabetes Mellitus. However, you should always consult a medical professional before using supplements to manage blood sugar.

Is ginseng good for brain function and memory?

There is moderate evidence, including Cochrane reviews, suggesting that ginseng may be effective for cognitive enhancement. It is often studied for its potential to improve mental clarity and cognitive performance.

Can ginseng support heart health?

There is moderate evidence indicating that ginseng supplementation may influence plasma lipid concentrations and various cardiovascular disease risk factors. This suggests a potential role in supporting overall cardiovascular health.

Are there any known drug interactions or safety concerns with ginseng?

No specific drug interactions or contraindications have been documented in the provided research. However, you should always consult a healthcare provider before starting ginseng to ensure it is safe for your specific health profile.

What is the recommended dose of ginseng?

The available research does not provide an explicitly defined effective dose range for ginseng. You should work with a healthcare professional to determine the appropriate dosage for your individual needs.

Answers generated from research evidence. Not medical advice.