🔴
Ginseng × Anticonvulsants
CRITICAL INTERACTION
⚠️ Mechanism
Ginseng is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
📋 Effect
Increased plasma levels of carbamazepine (anticonvulsants), potentially leading to toxicity or enhanced adverse effects.
💊 Management
Monitor for increased adverse effects of carbamazepine. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Plain Language Summary
This combination is considered dangerous because ginseng can prevent your body from breaking down anticonvulsant medication properly. This can cause the medicine to build up to unsafe levels in your bloodstream, increasing your risk of serious side effects.
Source
Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)
Supporting Research
Compound salvia pellet, a traditional Chinese medicine, for the treatment of chronic stable angina pectoris compared with nitrates: a meta-analysis
PMID:16369479
2006
Clinical efficacy and safety of Panax notoginseng saponins in treating chronic obstructive pulmonary disease with blood hypercoagulability: A meta-analysis of randomized controlled trials
PMID:38216446
DOI:10.1016/j.phymed.2023.155244
2024
[Dan'e-fukang soft extract for dysmenorrhea: a meta-analysis]
PMID:25187464
2014
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.