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Ginseng × ADHD Medications

MODERATE Cyp-Inferred Evidence

Mechanism

Ginseng is a weak inhibitor of CYP2D6, which decreases metabolism of CYP2D6 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect

Increased plasma levels of atomoxetine (adhd-medications), potentially leading to toxicity or enhanced adverse effects.

Management

Monitor for increased adverse effects of atomoxetine. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Plain Language Summary

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This combination may be unsafe because ginseng can slow down how your body processes certain ADHD medications. This can cause the medication to build up in your system, which may increase the risk of side effects.

Source

Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)

Research

Supporting Research

Treatments of Sexual Dysfunction in Opioid Substitution Therapy Patients: A Systematic Review and Meta-Analysis
PMID:33967614 DOI 2021
Compound salvia pellet, a traditional Chinese medicine, for the treatment of chronic stable angina pectoris compared with nitrates: a meta-analysis
PMID:16369479 2006
Efficacy of Ginseng Supplements on Fatigue and Physical Performance: a Meta-analysis
PMID:27822924 DOI 2016
Dose-response and temporal ergogenic effects of ginseng supplementation in athletes and active participants: A systematic review and meta-analysis
PMID:36604650 DOI 2022
Clinical efficacy and safety of Panax notoginseng saponins in treating chronic obstructive pulmonary disease with blood hypercoagulability: A meta-analysis of randomized controlled trials
PMID:38216446 DOI 2024
[Dan'e-fukang soft extract for dysmenorrhea: a meta-analysis]
PMID:25187464 2014
Efficacy of ginseng supplements on disease-related fatigue: A systematic review and meta-analysis
PMID:35776997 DOI 2022
The efficacy of ginseng supplementation on plasma lipid concentration in adults: A systematic review and meta-analysis
PMID:31987252 DOI 2020
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Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications.