Nicotinamide Riboside
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Evidence Summary
Nicotinamide Riboside (NR) is an NAD+ precursor that has been shown to effectively increase NAD+ levels in various populations, including healthy older adults and those with specific metabolic or muscle conditions. Research primarily focuses on its ability to augment the NAD+ metabolome and its potential anti-inflammatory effects.
Evidence by Condition
Chronic supplementation is well-tolerated and effectively elevates NAD+ levels in healthy middle-aged and older adults.
NR augments the NAD+ metabolome in aged human skeletal muscle and induces anti-inflammatory signatures.
Oral NR supplementation raises NAD+ and lowers certain biomarkers of neurodegenerative pathology in plasma extracellular vesicles.
Small-scale studies suggest NR combined with pterostilbene can increase NAD+ levels in AKI patients.
Research is investigating the effect of NR on airway inflammation in COPD patients.
Clinical trials are exploring the benefits of NR supplementation in patients with this rare progeroid syndrome.
Effective Doses
Specific dose ranges were not explicitly detailed in the provided research abstracts.
Key Findings
- Chronic NR supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults (PMID: 29599478)
- NR augments the aged human skeletal muscle NAD+ metabolome and induces anti-inflammatory signatures (PMID: 31412242)
- Oral NR raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles (PMID: 36515353)
- NR with pterostilbene increases NAD+ in patients with acute kidney injury (PMID: 32791973)
Limitations
Much of the current evidence is limited by small sample sizes in specific clinical populations (e.g., AKI) and a primary focus on NAD+ elevation rather than long-term clinical outcomes.
Safety & Interactions
Long-term administration of NIAGEN (NR chloride) has been demonstrated to be safe in healthy overweight adults (PMID: 31278280).
AI-generated summary from 10 peer-reviewed studies. Not medical advice. Always consult a healthcare provider.
Claims vs. Evidence
| Claim Type | % of Products | Evidence Required | Status |
|---|---|---|---|
| All Other | 100% | Tier D (Unclassified) | ✅ Supported |
| Structure/Function | 90% | Tier C (DSHEA Structure/Function (no pre-approval)) | ✅ Supported |
| Nutrient | 28% | Tier D (Unknown) | ✅ Supported |
Research by Topic
Research Evidence (10)
**Martens et al., 2018** | Nat Commun | Rct Martens Christopher R, Denman Blair A, ... Seals Douglas R. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun. 2018-Mar-29...
**Baichuan et al., 2023** | Front Nutr | Systematic Review Baichuan You, Gomes Reis Marcela, ... Sernizon Guimarães Nathalia. The effects of NAD+ precursor (nicotinic acid and nicotinamide) supplementation on weight loss and related hormones: a syste...
Chronic obstructive pulmonary disease (COPD) is a progressive, incurable disease associated with smoking and advanced age, ranking as the third leading cause of death worldwide. DNA damage and loss of the central metabolite nicotinamide adenine dinuc...
**Conze et al., 2019** | Sci Rep | Rct Conze Dietrich, Brenner Charles, Kruger Claire L. Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of ...
**Elhassan et al., 2019** | Cell Rep | Rct Elhassan Yasir S, Kluckova Katarina, ... Lavery Gareth G. Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. Cell Rep. ...
**Vreones et al., 2023** | Aging Cell | Rct Vreones Michael, Mustapic Maja, ... Martens Christopher R. Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal ...
**Simic et al., 2020** | BMC Nephrol | Rct Simic Petra, Vela Parada Xavier Fernando, ... Rhee Eugene P. Nicotinamide riboside with pterostilbene (NRPT) increases NAD+ in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-con...
**NCT ID**: NCT04809974 **Phase**: PHASE4 **Status**: COMPLETED **Enrollment**: 72 **Completion**: 2024-02-23
BACKGROUNDDuring aging, there is a functional decline in the pool of muscle stem cells (MuSCs) that influences the functional and regenerative capacity of skeletal muscle. Preclinical evidence has suggested that nicotinamide riboside (NR) and pterost...
Werner syndrome (WS) is a rare hereditary progeroid syndrome caused by mutations in the WRN gene. Patients frequently develop various age-associated diseases prematurely, often leading to early mortality (≤ 60 years of age). Depletion of nicotinamide...
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Frequently Asked Questions
What is Nicotinamide Riboside and how does it work?
Nicotinamide Riboside (NR) is a precursor to NAD+, a molecule essential for cellular function. There is strong evidence that NR supplementation can effectively increase NAD+ levels in healthy middle-aged and older adults.
Does Nicotinamide Riboside help with muscle aging?
There is moderate evidence that NR can support aged human skeletal muscle. Research indicates it can augment the NAD+ metabolome and induce anti-inflammatory signatures in the muscle.
Can Nicotinamide Riboside help with neurodegenerative diseases?
There is moderate evidence that oral NR supplementation can raise NAD+ levels and lower certain biomarkers of neurodegenerative pathology in the blood. However, more research is needed to confirm its full impact.
Is Nicotinamide Riboside safe to take long-term?
Chronic supplementation of NR is considered well-tolerated in healthy adults. Specifically, long-term administration of NIAGEN (NR chloride) has been demonstrated to be safe in healthy overweight adults.
Are there any known drug interactions with Nicotinamide Riboside?
There are currently no documented drug interactions for Nicotinamide Riboside. However, you should always consult with a healthcare provider before starting any new supplement.
What is the effective dose of Nicotinamide Riboside?
Specific effective dose ranges were not explicitly detailed in the available research. You should consult a medical professional to determine an appropriate dosage for your specific needs.
Can Nicotinamide Riboside help with COPD or kidney injury?
There is currently insufficient evidence to confirm if NR helps with COPD or acute kidney injury. While some small-scale studies are investigating these areas, more large-scale research is required.
Answers generated from research evidence. Not medical advice.