Celery Seed
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Evidence Summary
Celery seed extract is a botanical supplement primarily studied for its potential impact on cardiovascular and metabolic health. Current research suggests it may play a role in managing blood pressure and joint health, though evidence for other applications remains limited.
Evidence by Condition
Clinical trials and systematic reviews indicate that celery seed extract may help lower blood pressure and improve biochemical efficacy in hypertensive patients.
When used in combination with Boswellia serrata, celery seed extract may assist in managing knee osteoarthritis and cartilage degeneration.
A systematic review investigated the effects of celery on fertility, but the evidence base is limited by small sample sizes.
Research suggests potential effects on glucose and lipid profiles in adults, though more robust data is needed.
Effective Doses
Dose ranges are not specified in the provided research abstracts.
Key Findings
- Celery seed extract may positively influence blood pressure, glycemic, and lipid profiles in adults (PMID: 40765738).
- A combination of Boswellia serrata and Apium graveolens L. extract shows efficacy against knee osteoarthritis and cartilage degeneration (PMID: 39875757).
- Celery seed extract has been demonstrated to be safe and biochemically effective in hypertensive patients (PMID: 35536382).
Limitations
Research is limited by small sample sizes in systematic reviews and a lack of studies investigating the extract as a monotherapy for conditions like osteoarthritis or fertility.
Safety & Interactions
Safety evaluations in hypertensive patients suggest the extract is well-tolerated, but specific drug interactions and contraindications were not detailed in the provided studies.
AI-generated summary from 5 peer-reviewed studies. Not medical advice. Always consult a healthcare provider.
Claims vs. Evidence
| Claim Type | % of Products | Evidence Required | Status |
|---|---|---|---|
| All Other | 96% | Tier D (Unclassified) | ✅ Supported |
| Structure/Function | 86% | Tier C (DSHEA Structure/Function (no pre-approval)) | ⚠️ Unsupported |
| Nutrient | 4% | Tier D (Unknown) | ✅ Supported |
Research by Topic
Research Evidence (5)
**Liu et al., 2025** | Front Nutr | Systematic Review Liu Dangzhen, Zhao Haiyan, ... Hu Jingqing. Effects of celery (Apium graveolens) on blood pressure, glycemic and lipid profile in adults: a systematic review and meta-analysis of randomized contro...
**Vaidya et al., 2025** | Pharm Res | Rct Vaidya Narendra, Agarwal Ramshyam, ... Nair Sujit. Efficacy and Safety of Boswellia serrata and Apium graveolens L. Extract Against Knee Osteoarthritis and Cartilage Degeneration: A Randomized, Double-blind, ...
**Kooti et al., 2017** | J Complement Integr Med | Systematic Review Kooti Wesam, Moradi Maryam, ... Ghafourian Mehri. The effect of celery (Apium graveolens L.) on fertility: A systematic review. J Complement Integr Med. 2017-Oct-06;15(2). doi:10.15...
**Shayani et al., 2022** | Inflammopharmacology | Rct Shayani Rad Maryam, Moohebati Mohsen, ... Mohajeri Seyed Ahmad. Safety evaluation and biochemical efficacy of celery seed extract (Apium Graveolens) capsules in hypertensive patients: a randomized...
**Shayani et al., 2022** | Phytother Res | Rct Shayani Rad Maryam, Moohebati Mohsen, Mohajeri Seyed Ahmad. Effect of celery (Apium graveolens) seed extract on hypertension: A randomized, triple-blind, placebo-controlled, cross-over, clinical trial. P...
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Frequently Asked Questions
What is celery seed extract and what is it used for?
Celery seed extract is a botanical supplement primarily studied for its potential benefits to cardiovascular and metabolic health. While there is moderate evidence regarding its use for blood pressure, research into other health applications remains limited.
Does celery seed extract help with high blood pressure?
Yes, there is moderate evidence from clinical trials and systematic reviews suggesting that celery seed extract may help lower blood pressure and improve biochemical efficacy in hypertensive patients.
Can celery seed extract help with knee osteoarthritis?
There is weak evidence that celery seed extract may assist in managing knee osteoarthritis and cartilage degeneration, specifically when used in combination with Boswellia serrata.
Is there evidence that celery seed extract helps with fertility or blood sugar?
There is currently insufficient evidence to support the use of celery seed extract for improving fertility or managing glucose and lipid profiles. While some research suggests potential effects, more robust data is required.
What is the effective dose of celery seed extract?
Current research does not specify an effective dose range for celery seed extract. You should consult with a healthcare professional to determine an appropriate dosage for your needs.
Is celery seed extract safe to take and are there any side effects?
Safety evaluations in hypertensive patients suggest that the extract is well-tolerated. However, specific contraindications or details on who should avoid the supplement have not been fully documented in the available studies.
Are there any known drug interactions with celery seed extract?
There are currently no documented drug interactions for celery seed extract. However, it is always best to consult your doctor before starting a new supplement to ensure it is safe with your current medications.
Answers generated from research evidence. Not medical advice.