Home/ Supplements/ Celery Seed
Compound

Celery Seed

Also known as 3nb, apium graveolens, celery seed, celery seed extract

5 Research sources
87/100 Market safety
630.0 mg Median dose
57 Products on market

Key takeaways

  • Celery seed extract significantly impacts blood pressure, glycemic, and lipid profiles in adults (PMID: 40765738).
  • Celery seed extract demonstrated biochemical efficacy and safety in hypertensive patients (PMID: 35536382).
  • Combination of Apium graveolens and Boswellia serrata shows potential against knee osteoarthritis (PMID: 39875757).
Evidence

What the research shows

AI-synthesized from 5 peer-reviewed sources · Updated 2025

Celery seed extract (Apium graveolens) is used primarily for managing hypertension and inflammatory joint conditions. Current research suggests it may have beneficial effects on blood pressure and glycemic profiles, though evidence is limited by small sample sizes.

By condition

Hypertension Moderate
Multiple trials and a systematic review indicate that celery seed extract can effectively reduce blood pressure and improve lipid profiles.

Knee Osteoarthritis Weak
Preliminary evidence suggests efficacy in reducing cartilage degeneration when used in combination with Boswellia serrata.

Fertility Insufficient
A systematic review of very few participants suggests limited evidence regarding its effect on fertility.

Effective doses

Specific dose ranges were not provided in the abstracts, but efficacy was noted in capsule form across RCTs.

Safety & interactions

Generally reported as safe in clinical trials for hypertensive patients, but specific drug interactions were not detailed in the provided abstracts.

Limitations

Research is limited by small sample sizes in individual RCTs and a low number of participants in fertility-related reviews.

Products

Top-rated Celery Seed products

Ranked by safety score and evidence coverage

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Marketplace

How it's sold

Data aggregated from 57 product labels

Forms
Top brands
Claims vs evidence
67% Evidence-backed
86% Structure/function
33% Unsupported
Sources

Research evidence

Showing top 10 of 5 sources, sorted by quality

Systematic Review· Frontiers in nutrition· 2025· n=511· PMID 40765738

**Liu et al., 2025** | Front Nutr | Systematic Review Liu Dangzhen, Zhao Haiyan, ... Hu Jingqing. Effects of celery (Apium graveolens) on blood pressure, glycemic and lipid profile in adults: a systematic review and meta-analysis of randomi…

Rct· Pharmaceutical research· 2025· n=62· PMID 39875757

**Vaidya et al., 2025** | Pharm Res | Rct Vaidya Narendra, Agarwal Ramshyam, ... Nair Sujit. Efficacy and Safety of Boswellia serrata and Apium graveolens L. Extract Against Knee Osteoarthritis and Cartilage Degeneration: A Randomized, Doub…

Systematic Review· Journal of complementary & integrative medicine· 2017· n=16· PMID 28985183

**Kooti et al., 2017** | J Complement Integr Med | Systematic Review Kooti Wesam, Moradi Maryam, ... Ghafourian Mehri. The effect of celery (Apium graveolens L.) on fertility: A systematic review. J Complement Integr Med. 2017-Oct-06;15(2).…

Rct· Inflammopharmacology· 2022· n=51· PMID 35536382

**Shayani et al., 2022** | Inflammopharmacology | Rct Shayani Rad Maryam, Moohebati Mohsen, ... Mohajeri Seyed Ahmad. Safety evaluation and biochemical efficacy of celery seed extract (Apium Graveolens) capsules in hypertensive patients: a …

Rct· Phytotherapy research : PTR· 2022· PMID 35624525

**Shayani et al., 2022** | Phytother Res | Rct Shayani Rad Maryam, Moohebati Mohsen, Mohajeri Seyed Ahmad. Effect of celery (Apium graveolens) seed extract on hypertension: A randomized, triple-blind, placebo-controlled, cross-over, clinica…

FAQ

Frequently asked questions

What is celery seed extract and what is it used for?

Celery seed extract (Apium graveolens) is a supplement primarily used to manage hypertension and inflammatory joint conditions. Current research suggests it may also have beneficial effects on blood pressure and glycemic profiles, although the evidence is limited by small sample sizes.

Does celery seed extract work for high blood pressure?

There is moderate evidence indicating that celery seed extract can effectively reduce blood pressure and improve lipid profiles. Multiple trials and a systematic review support its use for hypertensive patients, showing it significantly impacts blood pressure and glycemic profiles.

Can celery seed extract help with knee osteoarthritis?

Evidence for this use is weak, though preliminary studies suggest it may help reduce cartilage degeneration when used in combination with Boswellia serrata. Research is limited, so more robust studies are needed to confirm its efficacy for knee osteoarthritis.

Is celery seed extract safe to take?

It is generally reported as safe in clinical trials for hypertensive patients, but specific long-term safety data is not detailed. You should avoid taking this supplement if you are pregnant, as safety for this group has not been established.

Does celery seed extract interact with any medications?

While specific drug interactions were not detailed in the provided abstracts, none were documented in the available data. However, because it affects blood pressure, you should consult a healthcare provider before combining it with antihypertensive medications to avoid adverse effects.

What is the effective dose of celery seed extract?

Specific dose ranges were not provided in the evidence summary, but efficacy was noted in capsule form across randomized controlled trials. Because exact dosing is not specified, you should consult a healthcare provider for personalized advice rather than relying on general guidelines.

Does celery seed extract improve fertility?

There is insufficient evidence to support this claim, as a systematic review of very few participants suggests limited evidence regarding its effect on fertility. It is not currently recommended for fertility purposes based on the available data.