Berberine is a bioactive compound with extensive research support for its role in metabolic health. Meta-analyses and systematic reviews consistently demonstrate its efficacy in managing dyslipidemia, glycemic control, and inflammatory markers.

Evidence by Condition

Dyslipidemia Strong

Berberine is effective for treating dyslipidaemias and can be used either alone or in combination with statins.

Type 2 Diabetes / Glycemic Control Strong

Research shows significant glucose-lowering effects and improvements in insulin-related traits.

Non-Alcoholic Fatty Liver Disease (NAFLD) Moderate

Berberine shows promise in improving liver enzymes and managing NAFLD, particularly in pre-fibrotic stages.

Inflammation Moderate

It helps reduce C-reactive protein and other inflammatory markers associated with metabolic syndrome.

Colorectal Adenomas Insufficient

There is evidence regarding its efficacy in preventing the recurrence of colorectal adenomas.

Effective Doses

Dose ranges are not explicitly stated in the provided research summaries.

Key Findings

Berberine is effective for treating dyslipidaemias (PMID: 30466986) and can be used alone or with statins (PMID: 31094214).
It provides significant glucose-lowering effects and improves insulin-related traits (PMID: 37598753, 36467075).
It reduces inflammatory markers such as C-reactive protein (PMID: 31519292, 35352233).
It shows efficacy in managing NAFLD and improving liver enzymes (PMID: 38429794, 35623810).

Limitations

Some evidence regarding atherosclerosis pathways is derived from animal studies, and more human-specific longitudinal data is needed.

Safety & Interactions

While studies frequently evaluate the safety of berberine, specific contraindications and drug interactions are not detailed in the provided summaries.

AI-generated summary from 98 peer-reviewed studies. Not medical advice. Always consult a healthcare provider.

Claims vs. Evidence

100% Evidence-Backed

0% Unsupported

86% Structure/Function

Claim Type	% of Products	Evidence Required	Status
All Other	100%	Tier D (Unclassified)	✅ Supported
Structure/Function	86%	Tier C (DSHEA Structure/Function (no pre-approval))	✅ Supported
Nutrient	4%	Tier D (Unknown)	✅ Supported
No Claim	0%	Tier D (No claim on label)	✅ Supported

Research by Topic

Berberine 92 studies

MET Efficacy and safety of berberine for dyslipidaemias: A syste...

MET Efficacy and safety of berberine for several cardiovascular ...

MET Effect of Berberine on C-reactive protein: A systematic revi...

+89 more

Dietary Supplement General 3 studies

CLI Berberine, Chlorogenic Acid and Tocotrienols in Menopause-as...

CLI Effect of Oral Combined Berberine and Curcumin Pharmacologic...

CLI Study of Berberine Hydrochloride in Prevention of Colorectal...

Milk Thistle Liver 1 studies

MET Effects berberine-silymarin on liver enzymes: A systematic r...

Coq10 1 studies

SYS Nutraceutical Approach to Non-Alcoholic Fatty Liver Disease ...

Red Yeast Rice 1 studies

MET Effects of a nutraceutical combination containing berberine ...

⚠️ FDA Safety Data

Adverse Event Profile: Berberine

Research Evidence (98)

Systematic Review: 48 Meta Analysis: 39 Rct: 4 Clinical Trial: 4 Other: 1 Narrative Review: 1 Openfda Safety: 1

B Efficacy and safety of berberine for dyslipidaemias: A systematic review and meta-analysis of randomized clinical trials

Meta Analysis Phytomedicine : international journal of phytotherapy and phytopharmacology 2018 n=2147

**Ju et al., 2018** | Phytomedicine | Meta Analysis Ju Jianqing, Li Jingen, ... Xu Hao. Efficacy and safety of berberine for dyslipidaemias: A systematic review and meta-analysis of randomized clinical trials. Phytomedicine. 2018-Nov-15;50:25-34. doi...

PubMed DOI

B Effects berberine-silymarin on liver enzymes: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Clinical nutrition ESPEN 2022 n=549

BACKGROUND & AIMS: Despite controversies, no study has systematically summarized findings from earlier studies on the effect of berberine (BBR)-silymarin on liver enzymes. Therefore, the current systematic review and meta-analysis aimed to investigat...

PubMed DOI

B Efficacy and safety of berberine for several cardiovascular diseases: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 n=4606

**Yang et al., 2023** | Phytomedicine | Meta Analysis Yang Lele, Zhu Wenyu, ... Shen Tao. Efficacy and safety of berberine for several cardiovascular diseases: A systematic review and meta-analysis of randomized controlled trials. Phytomedicine. 2023...

PubMed DOI

B Effect of Berberine on C-reactive protein: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Complementary therapies in medicine 2019 n=1242

**Beba et al., 2019** | Complement Ther Med | Meta Analysis Beba Mohammad, Djafarian Kurosh, Shab-Bidar Sakineh. Effect of Berberine on C-reactive protein: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med. 20...

PubMed DOI

B Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials

Meta Analysis The Journal of nutrition 2023 n=1761

**Zhao et al., 2023** | J Nutr | Meta Analysis Zhao Jie V, Huang Xin, ... Blais Joseph E. Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Nu...

PubMed DOI

B The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review

Meta Analysis Journal of translational medicine 2024 n=811

**Nie et al., 2024** | J Transl Med | Meta Analysis Nie Qilong, Li Mingyang, ... Li Jianhong. The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review. J Transl Med. 20...

PubMed DOI

B Berberine Effects in Pre-Fibrotic Stages of Non-Alcoholic Fatty Liver Disease-Clinical and Pre-Clinical Overview and Systematic Review of the Literature

Systematic Review International journal of molecular sciences 2024 n=73

**Ionita-Radu et al., 2024** | Int J Mol Sci | Systematic Review Ionita-Radu Florentina, Patoni Cristina, ... Bucurica Sandica. Berberine Effects in Pre-Fibrotic Stages of Non-Alcoholic Fatty Liver Disease-Clinical and Pre-Clinical Overview and Syste...

PubMed DOI

B Efficacy and Safety of Berberine Alone or Combined with Statins for the Treatment of Hyperlipidemia: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials

Meta Analysis The American journal of Chinese medicine 2019 n=1386

**Zhang et al., 2019** | Am J Chin Med | Meta Analysis Zhang Li-Shuang, Zhang Jun-Hua, ... Li Xue-Mei. Efficacy and Safety of Berberine Alone or Combined with Statins for the Treatment of Hyperlipidemia: A Systematic Review and Meta-Analysis of Rando...

PubMed DOI

B Effects of Berries, Phytochemicals, and Probiotics on Atherosclerosis through Gut Microbiota Modification: A Meta-Analysis of Animal Studies

Meta Analysis International journal of molecular sciences 2023

**Khalili et al., 2023** | Int J Mol Sci | Meta Analysis Khalili Leila, Centner Ann Marie, Salazar Gloria. Effects of Berries, Phytochemicals, and Probiotics on Atherosclerosis through Gut Microbiota Modification: A Meta-Analysis of Animal Studies. I...

PubMed DOI

B Berberine Ursodeoxycholate for the Treatment of Type 2 Diabetes: A Randomized Clinical Trial

Rct JAMA network open 2025 n=38

**Ji et al., 2025** | JAMA Netw Open | Rct Ji Linong, Ma Jianhua, ... Liu Liping. Berberine Ursodeoxycholate for the Treatment of Type 2 Diabetes: A Randomized Clinical Trial. JAMA Netw Open. 2025-Mar-03;8(3):e2462185. doi:10.1001/jamanetworkopen.202...

PubMed DOI

B The effects of berberine on inflammatory markers in Chinese patients with metabolic syndrome and related disorders: a meta‑analysis of randomized controlled trials

Meta Analysis Inflammopharmacology 2022 n=4616

**Lu et al., 2022** | Inflammopharmacology | Meta Analysis Lu Yuqiong, Zhang Xiwen, ... Chang Feng. The effects of berberine on inflammatory markers in Chinese patients with metabolic syndrome and related disorders: a meta‑analysis of randomized cont...

PubMed DOI

B Gegen Qinlian decoction ameliorates insulin resistance in type 2 diabetes: A systematic review and meta-analysis of RCTs with mechanistic insights into SIRT1/AMPK pathway activation

Meta Analysis Journal of ethnopharmacology 2026 n=3247

**Liao et al., 2026** | J Ethnopharmacol | Meta Analysis Liao Yifan, Yang Liu, ... Yue Rensong. Gegen Qinlian decoction ameliorates insulin resistance in type 2 diabetes: A systematic review and meta-analysis of RCTs with mechanistic insights into SI...

PubMed DOI

B Efficacy and safety of berberine in preventing recurrence of colorectal adenomas: A systematic review and meta-analysis

Meta Analysis Journal of ethnopharmacology 2022 n=1076

**Fang et al., 2022** | J Ethnopharmacol | Meta Analysis Fang ShuangShuang, Guo Song, ... Wei Wei. Efficacy and safety of berberine in preventing recurrence of colorectal adenomas: A systematic review and meta-analysis. J Ethnopharmacol. 2022-Jan-10;...

PubMed DOI

B Glucose-lowering effect of berberine on type 2 diabetes: A systematic review and meta-analysis

Systematic Review Frontiers in pharmacology 2022 n=3048

**Xie et al., 2022** | Front Pharmacol | Systematic Review Xie Wenting, Su Fugui, ... Chen Rongping. Glucose-lowering effect of berberine on type 2 diabetes: A systematic review and meta-analysis. Front Pharmacol. 2022;13:1015045. doi:10.3389/fphar.2...

PubMed DOI

B Overall and Sex-Specific Effect of Berberine for the Treatment of Dyslipidemia in Adults: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials

Meta Analysis Drugs 2023 n=1788

**Blais et al., 2023** | Drugs | Meta Analysis Blais Joseph E, Huang Xin, Zhao Jie V. Overall and Sex-Specific Effect of Berberine for the Treatment of Dyslipidemia in Adults: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Tri...

PubMed DOI

B Impact of Berberine or Berberine Combination Products on Lipoprotein, Triglyceride and Biological Safety Marker Concentrations in Patients with Hyperlipidemia: A Systematic Review and Meta-Analysis

Meta Analysis Journal of dietary supplements 2024 n=4838

**Hernandez et al., 2024** | J Diet Suppl | Meta Analysis Hernandez Adrian V, Hwang Jennifer, ... White C Michael. Impact of Berberine or Berberine Combination Products on Lipoprotein, Triglyceride and Biological Safety Marker Concentrations in Patie...

PubMed DOI

B Assessing Nutraceuticals for Hepatic Steatosis: A Standardized In Vitro Approach

Systematic Review Nutrients 2026 n=46

**Palasantzas et al., 2026** | Nutrients | Systematic Review Palasantzas Victoria E J M, Struik Dicky, ... Hoogerland Joanne A. Assessing Nutraceuticals for Hepatic Steatosis: A Standardized In Vitro Approach. Nutrients. 2026-Jan-24;18(3). doi:10.339...

PubMed DOI

B Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension

Meta Analysis Journal of ethnopharmacology 2015 n=2569

**Lan et al., 2015** | J Ethnopharmacol | Meta Analysis Lan Jiarong, Zhao Yanyun, ... Sun Guoli. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. J Ethnopharmacol. 2015-F...

PubMed DOI

B Effects of berberine and barberry on anthropometric measures: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Complementary therapies in medicine 2020 n=849

**Amini et al., 2020** | Complement Ther Med | Meta Analysis Amini Mohammad Reza, Sheikhhossein Fatemeh, ... Shab-Bidar Sakineh. Effects of berberine and barberry on anthropometric measures: A systematic review and meta-analysis of randomized control...

PubMed DOI

B Efficacy and Safety of Armolipid Plus®: An Updated PRISMA Compliant Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials

Meta Analysis Nutrients 2021

**Cicero et al., 2021** | Nutrients | Meta Analysis Cicero Arrigo F G, Kennedy Cormac, ... Fogacci Federica. Efficacy and Safety of Armolipid Plus®: An Updated PRISMA Compliant Systematic Review and Meta-Analysis of Randomized Controlled Clinical Tri...

PubMed DOI

B Effects of adjuvant berberine therapy on acute ischemic stroke: A meta-analysis

Meta Analysis Phytotherapy research : PTR 2023 n=1670

**Luo et al., 2023** | Phytother Res | Meta Analysis Luo Dan, Yu Baili, ... Shi Shihua. Effects of adjuvant berberine therapy on acute ischemic stroke: A meta-analysis. Phytother Res. 2023-Sep;37(9):3820-3838. doi:10.1002/ptr.7920 We conducted a meta...

PubMed DOI

B Effects of berberine and barberry on selected inflammatory biomarkers in adults: A systematic review and dose-response meta-analysis of randomized clinical trials

Meta Analysis Phytotherapy research : PTR 2023 n=1600

**Vahedi-Mazdabadi et al., 2023** | Phytother Res | Meta Analysis Vahedi-Mazdabadi Yasaman, Shahinfar Hossein, ... Shidfar Farzad. Effects of berberine and barberry on selected inflammatory biomarkers in adults: A systematic review and dose-response ...

PubMed DOI

B Efficacy and safety of berberine plus 5-ASA for ulcerative colitis: A systematic review and meta-analysis

Meta Analysis PloS one 2024 n=952

**Li et al., 2024** | PLoS One | Meta Analysis Li Jilei, Zhang Chenchen, ... Yang Lili. Efficacy and safety of berberine plus 5-ASA for ulcerative colitis: A systematic review and meta-analysis. PLoS One. 2024;19(9):e0309144. doi:10.1371/journal.pone...

PubMed DOI

B Nutraceutical Approach to Non-Alcoholic Fatty Liver Disease (NAFLD): The Available Clinical Evidence

Systematic Review Nutrients 2018

**Cicero et al., 2018** | Nutrients | Systematic Review Cicero Arrigo F G, Colletti Alessandro, Bellentani Stefano. Nutraceutical Approach to Non-Alcoholic Fatty Liver Disease (NAFLD): The Available Clinical Evidence. Nutrients. 2018-Aug-23;10(9). do...

PubMed DOI

B The Effect of Berberine on Metabolic Profiles in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Meta Analysis Oxidative medicine and cellular longevity 2021

**Guo et al., 2021** | Oxid Med Cell Longev | Meta Analysis Guo Jing, Chen Hongdong, ... Liu Wei Jing. The Effect of Berberine on Metabolic Profiles in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. O...

PubMed DOI

B Levodopa and Plant-Derived Bioactive Compounds in Parkinson's Disease: Mechanisms, Efficacy, and Future Perspectives

Systematic Review CNS neuroscience & therapeutics 2025

**Aktaş et al., 2025** | CNS Neurosci Ther | Systematic Review Aktaş Emre, Hanağası Haşmet Ayhan, Özgentürk Nehir Özdemir. Levodopa and Plant-Derived Bioactive Compounds in Parkinson's Disease: Mechanisms, Efficacy, and Future Perspectives. CNS Neuro...

PubMed DOI

B Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study)

Rct Nature communications 2020

**Zhang et al., 2020** | Nat Commun | Rct Zhang Yifei, Gu Yanyun, ... Wang Weiqing. Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study). Nat Commun. 2020-Oct-06;11(1):5015. doi:10.1038/s41467-020-18414-8 ...

PubMed DOI

B Berberine for the treatment of hypertension: A systematic review

Meta Analysis Complementary therapies in clinical practice 2021 n=614

**Suadoni et al., 2021** | Complement Ther Clin Pract | Meta Analysis Suadoni Marco Tullio, Atherton Iain. Berberine for the treatment of hypertension: A systematic review. Complement Ther Clin Pract. 2021-Feb;42:101287. doi:10.1016/j.ctcp.2020.10128...

PubMed DOI

B Efficacy and safety of berberine for premature ventricular contractions: a meta-analysis and systematic review of randomized controlled trials

Meta Analysis Pharmaceutical biology 2023 n=896

**Qiao et al., 2023** | Pharm Biol | Meta Analysis Qiao Meng, Lei Chao, ... Wang Zhifei. Efficacy and safety of berberine for premature ventricular contractions: a meta-analysis and systematic review of randomized controlled trials. Pharm Biol. 2023-...

PubMed DOI

B Metabolic effect of berberine-silymarin association: A meta-analysis of randomized, double-blind, placebo-controlled clinical trials

Meta Analysis Phytotherapy research : PTR 2019 n=497

**Fogacci et al., 2019** | Phytother Res | Meta Analysis Fogacci Federica, Grassi Davide, ... Cicero Arrigo F G. Metabolic effect of berberine-silymarin association: A meta-analysis of randomized, double-blind, placebo-controlled clinical trials. Phy...

PubMed DOI

B Berberine as adjuvant therapy for treating reduced fertility potential in women with polycystic ovary syndrome: A meta-analysis of randomized controlled trials

Meta Analysis Explore (New York, N.Y.) 2024 n=713

**Ha et al., 2024** | Explore (NY) | Meta Analysis Ha Sifu, Song Xiaoyu. Berberine as adjuvant therapy for treating reduced fertility potential in women with polycystic ovary syndrome: A meta-analysis of randomized controlled trials. Explore (NY). 20...

PubMed DOI

B Clinical Efficacy of Curcumin, Resveratrol, Silymarin, and Berberine on Cardio-Metabolic Risk Factors Among Patients With Type 2 Diabetes Mellitus: A Systemic Review and Bayesian Network Meta-Analysis

Systematic Review Phytotherapy research : PTR 2025 n=1337

**Miao et al., 2025** | Phytother Res | Systematic Review Miao Runyu, Zhang Boxun, ... Tong Xiaolin. Clinical Efficacy of Curcumin, Resveratrol, Silymarin, and Berberine on Cardio-Metabolic Risk Factors Among Patients With Type 2 Diabetes Mellitus: A...

PubMed DOI

B Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine

Rct The Journal of clinical endocrinology and metabolism 2008

**Zhang et al., 2008** | J Clin Endocrinol Metab | Rct Zhang Yifei, Li Xiaoying, ... Ning Guang. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab. 2008-Jul;93(7):2559-65. doi:10.1210/jc....

PubMed DOI

B The effects of berberine on blood lipids: a systemic review and meta-analysis of randomized controlled trials

Meta Analysis Planta medica 2013 n=874

**Dong et al., 2013** | Planta Med | Meta Analysis Dong Hui, Zhao Yan, ... Lu Fuer. The effects of berberine on blood lipids: a systemic review and meta-analysis of randomized controlled trials. Planta Med. 2013-Apr;79(6):437-46. doi:10.1055/s-0032-1...

PubMed DOI

B The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Clinical nutrition ESPEN 2020 n=12

**Asbaghi et al., 2020** | Clin Nutr ESPEN | Meta Analysis Asbaghi Omid, Ghanbari Niloofar, ... Asemi Zatollah. The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analy...

PubMed DOI

C Effects of berberine on blood glucose in patients with type 2 diabetes mellitus: a systematic literature review and a meta-analysis

Meta Analysis Endocrine journal 2019

**Liang et al., 2019** | Endocr J | Meta Analysis Liang Yaping, Xu Xiaojia, ... Ni Jindong. Effects of berberine on blood glucose in patients with type 2 diabetes mellitus: a systematic literature review and a meta-analysis. Endocr J. 2019-Jan-28;66(...

PubMed DOI

C Berberine and health outcomes: an overview of systematic reviews

Systematic Review BMC complementary medicine and therapies 2025

**Shi et al., 2025** | BMC Complement Med Ther | Systematic Review Shi Lanjun, Wang Wenya, ... Liao Xing. Berberine and health outcomes: an overview of systematic reviews. BMC Complement Med Ther. 2025-Apr-23;25(1):147. doi:10.1186/s12906-025-04872-4...

PubMed DOI

C The effects of Gegen Qinlian decoction and its main constituents on glucolipid metabolic disorders in diabetes: an overview of systematic reviews and meta-analysis

Meta Analysis Systematic reviews 2025 n=35

**Xue et al., 2025** | Syst Rev | Meta Analysis Xue Chongxiang, Chen Ying, ... Wang Han. The effects of Gegen Qinlian decoction and its main constituents on glucolipid metabolic disorders in diabetes: an overview of systematic reviews and meta-analys...

PubMed DOI

C Mapping the knowledge domain: a bibliometric analysis of global research on traditional Chinese medicine for non-alcoholic fatty liver disease (2000-2024)

Systematic Review Frontiers in medicine 2026

**Feng et al., 2026** | Front Med (Lausanne) | Systematic Review Feng Zhongwen, Lu Qingliu, ... Chen Xiaoyu. Mapping the knowledge domain: a bibliometric analysis of global research on traditional Chinese medicine for non-alcoholic fatty liver diseas...

PubMed DOI

C The effect of Berberine on weight loss in order to prevent obesity: A systematic review

Systematic Review Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020

**Ilyas et al., 2020** | Biomed Pharmacother | Systematic Review Ilyas Zahra, Perna Simone, ... Rondanelli Mariangela. The effect of Berberine on weight loss in order to prevent obesity: A systematic review. Biomed Pharmacother. 2020-Jul;127:110137. ...

PubMed DOI

C Protective effect of berberine in diabetic nephropathy: A systematic review and meta-analysis revealing the mechanism of action

Meta Analysis Pharmacological research 2022

**Hu et al., 2022** | Pharmacol Res | Meta Analysis Hu Shuangyuan, Wang Jundong, ... Ma Xiao. Protective effect of berberine in diabetic nephropathy: A systematic review and meta-analysis revealing the mechanism of action. Pharmacol Res. 2022-Nov;185...

PubMed DOI

C Novel Wound Care Practices in Bullous Pemphigoid: A Systematic Review

Meta Analysis Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2025

**Jacoby et al., 2025** | Wound Repair Regen | Meta Analysis Jacoby Ted, Yee Danielle, ... Isseroff Roslyn. Novel Wound Care Practices in Bullous Pemphigoid: A Systematic Review. Wound Repair Regen. 2025;33(6):e70109. doi:10.1111/wrr.70109 Bullous pe...

PubMed DOI

C The effect of berberine on obesity indices: a systematic review and meta-analysis

Meta Analysis International journal of obesity (2005) 2026

**Elahi et al., 2026** | Int J Obes (Lond) | Meta Analysis Elahi Vahed Iman, Shahir-Roudi Erfan, ... Rahmanian Mohammad. The effect of berberine on obesity indices: a systematic review and meta-analysis. Int J Obes (Lond). 2026-Jan;50(1):53-73. doi:1...

PubMed DOI

C Pre-clinical Evidence: Berberine as a Promising Cardioprotective Candidate for Myocardial Ischemia/Reperfusion Injury, a Systematic Review, and Meta-Analysis

Systematic Review Frontiers in cardiovascular medicine 2021

**Chen et al., 2021** | Front Cardiovasc Med | Systematic Review Chen Cong, Lin Qian, ... Li Dong. Pre-clinical Evidence: Berberine as a Promising Cardioprotective Candidate for Myocardial Ischemia/Reperfusion Injury, a Systematic Review, and Meta-An...

PubMed DOI

C High-fat Diet-associated Digestive Cancers: Mechanisms, Natural Product-based Therapies, and Drug Development

Systematic Review Phytomedicine : international journal of phytotherapy and phytopharmacology 2026

**Ma et al., 2026** | Phytomedicine | Systematic Review Ma Jia, Zhang Yuanhao, ... Efferth Thomas. High-fat Diet-associated Digestive Cancers: Mechanisms, Natural Product-based Therapies, and Drug Development. Phytomedicine. 2026-Jan;150:157574. doi:...

PubMed DOI

C Efficacy of Berberine Alone and in Combination for the Treatment of Hyperlipidemia: A Systematic Review

Systematic Review Journal of evidence-based complementary & alternative medicine 2017

**Koppen et al., 2017** | J Evid Based Complementary Altern Med | Systematic Review Koppen Laura M, Whitaker Andrea, ... Beckett Robert D. Efficacy of Berberine Alone and in Combination for the Treatment of Hyperlipidemia: A Systematic Review. J Evid...

PubMed DOI

C Neuroprotective effects of berberine in animal models of Alzheimer's disease: a systematic review of pre-clinical studies

Systematic Review BMC complementary and alternative medicine 2019 n=15

**Yuan et al., 2019** | BMC Complement Altern Med | Systematic Review Yuan Ning-Ning, Cai Cui-Zan, ... Lu Jia-Hong. Neuroprotective effects of berberine in animal models of Alzheimer's disease: a systematic review of pre-clinical studies. BMC Complem...

PubMed DOI

C Anticancer effect of berberine based on experimental animal models of various cancers: a systematic review and meta-analysis

Meta Analysis BMC cancer 2019 n=26

**Xu et al., 2019** | BMC Cancer | Meta Analysis Xu Jianhao, Long Yuming, ... Zhang Yusong. Anticancer effect of berberine based on experimental animal models of various cancers: a systematic review and meta-analysis. BMC Cancer. 2019-Jun-17;19(1):58...

PubMed DOI

C Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review

Systematic Review Journal of integrative medicine 2020

**Shinjyo et al., 2020** | J Integr Med | Systematic Review Shinjyo Noriko, Parkinson James, ... Bligh Annie. Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review. J Integr Med. 2020-Mar;18(2):125-1...

PubMed DOI

C Systematic Review and Network Meta-Analysis of the Effects of Plant Extracts on Cognitive Function and Quality of Life in Stroke Patients

Systematic Review Phytotherapy research : PTR 2025 n=33

**Li et al., 2025** | Phytother Res | Systematic Review Li Ji, Jin Jingfen, ... Zhang Ning. Systematic Review and Network Meta-Analysis of the Effects of Plant Extracts on Cognitive Function and Quality of Life in Stroke Patients. Phytother Res. 2025...

PubMed DOI

Showing top 50 of 98 sources, sorted by quality score.

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Frequently Asked Questions

What is Berberine and what is it used for?

Berberine is a bioactive compound used to support metabolic health. There is strong evidence that it is effective for managing blood sugar levels and unhealthy cholesterol levels.

Does Berberine help lower blood sugar?

Yes, there is strong evidence that Berberine provides significant glucose-lowering effects. It is also shown to improve insulin-related traits, making it useful for glycemic control.

Can Berberine help with high cholesterol?

There is strong evidence that Berberine is effective for treating dyslipidaemia (unhealthy lipid levels). Research suggests it can be used either alone or in combination with statins.

Is Berberine effective for fatty liver disease?

There is moderate evidence that Berberine shows promise in managing Non-Alcoholic Fatty Liver Disease (NAFLD). It may help improve liver enzymes, particularly in the pre-fibrotic stages of the condition.

Can Berberine reduce inflammation?

There is moderate evidence that Berberine helps reduce inflammation in the body. Specifically, it can help lower C-reactive protein and other inflammatory markers associated with metabolic syndrome.

What is the recommended dose of Berberine?

The provided research does not explicitly state a specific effective dose range. You should consult with a healthcare professional to determine the appropriate dosage for your needs.

Are there any side effects or drug interactions with Berberine?

While studies frequently evaluate its safety, specific contraindications were not detailed in the available research. Currently, no drug interactions are documented, but you should always consult a doctor before use.

Who should avoid taking Berberine?

The provided research does not specify particular groups who should avoid Berberine. However, because it has strong effects on blood sugar and lipids, individuals should discuss its use with a physician.

Answers generated from research evidence. Not medical advice.