Collagen is a structural protein, and research into its oral supplementation focuses primarily on its impact on skin health. A meta-analysis of randomized controlled trials suggests that hydrolyzed collagen can improve skin hydration and elasticity.

Evidence by Condition

skin Moderate

Oral hydrolyzed collagen supplementation has been shown to improve skin hydration and elasticity.

Effective Doses

Not specified in the provided research.

Key Findings

Oral hydrolyzed collagen supplementation improves skin hydration and elasticity (PMID: 37432180).

Limitations

The provided research is specifically focused on skin anti-aging, with limited evidence for other physiological benefits in the provided dataset.

Safety & Interactions

No safety information or contraindications were provided in the source text.

AI-generated summary from 280 peer-reviewed studies. Not medical advice. Always consult a healthcare provider.

Claims vs. Evidence

100% Evidence-Backed

0% Unsupported

95% Structure/Function

Claim Type	% of Products	Evidence Required	Status
All Other	99%	Tier D (Unclassified)	✅ Supported
Structure/Function	95%	Tier C (DSHEA Structure/Function (no pre-approval))	✅ Supported
Nutrient	80%	Tier D (Unknown)	✅ Supported
Qualified Health	0%	Tier B (FDA Qualified Health Claim)	✅ Supported

Research by Topic

Collagen 206 studies

MET Vascular closure devices for femoral arterial puncture site ...

MET Transepithelial versus epithelium-off corneal crosslinking f...

MET Bisphosphonate therapy for osteogenesis imperfecta

+203 more

Collagen Skin 23 studies

MET Effects of Oral Collagen for Skin Anti-Aging: A Systematic R...

MET Effects of Collagen Supplements on Skin Aging: A Systematic ...

MET Effects of hydrolyzed collagen supplementation on skin aging...

+20 more

Dietary Supplement General 14 studies

CLI Impact of Collagen Supplements on Dermal Collagen in Plastic...

CLI A Single-Group Clinical Trial to Evaluate the Effects of Hea...

CLI Clinical Effects of Two Oral Bioactive Collagen Peptides On ...

+11 more

Collagen Joint 10 studies

MET Effect of collagen supplementation on knee osteoarthritis: a...

RCT UC-II Undenatured Type II Collagen for Knee Joint Flexibilit...

RCT Management and Amelioration of Knee Joint Osteoarthritis in ...

+7 more

Vitamin C Exercise 7 studies

RCT Hydrolysed Collagen Supplementation Enhances Patellar Tendon...

RCT The Collagen Synthesis Response to an Acute Bout of Resistan...

RCT Collagen Peptides, in Association with Vitamin C, Sodium Hya...

+4 more

Vitamin C 3 studies

CLI Gelatin, Collagen, Gummy and PINP

CLI Resistance Exercise and Hydrolyzed Collagen Supplementation

CLI Resistance Training and Hydrolyzed Collagen Supplementation ...

Aloe Vera 2 studies

RCT Effects of Aloe Sterol Supplementation on Skin Elasticity, H...

RCT Effects of low-dose Aloe sterol supplementation on skin mois...

Chondroitin 2 studies

RCT Effect of an oral preparation containing hyaluronic acid, ch...

RCT [Comparative efficacy of a combination of undenatured type I...

Probiotics 1 studies

MET Interventions for primary vesicoureteric reflux

Guideline Supplements 1 studies

GUI Optimizing Collagen Biostimulator Choice in LATAM: Expert Co...

Calcium 1 studies

SYS Urethral injection therapy for urinary incontinence in women

Vitamin C Skin 1 studies

RCT The Effects of Dietary Supplementation with Collagen and Vit...

Magnesium Osteoporosis 1 studies

MET Osteoinductive Bone Morphogenic Protein, Collagen Scaffold, ...

Ala Diabetes 1 studies

RCT A randomized, double-blind, placebo controlled study to eval...

Resveratrol 1 studies

SYS Nutraceuticals: do they represent a new era in the managemen...

Zinc Wound 1 studies

RCT Multinutrient Supplementation Increases Collagen Synthesis d...

Glycine Sleep 1 studies

RCT Collagen peptide supplementation before bedtime reduces slee...

Zinc Skin 1 studies

RCT A Dermonutrient Containing Special Collagen Peptides Improve...

Riboflavin 1 studies

RCT Corneal Haze After Transepithelial Collagen Cross-linking fo...

Glucosamine 1 studies

RCT Randomized, double-blind, four-arm pilot study on the effect...

Vitamin D 1 studies

CLI Effects of Hydrolyzed Collagen and Vitamin C on Explosive Pe...

Royal Jelly 1 studies

OTH Royal jelly protects against ultraviolet B-induced photoagin...

⚠️ FDA Safety Data

Adverse Event Profile: Collagen

Research Evidence (281)

Meta Analysis: 141 Systematic Review: 72 Rct: 45 Clinical Trial: 18 Narrative Review: 2 Other: 1 Guideline: 1 Openfda Safety: 1

A Vascular closure devices for femoral arterial puncture site haemostasis

Meta Analysis The Cochrane database of systematic reviews 2016 n=19192

**Robertson et al., 2016** | Cochrane Database Syst Rev | Meta Analysis Robertson Lindsay, Andras Alina, ... Jackson Ralph. Vascular closure devices for femoral arterial puncture site haemostasis. Cochrane Database Syst Rev. 2016-Mar-07;3(3):CD009541...

PubMed DOI

B Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis

Meta Analysis Nutrients 2023 n=1721

This paper presents a systematic review and meta-analysis of 26 randomized controlled trials (RCTs) involving 1721 patients to assess the effects of hydrolyzed collagen (HC) supplementation on skin hydration and elasticity. The results showed that HC...

PubMed DOI

B Transepithelial versus epithelium-off corneal crosslinking for progressive keratoconus

Meta Analysis The Cochrane database of systematic reviews 2021 n=578

**Ng et al., 2021** | Cochrane Database Syst Rev | Meta Analysis Ng Sueko M, Ren Mark, ... Kuo Irene C. Transepithelial versus epithelium-off corneal crosslinking for progressive keratoconus. Cochrane Database Syst Rev. 2021-Mar-23;3(3):CD013512. doi...

PubMed DOI

B Bisphosphonate therapy for osteogenesis imperfecta

Meta Analysis The Cochrane database of systematic reviews 2014 n=819

**Dwan et al., 2014** | Cochrane Database Syst Rev | Meta Analysis Dwan Kerry, Phillipi Carrie A, ... Basel Donald. Bisphosphonate therapy for osteogenesis imperfecta. Cochrane Database Syst Rev. 2014-Jul-23(7):CD005088. doi:10.1002/14651858.CD005088...

PubMed DOI

B Punctal occlusion for dry eye syndrome

Meta Analysis The Cochrane database of systematic reviews 2017 n=711

**Ervin et al., 2017** | Cochrane Database Syst Rev | Meta Analysis Ervin Ann-Margret, Law Andrew, Pucker Andrew D. Punctal occlusion for dry eye syndrome. Cochrane Database Syst Rev. 2017-Jun-26;6(6):CD006775. doi:10.1002/14651858.CD006775.pub3 BACK...

PubMed DOI

B Dressings and topical agents containing hyaluronic acid for chronic wound healing

Systematic Review The Cochrane database of systematic reviews 2023 n=1108

**Roehrs et al., 2023** | Cochrane Database Syst Rev | Systematic Review Roehrs Hellen, Stocco Janislei Gd, ... Dias Fernando Al. Dressings and topical agents containing hyaluronic acid for chronic wound healing. Cochrane Database Syst Rev. 2023-Jul-...

PubMed DOI

B Efficacy of statins for osteoporosis: a systematic review and meta-analysis

Meta Analysis Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2017 n=314473

**An et al., 2017** | Osteoporos Int | Meta Analysis An T, Hao J, ... Zou M. Efficacy of statins for osteoporosis: a systematic review and meta-analysis. Osteoporos Int. 2017-Jan;28(1):47-57. doi:10.1007/s00198-016-3844-8 Our meta-analysis assessed t...

PubMed DOI

B Drugs to reduce bleeding and transfusion in major open vascular or endovascular surgery: a systematic review and network meta-analysis

Systematic Review The Cochrane database of systematic reviews 2023 n=3393

**Beverly et al., 2023** | Cochrane Database Syst Rev | Systematic Review Beverly Anair, Ong Giok, ... Estcourt Lise J. Drugs to reduce bleeding and transfusion in major open vascular or endovascular surgery: a systematic review and network meta-anal...

PubMed DOI

B Bisphosphonate therapy for osteogenesis imperfecta

Meta Analysis The Cochrane database of systematic reviews 2008 n=403

**Phillipi et al., 2008** | Cochrane Database Syst Rev | Meta Analysis Phillipi Carrie A, Remmington Tracey, Steiner Robert D. Bisphosphonate therapy for osteogenesis imperfecta. Cochrane Database Syst Rev. 2008-Oct-08(4):CD005088. doi:10.1002/146518...

PubMed DOI

B Bisphosphonates for osteoporosis in primary biliary cirrhosis

Meta Analysis The Cochrane database of systematic reviews 2011 n=106

**Rudic et al., 2011** | Cochrane Database Syst Rev | Meta Analysis Rudic Jelena S, Giljaca Vanja, ... Gluud Christian. Bisphosphonates for osteoporosis in primary biliary cirrhosis. Cochrane Database Syst Rev. 2011-Dec-07;2011(12):CD009144. doi:10.1...

PubMed DOI

B Interventions for replacing missing teeth: management of soft tissues for dental implants

Meta Analysis The Cochrane database of systematic reviews 2012 n=138

**Esposito et al., 2012** | Cochrane Database Syst Rev | Meta Analysis Esposito Marco, Maghaireh Hassan, ... Worthington Helen V. Interventions for replacing missing teeth: management of soft tissues for dental implants. Cochrane Database Syst Rev. 2...

PubMed DOI

B Corneal collagen cross-linking for treating keratoconus

Systematic Review The Cochrane database of systematic reviews 2015 n=2000

**Sykakis et al., 2015** | Cochrane Database Syst Rev | Systematic Review Sykakis Evripidis, Karim Rushmia, ... Hamada Samer. Corneal collagen cross-linking for treating keratoconus. Cochrane Database Syst Rev. 2015-Mar-24;2015(3):CD010621. doi:10.10...

PubMed DOI

B Bisphosphonate therapy for osteogenesis imperfecta

Meta Analysis The Cochrane database of systematic reviews 2016 n=819

**Dwan et al., 2016** | Cochrane Database Syst Rev | Meta Analysis Dwan Kerry, Phillipi Carrie A, ... Basel Donald. Bisphosphonate therapy for osteogenesis imperfecta. Cochrane Database Syst Rev. 2016-Oct-19;10(10):CD005088 BACKGROUND: Osteogenesis i...

PubMed

B Traditional suburethral sling operations for urinary incontinence in women

Meta Analysis The Cochrane database of systematic reviews 2017 n=75

**Rehman et al., 2017** | Cochrane Database Syst Rev | Meta Analysis Rehman Haroon, Bezerra Carlos A, ... Aluko Patricia. Traditional suburethral sling operations for urinary incontinence in women. Cochrane Database Syst Rev. 2017-Jul-26;7(7):CD00175...

PubMed DOI

B The worldwide prevalence of the Dupuytren disease: a comprehensive systematic review and meta-analysis

Meta Analysis Journal of orthopaedic surgery and research 2020 n=6628506

**Salari et al., 2020** | J Orthop Surg Res | Meta Analysis Salari Nader, Heydari Mohammadbagher, ... Daneshkhah Alireza. The worldwide prevalence of the Dupuytren disease: a comprehensive systematic review and meta-analysis. J Orthop Surg Res. 2020-...

PubMed DOI

B A 2022 Systematic Review and Meta-Analysis of Enriched Therapeutic Diets and Nutraceuticals in Canine and Feline Osteoarthritis

Meta Analysis International journal of molecular sciences 2022 n=72

**Barbeau-Grégoire et al., 2022** | Int J Mol Sci | Meta Analysis Barbeau-Grégoire Maude, Otis Colombe, ... Troncy Eric. A 2022 Systematic Review and Meta-Analysis of Enriched Therapeutic Diets and Nutraceuticals in Canine and Feline Osteoarthritis. ...

PubMed DOI

B Abemaciclib increases the risk of venous thromboembolism in breast cancer: Integrate meta-analysis, pharmacovigilance database analysis, and in vitro validation

Meta Analysis Cancer treatment reviews 2024 n=16903

**Hua et al., 2024** | Cancer Treat Rev | Meta Analysis Hua Manqi, Xiong Fei, ... Xiang Qian. Abemaciclib increases the risk of venous thromboembolism in breast cancer: Integrate meta-analysis, pharmacovigilance database analysis, and in vitro valida...

PubMed DOI

B Effects of Collagen Supplements on Skin Aging: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Meta Analysis The American journal of medicine 2025 n=1474

BACKGROUND: Collagen supplements are promoted to help aging skin. However, no meta-analysis of randomized controlled trials (RCTs) has examined their effects by funding source and study quality, which may influence outcomes. METHODS: PubMed, Embase, ...

PubMed DOI

B Interventions for hidradenitis suppurativa

Meta Analysis The Cochrane database of systematic reviews 2015 n=615

**Ingram et al., 2015** | Cochrane Database Syst Rev | Meta Analysis Ingram John R, Woo Pick-Ngor, ... Piguet Vincent. Interventions for hidradenitis suppurativa. Cochrane Database Syst Rev. 2015-Oct-07;2015(10):CD010081. doi:10.1002/14651858.CD01008...

PubMed DOI

B Fluoroquinolones Are Associated With Increased Risk of Aortic Aneurysm or Dissection: Systematic Review and Meta-analysis

Meta Analysis Seminars in thoracic and cardiovascular surgery 2021 n=2851646

**Vouga et al., 2021** | Semin Thorac Cardiovasc Surg | Meta Analysis Vouga Ribeiro Nuno, Gouveia Melo Ryan, ... Caldeira Daniel. Fluoroquinolones Are Associated With Increased Risk of Aortic Aneurysm or Dissection: Systematic Review and Meta-analysi...

PubMed DOI

B Endothelin receptor antagonists for pulmonary arterial hypertension

Meta Analysis The Cochrane database of systematic reviews 2006 n=482

**Liu et al., 2006** | Cochrane Database Syst Rev | Meta Analysis Liu C, Chen J. Endothelin receptor antagonists for pulmonary arterial hypertension. Cochrane Database Syst Rev. 2006-Jul-19(3):CD004434 BACKGROUND: Pulmonary arterial hypertension (PAH...

PubMed

B Interventions for primary vesicoureteric reflux

Meta Analysis The Cochrane database of systematic reviews 2019 n=34

**Williams et al., 2019** | Cochrane Database Syst Rev | Meta Analysis Williams Gabrielle, Hodson Elisabeth M, Craig Jonathan C. Interventions for primary vesicoureteric reflux. Cochrane Database Syst Rev. 2019-Feb-20;2(2):CD001532. doi:10.1002/14651...

PubMed DOI

B Fluoroquinolone Use and the Risk of Collagen-Associated Adverse Events: A Systematic Review and Meta-Analysis

Meta Analysis Drug safety 2019 n=19207552

**Yu et al., 2019** | Drug Saf | Meta Analysis Yu Xinyu, Jiang Ding-Sheng, ... Wei Xiang. Fluoroquinolone Use and the Risk of Collagen-Associated Adverse Events: A Systematic Review and Meta-Analysis. Drug Saf. 2019-Sep;42(9):1025-1033. doi:10.1007/s...

PubMed DOI

B Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis

Meta Analysis International journal of dermatology 2021 n=1125

Skin aging has become a recurring concern even for younger people, mainly owing to increased life expectancy. In this context, the use of nutricosmetics as supplements has increased in recent years. Moreover, numerous scientific studies have shown th...

PubMed DOI

B Effects of sodium-glucose cotransporter 2 inhibitors on bone metabolism in patients with type 2 diabetes mellitus: a systematic review and meta-analysis

Meta Analysis BMC endocrine disorders 2024 n=22828

**Wang et al., 2024** | BMC Endocr Disord | Meta Analysis Wang Jing, Li Xin, ... Lei Chen. Effects of sodium-glucose cotransporter 2 inhibitors on bone metabolism in patients with type 2 diabetes mellitus: a systematic review and meta-analysis. BMC E...

PubMed DOI

B Impact of Collagen Peptide Supplementation in Combination with Long-Term Physical Training on Strength, Musculotendinous Remodeling, Functional Recovery, and Body Composition in Healthy Adults: A Systematic Review with Meta-analysis

Meta Analysis Sports medicine (Auckland, N.Z.) 2024 n=768

**Bischof et al., 2024** | Sports Med | Meta Analysis Bischof Kevin, Moitzi Anna Maria, ... König Daniel. Impact of Collagen Peptide Supplementation in Combination with Long-Term Physical Training on Strength, Musculotendinous Remodeling, Functional ...

PubMed DOI

B Transurethral radiofrequency collagen denaturation for the treatment of women with urinary incontinence

Systematic Review The Cochrane database of systematic reviews 2015 n=173

**Kang et al., 2015** | Cochrane Database Syst Rev | Systematic Review Kang Diana, Han Julia, ... Dahm Philipp. Transurethral radiofrequency collagen denaturation for the treatment of women with urinary incontinence. Cochrane Database Syst Rev. 2015-...

PubMed DOI

B Janus kinase-1 and Janus kinase-2 inhibitors for treating myelofibrosis

Systematic Review The Cochrane database of systematic reviews 2015 n=528

**Martí-Carvajal et al., 2015** | Cochrane Database Syst Rev | Systematic Review Martí-Carvajal Arturo J, Anand Vidhu, Solà Ivan. Janus kinase-1 and Janus kinase-2 inhibitors for treating myelofibrosis. Cochrane Database Syst Rev. 2015-Apr-10;2015(4)...

PubMed DOI

B Corneal collagen cross-linking for bacterial infectious keratitis

Meta Analysis The Cochrane database of systematic reviews 2020 n=59

**Davis et al., 2020** | Cochrane Database Syst Rev | Meta Analysis Davis Shadi A, Bovelle Renee, ... Kwagyan John. Corneal collagen cross-linking for bacterial infectious keratitis. Cochrane Database Syst Rev. 2020-Jun-17;6(6):CD013001. doi:10.1002/...

PubMed DOI

B Meta-analysis of the relationship between collagen characteristics and meat tenderness

Meta Analysis Meat science 2022

**Li et al., 2022** | Meat Sci | Meta Analysis Li Xiying, Ha Minh, ... Dunshea Frank R. Meta-analysis of the relationship between collagen characteristics and meat tenderness. Meat Sci. 2022-Mar;185:108717. doi:10.1016/j.meatsci.2021.108717 Meta-anal...

PubMed DOI

B Blosozumab in the treatment of postmenopausal women with osteoporosis: a systematic review and meta-analysis

Meta Analysis Annals of palliative medicine 2022 n=105

**Su et al., 2022** | Ann Palliat Med | Meta Analysis Su Yanlin, Wang Wenzhao, ... Ma Liang. Blosozumab in the treatment of postmenopausal women with osteoporosis: a systematic review and meta-analysis. Ann Palliat Med. 2022-Oct;11(10):3203-3212. doi...

PubMed DOI

B Effects of dietary supplements on patients with osteoarthritis: A systematic review and network meta-analysis

Systematic Review Journal of integrative medicine 2025 n=2455

**Chen et al., 2025** | J Integr Med | Systematic Review Chen Chang-Shun, Wen Lei, ... Gu Jin-Yi. Effects of dietary supplements on patients with osteoarthritis: A systematic review and network meta-analysis. J Integr Med. 2025-Jul;23(4):357-369. doi...

PubMed DOI

B Optimizing Collagen Biostimulator Choice in LATAM: Expert Consensus on Patient Selection, Ethnic Skin Phenotypes, and Accessibility.

Guideline Journal of cosmetic dermatology 2025

BACKGROUND: The diverse ethnic skin phenotypes and socioeconomic landscape of Latin America (LATAM) necessitate tailored approaches to collagen biostimulators, calcium hydroxylapatite (CaHA) and poly-l-lactic acid (PLLA). A region-specific consensus ...

PubMed DOI

B Punctal occlusion for dry eye syndrome

Systematic Review The Cochrane database of systematic reviews 2010 n=305

**Ervin et al., 2010** | Cochrane Database Syst Rev | Systematic Review Ervin Ann-Margret, Wojciechowski Robert, Schein Oliver. Punctal occlusion for dry eye syndrome. Cochrane Database Syst Rev. 2010-Sep-08(9):CD006775. doi:10.1002/14651858.CD006775...

PubMed DOI

B The Effect of Amino Acids on Wound Healing: A Systematic Review and Meta-Analysis on Arginine and Glutamine

Meta Analysis Nutrients 2021

**Arribas-López et al., 2021** | Nutrients | Meta Analysis Arribas-López Elena, Zand Nazanin, ... Kochhar Tony. The Effect of Amino Acids on Wound Healing: A Systematic Review and Meta-Analysis on Arginine and Glutamine. Nutrients. 2021-Jul-22;13(8)....

PubMed DOI

B Epithelium-on versus epithelium-off corneal collagen crosslinking for keratoconus: a systematic review and meta-analysis

Meta Analysis Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 2024 n=1399

**Borchert et al., 2024** | Graefes Arch Clin Exp Ophthalmol | Meta Analysis Borchert Grace A, Kandel Himal, Watson Stephanie L. Epithelium-on versus epithelium-off corneal collagen crosslinking for keratoconus: a systematic review and meta-analysis....

PubMed DOI

B Effect of vitamin D supplementation or fortification on bone turnover markers in women: a systematic review and meta-analysis

Meta Analysis The British journal of nutrition 2024 n=100

**Nasimi et al., 2024** | Br J Nutr | Meta Analysis Nasimi Nasrin, Jamshidi Sanaz, ... Faghih Shiva. Effect of vitamin D supplementation or fortification on bone turnover markers in women: a systematic review and meta-analysis. Br J Nutr. 2024-May-14...

PubMed DOI

B Peripheral Biomarkers of Anorexia Nervosa: A Meta-Analysis

Meta Analysis Nutrients 2024

**Wu et al., 2024** | Nutrients | Meta Analysis Wu Ya-Ke, Watson Hunna J, ... Baker Jessica H. Peripheral Biomarkers of Anorexia Nervosa: A Meta-Analysis. Nutrients. 2024-Jun-30;16(13). doi:10.3390/nu16132095 The pathogenesis of anorexia nervosa (AN)...

PubMed DOI

B Endothelin receptor antagonists for pulmonary arterial hypertension

Meta Analysis The Cochrane database of systematic reviews 2005 n=423

**Liu et al., 2005** | Cochrane Database Syst Rev | Meta Analysis Liu C, Cheng J. Endothelin receptor antagonists for pulmonary arterial hypertension. Cochrane Database Syst Rev. 2005-Jan-25(1):CD004434 BACKGROUND: Pulmonary arterial hypertension (PA...

PubMed

B Gentamicin-collagen sponge reduces the risk of sternal wound infections after heart surgery: Meta-analysis

Meta Analysis The Journal of thoracic and cardiovascular surgery 2015 n=22135

**Kowalewski et al., 2015** | J Thorac Cardiovasc Surg | Meta Analysis Kowalewski Mariusz, Pawliszak Wojciech, ... Anisimowicz Lech. Gentamicin-collagen sponge reduces the risk of sternal wound infections after heart surgery: Meta-analysis. J Thorac ...

PubMed DOI

B Interventions for morphea

Systematic Review The Cochrane database of systematic reviews 2019 n=70

**Albuquerque et al., 2019** | Cochrane Database Syst Rev | Systematic Review Albuquerque Julia V de, Andriolo Brenda Ng, ... Trevisani Virginia Fm. Interventions for morphea. Cochrane Database Syst Rev. 2019-Jul-16;7(7):CD005027. doi:10.1002/1465185...

PubMed DOI

B Comparative effects of furosemide and other diuretics in the treatment of heart failure: a systematic review and combined meta-analysis of randomized controlled trials

Systematic Review Heart failure reviews 2021 n=10740

**Eid et al., 2021** | Heart Fail Rev | Systematic Review Eid Peter Samuel, Ibrahim Doaa Alaa, ... Huy Nguyen Tien. Comparative effects of furosemide and other diuretics in the treatment of heart failure: a systematic review and combined meta-analysi...

PubMed DOI

B Minodronate in the treatment of osteoporosis: A systematic review and meta-analysis

Meta Analysis Medicine 2020 n=3740

**Liu et al., 2020** | Medicine (Baltimore) | Meta Analysis Liu Qingshan, Chen Dongmei, ... Huang Xuemei. Minodronate in the treatment of osteoporosis: A systematic review and meta-analysis. Medicine (Baltimore). 2020-Oct-02;99(40):e22542. doi:10.109...

PubMed DOI

B The effects of oestrogen on vaginal wound healing: A systematic review and meta-analysis

Meta Analysis Neurourology and urodynamics 2022 n=1474

**Vodegel et al., 2022** | Neurourol Urodyn | Meta Analysis Vodegel Eva V, Kastelein Arnoud W, ... Guler Zeliha. The effects of oestrogen on vaginal wound healing: A systematic review and meta-analysis. Neurourol Urodyn. 2022-Jan;41(1):115-126. doi:1...

PubMed DOI

B Risk of meningitis after posterior fossa decompression with duraplasty using different graft types in patients with Chiari malformation type I and syringomyelia: a systematic review and meta-analysis

Meta Analysis Neurosurgical review 2022 n=1404

**Jbarah et al., 2022** | Neurosurg Rev | Meta Analysis Jbarah Omar F, Aburayya Bahaa I, ... Jamous Mohammad A. Risk of meningitis after posterior fossa decompression with duraplasty using different graft types in patients with Chiari malformation ty...

PubMed DOI

B Comparison of the Effects of Metformin and Thiazolidinediones on Bone Metabolism: A Systematic Review and Meta-Analysis

Meta Analysis Medicina (Kaunas, Lithuania) 2023 n=1656

**Chen et al., 2023** | Medicina (Kaunas) | Meta Analysis Chen Ru-Dong, Yang Cong-Wen, ... Han Shi-Jie. Comparison of the Effects of Metformin and Thiazolidinediones on Bone Metabolism: A Systematic Review and Meta-Analysis. Medicina (Kaunas). 2023-M...

PubMed DOI

B Efficacy and safety of Vosoritide in achondroplasia: A systematic review and meta-analysis

Meta Analysis The Indian journal of medical research 2026 n=156

**Pahuja et al., 2026** | Indian J Med Res | Meta Analysis Pahuja Monika, Prakash Chander, ... Chatterjee Nabendu Sekhar. Efficacy and safety of Vosoritide in achondroplasia: A systematic review and meta-analysis. Indian J Med Res. 2026-Jan;163(1):78...

PubMed DOI

B Meta-analysis of the effect of animal maturity on muscle characteristics in different muscles, breeds, and sexes of cattle

Meta Analysis Journal of animal science 2008

**Schreurs et al., 2008** | J Anim Sci | Meta Analysis Schreurs N M, Garcia F, ... Picard B. Meta-analysis of the effect of animal maturity on muscle characteristics in different muscles, breeds, and sexes of cattle. J Anim Sci. 2008-Nov;86(11):2872-...

PubMed DOI

B Urethral injection therapy for urinary incontinence in women

Systematic Review The Cochrane database of systematic reviews 2017 n=14

**Kirchin et al., 2017** | Cochrane Database Syst Rev | Systematic Review Kirchin Vivienne, Page Tobias, ... Aluko Patricia. Urethral injection therapy for urinary incontinence in women. Cochrane Database Syst Rev. 2017-Jul-25;7(7):CD003881. doi:10.1...

PubMed DOI

B Effectiveness of electroacupuncture as a treatment for osteoporosis: A systematic review and meta-analysis

Meta Analysis Medicine 2021 n=731

**Fan et al., 2021** | Medicine (Baltimore) | Meta Analysis Fan Linyan, Wu Zhifang, ... Jiang Ganghui. Effectiveness of electroacupuncture as a treatment for osteoporosis: A systematic review and meta-analysis. Medicine (Baltimore). 2021-Jan-22;100(3...

PubMed DOI

Showing top 50 of 281 sources, sorted by quality score.

Related Supplements

Vitamin C 14 shared sources Electrolytes 5 shared sources Hyaluronic Acid 4 shared sources Calcium 4 shared sources Zinc 3 shared sources Vitamin D 3 shared sources Riboflavin 3 shared sources Chondroitin 3 shared sources

Frequently Asked Questions

What is collagen and what is it used for?

Collagen is a structural protein found in the body. Oral supplementation, specifically in hydrolyzed form, is primarily researched for its potential to improve skin health.

Does collagen help with skin hydration and elasticity?

Yes, there is moderate evidence that oral hydrolyzed collagen supplementation can improve both skin hydration and elasticity. These findings are supported by meta-analyses of randomized controlled trials.

What is the effective dose of collagen for skin health?

The provided research does not specify an effective dose for collagen supplementation. You should consult a healthcare professional to determine an appropriate dosage for your needs.

Is collagen safe to take?

There is currently no specific safety information or contraindications provided in the available research. However, you should always consult a doctor before starting any new supplement.

Are there any known drug interactions with collagen?

There are no documented drug interactions for collagen in the current research. It is still recommended to check with your physician to ensure it does not interfere with your specific medications.

Who should avoid taking collagen supplements?

The available research does not identify any specific groups of people who should avoid collagen. As with any supplement, individuals with underlying health conditions should consult a medical professional first.

Answers generated from research evidence. Not medical advice.