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Garlic × ARB

MODERATE Cyp-Inferred Evidence

Mechanism

Garlic is a weak inhibitor of CYP2C9, which decreases metabolism of CYP2C9 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect

Increased plasma levels of losartan (arb), potentially leading to toxicity or enhanced adverse effects.

Management

Monitor for increased adverse effects of losartan. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Plain Language Summary

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This combination may be moderately risky because garlic can slow down how your body breaks down certain blood pressure medications. This can cause the medication to build up in your system, which may increase the risk of side effects.

Source

Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)

Research

Supporting Research

Garlic supplementation for the treatment of chronic liver disease: a meta-analysis of randomized controlled trials
PMID:38223588 DOI 2023
Consumption of large amounts of Allium vegetables reduces risk for gastric cancer in a meta-analysis
PMID:21473867 DOI 2011
Garlic for the common cold
PMID:25386977 DOI 2014
Effects of Garlic Supplementation on Cardiovascular Risk Factors in Adults: A Comprehensive Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials
PMID:40580481 DOI 2026
Effects of seasoning on the formation of heterocyclic amines and polycyclic aromatic hydrocarbons in meats: A meta-analysis
PMID:33443787 DOI 2021
A Systematic Review and Meta-Analysis of Ayurvedic Herbal Preparations for Hypercholesterolemia
PMID:34071454 DOI 2021
Garlic intake lowers fasting blood glucose: meta-analysis of randomized controlled trials
PMID:26693740 DOI 2015
Garlic for the common cold
PMID:22419312 DOI 2012
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Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications.