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Ginger × ARB

MODERATE Cyp-Inferred Evidence

Mechanism

Ginger is a weak inhibitor of CYP2C9, which decreases metabolism of CYP2C9 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect

Increased plasma levels of losartan (arb), potentially leading to toxicity or enhanced adverse effects.

Management

Monitor for increased adverse effects of losartan. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Plain Language Summary

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This combination may be moderately risky because ginger can cause your blood pressure medication to stay in your system longer. This could lead to higher levels of the drug in your body and an increased risk of side effects.

Source

Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)

Research

Supporting Research

Antibiofilm Effects of Novel Compounds in Otitis Media Treatment: Systematic Review
PMID:39684553 DOI 2024
Interventions for treating urinary incontinence after stroke in adults
PMID:30706461 DOI 2019
The effects of ginger intake on weight loss and metabolic profiles among overweight and obese subjects: A systematic review and meta-analysis of randomized controlled trials
PMID:29393665 DOI 2019
Ginger supplementation for the treatment of non-alcoholic fatty liver disease: a meta-analysis of randomized controlled trials
PMID:37545930 DOI 2023
Herbal medications for anxiety, depression, pain, nausea and vomiting related to preoperative surgical patients: a systematic review and meta-analysis of randomised controlled trials
PMID:31129571 DOI 2019
The frontal association area: exercise-induced brain plasticity in children and adolescents and implications for cognitive intervention practice
PMID:39301538 DOI 2024
Zingerone as a Neuroprotective Agent Against Cognitive Disorders: A Systematic Review of Preclinical Studies
PMID:40649889 DOI 2025
Ginger intervention on body weight and body composition in adults: a GRADE-assessed systematic review and dose-response meta-analysis of 27 randomized controlled trials
PMID:38261398 DOI 2024
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Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications.