🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

2 Tablet(s) Serving Size
30 Servings
Non-Nutrient/Non-Botanical Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

📊 Market median: 200.0mg (52 products) 📚 10 studies (Tier A: 0, B: 6)
This product: 400mg

Other Ingredients

Cellulose Mannitol Citric Acid Stearic Acid Silica Sodium Starch Glycolate modified Cellulose Gum coating ingredients

Label Claims — Verification

All Other
Structure/Function
All Other (100% of products) Structure/Function (83% of products) Nutrient (6% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Directions: As a dietary supplement for adults, take two tablets daily, preferably with a meal, or as directed by a healthcare professional.

⚠️ Warnings & Precautions

WARNING: Consult a healthcare professional before taking this product if you are pregnant or nursing.

Discontinue use and consult your healthcare professional if any adverse reactions occur.

Do not use if blister foil is punctured or appears in any way to have been tampered with.

If you are currently taking prescription antidepressants, consult your physician before using SAMe. If you suffer from bipolar (manic) depression, do not use this product.

Keep out of reach of children.

🧪 Formulation Notes

ACTIVE S-ADENOSYL METHIONINE PER TABLET

Additional Information

Store at room temperature. Protect from light.

Made in USA

235 REF 0112

SAMe is an important physiological agent synthesized by the body. SAMe is involved in over 40 biochemical reactions in the body. In fact, SAMe is found in every organism. SAMe and Emotional Well Being* SAMe is important to the manufacture of important brain compounds such as neurotransmitters and phospholipids. Supplementing the diet with SAMe can result in an increase in the levels of serotonin and phosphatidylserine which can enhance mood and emotional well being.

Clinically Shown to Enhance: * Mood & emotional well being Healthy liver function Joint health and comfort Joint mobility

BRAIN SUPPORT

EST 1960

Product Details

UPC / SKU 7 16563 23501 7
DSLD Entry Date 2012-03-23
Product Type Non-Nutrient/Non-Botanical
Form Tablet or Pill
DSLD ID 6962
Data Updated 2026-04-11

Research Evidence

12 Research Sources
58 Avg Quality Score
8 Meta Analysis
3 Systematic Review
1 Rct
B S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2006
B S-adenosyl methionine (SAMe) for depression in adults
Meta Analysis The Cochrane database of systematic reviews 2016
B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
Meta Analysis Annals of the rheumatic diseases 2024
B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024
B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
Meta Analysis General hospital psychiatry 2024
B S-adenosyl-L-methionine for alcoholic liver diseases
Systematic Review The Cochrane database of systematic reviews 2001
B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2015
C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
Meta Analysis PloS one 2015
C S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Systematic Review Nutrients 2024
C SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and Meta-Analysis
Meta Analysis The Annals of pharmacotherapy 2024
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