🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Tablet(s) Serving Size
60 Servings
Non-Nutrient/Non-Botanical Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

📊 Market median: 200.0mg (52 products) 📚 10 studies (Tier A: 0, B: 6)
This product: 400mg

Other Ingredients

Cellulose Gel Methacrylic Acid Copolymer Compritol 888ATO Talc Triethyl Citrate Titanium Dioxide Magnesium Stearate Mannitol Glycerol Palmitostearate Silica Medium Chain Triglycerides Sodium Starch Glycolate Iron Oxide

Label Claims — Verification

All Other
Structure/Function
All Other (100% of products) Structure/Function (83% of products) Nutrient (6% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Suggested Adult Use: Take 1 tablet daily away from food, or as directed by a health care professional. Do not chew or crush tablet.

⚠️ Warnings & Precautions

Individuals using antidepressant medications should consult with their prescribing physician prior to using this product.

Individuals diagnosed wit bipolar disease or manic depression should avoid supplementing with SAMe.

Do not use if pregnant or nursing.

May cause gastrointestinal discomfort is a small percentage of people.

🧪 Formulation Notes

Our Double-Strength SAMe 400 contains 400mg of active SAMe in each tablet.

Dietary Supplement with 400mg Active S-Adenosyl Methionine Per Tablet

The SAMe found in Doctor's Best SAMe 400mg (Double Strength) is free from yeast, dairy, gluten, soy, wheat, and artificial flavoring.

Suitable for Vegetarians

Additional Information

S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Mehtylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissues including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.

Supplementing with SAMe The manufacturing process of SAMe yields two forms, the S,S and R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in our SAMe 400 is processed to yield the highest available percentage of the active pure S,S form on the market.

SAMe and Joint Function SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential somponents of connective tissue. Clinical studies show and ability of SAMe to enhance mobility and movement, and promote joint comfort.

SAMe and Neural Health SAMe-catalyzed methylation reactions promote he symthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidycholine, supporting cognitive function.

SAMe and Liver Function SAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes detoxification and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.

Doctor's Best utilizes only the highest quality Italian SAMe available on e market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none.

Double-Strength SAMe is sealed in blister packs for freshness and stability. Store product in a cool, dry place to ensure maximum quality.

Enhances Mood & Neural Function Promotes Joint Comfort & Mobility Supports Liver Health & Detoxification Pharmaceutical Grade Made in Italy

Sealed in Blister Packs for Freshness & Convenience

CONTAINS NOTHING OTHER THAN LISTED INGREDIENTS

P 03/11

Product Details

UPC / SKU 7 53950 00252 4
DSLD Entry Date 2013-09-25
Product Type Non-Nutrient/Non-Botanical
Form Tablet or Pill
DSLD ID 25576
Data Updated 2026-04-11

Research Evidence

12 Research Sources
58 Avg Quality Score
8 Meta Analysis
3 Systematic Review
1 Rct
B S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2006
B S-adenosyl methionine (SAMe) for depression in adults
Meta Analysis The Cochrane database of systematic reviews 2016
B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
Meta Analysis Annals of the rheumatic diseases 2024
B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024
B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
Meta Analysis General hospital psychiatry 2024
B S-adenosyl-L-methionine for alcoholic liver diseases
Systematic Review The Cochrane database of systematic reviews 2001
B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2015
C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
Meta Analysis PloS one 2015
C S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Systematic Review Nutrients 2024
C SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and Meta-Analysis
Meta Analysis The Annals of pharmacotherapy 2024
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