Double-Strength SAMe 400
This product looks safe
- No ingredients exceed tolerable upper intake levels
- 100% of ingredients have research evidence
What the Evidence Says
AI-generated · Qwen 3.6 · grounded in 1 source · methodologyS-Adenosyl Methionine is researched for its role in supporting mood and joint health. There is moderate evidence suggesting its efficacy in managing depressive symptoms. However, overall evidence coverage for this specific profile remains very limited.
AI-generated summary based on research evidence. Not medical advice.
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Label Data
Supplement Facts — Evidence Check
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Product Information
Directions for Use
Suggested Adult Use: Take 1 tablet daily away from food, or as directed by a health care professional. Do not chew or crush tablet.
Warnings & Precautions
Individuals using antidepressant medications should consult with their prescribing physician prior to using this product.
Individuals diagnosed wit bipolar disease or manic depression should avoid supplementing with SAMe.
Do not use if pregnant or nursing.
May cause gastrointestinal discomfort is a small percentage of people.
Formulation Notes
Our Double-Strength SAMe 400 contains 400mg of active SAMe in each tablet.
Dietary Supplement with 400mg Active S-Adenosyl Methionine Per Tablet
The SAMe found in Doctor's Best SAMe 400mg (Double Strength) is free from yeast, dairy, gluten, soy, wheat, and artificial flavoring.
Suitable for Vegetarians
Additional Information
S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Mehtylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissues including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.
Supplementing with SAMe The manufacturing process of SAMe yields two forms, the S,S and R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in our SAMe 400 is processed to yield the highest available percentage of the active pure S,S form on the market.
SAMe and Joint Function SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential somponents of connective tissue. Clinical studies show and ability of SAMe to enhance mobility and movement, and promote joint comfort.
SAMe and Neural Health SAMe-catalyzed methylation reactions promote he symthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidycholine, supporting cognitive function.
SAMe and Liver Function SAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes detoxification and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.
Doctor's Best utilizes only the highest quality Italian SAMe available on e market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none.
Double-Strength SAMe is sealed in blister packs for freshness and stability. Store product in a cool, dry place to ensure maximum quality.
Enhances Mood & Neural Function Promotes Joint Comfort & Mobility Supports Liver Health & Detoxification Pharmaceutical Grade Made in Italy
Sealed in Blister Packs for Freshness & Convenience
CONTAINS NOTHING OTHER THAN LISTED INGREDIENTS
P 03/11
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Research Evidence
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.