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SAMe Enteric Coated 400 mg

product on market Tablet or Pill The Vitamin Shoppe Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

S-Adenosyl-L-Methionine is used to support mood and joint health. There is moderate evidence suggesting its efficacy in managing depressive symptoms, though overall evidence coverage for this specific formulation is limited. The ingredient profile maintains a high safety score.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for SAMe Enteric Coated 400 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
Non-Nutrient/Non-Botanical
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 200.0mg (52 products) 12 studies (A:0, B:6)

Other Ingredients

Cellulose Silica Magnesium Stearate Riboflavin Ethyl Cellulose Oleic Acid Medium Chain Triglycerides Sodium Alginate Modified Cellulose Triacetin Calcium Carbonate Ammonium Hydroxide
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

DIRECTIONS: As a dietary supplement, take one (1) tablet per day on an empty stomach, or as directed by your physician.

Warnings & Precautions

WARNING: Consult your healthcare provider prior to use if you are pregnant, nursing, taking any medication or have any medical conditions.

KEEP OUT OF REACH OF CHILDREN.

TAMPER EVIDENT Do not use if outer seal is broken or missing.

Formulation Notes

gluten free dairy free soy free nut free

Does not contain: Wheat, Gluten, Sugar, Soy, Dairy, Citrus, Fish, Animal Derivatives, Preservatives or Artificial Flavors.

Additional Information

specialty

mood joint liver

{tablet} actual size

STORE IN A COOL, DRY PLACE.

Visit www.vitaminshoppe.com or call 1-800-223-1216 for more information and to reorder.

Item No. VS-2293 1563865 JP 53

Metadata

Product Details

UPC / SKU7 66536 02293 9
DSLD Entry Date2015-12-23
Product TypeNon-Nutrient/Non-Botanical
FormTablet or Pill
DSLD ID54955
Data Updated2026-04-11
Research

Research Evidence

12
Research Sources
58
Avg Quality
8
Meta Analysis
3
Systematic Review
1
Rct
B S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B S-adenosyl methionine (SAMe) for depression in adults
Meta Analysis The Cochrane database of systematic reviews 2016 PubMed
B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
Meta Analysis Annals of the rheumatic diseases 2024 PubMed DOI
B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024 PubMed DOI
B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
Meta Analysis General hospital psychiatry 2024 PubMed DOI
B S-adenosyl-L-methionine for alcoholic liver diseases
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
Meta Analysis PloS one 2015 PubMed DOI
C S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Systematic Review Nutrients 2024 PubMed DOI
C SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and Meta-Analysis
Meta Analysis The Annals of pharmacotherapy 2024 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.