Same × Tricyclic Antidepressants Interaction

Mechanism

SAMe may enhance antidepressant effect of tricyclics, potentially causing excessive serotonergic/noradrenergic activity.

Effect

Possible serotonin syndrome or excessive antidepressant effect

Management

Monitor closely. May allow lower tricyclic doses under medical supervision.

Plain Language Summary

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This combination carries a moderate risk and should be approached with caution. SAMe may increase the effects of tricyclic antidepressants, which could potentially lead to an overabundance of certain brain chemicals.

Source

Berlanga C et al. J Clin Psychopharmacol 1992

Research

Supporting Research

S-adenosyl-L-methionine for alcoholic liver diseases

PMID:16625556 2006

S-adenosyl methionine (SAMe) for depression in adults

PMID:27727432 2016

Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease

PMID:39317414 DOI 2024

S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis

PMID:38199136 DOI 2024

S-adenosyl-L-methionine for alcoholic liver diseases

PMID:11687153 2001

WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases

PMID:26560497 DOI 2015

S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis

PMID:25774783 DOI 2015

S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review

PMID:39519500 DOI 2024

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Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications.