Same × Ssri
MODERATE
Probable Evidence
Mechanism
SAMe may enhance serotonin synthesis and signaling; combined with SSRIs may increase serotonin levels excessively.
Effect
Possible serotonin syndrome
Management
Avoid combination. If used together, monitor closely for serotonin syndrome.
Plain Language Summary
AI-generated · Qwen 3.6 · grounded in 2 sources · methodologyThis combination can be dangerous because it may cause serotonin levels in the body to rise too high. This excess serotonin can lead to a serious condition called serotonin syndrome.
Source
Mischoulon D, Fava M. J Clin Psychiatry 2002; Papakostas GI et al. J Clin Psychopharmacol 2010
Research
Supporting Research
S-adenosyl-L-methionine for alcoholic liver diseases
PMID:16625556
2006
S-adenosyl methionine (SAMe) for depression in adults
PMID:27727432
2016
Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
S-adenosyl-L-methionine for alcoholic liver diseases
PMID:11687153
2001
WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications.