🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 55% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

2 Caplet(s) Serving Size
Other Combinations Product Type
55% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin A
2000 IU (40% DV)
Vitamin C
250 mg (417% DV)
200 IU (50% DV)
✅ Within RDA (0.3× RDA of 0.015 mg) 📚 604 studies (Tier A: 16, B: 251)
RDA 0.015mg This product: 0.005mg UL 0.1mg
100 IU (334% DV)
📊 4.5× RDA — above typical dose (UL: 1000 mg) 📚 177 studies (Tier A: 3, B: 90)
RDA 15mg This product: 67.0mg UL 1000mg
10 mg (667% DV)
📊 8.3× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 10mg
10 mg (588% DV)
📊 7.7× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 10mg
10 mg (50% DV)
✅ Within RDA (0.7× RDA of 14 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 10mg UL 35mg
10 mg (500% DV)
📊 7.7× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 10mg UL 100mg
400 mcg (100% DV)
✅ Within RDA (1.0× RDA of 0.4 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 0.4mg UL 1.0mg
10 mcg (167% DV)
📊 4.2× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.01mg
75 mcg (25% DV)
✅ 2.5× RDA — within safe limits 📚 26 studies (Tier A: 0, B: 11)
RDA 0.03mg This product: 0.075mg
12.5 mg (125% DV)
✅ 2.5× RDA — within safe limits 📚 1 studies — no high-quality reviews
RDA 5mg This product: 12.5mg
Calcium
166 mg (17% DV)
37.5 mcg (25% DV)
✅ Within RDA (0.2× RDA of 0.15 mg) 📚 243 studies (Tier A: 4, B: 133)
RDA 0.15mg This product: 0.0375mg UL 1.1mg
100 mg (25% DV)
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 100mg
7.5 mg (50% DV)
✅ Within RDA (0.7× RDA of 11 mg) 📚 258 studies (Tier A: 6, B: 134)
RDA 11mg This product: 7.5mg UL 40mg
50 mcg (71% DV)
✅ Within RDA (0.9× RDA of 0.055 mg) 📚 172 studies (Tier A: 0, B: 67)
RDA 0.055mg This product: 0.05mg UL 0.4mg
0.075 mg (4% DV)
✅ Within RDA (0.1× RDA of 0.9 mg) 📚 36 studies (Tier A: 0, B: 11)
RDA 0.9mg This product: 0.075mg UL 10mg
0.5 mg (25% DV)
✅ Within RDA (0.2× RDA of 2.3 mg) 📚 8 studies — no high-quality reviews
RDA 2.3mg This product: 0.5mg UL 11mg
50 mcg (42% DV)
✅ 1.4× RDA — within safe limits 📚 197 studies (Tier A: 1, B: 55)
RDA 0.035mg This product: 0.05mg
37.5 mcg (50% DV)
✅ Within RDA (0.8× RDA of 0.045 mg) 📚 2 studies — no high-quality reviews
RDA 0.045mg This product: 0.0375mg UL 2mg
Potassium
25 mg (2% DV)
250 mcg
📊 Market median: 3.0mg (58 products) 📚 2 studies — no high-quality reviews
This product: 0.25mg UL 20mg
250 mcg
📊 Market median: 0.5mg (6 products) 📚 1 studies (Tier A: 0, B: 1)
This product: 0.25mg UL 1.8mg
Trace Mineral Complex
15 mg
25 mg
📊 Market median: 125.0mg (294 products) 📚 36 studies (Tier A: 1, B: 7)
RDA 550mg This product: 25mg UL 3500mg
25 mg
📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)
This product: 25mg
7.5 mg
📊 Market median: 496.0mg (192 products) 📚 20 studies — no high-quality reviews
This product: 7.5mg
Papain
12.5 mg
12.5 mg
📊 Market median: 200.0mg (136 products) 📚 3 studies — no high-quality reviews
This product: 12.5mg
N-Acetyl L-Cysteine
50 mg
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 50mg
5 mg
📊 Market median: 500.0mg (159 products)
Median 500.0mg This product: 5mg
7.5 mg
📊 Market median: 500.0mg (180 products) 📚 5 studies (Tier A: 0, B: 1)
This product: 7.5mg
7.5 mg
📊 Market median: 500.0mg (193 products) 📚 7 studies — no high-quality reviews
This product: 7.5mg
📊 Market median: 500.0mg (283 products) 📚 173 studies (Tier A: 0, B: 62)
This product: 5mg
5 mg
📊 Market median: 500.0mg (19 products)
This product: 5mg
Hesperidin Complex
5 mg
📊 Market median: 420.0mg (127 products) 📚 1 studies (Tier A: 0, B: 1)
This product: 2.5mg
📊 Market median: 100.0mg (284 products) 📚 10 studies (Tier A: 0, B: 4)
This product: 5mg
📊 Market median: 100.0mg (120 products)
Median 100.0mg This product: 5mg
Chlorophyllin
10 mg
📊 Market median: 120.0mg (440 products) 📚 187 studies (Tier A: 1, B: 71)
This product: 5mg
2.5 mg
📊 Market median: 10.0mg (105 products) 📚 1 studies (Tier A: 0, B: 1)
This product: 2.5mg
📊 Market median: 200.0mg (198 products) 📚 6 studies — no high-quality reviews
This product: 25mg
6.25 mg
📊 Market median: 100.0mg (283 products) 📚 142 studies (Tier A: 1, B: 64)
This product: 6.25mg UL 1200mg
📊 Market median: 500.0mg (283 products) 📚 173 studies (Tier A: 0, B: 62)
This product: 5mg
📊 Market median: 108.0mg (8 products) 📚 9 studies (Tier A: 0, B: 4)
This product: 0.36mg
High-ORAC Fruit/Veggie/Botanical Antioxidant Blend
200 mg
Herbal Actives Blend
100 mg

Other Ingredients

Microcrystalline Cellulose Croscarmellose Sodium Stearic Acid Magnesium Stearate Silica Spirulina film coating

Label Claims — Verification

All Other
Structure/Function
All Other (99% of products) Structure/Function (76% of products) Nutrient (58% of products)

Target Groups

Adult (18 - 50 Years) Sugar Free

Product Information

📋 Directions for Use

Directions Dr. Perricone recommends taking one packet twice daily with meals. A 30-day program.

⚠️ Warnings & Precautions

Warning: Before using any dietary supplement, pregnant or lactating women should consult with a physician or health professional.

Keep out of the reach of children.

To preserve quality and freshness, store in a cool, dry place at controlled room temperature 15(0)-30(0)C Tamper evident: Do not use if packet is cut, torn, or broken.

🧪 Formulation Notes

Nourishes the body and the skin.

Product Benefits Targeted nutritional supplements are an essential part of Dr. Perricone's 3-Tier philosophy to healthy aging and beautiful skin. This daily program of nutrients is especially designed to support the health of skin. It also supports bone and joint function and healthy hair and nails.

Free of sugar, preservatives, yeast, artificial colors-flavors-dyes.

Additional Information

Each packet contains: 3 softgels, 2 capsules and 3 caplets.

Clinical studies In a 8 week study, 86% reported improved skin texture. 78% reported healthier skin appearance. 65% reported lessening of crow's feet & lines and wrinkles.

Decades of research Perricone MD products are unique in that they are patented, researched and formulated by Nicholas Perricone, M.D., board certified dermatologist and anti-aging expert.

To preserve quality and freshness, store in a cool, dry place at controlled room temperature 15(0)-30(0)C Tamper evident: Do not use if packet is cut, torn, or broken.

This carton is fully recyclable. It's manufactured using wind power and printed in a carbon neutral facility.

Made in USA.

C6 Carbon neutral

Product Details

DSLD Entry Date 2019-12-22
Product Type Other Combinations
Form Other (e.g. tea bag)
Bundle Skin & Total Body
DSLD ID 209856
Data Updated 2026-04-11

Research Evidence

337 Research Sources
54 Avg Quality Score
161 Meta Analysis
68 Systematic Review
51 Rct
48 Clinical Trial
2 Other
2 Regulatory Source
1 Narrative Review
1 Cochrane Review
1 Guideline
1 Openfda Safety
A Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age
Meta Analysis The Cochrane database of systematic reviews 2017
A Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less
Meta Analysis The Cochrane database of systematic reviews 2011
A Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection
Meta Analysis The Cochrane database of systematic reviews 2011
A Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis
Meta Analysis BMJ (Clinical research ed.) 2011
A Fortification of staple foods with vitamin A for vitamin A deficiency
Systematic Review The Cochrane database of systematic reviews 2019
A Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age
Narrative Review The Cochrane database of systematic reviews 2016
A Vitamin A and fish oils for preventing the progression of retinitis pigmentosa
Meta Analysis The Cochrane database of systematic reviews 2020
A Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Journal of sport and health science 2023
A Food fortification with multiple micronutrients: impact on health outcomes in general population
Meta Analysis The Cochrane database of systematic reviews 2019
A Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age
Meta Analysis The Cochrane database of systematic reviews 2024
View all evidence for Vitamin A →

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