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50 Plus

product on market Other (e.g. tea bag) GNC Mega Men Safety: 99/100
99/100

This product looks safe

  • Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)
  • Folate: 680mg is 680.0× the Tolerable Upper Intake Level (1.0mg)
  • 64% of ingredients have research evidence
D Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

The profile contains essential fat-soluble and water-soluble vitamins that support immune function, bone health, and antioxidant activity. There is strong research evidence supporting the roles of these vitamins in maintaining general physiological health. The formulation maintains a high safety score with minimal reported concerns.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)

Folate: 680mg is 680.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for 50 Plus
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Caplet(s)
Serving Size
60
Servings
Other Combinations
Product Type
64%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Vitamin A
1500 mcg RAE (167% DV)
Vitamin C
300 mg (333% DV)
40 mcg (200% DV)
2.7× RDA — within safe limits 608 studies (A:16, B:251)
20.1 mg (134% DV)
1.3× RDA — within safe limits 179 studies (A:3, B:90)
80 mcg (67% DV)
Within RDA (0.7× RDA) 275 studies (A:9, B:175)
50 mg (4167% DV)
41.7× RDA — above typical dose 76 studies (A:0, B:33)
50 mg (3846% DV)
38.5× RDA — above typical dose 13 studies (A:0, B:1)
50 mg (313% DV)
Exceeds UL by 1.4× (UL: 35 mg) 196 studies (A:5, B:63)
50 mg (2941% DV)
38.5× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
680 mcg DFE (170% DV)
Exceeds UL by 680.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
50 mcg (2083% DV)
20.8× RDA — above typical dose 139 studies (A:1, B:44)
300 mcg (1000% DV)
10.0× RDA — above typical dose 27 studies (A:0, B:11)
50 mg (1000% DV)
10.0× RDA — above typical dose 2 studies — no high-quality reviews
10 mg (2% DV)
Market median: 125.0mg (294 products) 38 studies (A:1, B:7)
Calcium
200 mg (15% DV)
150 mcg (100% DV)
Within RDA (1.0× RDA) 245 studies (A:4, B:133)
100 mg (24% DV)
Within RDA (0.2× RDA) 316 studies (A:8, B:159)
25 mg (227% DV)
2.3× RDA — within safe limits 263 studies (A:6, B:134)
200 mcg (364% DV)
3.6× RDA — above typical dose (UL: 0.4 mg) 173 studies (A:0, B:67)
2 mg (222% DV)
2.2× RDA — within safe limits 37 studies (A:0, B:11)
2 mg (87% DV)
Within RDA (0.9× RDA) 9 studies — no high-quality reviews
120 mcg (343% DV)
3.4× RDA — above typical dose 199 studies (A:1, B:55)
75 mcg (167% DV)
1.7× RDA — within safe limits 3 studies — no high-quality reviews
Market median: 320.0mg (426 products) 26 studies (A:0, B:5)
100 mg
Market median: 500.0mg (143 products)
Market median: 200.0mg (198 products) 6 studies — no high-quality reviews
10 mg
Market median: 550.0mg (217 products) 29 studies (A:0, B:5)
Pumpkin, Powder
10 mg
Market median: 120.0mg (440 products) 191 studies (A:1, B:71)
4 mg
Market median: 108.0mg (8 products) 9 studies (A:0, B:4)
2 mg
Market median: 3.0mg (58 products) 3 studies — no high-quality reviews
2 mg
Market median: 10.0mg (105 products) 2 studies (A:0, B:1)
Bacopa monnieri leaf extract
1.5 mg
Market median: 100.0mg (284 products) 10 studies (A:0, B:4)
Market median: 167.0mg (311 products) 183 studies (A:0, B:65)
1 mg
Market median: 10.0mg (35 products) 6 studies (A:0, B:2)
Phosphatidyl serine
1 mg
Market median: 450.0mg (254 products) 243 studies (A:0, B:100)
400 mcg
Market median: 4.0mg (32 products)
50 mcg
Market median: 4.0mg (47 products)
10 mcg
Market median: 0.5mg (6 products) 1 studies (A:0, B:1)
Beta-Cryptoxanthin
10 mcg

Other Ingredients

Microcrystalline Cellulose Cellulose Maltodextrin Hydroxypropyl Methylcellulose Hydroxypropyl Cellulose Dicalcium Phosphate Stearic Acid Magnesium Stearate Food Starch, Modified Mannitol Gelatin Corn Starch Sugar Calcium Silicate natural Vanilla Mint flavor Sodium Ascorbate DL-Alpha Tocopherol Methylcellulose Glucose Syrup Stevia leaf extract Vegetable oil BHT BHA Povidone Mixed Tocopherols Ascorbyl Palmitate Titanium Dioxide Caramel color Gum Arabic Polyethylene Glycol Talc Tricalcium Phosphate Paprika Extract Medium Chain Triglyceride Polyglycerol Fatty Acid Esters Polysorbate Sodium Aluminum Silicate Sodium Carboxymethylcellulose
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: As a dietary supplement, take two caplets daily with food.

Warnings & Precautions

Warning: Cancer and reproductive harm - www.P65Warnings.ca.gov.

Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition.

Discontinue use two weeks prior to surgery. Inform your physician of this product's biotin content before any lab test. Niacin may cause a temporary flushing reaction.

Keep out of reach of children.

Contains: Soybeans and fish (anchovy, mackerel, sardine, smelt, salmon, tuna, cod or a combination thereof).

Formulation Notes

No artificial flavors, gluten free.

Achieve your daily nutritional goals with a multivitamin that has more than 30 clinically studied ingredients. Men's Health Contains a clinically studied men's multivitamin blend shown to work better than a basic multivitamin. Helps support prostate health. Antioxidants Packed with antioxidants to help protect against harmful free radicals that can destroy healthy cells and promote cell aging. Heart Health Includes vitamin B-6 and folic acid, which provide dietary support for your cardiovascular system. Prostate & circulatory support Features lycopene and saw palmetto to support prostate function, and L-arginine, which helps to maintain blood vessel tone and plays a key role in sexual health.

Clinically studied multivitamin blend In a randomized, double-blind, placebo-controlled study of 112 healthy volunteers, subjects taking the GNC vitamin and mineral blends for six weeks experienced significant improvements in serum levels of certain key nutrients compared to a placebo and a leading multivitamin formula based upon multivariate statistical analyses of a group of B vitamins (thiamin, niacin, riboflavin, pantothenic acid, biotin, folic acid and vitamins B-6 and B-12) and key antioxidants and carotenoids (a group of beta-carotene, alpha-tocopherol, selenium, lutein and lycopene). Statistical improvements in SF-36 Vitality and Mental Health scores were also observed compared to placebo.

Timed-release Clinically studied

Additional Information

Store in a cool, dry place.

For more information: 1-888-462-2548 GNC.com

Our quality commitment to you Since 1935, our mission as the industry leader has been to provide you with the highest-quality nutritional supplements. We continue to stand behind this mission. If you're not 100% satisfied with your purchase, return the unused portion of the product with your receipt within 30 days and we'll either refund your money or find a replacement product that is right for you.

60-Day supply

Metadata

Product Details

DSLD Entry Date2024-03-22
Product TypeOther Combinations
FormOther (e.g. tea bag)
BrandGNC Mega Men
DSLD ID304604
Data Updated2026-04-11
Research

Research Evidence

337
Research Sources
54
Avg Quality
161
Meta Analysis
68
Systematic Review
51
Rct
48
Clinical Trial
2
Other
2
Regulatory Source
1
Narrative Review
1
Cochrane Review
1
Guideline
1
Openfda Safety
A Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less
Meta Analysis The Cochrane database of systematic reviews 2011 PubMed DOI
A Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection
Meta Analysis The Cochrane database of systematic reviews 2011 PubMed DOI
A Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis
Meta Analysis BMJ (Clinical research ed.) 2011 PubMed DOI
A Fortification of staple foods with vitamin A for vitamin A deficiency
Systematic Review The Cochrane database of systematic reviews 2019 PubMed DOI
A Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age
Narrative Review The Cochrane database of systematic reviews 2016 PubMed DOI
A Vitamin A and fish oils for preventing the progression of retinitis pigmentosa
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
A Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Journal of sport and health science 2023 PubMed DOI
A Food fortification with multiple micronutrients: impact on health outcomes in general population
Meta Analysis The Cochrane database of systematic reviews 2019 PubMed DOI
A Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age
Meta Analysis The Cochrane database of systematic reviews 2024 PubMed DOI
View all evidence for Vitamin A →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.