🟢 99/100

This product looks safe

  • Niacin: 862mg is 24.6× the Tolerable Upper Intake Level (35mg)
  • Vitamin B6: 105mg is 1.1× the Tolerable Upper Intake Level (100mg)
  • 60% of ingredients have research evidence
D Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 862mg is 24.6× the Tolerable Upper Intake Level (35mg)
⚠️ Vitamin B6: 105mg is 1.1× the Tolerable Upper Intake Level (100mg)

Label Data

3 Tablet(s) Serving Size
35 Servings
Other Combinations Product Type
60% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin A
5000 IU (100% DV)
Vitamin C
2000 mg (3333% DV)
2000 IU (500% DV)
📊 3.3× RDA — above typical dose (UL: 0.1 mg) 📚 604 studies (Tier A: 16, B: 251)
RDA 0.015mg This product: 0.05mg UL 0.1mg
100 IU (333% DV)
📊 4.5× RDA — above typical dose (UL: 1000 mg) 📚 177 studies (Tier A: 3, B: 90)
RDA 15mg This product: 67.0mg UL 1000mg
125 mg (8333% DV)
📊 104.2× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 125mg
50 mg (2941% DV)
📊 38.5× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 50mg
862 mg (4310% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 24.6× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 862mg UL 35mg
105 mg (5250% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 1.1× (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 105mg UL 100mg
400 mcg (100% DV)
✅ Within RDA (1.0× RDA of 0.4 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 0.4mg UL 1.0mg
600 mcg (10000% DV)
📊 250.0× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.6mg
3000 mcg (1000% DV)
📊 100.0× RDA — above typical dose 📚 26 studies (Tier A: 0, B: 11)
RDA 0.03mg This product: 3.0mg
600 mg (6000% DV)
📊 120.0× RDA — above typical dose 📚 1 studies — no high-quality reviews
RDA 5mg This product: 600mg
Calcium
218 mg (22% DV)
150 mcg (100% DV)
✅ Within RDA (1.0× RDA of 0.15 mg) 📚 243 studies (Tier A: 4, B: 133)
RDA 0.15mg This product: 0.15mg UL 1.1mg
400 mg (100% DV)
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 400mg
35 mg (233% DV)
📊 3.2× RDA — above typical dose (UL: 40 mg) 📚 258 studies (Tier A: 6, B: 134)
RDA 11mg This product: 35mg UL 40mg
200 mcg (286% DV)
📊 3.6× RDA — above typical dose (UL: 0.4 mg) 📚 172 studies (Tier A: 0, B: 67)
RDA 0.055mg This product: 0.2mg UL 0.4mg
1 mg (50% DV)
✅ 1.1× RDA — within safe limits 📚 36 studies (Tier A: 0, B: 11)
RDA 0.9mg This product: 1mg UL 10mg
1 mg (50% DV)
✅ Within RDA (0.4× RDA of 2.3 mg) 📚 8 studies — no high-quality reviews
RDA 2.3mg This product: 1mg UL 11mg
500 mcg (417% DV)
📊 14.3× RDA — above typical dose 📚 197 studies (Tier A: 1, B: 55)
RDA 0.035mg This product: 0.5mg
125 mcg (167% DV)
✅ 2.8× RDA — within safe limits 📚 2 studies — no high-quality reviews
RDA 0.045mg This product: 0.125mg UL 2mg
Potassium
37.4 mg (1% DV)
N-Acetyl-L-Cysteine
600 mg
200 mg
📊 Market median: 500.0mg (180 products) 📚 5 studies (Tier A: 0, B: 1)
This product: 200mg
250 mg
📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)
This product: 250mg
✅ Within RDA (0.3× RDA of 550 mg) 📚 36 studies (Tier A: 1, B: 7)
RDA 550mg This product: 150mg UL 3500mg
120 mg
✅ Within RDA (0.2× RDA of 550 mg) 📚 36 studies (Tier A: 1, B: 7)
RDA 550mg This product: 120mg UL 3500mg
3 mg
📊 Market median: 3.0mg (58 products) 📚 2 studies — no high-quality reviews
This product: 3mg UL 20mg
📊 Market median: 496.0mg (192 products) 📚 20 studies — no high-quality reviews
This product: 100mg
📊 Market median: 500.0mg (283 products) 📚 173 studies (Tier A: 0, B: 62)
This product: 200mg
Broccoli Concentrate Blend
725 mg
📊 Market median: 260.0mg (249 products) 📚 156 studies (Tier A: 4, B: 61)
This product: 325mg
Acerola extract
300 mg
Fruit/Berry Complex
200 mg
Wild Blueberry Anthocyanin extract
150 mg
📊 Market median: 250.0mg (562 products) 📚 53 studies (Tier A: 0, B: 19)
This product: 100mg
Maqui berry (Aristotelia chilensis) Anthocyanin extract
100 mg
📊 Market median: 100.0mg (284 products) 📚 10 studies (Tier A: 0, B: 4)
This product: 85mg
📊 Market median: 250.0mg (182 products) 📚 10 studies (Tier A: 0, B: 2)
This product: 85mg
📊 4.0× RDA — above typical dose (UL: 1000 mg) 📚 177 studies (Tier A: 3, B: 90)
RDA 15mg This product: 60mg UL 1000mg
MirtoSelect Bilberrry extract
30 mg
📊 Market median: 100.0mg (284 products) 📚 10 studies (Tier A: 0, B: 4)
This product: 25mg
📊 Market median: 100.0mg (284 products) 📚 10 studies (Tier A: 0, B: 4)
This product: 25mg
15 mg
📊 Market median: 200.0mg (136 products) 📚 3 studies — no high-quality reviews
This product: 15mg
Delphinidins
2 mg
15 mg
📊 Market median: 10.0mg (105 products) 📚 1 studies (Tier A: 0, B: 1)
This product: 15mg
Olive juice extract
12.5 mg
📊 Market median: 200.0mg (52 products) 📚 10 studies (Tier A: 0, B: 6)
This product: 10mg
Luteolin
8 mg
3 mg
📊 Market median: 10.0mg (35 products) 📚 5 studies (Tier A: 0, B: 2)
This product: 3mg
Cyanidin-3-Glucoside
1.25 mg
📊 Market median: 167.0mg (311 products) 📚 182 studies (Tier A: 0, B: 65)
This product: 0.5mg
📊 Market median: 300.0mg (26 products) 📚 7 studies (Tier A: 0, B: 1)
This product: 2mg

Other Ingredients

Microcrystalline Cellulose Stearic Acid Maltodextrin Aqueous Film Coating Vegetable Stearate Croscarmellose Sodium Medium Chain Triglycerides

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Directions: Take nine (9) tablets per day in divided doses with meals, or as recommended by a healthcare practitioner.

⚠️ Warnings & Precautions

Caution: Temporary flushing, itching, rash, or gastric disturbances may occur.

Contains fish (tilapia) and soybeans.

Warnings: - Keep out of reach of children.

- Do not exceed recommended dose.

- Do not purchase if outer seal is broken or damaged.

- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Warning: This product contains a chemical known to the State of California to cause birth defects or other reproductive harm.

Consult with your doctor before using this product if you are taking anticoagulant medications.

Individuals consuming more than 2,000 IU/day of vitamin D (from diet and supplements) should periodically obtain a serum 25-hydroxy vitamin D measurement. Vitamin D supplementation is not recommended for individuals with high blood calcium levels. Individuals with in-born errors of copper metabolism (e.g. Wilson’s disease) should avoid daily, chronic use of this product.

Liver function testing is recommended when niacin is taken in excess of 500 mg daily. Those with gout or liver diseases should avoid taking high doses of niacin.

🧪 Formulation Notes

Contains fish (tilapia) and soybeans.

Life Extension Mix Tablets With Extra Niacin

Additional Information

Scan for product info

QE01957C

State-of-the-art multi-nutrient formula

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Store tightly closed in a cool, dry place.

Product Details

UPC / SKU 7 37870 19573 3
DSLD Entry Date 2016-06-24
Product Type Other Combinations
Form Tablet or Pill
DSLD ID 62097
Data Updated 2026-04-11

Research Evidence

241 Research Sources
55 Avg Quality Score
113 Meta Analysis
75 Systematic Review
32 Rct
11 Clinical Trial
3 Other
3 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016
View all evidence for Niacin →

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