🟢 89/100

This product is generally safe

  • Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)
  • Contains proprietary blend — exact ingredient amounts not disclosed
  • 69% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)
ℹ️ Contains proprietary blend — exact ingredient amounts not disclosed

Label Data

2 Caplet(s) Serving Size
45 Servings
Other Combinations Product Type
69% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin A
5000 IU (100% DV)
Vitamin C
300 mg (500% DV)
1600 IU (400% DV)
✅ 2.7× RDA — within safe limits 📚 604 studies (Tier A: 16, B: 251)
RDA 0.015mg This product: 0.04mg UL 0.1mg
30 IU (100% DV)
✅ 1.3× RDA — within safe limits 📚 177 studies (Tier A: 3, B: 90)
RDA 15mg This product: 20.1mg UL 1000mg
80 mcg (100% DV)
✅ Within RDA (0.7× RDA of 0.12 mg) 📚 273 studies (Tier A: 9, B: 175)
RDA 0.12mg This product: 0.08mg
50 mg (3333% DV)
📊 41.7× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 50mg
50 mg (2941% DV)
📊 38.5× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 50mg
50 mg (250% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 1.4× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 50mg UL 35mg
50 mg (2500% DV)
📊 38.5× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 50mg UL 100mg
400 mcg (100% DV)
✅ Within RDA (1.0× RDA of 0.4 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 0.4mg UL 1.0mg
50 mcg (833% DV)
📊 20.8× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.05mg
300 mcg (100% DV)
📊 10.0× RDA — above typical dose 📚 26 studies (Tier A: 0, B: 11)
RDA 0.03mg This product: 0.3mg
50 mg (500% DV)
📊 10.0× RDA — above typical dose 📚 1 studies — no high-quality reviews
RDA 5mg This product: 50mg
Calcium
200 mg (20% DV)
150 mcg (100% DV)
✅ Within RDA (1.0× RDA of 0.15 mg) 📚 243 studies (Tier A: 4, B: 133)
RDA 0.15mg This product: 0.15mg UL 1.1mg
100 mg (25% DV)
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 100mg
25 mg (167% DV)
✅ 2.3× RDA — within safe limits 📚 258 studies (Tier A: 6, B: 134)
RDA 11mg This product: 25mg UL 40mg
200 mcg (286% DV)
📊 3.6× RDA — above typical dose (UL: 0.4 mg) 📚 172 studies (Tier A: 0, B: 67)
RDA 0.055mg This product: 0.2mg UL 0.4mg
2 mg (100% DV)
✅ 2.2× RDA — within safe limits 📚 36 studies (Tier A: 0, B: 11)
RDA 0.9mg This product: 2mg UL 10mg
2 mg (100% DV)
✅ Within RDA (0.9× RDA of 2.3 mg) 📚 8 studies — no high-quality reviews
RDA 2.3mg This product: 2mg UL 11mg
120 mcg (100% DV)
📊 3.4× RDA — above typical dose 📚 197 studies (Tier A: 1, B: 55)
RDA 0.035mg This product: 0.12mg
75 mcg (100% DV)
✅ 1.7× RDA — within safe limits 📚 2 studies — no high-quality reviews
RDA 0.045mg This product: 0.075mg UL 2mg
Energy & Metabolism Blend
119 mg
📊 Market median: 500.0mg (180 products) 📚 5 studies (Tier A: 0, B: 1)
This product: 100mg
📊 Market median: 260.0mg (249 products) 📚 156 studies (Tier A: 4, B: 61)
This product: 40mg
📊 Market median: 200.0mg (198 products) 📚 6 studies — no high-quality reviews
This product: 25mg
10 mg
📊 Market median: 125.0mg (294 products) 📚 36 studies (Tier A: 1, B: 7)
RDA 550mg This product: 10mg UL 3500mg
10 mg
📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)
This product: 10mg
4 mg
📊 Market median: 108.0mg (8 products) 📚 9 studies (Tier A: 0, B: 4)
This product: 4mg
2 mg
📊 Market median: 3.0mg (58 products) 📚 2 studies — no high-quality reviews
This product: 2mg UL 20mg
📊 Market median: 10.0mg (105 products) 📚 1 studies (Tier A: 0, B: 1)
This product: 0.95mg
950 mcg
📊 Market median: 10.0mg (35 products) 📚 5 studies (Tier A: 0, B: 2)
This product: 0.95mg
190 mcg
📊 Market median: 4.0mg (32 products)
This product: 0.19mg
50 mcg
📊 Market median: 4.0mg (47 products)
This product: 0.05mg
10 mcg
📊 Market median: 0.5mg (6 products) 📚 1 studies (Tier A: 0, B: 1)
This product: 0.01mg UL 1.8mg

Other Ingredients

Cellulose Titanium Dioxide Vegetable Acetoglycerides Caramel color Ethyl Vanillin

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (76% of products) Nutrient (58% of products)

Target Groups

Adult Male (18-50 Years)

Product Information

📋 Directions for Use

Directions: As a dietary supplement, take two caplets daily with food.

⚠️ Warnings & Precautions

KEEP OUT OF REACH OF CHILDREN.

🧪 Formulation Notes

CONTAINS: Fish and Soybeans.

No Artificial Colors, No Wheat, No Gluten, No Dairy, Yeast Free.

Additional Information

Store in a cool, dry place.

2X MORE D-3

ACTUAL SIZE

CLINICALLY STUDIED

CLINICALLY STUDIED MULTIVITAMIN

CODE 177512 ILG

Compared to leading brands.

Energy

Frank J. Costa, M.D., an acclaimed urological surgeon and men's health expert, is part of the GNC Medical Advisory Board. One of "America's Top Physicians," Dr. Costa lectures nationally and internationally on men's health topics. Dr. Costa is regularly featured in television, radio and newspaper interviews and has published articles in both professional journals and popular magazines. "Lack of energy and slow metabolisms are common concerns of many of my patients. When a regular multivitamin isn't enough, I suggest Mega Men(R) Energy & Metabolism for the extra boost to help them through their busy schedules."

GNC GUARANTEE Use any GNC supplement for as little as 10 days. If you are not 100% completely satisfied, return the unused portion of the product with proof of purchase to your GNC store for a complete refund of your purchase price. No questions asked!

GNC QUALITY COMMITMENT GNC, the leader in the development and manufacture of dietary supplements, is committed to producing the highest quality products available. This commitment begins with quality designed supplement formulations. Every raw material that goes into a GNC supplement is guaranteed as to quality and potency. Each product is dated and then shipped immediately to our stores, so you can be sure you are purchasing the freshest supplements available. At GNC, we extend our quality commitment to you by offering our money-back guarantee.

MEGA MEN(R) ENERGY & METABOLISM Taking a daily multivitamin keeps you on the right track for filling your nutritional gaps. Mega Men(R) Energy & Metabolism is an enhanced multivitamin that provides the same clinically studied base as our Mega Men(R) formula with ingredients that help boost your energy! Advanced Nutritional Support Includes 1,600 IU of vitamin D-3. Emerging research suggests that adequate daily vitamin D intake may play a role in supporting colon and immune health. Supplies B-vitamins that are essential for energy production and metabolism. Calorie Burning Support Features an energy and metabolism blend that helps boost energy and metabolism and supports calorie burning. The components in this blend also help support mental focus. Antioxidant Protection Contains a premium blend of antioxidants including selenium, vitamin C and vitamin E to aid in supporting the body's immunity. Combines lutein and zeaxanthin, to support eye health, with lycopene, an antioxidant from tomatoes to support cardiovascular health. Timed-release caplets provide a gradual release of vital nutrients.

Timed-Release

With 1,600 IU of vitamin D-3 for colon health and immune support Boosts energy and metabolism Supports mental focus Calorie burning support

Confroms to USP <2091> for weight.

Please recycle this box.

Product Details

DSLD Entry Date 2011-10-26
Product Type Other Combinations
Form Other (e.g. tea bag)
Brand GNC Mega Men
DSLD ID 781
Data Updated 2026-04-11

Research Evidence

337 Research Sources
54 Avg Quality Score
161 Meta Analysis
68 Systematic Review
51 Rct
48 Clinical Trial
2 Other
2 Regulatory Source
1 Narrative Review
1 Cochrane Review
1 Guideline
1 Openfda Safety
A Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age
Meta Analysis The Cochrane database of systematic reviews 2017
A Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less
Meta Analysis The Cochrane database of systematic reviews 2011
A Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection
Meta Analysis The Cochrane database of systematic reviews 2011
A Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis
Meta Analysis BMJ (Clinical research ed.) 2011
A Fortification of staple foods with vitamin A for vitamin A deficiency
Systematic Review The Cochrane database of systematic reviews 2019
A Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age
Narrative Review The Cochrane database of systematic reviews 2016
A Vitamin A and fish oils for preventing the progression of retinitis pigmentosa
Meta Analysis The Cochrane database of systematic reviews 2020
A Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Journal of sport and health science 2023
A Food fortification with multiple micronutrients: impact on health outcomes in general population
Meta Analysis The Cochrane database of systematic reviews 2019
A Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age
Meta Analysis The Cochrane database of systematic reviews 2024
View all evidence for Vitamin A →

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