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Life Extension Mix Tablets with Extra Niacin

product on market Tablet or Pill Life Extension Safety: 97/100
97/100

This product looks safe

  • Niacin: 862mg is 24.6× the Tolerable Upper Intake Level (35mg)
  • Vitamin B6: 105mg is 1.1× the Tolerable Upper Intake Level (100mg)
  • Folate: 680mg is 680.0× the Tolerable Upper Intake Level (1.0mg)
  • Magnesium: 420mg is 1.2× the Tolerable Upper Intake Level (350mg)
  • 50% of ingredients have research evidence
F Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This profile contains essential vitamins A, C, D3, E, and thiamine, which support immune function and cellular health. There is strong research evidence supporting the roles of these nutrients in maintaining general physiological homeostasis. The formulation maintains a high safety score, indicating a low risk of adverse effects for most users.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 862mg is 24.6× the Tolerable Upper Intake Level (35mg)

Vitamin B6: 105mg is 1.1× the Tolerable Upper Intake Level (100mg)

Folate: 680mg is 680.0× the Tolerable Upper Intake Level (1.0mg)

Magnesium: 420mg is 1.2× the Tolerable Upper Intake Level (350mg)

Label

Product Label

Label for Life Extension Mix Tablets with Extra Niacin
Open Full PDF View on NIH DSLD →
Details

Label Data

8 Tablet(s)
Serving Size
30
Servings
Other Combinations
Product Type
50%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Vitamin A
1500 mcg RAE (167% DV)
Vitamin C
970 mg (1078% DV)
50 mcg (250% DV)
3.3× RDA — above typical dose (UL: 0.1 mg) 608 studies (A:16, B:251)
67 mg (447% DV)
4.5× RDA — above typical dose (UL: 1000 mg) 179 studies (A:3, B:90)
125 mg (10417% DV)
104.2× RDA — above typical dose 76 studies (A:0, B:33)
50 mg (3846% DV)
38.5× RDA — above typical dose 13 studies (A:0, B:1)
862 mg NE (5388% DV)
Exceeds UL by 24.6× (UL: 35 mg) 196 studies (A:5, B:63)
105 mg (6176% DV)
Exceeds UL by 1.1× (UL: 100 mg) 114 studies (A:3, B:35)
680 mcg DFE (5388% DV)
Exceeds UL by 680.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
600 mcg (25000% DV)
250.0× RDA — above typical dose 139 studies (A:1, B:44)
3000 mcg (10000% DV)
100.0× RDA — above typical dose 27 studies (A:0, B:11)
600 mg (12000% DV)
120.0× RDA — above typical dose 2 studies — no high-quality reviews
Calcium
500 mg (38% DV)
150 mcg (100% DV)
Within RDA (1.0× RDA) 245 studies (A:4, B:133)
420 mg (100% DV)
Exceeds UL by 1.2× (UL: 350 mg) 316 studies (A:8, B:159)
35 mg (318% DV)
3.2× RDA — above typical dose (UL: 40 mg) 263 studies (A:6, B:134)
200 mcg (364% DV)
3.6× RDA — above typical dose (UL: 0.4 mg) 173 studies (A:0, B:67)
1 mg (111% DV)
1.1× RDA — within safe limits 37 studies (A:0, B:11)
1 mg (43% DV)
Within RDA (0.4× RDA) 9 studies — no high-quality reviews
500 mcg (1429% DV)
14.3× RDA — above typical dose 199 studies (A:1, B:55)
125 mcg (278% DV)
2.8× RDA — within safe limits 3 studies — no high-quality reviews
125 mcg (278% DV)
2.8× RDA — within safe limits 3 studies — no high-quality reviews
Potassium
35 mg (1% DV)
Market median: 600.0mg (7 products) 39 studies (A:2, B:13)
Broccoli Concentrate Blend
525 mg
Market median: 260.0mg (249 products) 158 studies (A:4, B:61)
Acerola Berry Extract
300 mg
250 mg
Market median: 550.0mg (217 products) 29 studies (A:0, B:5)
Market median: 983.0mg (16 products) 7 studies (A:0, B:1)
Fruit/Berry Proprietary Blend
200 mg
200 mg
Market median: 500.0mg (180 products) 5 studies (A:0, B:1)
Wild Blueberry Fruit Extract
150 mg
125 mg
Market median: 450.0mg (502 products) 28 studies (A:0, B:8)
100 mg
Market median: 250.0mg (562 products) 55 studies (A:0, B:19)
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews
CherryPURE
85 mg
Pomella
85 mg
4.0× RDA — above typical dose (UL: 1000 mg) 179 studies (A:3, B:90)
MirtoSelect
30 mg
BioVin
25 mg
Leucoselect
25 mg
Market median: 500.0mg (283 products) 174 studies (A:0, B:62)
15 mg
Market median: 200.0mg (136 products) 3 studies — no high-quality reviews
15 mg
Market median: 10.0mg (105 products) 2 studies (A:0, B:1)
Olive Fruit Extract
12.5 mg
Market median: 200.0mg (52 products) 12 studies (A:0, B:6)
Luteolin
8 mg
Apigenin
5 mg
3 mg
Market median: 3.0mg (58 products) 3 studies — no high-quality reviews
LycoBeads
3 mg
Delphinol
2 mg
Cyanidin-3-Glucoside
1.25 mg

Other Ingredients

Microcrystalline Cellulose Maltodextrin Stearic Acid Croscarmellose Sodium Silica Stearate Starch Water, Purified Hydroxypropyl Methylcellulose Glycerin
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Info

Product Information

Directions for Use

Directions: Take eight (8) tablets daily in divided doses with meals, or as recommended by a healthcare practitioner.

Warnings & Precautions

Contains sesame. Bioengineered food.

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Caution: Temporary flushing, itching, rash, or gastric disturbances may occur. Liver function testing is recommended when niacin is taken in excess of 500 mg daily. Those with gout or liver diseases should avoid taking high doses of niacin.

Consult with your doctor before using this product if you are taking anticoagulant medications.

Individuals consuming more than 50 mcg (2,000 IU)/day of vitamin D (from diet and supplements) should periodically obtain a serum 25-hydroxy vitamin D measurement. Vitamin D supplementation is not recommended for individuals with high blood calcium levels. Individuals with in-born errors of copper metabolism (e.g. Wilson's disease) should avoid daily, chronic use of this product.

Warnings: Keep out of reach of children.

Do not exceed recommended dose. Do not purchase if outer seal is damaged.

Consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Warning: Reproductive harm - www.P65Warnings.ca.gov.

Formulation Notes

Gluten free

State-of-the-art multi-nutrient formula

Additional Information

Scan for product info

Store tightly closed in a cool, dry place.

RAE (retinol activity equivalents). DFE (dietary folate equivalents). NE (niacin equivalents).

Metadata

Product Details

UPC / SKU7 37870 23572 9
DSLD Entry Date2025-09-25
Product TypeOther Combinations
FormTablet or Pill
BrandLife Extension
DSLD ID328518
Data Updated2026-04-11
Research

Research Evidence

241
Research Sources
55
Avg Quality
113
Meta Analysis
75
Systematic Review
32
Rct
11
Clinical Trial
3
Other
3
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014 PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024 PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010 PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010 PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019 PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016 PubMed DOI
View all evidence for Niacin →
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Niacin research Best Niacin All Niacin products More from Life Extension View on NIH DSLD →

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.