What the Evidence Says
✨ AI-generated · Qwen 3.6
· methodology
This formula contains essential vitamins A, C, D, E, and K, which are supported by strong evidence for maintaining immune function and bone health in older adults. Research indicates these nutrients play critical roles in cellular protection and coagulation. The product maintains a high safety profile for general use.
AI-generated summary based on research evidence. Not medical advice.
Safety Alerts
⚠️ Folate: 666mg is 666.0× the Tolerable Upper Intake Level (1.0mg)
Label Data
2 Time Release Caplet(s)
Serving Size
125
Servings
Other Combinations
Product Type
63%
Evidence Coverage
Supplement Facts — Evidence Check
📊 3.3× RDA — above typical dose (UL: 0.1 mg)
📚 608 studies (Tier A: 16, B: 251)
RDA 0.015mg
This product: 0.05mg
UL 0.1mg
✅ 1.3× RDA — within safe limits
📚 179 studies (Tier A: 3, B: 90)
RDA 15mg
This product: 20.1mg
UL 1000mg
✅ Within RDA (0.1× RDA of 0.12 mg)
📚 275 studies (Tier A: 9, B: 175)
RDA 0.12mg
This product: 0.01mg
📊 20.8× RDA — above typical dose
📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg
This product: 25mg
📊 19.2× RDA — above typical dose
📚 13 studies (Tier A: 0, B: 1)
RDA 1.3mg
This product: 25mg
✅ 1.8× RDA — within safe limits
📚 196 studies (Tier A: 5, B: 63)
RDA 14mg
This product: 25mg
UL 35mg
📊 19.2× RDA — above typical dose (UL: 100 mg)
📚 114 studies (Tier A: 3, B: 35)
RDA 1.3mg
This product: 25mg
UL 100mg
⚠️ Exceeds Tolerable Upper Intake Level by 666.0× (UL: 1.0 mg)
📚 226 studies (Tier A: 10, B: 105)
RDA 0.4mg
This product: 666mg
UL 1.0mg
📊 208.3× RDA — above typical dose
📚 139 studies (Tier A: 1, B: 44)
RDA 0.0024mg
This product: 0.5mg
📊 20.0× RDA — above typical dose
📚 27 studies (Tier A: 0, B: 11)
RDA 0.03mg
This product: 0.6mg
📊 5.0× RDA — above typical dose
📚 2 studies — no high-quality reviews
RDA 5mg
This product: 25mg
✅ Within RDA (1.0× RDA of 0.15 mg)
📚 245 studies (Tier A: 4, B: 133)
RDA 0.15mg
This product: 0.15mg
UL 1.1mg
✅ Within RDA (0.1× RDA of 420 mg)
📚 316 studies (Tier A: 8, B: 159)
RDA 420mg
This product: 50mg
UL 350mg
✅ 1.4× RDA — within safe limits
📚 263 studies (Tier A: 6, B: 134)
RDA 11mg
This product: 15mg
UL 40mg
📊 3.6× RDA — above typical dose (UL: 0.4 mg)
📚 173 studies (Tier A: 0, B: 67)
RDA 0.055mg
This product: 0.2mg
UL 0.4mg
✅ 2.2× RDA — within safe limits
📚 37 studies (Tier A: 0, B: 11)
RDA 0.9mg
This product: 2mg
UL 10mg
✅ Within RDA (0.9× RDA of 2.3 mg)
📚 9 studies — no high-quality reviews
RDA 2.3mg
This product: 2mg
UL 11mg
📊 5.7× RDA — above typical dose
📚 199 studies (Tier A: 1, B: 55)
RDA 0.035mg
This product: 0.2mg
✅ Within RDA (0.6× RDA of 0.045 mg)
📚 3 studies — no high-quality reviews
RDA 0.045mg
This product: 0.025mg
UL 2mg
📊 Market median: 3.0mg (58 products)
📚 3 studies — no high-quality reviews
This product: 1mg
UL 20mg
📊 Market median: 125.0mg (294 products)
📚 38 studies (Tier A: 1, B: 7)
RDA 550mg
This product: 20mg
UL 3500mg
📊 Market median: 550.0mg (217 products)
📚 29 studies (Tier A: 0, B: 5)
📊 Market median: 500.0mg (19 products)
📊 Market median: 500.0mg (283 products)
📚 174 studies (Tier A: 0, B: 62)
📊 Market median: 496.0mg (192 products)
📚 20 studies — no high-quality reviews
📊 Market median: 100.0mg (283 products)
📚 144 studies (Tier A: 1, B: 64)
This product: 1mg
UL 1200mg
📊 Market median: 500.0mg (497 products)
📚 135 studies (Tier A: 0, B: 40)
📊 Market median: 10.0mg (105 products)
📚 2 studies (Tier A: 0, B: 1)
📊 Market median: 200.0mg (198 products)
📚 6 studies — no high-quality reviews
Other Ingredients
Cellulose
Silica
Stearic Acid
Acacia Gum
natural Palm leaf glaze
Magnesium Stearate
Label Claims — Verification
❓
All Other
❓
Structure/Function
All Other (99% of products)
Structure/Function (76% of products)
Nutrient (58% of products)
Target Groups
Seniors/Mature (>50 Years)
Gluten Free
Dairy Free
Sugar Free
Product Information
📋 Directions for Use
Directions: For adults, take two (2) caplets daily, preferably with a meal.
⚠️ Warnings & Precautions
Contains bioengineered food ingredients.
Warning: Not intended for use by pregnant or nursing women. If you are taking any medications, including blood thinners, planning any medical or surgical procedure, have any medical condition or are planning to undergo any clinical lab testing, consult your doctor before use. Some supplements may interact with certain medications and/or interfere with certain lab tests.
It is advisable to consult your doctor before using biotin doses above 2,500 mcg per day.
Avoid this product if you are allergic to yeast.
If any adverse reactions occur, stop use and consult your doctor.
Keep out of reach of children.
Do not use if seal under cap is broken or missing.
🧪 Formulation Notes
No artificial color or flavor, no sugar, no milk, no lactose, no gluten, no wheat no yeast, no fish.
Premium performance formula for seniors
Timed release
Additional Information
Store at room temperature.
To reorder item #10273 www.puritan.com 1-800-645-1030
QA Quality Assured
Product Details
UPC / SKU
0 25077 10273 0
DSLD Entry Date
2023-05-24
Product Type
Other Combinations
Form
Other (e.g. tea bag)
Data Updated
2026-04-11
Research Evidence
337
Research Sources
54
Avg Quality Score
161
Meta Analysis
68
Systematic Review
51
Rct
48
Clinical Trial
2
Other
2
Regulatory Source
1
Narrative Review
1
Cochrane Review
1
Guideline
1
Openfda Safety
Meta Analysis
The Cochrane database of systematic reviews
2017
Meta Analysis
The Cochrane database of systematic reviews
2011
Meta Analysis
The Cochrane database of systematic reviews
2011
Meta Analysis
BMJ (Clinical research ed.)
2011
Systematic Review
The Cochrane database of systematic reviews
2019
Narrative Review
The Cochrane database of systematic reviews
2016
Meta Analysis
The Cochrane database of systematic reviews
2020
Meta Analysis
Journal of sport and health science
2023
Meta Analysis
The Cochrane database of systematic reviews
2019
Meta Analysis
The Cochrane database of systematic reviews
2024
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