🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 68% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Capsule(s) Serving Size
120 Servings
Other Combinations Product Type
68% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin A
5000 IU (100% DV)
Vitamin C
100 mg (167% DV)
2000 IU (500% DV)
📊 3.3× RDA — above typical dose (UL: 0.1 mg) 📚 604 studies (Tier A: 16, B: 251)
RDA 0.015mg This product: 0.05mg UL 0.1mg
30 IU (100% DV)
✅ 1.3× RDA — within safe limits 📚 177 studies (Tier A: 3, B: 90)
RDA 15mg This product: 20.1mg UL 1000mg
300 mcg (375% DV)
✅ 2.5× RDA — within safe limits 📚 273 studies (Tier A: 9, B: 175)
RDA 0.12mg This product: 0.3mg
10 mg (667% DV)
📊 8.3× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 10mg
10 mg (588% DV)
📊 7.7× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 10mg
20 mg (100% DV)
✅ 1.4× RDA — within safe limits 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 20mg UL 35mg
10 mg (500% DV)
📊 7.7× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 10mg UL 100mg
800 mcg (200% DV)
✅ 2.0× RDA — within safe limits 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 0.8mg UL 1.0mg
100 mcg (1667% DV)
📊 41.7× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.1mg
500 mcg (167% DV)
📊 16.7× RDA — above typical dose 📚 26 studies (Tier A: 0, B: 11)
RDA 0.03mg This product: 0.5mg
10 mg (100% DV)
✅ 2.0× RDA — within safe limits 📚 1 studies — no high-quality reviews
RDA 5mg This product: 10mg
Calcium
10 mg (1% DV)
150 mcg (100% DV)
✅ Within RDA (1.0× RDA of 0.15 mg) 📚 243 studies (Tier A: 4, B: 133)
RDA 0.15mg This product: 0.15mg UL 1.1mg
15 mg (100% DV)
✅ 1.4× RDA — within safe limits 📚 258 studies (Tier A: 6, B: 134)
RDA 11mg This product: 15mg UL 40mg
200 mcg (286% DV)
📊 3.6× RDA — above typical dose (UL: 0.4 mg) 📚 172 studies (Tier A: 0, B: 67)
RDA 0.055mg This product: 0.2mg UL 0.4mg
0.5 mg (25% DV)
✅ Within RDA (0.6× RDA of 0.9 mg) 📚 36 studies (Tier A: 0, B: 11)
RDA 0.9mg This product: 0.5mg UL 10mg
2 mg (100% DV)
✅ Within RDA (0.9× RDA of 2.3 mg) 📚 8 studies — no high-quality reviews
RDA 2.3mg This product: 2mg UL 11mg
200 mcg (167% DV)
📊 5.7× RDA — above typical dose 📚 197 studies (Tier A: 1, B: 55)
RDA 0.035mg This product: 0.2mg
75 mcg (100% DV)
✅ 1.7× RDA — within safe limits 📚 2 studies — no high-quality reviews
RDA 0.045mg This product: 0.075mg UL 2mg
📊 Market median: 200.0mg (198 products) 📚 6 studies — no high-quality reviews
This product: 100mg
100 mg
📊 Market median: 100.0mg (283 products) 📚 142 studies (Tier A: 1, B: 64)
This product: 100mg UL 1200mg
📊 Market median: 260.0mg (249 products) 📚 156 studies (Tier A: 4, B: 61)
This product: 100mg
50 mg
📊 Market median: 500.0mg (283 products) 📚 173 studies (Tier A: 0, B: 62)
This product: 50mg
📊 Market median: 100.0mg (284 products) 📚 10 studies (Tier A: 0, B: 4)
This product: 25mg
Red Wine extract
25 mg
📊 Market median: 167.0mg (311 products) 📚 182 studies (Tier A: 0, B: 65)
This product: 10mg
6 mg
📊 Market median: 10.0mg (105 products) 📚 1 studies (Tier A: 0, B: 1)
This product: 6mg
Black Pepper extract
5 mg
300 mcg
📊 Market median: 4.0mg (32 products)
This product: 0.3mg

Other Ingredients

Gelatin Cellulose Vegetable Magnesium Stearate Silicon Dioxide

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (76% of products) Nutrient (58% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions As a dietary supplement for adults 18 years of age and over, take 1 capsule daily with food, including fat, preferably a healthy fat such as extra-virgin olive oil, to improve the absorption of fat-soluble nutrients, or as directed by a healthcare professional.

(Note: To complete your daily nutritional needs, we suggest adding Vitacost Calcium & Magnesium, which provides recommended DV levels of calcium (500mg, as calcium citrate malate, the most absorbable form) and magnesium (250 mg). Even with today's advanced technology, it's impossible to compress every essential nutrient into one easily swallowed daily pill.

⚠️ Warnings & Precautions

Warnings Pregnant or lactating women, diabetics, hypoglycemics and people with known medical conditions and/or taking drugs should consult with a licensed physician and/or pharmacist prior to taking dietary supplements. Individuals taking anticoagulants (e.g., warfarin, heparin) should consult with their physician before taking supplements containing vitamin K.

Keep out of reach of children.

Contains: Soy.

🧪 Formulation Notes

Vitacost Synergy Once Daily Multi-Vitamin description HIgh-potency multi-vitamin with 21 essential vitamins and minerals – plus powerful antioxidants such as green tea, resveratrol, CoQ10 and more.

What is Vitacost Synergy Once Daily? Vitacost Synergy Once Daily is a comprehensive daily multi-vitamin that combines 21 essential vitamins and minerals with added antioxidant nutrients including green tea, resveratrol, coenzyme Q10 (CoQ10) and more.

Better Ingredients Most store-bought multi-vitamins contain low-cost, low-quality ingredients - allowing manufacturers to make a profit. Vitacost, however, puts your health first. Synergy Once Daily is made with premium-quality, name-brand ingredients you can trust. For example, vitamin A is included as Betatene - a patented blend of natural mixed carotenoids. In addition, nutrients are supplied in ideal form (such as vitamin D as cholecalciferol, the type naturally produced by skin when exposed to sunlight).

Vitacost Synergy Once Daily supplies extracts of green tea, red wine, grape seed, resveratrol, CoQ10, alpha lipoic acid, quercetin, lutein and zeaxanthin.

Free of Milk, eggs, peanuts, tree nuts, crustacean shellfish, fish, gluten, titanium dioxide.

Enhanced absorption Synergy Once Daily contains BioPerine, a standardized extract of black pepper fruit that enhances the bioavailability of various nutrients.

Individuals taking anticoagulants (e.g., warfarin, heparin) should consult with their physician before taking supplements containing vitamin K.

How does Vitacost Synergy Once Daily support health? Provides 21 essential vitamins and minerals Provides nine additional antioxidant nutrients to help protect healthy cells from free redical damage. Features 2,000 IU of vitamin D3 for bone, immune and nervous system health.

Contains antioxidant nutrients not found in most multis

Contains: Soy.

Bioperine Lutemax Free Lutein Selenium SeLECT AdvanC Betatene L-OptiZinc ChromeMate

Contains vitamin K for bone and vascular health Contains folic acid to help support healthy brain function, memory and mood Contains CoQ10, a powerful antioxidant essential for energy production

Contains green tea, an antioxidant that may help support cardiovascular, immune health and more Supplies lutein and zeaxanthin, antioxidants that may also play a part in healthy vision.

Additional Information

Physician formulated

Once daily formula is convenient and easy to take.

Unlike common, store bought multi-vitamins, Vitacost Synergy Once Daily is a premium product that features effective levels and forms of potent, high-quality ingredients to provide real benefits for your health. Synergy Once Daily stands apart from other multis for the following reasons: Higher nutrients levels Included in Synergy Once Daily is an impressive 100% or more of the daily value (DV) for 19 of the 21 essential vitamins and minerals provided. Compare the label with that of other multis, and you'll see that Synergy Once Daily contains significantly higher nutrient levels than most. For many nutrients, levels are above and beyond what's recommended to provide maximum nutritive benefits.

Added antioxidants Besides 21 essential vitamins and minerals, Synergy Once Daily provides nine antioxidant nutrients rarely included in other one-a-day formulas. Antioxidants are natural substances found in plants and foods that help protect healthy cells from free radical damage.

Keep dry and at room temperature (59(0)-86(0)F [15(0)-30(0)C]).

About Vitacost Vitacost nutritional products are manufactured to high standards of quality, efficacy and safety. Each Vitacost product meets or exceeds the standards and requirements set forth in the FDA's Code of Federal Regulation (21 CFR, 111) Current Good Manufacturing Practices (CGMP).

Why choose Vitacost Synergy Once Daily Multi-vitamin? Nutrient-packed formula with more than 100% of the DV for 19 essential vitamins and minerals

Features safe, brand-name ingredients Features optimal levels of nutrients Exceptional quality at an extraordinary value

Research shows that CoQ10 is important for heart health

Product Details

UPC / SKU 8 44197 01933 5
DSLD Entry Date 2019-11-21
Product Type Other Combinations
Form Capsule
DSLD ID 207788
Data Updated 2026-04-11

Research Evidence

337 Research Sources
54 Avg Quality Score
161 Meta Analysis
68 Systematic Review
51 Rct
48 Clinical Trial
2 Other
2 Regulatory Source
1 Narrative Review
1 Cochrane Review
1 Guideline
1 Openfda Safety
A Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age
Meta Analysis The Cochrane database of systematic reviews 2017
A Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less
Meta Analysis The Cochrane database of systematic reviews 2011
A Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection
Meta Analysis The Cochrane database of systematic reviews 2011
A Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis
Meta Analysis BMJ (Clinical research ed.) 2011
A Fortification of staple foods with vitamin A for vitamin A deficiency
Systematic Review The Cochrane database of systematic reviews 2019
A Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age
Narrative Review The Cochrane database of systematic reviews 2016
A Vitamin A and fish oils for preventing the progression of retinitis pigmentosa
Meta Analysis The Cochrane database of systematic reviews 2020
A Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Journal of sport and health science 2023
A Food fortification with multiple micronutrients: impact on health outcomes in general population
Meta Analysis The Cochrane database of systematic reviews 2019
A Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age
Meta Analysis The Cochrane database of systematic reviews 2024
View all evidence for Vitamin A →

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