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Once Daily Multi-Vitamin

product on market Capsule Vitacost Synergy Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 68% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

The formulation includes essential vitamins A, C, D, E, and K, which are supported by strong evidence for maintaining immune function and bone health. These nutrients play critical roles in cellular protection and coagulation. However, the overall evidence coverage for this specific profile is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Once Daily Multi-Vitamin
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
120
Servings
Other Combinations
Product Type
68%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Vitamin A
5000 IU (100% DV)
Vitamin C
100 mg (167% DV)
2000 IU (500% DV)
3.3× RDA — above typical dose (UL: 0.1 mg) 608 studies (A:16, B:251)
30 IU (100% DV)
1.3× RDA — within safe limits 179 studies (A:3, B:90)
300 mcg (375% DV)
2.5× RDA — within safe limits 275 studies (A:9, B:175)
10 mg (667% DV)
8.3× RDA — above typical dose 76 studies (A:0, B:33)
10 mg (588% DV)
7.7× RDA — above typical dose 13 studies (A:0, B:1)
20 mg (100% DV)
1.4× RDA — within safe limits 196 studies (A:5, B:63)
10 mg (500% DV)
7.7× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
800 mcg (200% DV)
2.0× RDA — within safe limits 226 studies (A:10, B:105)
100 mcg (1667% DV)
41.7× RDA — above typical dose 139 studies (A:1, B:44)
500 mcg (167% DV)
16.7× RDA — above typical dose 27 studies (A:0, B:11)
10 mg (100% DV)
2.0× RDA — within safe limits 2 studies — no high-quality reviews
Calcium
10 mg (1% DV)
150 mcg (100% DV)
Within RDA (1.0× RDA) 245 studies (A:4, B:133)
15 mg (100% DV)
1.4× RDA — within safe limits 263 studies (A:6, B:134)
200 mcg (286% DV)
3.6× RDA — above typical dose (UL: 0.4 mg) 173 studies (A:0, B:67)
0.5 mg (25% DV)
Within RDA (0.6× RDA) 37 studies (A:0, B:11)
2 mg (100% DV)
Within RDA (0.9× RDA) 9 studies — no high-quality reviews
200 mcg (167% DV)
5.7× RDA — above typical dose 199 studies (A:1, B:55)
75 mcg (100% DV)
1.7× RDA — within safe limits 3 studies — no high-quality reviews
Market median: 200.0mg (198 products) 6 studies — no high-quality reviews
100 mg
Market median: 100.0mg (283 products) 144 studies (A:1, B:64)
Market median: 260.0mg (249 products) 158 studies (A:4, B:61)
50 mg
Market median: 500.0mg (283 products) 174 studies (A:0, B:62)
Market median: 100.0mg (284 products) 10 studies (A:0, B:4)
Red Wine extract
25 mg
Market median: 167.0mg (311 products) 183 studies (A:0, B:65)
6 mg
Market median: 10.0mg (105 products) 2 studies (A:0, B:1)
Black Pepper extract
5 mg
300 mcg
Market median: 4.0mg (32 products)

Other Ingredients

Gelatin Cellulose Vegetable Magnesium Stearate Silicon Dioxide
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions As a dietary supplement for adults 18 years of age and over, take 1 capsule daily with food, including fat, preferably a healthy fat such as extra-virgin olive oil, to improve the absorption of fat-soluble nutrients, or as directed by a healthcare professional.

(Note: To complete your daily nutritional needs, we suggest adding Vitacost Calcium & Magnesium, which provides recommended DV levels of calcium (500mg, as calcium citrate malate, the most absorbable form) and magnesium (250 mg). Even with today's advanced technology, it's impossible to compress every essential nutrient into one easily swallowed daily pill.

Warnings & Precautions

Warnings Pregnant or lactating women, diabetics, hypoglycemics and people with known medical conditions and/or taking drugs should consult with a licensed physician and/or pharmacist prior to taking dietary supplements. Individuals taking anticoagulants (e.g., warfarin, heparin) should consult with their physician before taking supplements containing vitamin K.

Keep out of reach of children.

Contains: Soy.

Formulation Notes

Vitacost Synergy Once Daily Multi-Vitamin description HIgh-potency multi-vitamin with 21 essential vitamins and minerals – plus powerful antioxidants such as green tea, resveratrol, CoQ10 and more.

What is Vitacost Synergy Once Daily? Vitacost Synergy Once Daily is a comprehensive daily multi-vitamin that combines 21 essential vitamins and minerals with added antioxidant nutrients including green tea, resveratrol, coenzyme Q10 (CoQ10) and more.

Better Ingredients Most store-bought multi-vitamins contain low-cost, low-quality ingredients - allowing manufacturers to make a profit. Vitacost, however, puts your health first. Synergy Once Daily is made with premium-quality, name-brand ingredients you can trust. For example, vitamin A is included as Betatene - a patented blend of natural mixed carotenoids. In addition, nutrients are supplied in ideal form (such as vitamin D as cholecalciferol, the type naturally produced by skin when exposed to sunlight).

Vitacost Synergy Once Daily supplies extracts of green tea, red wine, grape seed, resveratrol, CoQ10, alpha lipoic acid, quercetin, lutein and zeaxanthin.

Free of Milk, eggs, peanuts, tree nuts, crustacean shellfish, fish, gluten, titanium dioxide.

Enhanced absorption Synergy Once Daily contains BioPerine, a standardized extract of black pepper fruit that enhances the bioavailability of various nutrients.

Individuals taking anticoagulants (e.g., warfarin, heparin) should consult with their physician before taking supplements containing vitamin K.

How does Vitacost Synergy Once Daily support health? Provides 21 essential vitamins and minerals Provides nine additional antioxidant nutrients to help protect healthy cells from free redical damage. Features 2,000 IU of vitamin D3 for bone, immune and nervous system health.

Contains antioxidant nutrients not found in most multis

Contains: Soy.

Bioperine Lutemax Free Lutein Selenium SeLECT AdvanC Betatene L-OptiZinc ChromeMate

Contains vitamin K for bone and vascular health Contains folic acid to help support healthy brain function, memory and mood Contains CoQ10, a powerful antioxidant essential for energy production

Contains green tea, an antioxidant that may help support cardiovascular, immune health and more Supplies lutein and zeaxanthin, antioxidants that may also play a part in healthy vision.

Additional Information

Physician formulated

Once daily formula is convenient and easy to take.

Unlike common, store bought multi-vitamins, Vitacost Synergy Once Daily is a premium product that features effective levels and forms of potent, high-quality ingredients to provide real benefits for your health. Synergy Once Daily stands apart from other multis for the following reasons: Higher nutrients levels Included in Synergy Once Daily is an impressive 100% or more of the daily value (DV) for 19 of the 21 essential vitamins and minerals provided. Compare the label with that of other multis, and you'll see that Synergy Once Daily contains significantly higher nutrient levels than most. For many nutrients, levels are above and beyond what's recommended to provide maximum nutritive benefits.

Added antioxidants Besides 21 essential vitamins and minerals, Synergy Once Daily provides nine antioxidant nutrients rarely included in other one-a-day formulas. Antioxidants are natural substances found in plants and foods that help protect healthy cells from free radical damage.

Keep dry and at room temperature (59(0)-86(0)F [15(0)-30(0)C]).

About Vitacost Vitacost nutritional products are manufactured to high standards of quality, efficacy and safety. Each Vitacost product meets or exceeds the standards and requirements set forth in the FDA's Code of Federal Regulation (21 CFR, 111) Current Good Manufacturing Practices (CGMP).

Why choose Vitacost Synergy Once Daily Multi-vitamin? Nutrient-packed formula with more than 100% of the DV for 19 essential vitamins and minerals

Features safe, brand-name ingredients Features optimal levels of nutrients Exceptional quality at an extraordinary value

Research shows that CoQ10 is important for heart health

Metadata

Product Details

UPC / SKU8 44197 01933 5
DSLD Entry Date2019-11-21
Product TypeOther Combinations
FormCapsule
DSLD ID207788
Data Updated2026-04-11
Research

Research Evidence

337
Research Sources
54
Avg Quality
161
Meta Analysis
68
Systematic Review
51
Rct
48
Clinical Trial
2
Other
2
Regulatory Source
1
Narrative Review
1
Cochrane Review
1
Guideline
1
Openfda Safety
A Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less
Meta Analysis The Cochrane database of systematic reviews 2011 PubMed DOI
A Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection
Meta Analysis The Cochrane database of systematic reviews 2011 PubMed DOI
A Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis
Meta Analysis BMJ (Clinical research ed.) 2011 PubMed DOI
A Fortification of staple foods with vitamin A for vitamin A deficiency
Systematic Review The Cochrane database of systematic reviews 2019 PubMed DOI
A Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age
Narrative Review The Cochrane database of systematic reviews 2016 PubMed DOI
A Vitamin A and fish oils for preventing the progression of retinitis pigmentosa
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
A Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Journal of sport and health science 2023 PubMed DOI
A Food fortification with multiple micronutrients: impact on health outcomes in general population
Meta Analysis The Cochrane database of systematic reviews 2019 PubMed DOI
A Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age
Meta Analysis The Cochrane database of systematic reviews 2024 PubMed DOI
View all evidence for Vitamin A →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.