Heart

product on market Unknown GNC Mega Men Safety: 99/100
99/100

This product looks safe

  • Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)
  • 65% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

The profile consists of essential fat-soluble and antioxidant vitamins that support immune function and cardiovascular health. There is strong research evidence supporting the roles of vitamins A, C, D, E, and K in maintaining cellular integrity. The formulation maintains a high safety profile for general use.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)

Label

Product Label

Label for Heart
Open Full PDF View on NIH DSLD →
Details

Label Data

3 Caplet(s)
Serving Size
30
Servings
Other Combinations
Product Type
65%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Vitamin A
5000 IU (100% DV)
Vitamin C
300 mg (500% DV)
1600 IU (400% DV)
2.7× RDA — within safe limits 608 studies (A:16, B:251)
30 IU (100% DV)
1.3× RDA — within safe limits 179 studies (A:3, B:90)
80 mcg (100% DV)
Within RDA (0.7× RDA) 275 studies (A:9, B:175)
50 mg (3333% DV)
41.7× RDA — above typical dose 76 studies (A:0, B:33)
50 mg (2941% DV)
38.5× RDA — above typical dose 13 studies (A:0, B:1)
50 mg (250% DV)
Exceeds UL by 1.4× (UL: 35 mg) 196 studies (A:5, B:63)
50 mg (2500% DV)
38.5× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
400 mcg (100% DV)
Within RDA (1.0× RDA) 226 studies (A:10, B:105)
50 mcg (833% DV)
20.8× RDA — above typical dose 139 studies (A:1, B:44)
300 mcg (100% DV)
10.0× RDA — above typical dose 27 studies (A:0, B:11)
50 mg (500% DV)
10.0× RDA — above typical dose 2 studies — no high-quality reviews
Calcium
200 mg (20% DV)
150 mcg (100% DV)
Within RDA (1.0× RDA) 245 studies (A:4, B:133)
100 mg (25% DV)
Within RDA (0.2× RDA) 316 studies (A:8, B:159)
25 mg (167% DV)
2.3× RDA — within safe limits 263 studies (A:6, B:134)
200 mcg (286% DV)
3.6× RDA — above typical dose (UL: 0.4 mg) 173 studies (A:0, B:67)
2 mg (100% DV)
2.2× RDA — within safe limits 37 studies (A:0, B:11)
2 mg (100% DV)
Within RDA (0.9× RDA) 9 studies — no high-quality reviews
120 mcg (100% DV)
3.4× RDA — above typical dose 199 studies (A:1, B:55)
75 mcg (100% DV)
1.7× RDA — within safe limits 3 studies — no high-quality reviews
Phytosterols
800 mg
Heart Protection Blend
100 mg
Market median: 200.0mg (198 products) 6 studies — no high-quality reviews
10 mg
Market median: 125.0mg (294 products) 38 studies (A:1, B:7)
10 mg
Market median: 550.0mg (217 products) 29 studies (A:0, B:5)
4 mg
Market median: 108.0mg (8 products) 9 studies (A:0, B:4)
2 mg
Market median: 3.0mg (58 products) 3 studies — no high-quality reviews
Market median: 10.0mg (105 products) 2 studies (A:0, B:1)
950 mcg
Market median: 10.0mg (35 products) 6 studies (A:0, B:2)
190 mcg
Market median: 4.0mg (32 products)
50 mcg
Market median: 4.0mg (47 products)
10 mcg
Market median: 0.5mg (6 products) 1 studies (A:0, B:1)

Other Ingredients

Cellulose Titanium Dioxide Vegetable Acetoglycerides Caramel color Ethyl Vanillin
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

DIRECTIONS: As a dietary supplement, take three caplets daily with food.

Warnings & Precautions

KEEP OUT OF REACH OF CHILDREN.

WARNING: Do not exceed recommended daily intake. Use only as directed. Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition. Discontinue use two weeks prior to surgery.

Formulation Notes

CONTAINS: Fish and Soybeans.

No Artificial Colors, No Wheat, No Gluten, No Dairy, Yeast Free.

Additional Information

Store in a cool, dry place.

2X MORE D-3

ACTUAL SIZE

CLINICALLY STUDIED

CLINICALLY STUDIED MULTIVITAMIN

CODE 177412 EMG

Compared to leading brands.

Frank J. Costa, M.D., an acclaimed urological surgeon and men's health expert, is part of the GNC Medical Advisory Board. One of "America's Top Physicians," Dr. Costa lectures nationally and internationally on men's health topics. Dr. Costa is regularly featured in television, radio and newspaper interviews and has published articles in both professional journals and popular magazines. "Heart health is a big concern for many men, and protecting your heart is one of the best things you can do to live well, I recommend Mega Men(R) Heart because it provides a full range of vitamins and minerals, plus phytosterols to help lower cholesterol.

GNC GUARANTEE Use any GNC supplement for as little as 10 days. If you are not 100% completely satisfied, return the unused portion of the product with proof of purchase to your GNC store for a complete refund of your purchase price. No questions asked!

GNC QUALITY COMMITMENT GNC, the leader in the development and manufacture of dietary supplements, is committed to producing the highest quality products available. This commitment begins with quality designed supplement formulations. Every raw material that goes into a GNC supplement is guaranteed as to quality and potency. Each product is dated and then shipped immediately to our stores, so you can be sure you are purchasing the freshest supplements available. At GNC, we extend our quality commitment to you by offering our money-back guarantee.

Heart

MEGA MEN(R) HEART Heart Health Features phytosterols that lower LDL (bad) cholesterol. These natural compounds found in fruits, vegetables and whole grain products work by blocking cholestrol absorption. Scientific research shows that a minimum of 400 mg per serving of free phytosterols taken twice a day with meals for a daily total of at least 800 mg, as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease. Each serving of Mega Men(R) Heart supplies 800 mg of phytosterols. Supplies Heart ProtectionBlend with L-arginine, L-carnitine, policosanol and CoQ-10 to support a healthy heart and maintain blood vessel tone. Includes B-vitamins that play a vital role in the maintainance of normal homocysteine levels. Homocysteine levels are a recognized marker for cardiovascular health. Contains calcium and folic acid which may help maintain healthy blood pressure already within normal range. Also supplies lycopene to support cardiovascular health. Advanced Nutritional Support Combines a B-vitamin complex that is essential for carbohydrate metabolism and energy production with key minerals such as copper which is involved in the production of cellular energy and chromium that plays an important role in normal glucose utilization. Includes 1,600 IU of vitamin D-3. Emerging research suggests that adequate daily vitamin D intake may help play a role in supporting colon and immune health. Timed-release caplets provide a gradual release of vital nutrients.

Timed-Release

With 1,600 IU of vitamin D-3 Lowers LDL (bad) cholesterol with phytosterols Promotes healthy blood pressure levels Supports normal, healthy blood vessel function

Conforms to USP <2091> for weight.

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Metadata

Product Details

DSLD Entry Date2011-10-26
Product TypeOther Combinations
FormUnknown
DSLD ID780
Data Updated2026-04-11
Research

Research Evidence

337
Research Sources
54
Avg Quality
161
Meta Analysis
68
Systematic Review
51
Rct
48
Clinical Trial
2
Other
2
Regulatory Source
1
Narrative Review
1
Cochrane Review
1
Guideline
1
Openfda Safety
A Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less
Meta Analysis The Cochrane database of systematic reviews 2011 PubMed DOI
A Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection
Meta Analysis The Cochrane database of systematic reviews 2011 PubMed DOI
A Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis
Meta Analysis BMJ (Clinical research ed.) 2011 PubMed DOI
A Fortification of staple foods with vitamin A for vitamin A deficiency
Systematic Review The Cochrane database of systematic reviews 2019 PubMed DOI
A Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age
Narrative Review The Cochrane database of systematic reviews 2016 PubMed DOI
A Vitamin A and fish oils for preventing the progression of retinitis pigmentosa
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
A Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Journal of sport and health science 2023 PubMed DOI
A Food fortification with multiple micronutrients: impact on health outcomes in general population
Meta Analysis The Cochrane database of systematic reviews 2019 PubMed DOI
A Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age
Meta Analysis The Cochrane database of systematic reviews 2024 PubMed DOI
View all evidence for Vitamin A →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.