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Energy & Metabolism

product on market Other (e.g. tea bag) GNC Mega Men Safety: 98/100
98/100

This product looks safe

  • Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)
  • Folate: 680mg is 680.0× the Tolerable Upper Intake Level (1.0mg)
  • 63% of ingredients have research evidence
D Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This profile contains essential fat-soluble and water-soluble vitamins that support immune function and metabolic processes. There is strong evidence for the roles of vitamins A, C, D, E, and K in maintaining general cellular health. The formulation maintains a high safety score, indicating a low risk of adverse effects at standard dosages.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)

Folate: 680mg is 680.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Energy & Metabolism
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Caplet(s)
Serving Size
90
Servings
Other Combinations
Product Type
63%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Vitamin A
1500 mcg RAE (167% DV)
Vitamin C
300 mg (333% DV)
50 mcg (250% DV)
3.3× RDA — above typical dose (UL: 0.1 mg) 608 studies (A:16, B:251)
20.1 mg (134% DV)
1.3× RDA — within safe limits 179 studies (A:3, B:90)
80 mcg (67% DV)
Within RDA (0.7× RDA) 275 studies (A:9, B:175)
50 mg (4167% DV)
41.7× RDA — above typical dose 76 studies (A:0, B:33)
50 mg (3846% DV)
38.5× RDA — above typical dose 13 studies (A:0, B:1)
50 mg (313% DV)
Exceeds UL by 1.4× (UL: 35 mg) 196 studies (A:5, B:63)
50 mg (2941% DV)
38.5× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
680 mcg DFE (170% DV)
Exceeds UL by 680.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
50 mcg (2083% DV)
20.8× RDA — above typical dose 139 studies (A:1, B:44)
300 mcg (1000% DV)
10.0× RDA — above typical dose 27 studies (A:0, B:11)
50 mg (1000% DV)
10.0× RDA — above typical dose 2 studies — no high-quality reviews
10 mg (2% DV)
Market median: 125.0mg (294 products) 38 studies (A:1, B:7)
Calcium
210 mg (16% DV)
150 mcg (100% DV)
Within RDA (1.0× RDA) 245 studies (A:4, B:133)
120 mg (29% DV)
Within RDA (0.3× RDA) 316 studies (A:8, B:159)
25 mg (227% DV)
2.3× RDA — within safe limits 263 studies (A:6, B:134)
200 mcg (364% DV)
3.6× RDA — above typical dose (UL: 0.4 mg) 173 studies (A:0, B:67)
2 mg (222% DV)
2.2× RDA — within safe limits 37 studies (A:0, B:11)
2 mg (87% DV)
Within RDA (0.9× RDA) 9 studies — no high-quality reviews
120 mcg (343% DV)
3.4× RDA — above typical dose 199 studies (A:1, B:55)
75 mcg (167% DV)
1.7× RDA — within safe limits 3 studies — no high-quality reviews
Coffee, Powder
102 mg
Market median: 200.0mg (198 products) 6 studies — no high-quality reviews
10 mg
Market median: 550.0mg (217 products) 29 studies (A:0, B:5)
Capsicum Seed Extract
10 mg
4 mg
Market median: 108.0mg (8 products) 9 studies (A:0, B:4)
Black Pepper Fruit Extract
2.6 mg
2 mg
Market median: 3.0mg (58 products) 3 studies — no high-quality reviews
2 mg
Market median: 10.0mg (105 products) 2 studies (A:0, B:1)
2 mg
Market median: 10.0mg (35 products) 6 studies (A:0, B:2)
400 mcg
Market median: 4.0mg (32 products)
50 mcg
Market median: 4.0mg (47 products)
10 mcg
Market median: 0.5mg (6 products) 1 studies (A:0, B:1)

Other Ingredients

Cellulose Corn Starch Stearic Acid Polyvinyl Alcohol Magnesium Stearate Titanium Dioxide Polyethylene Glycol Talc Caramel color Vanilla Mint Flavor, Natural Steviol Glycosides
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: As a dietary supplement, take two caplets daily with food.

Warnings & Precautions

Warning: Cancer and reproductive harm - www.P65Warnings.ca.gov.

Consult your physician prior to using this product if you are pregnant, nursing, taking medication or have a medical condition.

Discontinue use two weeks prior to surgery. Inform your physician of this product's biotin content before any lab test. Niacin may cause a temporary flushing reaction. Contains 100 mg of caffeine.

Keep out of reach of children.

Do not take before bedtime.

Contains: Soybeans, fish (anchovy, mackerel, sardine, smelt, whiting, pollock, salmon, tuna, cod or a combination thereof). Contains bioengineered food ingredients.

Formulation Notes

No artificial flavors, gluten free, no milk. Gf Gluten free

Our Quality Commitment to You Since 1935, our mission as the industry leader has been to provide you with the highest-quality nutritional supplements. We continue to stand behind this mission. If you're not 100% satisfied with your purchase, return the unused portion of the product with your receipt within 30 days and we'll either refund your money or find a replacement product that is right for you.

Multivitamin

Men's health

Contains a clinicall studied multivitamin blend shown to work better than a basic multivitamin. Helps support prostate health. Energy Shown to improve levels of key B vitamins essential for energy production. Calorie Burning Contains a combination of thermogenic ingredients that may support calorie burning and mental sharpness. Antioxidants Packed with antioxidants to help fight free radicals that can be produced during intense exercise. In a randomized, double-blind, placebo-controlled study of 112 healthy volunteers, subjects taking the GNC vitamin and mineral blends for six weeks experienced significant improvements in serum levels of certain key nutrients compared to a placebo and a leading multivitamin formula based upon mutivariate statistical analyses of a group of B vitamins (thiamin, niacin, riboflavin, pantothenic acid, biotin, folic acid and vitamins B-6 and B-12) and key antioxidants and carotenoids (a group of beta-carotene, alpha-tocopherol, selenium, lutein and lycopene). Statistical improvements in SF-36 Vitality and Mental Health scores were also observed compared to placebo. Packed with antioxidants to help fight free radicals that can be produced during intense exercise.

Multivitamin with clinically proven blend

Energy Calorie burning Antioxidants Timed release

Additional Information

For more information: 1-888-462-2548 gnc.com

90-day supply

Store in a cool, dry place.

Metadata

Product Details

DSLD Entry Date2025-09-25
Product TypeOther Combinations
FormOther (e.g. tea bag)
BrandGNC Mega Men
DSLD ID334078
Data Updated2026-04-11
Research

Research Evidence

337
Research Sources
54
Avg Quality
161
Meta Analysis
68
Systematic Review
51
Rct
48
Clinical Trial
2
Other
2
Regulatory Source
1
Narrative Review
1
Cochrane Review
1
Guideline
1
Openfda Safety
A Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less
Meta Analysis The Cochrane database of systematic reviews 2011 PubMed DOI
A Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection
Meta Analysis The Cochrane database of systematic reviews 2011 PubMed DOI
A Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis
Meta Analysis BMJ (Clinical research ed.) 2011 PubMed DOI
A Fortification of staple foods with vitamin A for vitamin A deficiency
Systematic Review The Cochrane database of systematic reviews 2019 PubMed DOI
A Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age
Narrative Review The Cochrane database of systematic reviews 2016 PubMed DOI
A Vitamin A and fish oils for preventing the progression of retinitis pigmentosa
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
A Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Journal of sport and health science 2023 PubMed DOI
A Food fortification with multiple micronutrients: impact on health outcomes in general population
Meta Analysis The Cochrane database of systematic reviews 2019 PubMed DOI
A Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age
Meta Analysis The Cochrane database of systematic reviews 2024 PubMed DOI
View all evidence for Vitamin A →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.