50 Plus

product on market Other (e.g. tea bag) GNC Mega Men Safety: 99/100
99/100

This product looks safe

  • Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)
  • 65% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

The profile includes essential vitamins A, C, D, E, and K, which are supported by strong evidence for maintaining immune function and bone health. These nutrients play critical roles in antioxidant defense and cellular regulation. The formulation maintains a high safety score, indicating a low risk of adverse effects.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)

Label

Product Label

Label for 50 Plus
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Caplet(s)
Serving Size
60
Servings
Other Combinations
Product Type
65%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Vitamin A
5000 IU (100% DV)
Vitamin C
300 mg (500% DV)
1600 IU (400% DV)
2.7× RDA — within safe limits 608 studies (A:16, B:251)
30 IU (100% DV)
1.3× RDA — within safe limits 179 studies (A:3, B:90)
80 mcg (100% DV)
Within RDA (0.7× RDA) 275 studies (A:9, B:175)
50 mg (3333% DV)
41.7× RDA — above typical dose 76 studies (A:0, B:33)
50 mg (2941% DV)
38.5× RDA — above typical dose 13 studies (A:0, B:1)
50 mg (250% DV)
Exceeds UL by 1.4× (UL: 35 mg) 196 studies (A:5, B:63)
50 mg (2500% DV)
38.5× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
400 mcg (100% DV)
Within RDA (1.0× RDA) 226 studies (A:10, B:105)
50 mcg (833% DV)
20.8× RDA — above typical dose 139 studies (A:1, B:44)
300 mcg (100% DV)
10.0× RDA — above typical dose 27 studies (A:0, B:11)
50 mg (500% DV)
10.0× RDA — above typical dose 2 studies — no high-quality reviews
Calcium
200 mg (20% DV)
150 mcg (100% DV)
Within RDA (1.0× RDA) 245 studies (A:4, B:133)
100 mg (25% DV)
Within RDA (0.2× RDA) 316 studies (A:8, B:159)
25 mg (167% DV)
2.3× RDA — within safe limits 263 studies (A:6, B:134)
200 mcg (286% DV)
3.6× RDA — above typical dose (UL: 0.4 mg) 173 studies (A:0, B:67)
2 mg (100% DV)
2.2× RDA — within safe limits 37 studies (A:0, B:11)
2 mg (100% DV)
Within RDA (0.9× RDA) 9 studies — no high-quality reviews
120 mcg (100% DV)
3.4× RDA — above typical dose 199 studies (A:1, B:55)
75 mcg (100% DV)
1.7× RDA — within safe limits 3 studies — no high-quality reviews
Market median: 320.0mg (426 products) 26 studies (A:0, B:5)
100 mg
Market median: 500.0mg (143 products)
Healthy Aging Free Radical Protection Blend
70 mg
Memory Health Blend
20 mg
10 mg
Market median: 550.0mg (217 products) 29 studies (A:0, B:5)
4 mg
Market median: 108.0mg (8 products) 9 studies (A:0, B:4)
2 mg
Market median: 3.0mg (58 products) 3 studies — no high-quality reviews
Market median: 10.0mg (105 products) 2 studies (A:0, B:1)
950 mcg
Market median: 10.0mg (35 products) 6 studies (A:0, B:2)
190 mcg
Market median: 4.0mg (32 products)
50 mcg
Market median: 4.0mg (47 products)
10 mcg
Market median: 0.5mg (6 products) 1 studies (A:0, B:1)

Other Ingredients

Cellulose Titanium Dioxide Vegetable Acetoglycerides Caramel color Ethyl Vanillin
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

DIRECTIONS: As a dietary supplement, take two caplets daily with food.

Warnings & Precautions

KEEP OUT OF REACH OF CHILDREN.

CONTAINS: Fish and Soybeans.

WARNING: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition.

Discontinue use two weeks prior to surgery.

Formulation Notes

- With 1,600 IU of Vitamin D-3 for colon health and immune support

CONTAINS: Fish and Soybeans.

No Artificial Colors, No Wheat, No Gluten, No Dairy, Yeast Free.

MEGA MEN(R) 50 PLUS

Additional Information

GNC QUALITY COMMITMENT GNC, the leader in the development and manufacture of dietary supplements, is committed to producing the highest quality products available. This commitment begins with quality designed supplement formulations. Every raw material that goes into a GNC supplement is guaranteed as to quality and potency. Each product is dated and then shipped immediately to our stores, so you can be sure you are purchasing the freshest supplements available. At GNC, we extend our quality commitment to you by offering our money-back guarantee.

GNC GUARANTEE Use any GNC supplement for as little as 10 days. If you are not 100% completely satisfied, return the unused portion of the product with proof of purchase to your GNC store for a complete refund of your purchase price. No questions asked!

{recycle} Please recycle this box.

{signature} Dr. Frank J. Costa M.D.

In a randomized, double-blind, placebo-controlled study of 112 healthy volunteers, subjects taking the GNC vitamin and mineral blend in this product for six weeks experienced statistically significant improvements in markers of B vitamin and antioxidant status, as well as improvements in SF-36 Vitality and Mental Health scores compared to those taking a placebo.

Compared to leading brands.

Store in a cool, dry place.

ACTUAL SIZE

The keys to healthy aging include the appropriate nutritional support. This premium multivitamin includes antioxidants, vitamins and minerals that are essential to addressing the factors of aging. Memory Health Blend - Features choline, which serves as a precursor of acetylcholine, one of the neurotransmitters responsible for memory function and phosphatidylserine to help promote a healthy nervous system and support memory function. Premium Prostate Blend - Combines saw palmetto with powerful antioxidants, selenium and lycopene to help support optimal prostate health and health urinary flow. Healthy Aging - Includes 1,600 IU of vitamin D-3. Emerging research suggests that adequate daily vitamin D intake may play a role in supporting colon and immune health. - Features lutein and zeaxanthin to support eye health and an advanced free radical protection blend with resveratrol, alpha-lipoic acid and green tea. These ingredients offer protection from excess free radicals that can destroy healthy cells and promote the cell-aging process. -Supplies L-arginine, an amino acid shown to help maintain blood vessel tone and play a role in sexual health. Timed-release caplets provide a slow gradual release of vital nutrients.

CLINICALLY STUDIED MULTIVITAMIN

CODE 177322 ILG

Conforms to USP <2091> for weight.

Lutemax(TM) 2020 LUTEIN & ZEAXANTHIN

Frank J. Costa, M.D., an acclaimed urological surgeon and men's health expert, is part of the GNC medical Advisory Board. One of "America's Top Physician's," Dr. Costa lectures nationally and internationally on men's health topics. Dr. Costa is regularly in television, radio and newspaper interviews and has published articles in both professional journals and popular magazines. "As you get older, your nutritional needs change.

2X MORE D-3

- Supports memory function - Premium prostate formula with saw palmetto, lycopene and selenium - Fights cell aging with advanced antioxidant blend - B-vitamins for energy support

Timed-Release

CLINICALLY STUDIED

Metadata

Product Details

DSLD Entry Date2013-10-25
Product TypeOther Combinations
FormOther (e.g. tea bag)
DSLD ID27160
Data Updated2026-04-11
Research

Research Evidence

337
Research Sources
54
Avg Quality
161
Meta Analysis
68
Systematic Review
51
Rct
48
Clinical Trial
2
Other
2
Regulatory Source
1
Narrative Review
1
Cochrane Review
1
Guideline
1
Openfda Safety
A Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less
Meta Analysis The Cochrane database of systematic reviews 2011 PubMed DOI
A Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection
Meta Analysis The Cochrane database of systematic reviews 2011 PubMed DOI
A Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis
Meta Analysis BMJ (Clinical research ed.) 2011 PubMed DOI
A Fortification of staple foods with vitamin A for vitamin A deficiency
Systematic Review The Cochrane database of systematic reviews 2019 PubMed DOI
A Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age
Narrative Review The Cochrane database of systematic reviews 2016 PubMed DOI
A Vitamin A and fish oils for preventing the progression of retinitis pigmentosa
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
A Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Journal of sport and health science 2023 PubMed DOI
A Food fortification with multiple micronutrients: impact on health outcomes in general population
Meta Analysis The Cochrane database of systematic reviews 2019 PubMed DOI
A Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age
Meta Analysis The Cochrane database of systematic reviews 2024 PubMed DOI
View all evidence for Vitamin A →
Compare

Similar Products

View all Vitamin A products →

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.