Cofactors Support
99/100
This product looks safe
- Niacin: 130mg is 3.7× the Tolerable Upper Intake Level (35mg)
- 72% of ingredients have research evidence
C
Label Compliance Grade
Product Label
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Safety Alerts
⚠️ Niacin: 130mg is 3.7× the Tolerable Upper Intake Level (35mg)
Label Data
6 Vegetarian Capsule(s)
Serving Size
30
Servings
Other Combinations
Product Type
72%
Evidence Coverage
Supplement Facts — Evidence Check
Vitamin A
27500 IU
(550% DV)
Vitamin C
600 mg
(1000% DV)
1000 IU
(250% DV)
✅ 1.7× RDA — within safe limits
📚 604 studies (Tier A: 16, B: 251)
400 IU
(1333% DV)
📊 17.9× RDA — above typical dose (UL: 1000 mg)
📚 177 studies (Tier A: 3, B: 90)
50 mcg
(63% DV)
✅ Within RDA (0.4× RDA of 0.12 mg)
📚 273 studies (Tier A: 9, B: 175)
100 mg
(6667% DV)
📊 83.3× RDA — above typical dose
📚 76 studies (Tier A: 0, B: 33)
50 mg
(2941% DV)
📊 38.5× RDA — above typical dose
📚 12 studies (Tier A: 0, B: 1)
130 mg
(650% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 3.7× (UL: 35 mg)
📚 193 studies (Tier A: 5, B: 63)
100 mg
(5000% DV)
📊 76.9× RDA — above typical dose (UL: 100 mg)
📚 113 studies (Tier A: 3, B: 35)
500 mcg
(125% DV)
✅ 1.2× RDA — within safe limits
📚 225 studies (Tier A: 10, B: 105)
500 mcg
(8334% DV)
📊 208.3× RDA — above typical dose
📚 138 studies (Tier A: 1, B: 44)
200 mcg
(67% DV)
📊 6.7× RDA — above typical dose
📚 26 studies (Tier A: 0, B: 11)
200 mg
(2000% DV)
📊 40.0× RDA — above typical dose
📚 1 studies — no high-quality reviews
Calcium
200 mg
(20% DV)
100 mcg
(67% DV)
✅ Within RDA (0.7× RDA of 0.15 mg)
📚 243 studies (Tier A: 4, B: 133)
300 mg
(75% DV)
📊 Market median: 4002.0mg (1 products)
📚 20 studies (Tier A: 0, B: 2)
20 mg
(133% DV)
✅ 1.8× RDA — within safe limits
📚 258 studies (Tier A: 6, B: 134)
200 mcg
(286% DV)
📊 3.6× RDA — above typical dose (UL: 0.4 mg)
📚 172 studies (Tier A: 0, B: 67)
2 mg
(100% DV)
✅ 2.2× RDA — within safe limits
📚 36 studies (Tier A: 0, B: 11)
6 mg
(300% DV)
✅ 2.6× RDA — within safe limits
📚 8 studies — no high-quality reviews
100 mcg
(83% DV)
✅ 2.9× RDA — within safe limits
📚 197 studies (Tier A: 1, B: 55)
100 mcg
(133% DV)
✅ 2.2× RDA — within safe limits
📚 2 studies — no high-quality reviews
Potassium
90 mg
(3% DV)
100 mg
✅ Within RDA (0.2× RDA of 550 mg)
📚 36 studies (Tier A: 1, B: 7)
100 mg
📊 Market median: 550.0mg (217 products)
📚 29 studies (Tier A: 0, B: 5)
3 mg
📊 Market median: 3.0mg (58 products)
📚 2 studies — no high-quality reviews
30 mcg
📊 Market median: 0.5mg (6 products)
📚 1 studies (Tier A: 0, B: 1)
100 mg
📊 Market median: 260.0mg (249 products)
📚 156 studies (Tier A: 4, B: 61)
100 mg
📊 Market median: 450.0mg (254 products)
📚 240 studies (Tier A: 0, B: 100)
Other Ingredients
Silicon Dioxide
Arabic Gum
Sucrose
Starch
Sodium Hydroxide
Tricalcium Phosphate
Maltodextrin
Vegetarian Capsule
Label Claims — Verification
❓
All Other
❓
Structure/Function
All Other (99% of products)
Structure/Function (76% of products)
Nutrient (58% of products)
Target Groups
Vegetarian
Adult (18 - 50 Years)
Product Information
📋 Directions for Use
Recommendations: Take six (6) capsules daily. For best results take two (2) capsules three times daily with meals, or as directed by a physician.
⚠️ Warnings & Precautions
Warning: If you are pregnant or breast feeding, consult your physician before using this product.
Keep out of reach of children.
🧪 Formulation Notes
Contains no preservatives.
Vegetarian formulation
Non-GMO
Additional Information
Keep container tightly closed, store in a cool, dry place.
Bisphenol-A (BPA) & Phthalate Free
GMP Certified
Priority One Nutritional Supplements Inc since 1988
Formulated by: Dr. Marianne Marchese
For professional use only.
Product Details
UPC / SKU
8 15354 02184 3
DSLD Entry Date
2020-09-25
Product Type
Other Combinations
Form
Capsule
DSLD ID
235718
Data Updated
2026-04-11
Research Evidence
337
Research Sources
54
Avg Quality Score
161
Meta Analysis
68
Systematic Review
51
Rct
48
Clinical Trial
2
Other
2
Regulatory Source
1
Narrative Review
1
Cochrane Review
1
Guideline
1
Openfda Safety
A
Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age
A
Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less
A
Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection
A
Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis
A
Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age
A
Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials
A
Food fortification with multiple micronutrients: impact on health outcomes in general population
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