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Cofactors Support

product on market Capsule Priority One Nutritional Supplements Safety: 99/100
99/100

This product looks safe

  • Niacin: 130mg is 3.7× the Tolerable Upper Intake Level (35mg)
  • 72% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula contains fat-soluble vitamins A, D3, E, and K1 alongside vitamin C, which are supported by strong evidence for maintaining immune function and bone health. These nutrients act as essential cofactors for various metabolic processes. The profile maintains a high safety score, indicating a low risk of adverse effects at standard dosages.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 130mg is 3.7× the Tolerable Upper Intake Level (35mg)

Label

Product Label

Label for Cofactors Support
Open Full PDF View on NIH DSLD →
Details

Label Data

6 Vegetarian Capsule(s)
Serving Size
30
Servings
Other Combinations
Product Type
72%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Vitamin A
27500 IU (550% DV)
Vitamin C
600 mg (1000% DV)
1000 IU (250% DV)
1.7× RDA — within safe limits 608 studies (A:16, B:251)
400 IU (1333% DV)
17.9× RDA — above typical dose (UL: 1000 mg) 179 studies (A:3, B:90)
50 mcg (63% DV)
Within RDA (0.4× RDA) 275 studies (A:9, B:175)
100 mg (6667% DV)
83.3× RDA — above typical dose 76 studies (A:0, B:33)
50 mg (2941% DV)
38.5× RDA — above typical dose 13 studies (A:0, B:1)
130 mg (650% DV)
Exceeds UL by 3.7× (UL: 35 mg) 196 studies (A:5, B:63)
100 mg (5000% DV)
76.9× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
500 mcg (125% DV)
1.2× RDA — within safe limits 226 studies (A:10, B:105)
500 mcg (8334% DV)
208.3× RDA — above typical dose 139 studies (A:1, B:44)
200 mcg (67% DV)
6.7× RDA — above typical dose 27 studies (A:0, B:11)
200 mg (2000% DV)
40.0× RDA — above typical dose 2 studies — no high-quality reviews
Calcium
200 mg (20% DV)
100 mcg (67% DV)
Within RDA (0.7× RDA) 245 studies (A:4, B:133)
300 mg (75% DV)
Within RDA (0.7× RDA) 316 studies (A:8, B:159)
20 mg (133% DV)
1.8× RDA — within safe limits 263 studies (A:6, B:134)
200 mcg (286% DV)
3.6× RDA — above typical dose (UL: 0.4 mg) 173 studies (A:0, B:67)
2 mg (100% DV)
2.2× RDA — within safe limits 37 studies (A:0, B:11)
6 mg (300% DV)
2.6× RDA — within safe limits 9 studies — no high-quality reviews
100 mcg (83% DV)
2.9× RDA — within safe limits 199 studies (A:1, B:55)
100 mcg (133% DV)
2.2× RDA — within safe limits 3 studies — no high-quality reviews
Potassium
90 mg (3% DV)
100 mg
Within RDA (0.2× RDA) 38 studies (A:1, B:7)
100 mg
Market median: 550.0mg (217 products) 29 studies (A:0, B:5)
3 mg
Market median: 3.0mg (58 products) 3 studies — no high-quality reviews
30 mcg
Market median: 0.5mg (6 products) 1 studies (A:0, B:1)
Market median: 260.0mg (249 products) 158 studies (A:4, B:61)
100 mg
Market median: 450.0mg (254 products) 243 studies (A:0, B:100)

Other Ingredients

Silicon Dioxide Arabic Gum Sucrose Starch Sodium Hydroxide Tricalcium Phosphate Maltodextrin Vegetarian Capsule
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Recommendations: Take six (6) capsules daily. For best results take two (2) capsules three times daily with meals, or as directed by a physician.

Warnings & Precautions

Warning: If you are pregnant or breast feeding, consult your physician before using this product.

Keep out of reach of children.

Formulation Notes

Contains no preservatives.

Vegetarian formulation

Non-GMO

Additional Information

Keep container tightly closed, store in a cool, dry place.

Bisphenol-A (BPA) & Phthalate Free

GMP Certified

Priority One Nutritional Supplements Inc since 1988

Formulated by: Dr. Marianne Marchese

For professional use only.

Metadata

Product Details

UPC / SKU8 15354 02184 3
DSLD Entry Date2020-09-25
Product TypeOther Combinations
FormCapsule
BrandPriority One Nutritional Supplements
DSLD ID235718
Data Updated2026-04-11
Research

Research Evidence

337
Research Sources
54
Avg Quality
161
Meta Analysis
68
Systematic Review
51
Rct
48
Clinical Trial
2
Other
2
Regulatory Source
1
Narrative Review
1
Cochrane Review
1
Guideline
1
Openfda Safety
A Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less
Meta Analysis The Cochrane database of systematic reviews 2011 PubMed DOI
A Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection
Meta Analysis The Cochrane database of systematic reviews 2011 PubMed DOI
A Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis
Meta Analysis BMJ (Clinical research ed.) 2011 PubMed DOI
A Fortification of staple foods with vitamin A for vitamin A deficiency
Systematic Review The Cochrane database of systematic reviews 2019 PubMed DOI
A Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age
Narrative Review The Cochrane database of systematic reviews 2016 PubMed DOI
A Vitamin A and fish oils for preventing the progression of retinitis pigmentosa
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
A Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Journal of sport and health science 2023 PubMed DOI
A Food fortification with multiple micronutrients: impact on health outcomes in general population
Meta Analysis The Cochrane database of systematic reviews 2019 PubMed DOI
A Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age
Meta Analysis The Cochrane database of systematic reviews 2024 PubMed DOI
View all evidence for Vitamin A →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.