HeadacheFree by Headache Free — Ingredients, Evidence & Safety

🟢 100/100

This product looks safe

No ingredients exceed tolerable upper intake levels
72% of ingredients have research evidence

A Label Compliance Grade

Product Label

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Label Data

2 Tablet(s) Serving Size

30 Servings

Other Combinations Product Type

72% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin A

5000 IU (100% DV)

Vitamin C

60 mg (100% DV)

Vitamin D3

400 IU (100% DV)

✅ Within RDA (0.7× RDA of 0.015 mg) 📚 604 studies (Tier A: 16, B: 251)

RDA 0.015mg This product: 0.01mg UL 0.1mg

Vitamin E

30 IU (100% DV)

✅ 1.3× RDA — within safe limits 📚 177 studies (Tier A: 3, B: 90)

RDA 15mg This product: 20.1mg UL 1000mg

Vitamin K

25 mcg (31% DV)

✅ Within RDA (0.2× RDA of 0.12 mg) 📚 273 studies (Tier A: 9, B: 175)

RDA 0.12mg This product: 0.025mg

Vitamin B1

1.5 mg (100% DV)

✅ 1.2× RDA — within safe limits 📚 76 studies (Tier A: 0, B: 33)

RDA 1.2mg This product: 1.5mg

Vitamin B2

400 mg (23529% DV)

📊 307.7× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)

RDA 1.3mg This product: 400mg

Vitamin B3

20 mg (100% DV)

✅ 1.4× RDA — within safe limits 📚 193 studies (Tier A: 5, B: 63)

RDA 14mg This product: 20mg UL 35mg

Vitamin B6

2 mg (100% DV)

✅ 1.5× RDA — within safe limits 📚 113 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 2mg UL 100mg

Folic Acid

400 mcg (100% DV)

✅ Within RDA (1.0× RDA of 0.4 mg) 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 0.4mg UL 1.0mg

Vitamin B12

6 mcg (100% DV)

✅ 2.5× RDA — within safe limits 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 0.006mg

Biotin

30 mcg (10% DV)

✅ Within RDA (1.0× RDA of 0.03 mg) 📚 26 studies (Tier A: 0, B: 11)

RDA 0.03mg This product: 0.03mg

Vitamin B5

10 mg (100% DV)

✅ 2.0× RDA — within safe limits 📚 1 studies — no high-quality reviews

RDA 5mg This product: 10mg

Calcium

162 mg (16% DV)

Iron

8 mg (44% DV)

Phosphorus

109 mg (11% DV)

✅ Within RDA (0.2× RDA of 700 mg) 📚 12 studies (Tier A: 0, B: 3)

RDA 700mg This product: 109mg UL 4000mg

Iodine

150 mcg (100% DV)

✅ Within RDA (1.0× RDA of 0.15 mg) 📚 243 studies (Tier A: 4, B: 133)

RDA 0.15mg This product: 0.15mg UL 1.1mg

Magnesium

400 mg (100% DV)

📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)

This product: 400mg

Zinc

15 mg (100% DV)

✅ 1.4× RDA — within safe limits 📚 258 studies (Tier A: 6, B: 134)

RDA 11mg This product: 15mg UL 40mg

Selenium

20 mcg (29% DV)

✅ Within RDA (0.4× RDA of 0.055 mg) 📚 172 studies (Tier A: 0, B: 67)

RDA 0.055mg This product: 0.02mg UL 0.4mg

Copper

2 mg (100% DV)

✅ 2.2× RDA — within safe limits 📚 36 studies (Tier A: 0, B: 11)

RDA 0.9mg This product: 2mg UL 10mg

Manganese

2 mg (100% DV)

✅ Within RDA (0.9× RDA of 2.3 mg) 📚 8 studies — no high-quality reviews

RDA 2.3mg This product: 2mg UL 11mg

Chromium

120 mcg (100% DV)

📊 3.4× RDA — above typical dose 📚 197 studies (Tier A: 1, B: 55)

RDA 0.035mg This product: 0.12mg

Molybdenum

75 mcg (100% DV)

✅ 1.7× RDA — within safe limits 📚 2 studies — no high-quality reviews

RDA 0.045mg This product: 0.075mg UL 2mg

Chloride

72 mg (2% DV)

📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)

This product: 72mg

Boron

150 mcg

📊 Market median: 3.0mg (58 products) 📚 2 studies — no high-quality reviews

This product: 0.15mg UL 20mg

Vanadium

10 mcg

📊 Market median: 0.5mg (6 products) 📚 1 studies (Tier A: 0, B: 1)

This product: 0.01mg UL 1.8mg

Silicon

2 mg

📊 Market median: 108.0mg (8 products) 📚 9 studies (Tier A: 0, B: 4)

This product: 2mg

Lutein

250 mcg

📊 Market median: 10.0mg (105 products) 📚 1 studies (Tier A: 0, B: 1)

This product: 0.25mg

Other Ingredients

Microcrystalline Methyl {Cellulose} Hydroxypropyl Cellulose Garlic Magnesium Stearate Molasses Extract PABA Alpha Lipoic Acid Beet Rice Bran extract Hypromellose Triacetin Titanium Dioxide Talc Carnauba Wax

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (76% of products) Nutrient (58% of products)

Target Groups

Adult (18 - 50 Years) No Allergies Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

With HeadacheFree, you take just two tablets a day.

INSTRUCTIONS: As a dietary supplement, take two tablets daily or as directed by your healthcare professional.

⚠️ Warnings & Precautions

WARNING: Accidental overdose of iron-containing products is a leading cause of fatal poisoning of children under 6. In case of accidental overdose, call a doctor or poison control center immediately.

🧪 Formulation Notes

~ Contains no known allergens

Physician-formulated with added B2 and magnesium for natural headache prevention

HeadacheFree combines 400mg of riboflavin (vitamin B2) and 400 mg of magnesium with a comlpete, food-based multivitamin to provide a drug-free alternative to aid in the prevention and management of headaches.

~ No starch, wheat, gluten, or soy ~ No dairy, animal by-products or stearic acid ~ No salt, sugar, artificial flavoring/coloring ~ No digestible plastic or heavy metals

Additional Information

As a board-certified neurologist specializing in the diagnosis and treatment of headache, I have always prided myself on taking my patients' concerns seriously. All headache sufferers want to regain control of their lives.

Based on clinical trials, best results are realized after 60-90 days of consecutive use.

Complete Multivitamin

Distributed by Headache Free, LLC headquartered in Warwick, RI 02886

~ Maximum health benefit, minimum cost

Until now, patients wanting to manage their headaches - without the use of prescription drugs - had to take as many as 15 pills a day to get all of the important daily vitamins and minerals, along with the recommended amounts of riboflavin (B2) and magnesium for headache prevention.

~ Complete multivitamin and headache preventive supplement in one ~ Developed by a board-certified neurologist ~ Clinically proven headache preventive ingredients

Because the goal with HeadacheFree is the same as it is in my practice - headache relief in as natural a way as possible. {signature} Gary A. L'Europa, MD U.S. Board-certified in Neurology and Headache Management

HeadacheFree is made using a blend of food-based, natural, and best-grade synthetic ingredients to allow optimal nutrient absorption from the smallest possible dosage.

Product Details

DSLD Entry Date 2014-06-25

Product Type Other Combinations

Form Tablet or Pill

Brand Headache Free

DSLD ID 34179

Data Updated 2026-04-11

Research Evidence

337 Research Sources

54 Avg Quality Score

161 Meta Analysis

68 Systematic Review

51 Rct

48 Clinical Trial

2 Other

2 Regulatory Source

1 Narrative Review

1 Cochrane Review

1 Guideline

1 Openfda Safety

A Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age

Meta Analysis The Cochrane database of systematic reviews 2017

PubMed DOI Cochrane

A Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less

Meta Analysis The Cochrane database of systematic reviews 2011

PubMed DOI Cochrane

A Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection

Meta Analysis The Cochrane database of systematic reviews 2011

PubMed DOI Cochrane

A Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis

Meta Analysis BMJ (Clinical research ed.) 2011

PubMed DOI

A Fortification of staple foods with vitamin A for vitamin A deficiency

Systematic Review The Cochrane database of systematic reviews 2019

PubMed DOI Cochrane

A Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age

Narrative Review The Cochrane database of systematic reviews 2016

PubMed DOI Cochrane

A Vitamin A and fish oils for preventing the progression of retinitis pigmentosa

Meta Analysis The Cochrane database of systematic reviews 2020

PubMed DOI

A Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Journal of sport and health science 2023

PubMed DOI

A Food fortification with multiple micronutrients: impact on health outcomes in general population

Meta Analysis The Cochrane database of systematic reviews 2019

PubMed DOI

A Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age

Meta Analysis The Cochrane database of systematic reviews 2024

PubMed DOI

View all evidence for Vitamin A →