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HeadacheFree

product on market Tablet or Pill Headache Free Safety: 99/100
99/100

This product looks safe

  • Magnesium: 400mg is 1.1× the Tolerable Upper Intake Level (350mg)
  • 72% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This product contains a blend of fat-soluble and water-soluble vitamins that support general cellular function and immune health. While these nutrients are essential for bodily maintenance, there is limited evidence supporting their efficacy specifically for headache relief. The ingredient profile maintains a high safety score.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Magnesium: 400mg is 1.1× the Tolerable Upper Intake Level (350mg)

Label

Product Label

Label for HeadacheFree
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Tablet(s)
Serving Size
30
Servings
Other Combinations
Product Type
72%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Vitamin A
5000 IU (100% DV)
Vitamin C
60 mg (100% DV)
400 IU (100% DV)
Within RDA (0.7× RDA) 608 studies (A:16, B:251)
30 IU (100% DV)
1.3× RDA — within safe limits 179 studies (A:3, B:90)
25 mcg (31% DV)
Within RDA (0.2× RDA) 275 studies (A:9, B:175)
1.5 mg (100% DV)
1.2× RDA — within safe limits 76 studies (A:0, B:33)
400 mg (23529% DV)
307.7× RDA — above typical dose 13 studies (A:0, B:1)
20 mg (100% DV)
1.4× RDA — within safe limits 196 studies (A:5, B:63)
2 mg (100% DV)
1.5× RDA — within safe limits 114 studies (A:3, B:35)
400 mcg (100% DV)
Within RDA (1.0× RDA) 226 studies (A:10, B:105)
6 mcg (100% DV)
2.5× RDA — within safe limits 139 studies (A:1, B:44)
30 mcg (10% DV)
Within RDA (1.0× RDA) 27 studies (A:0, B:11)
10 mg (100% DV)
2.0× RDA — within safe limits 2 studies — no high-quality reviews
Calcium
162 mg (16% DV)
Iron
8 mg (44% DV)
109 mg (11% DV)
Within RDA (0.2× RDA) 13 studies (A:0, B:3)
150 mcg (100% DV)
Within RDA (1.0× RDA) 245 studies (A:4, B:133)
400 mg (100% DV)
Exceeds UL by 1.1× (UL: 350 mg) 316 studies (A:8, B:159)
15 mg (100% DV)
1.4× RDA — within safe limits 263 studies (A:6, B:134)
20 mcg (29% DV)
Within RDA (0.4× RDA) 173 studies (A:0, B:67)
2 mg (100% DV)
2.2× RDA — within safe limits 37 studies (A:0, B:11)
2 mg (100% DV)
Within RDA (0.9× RDA) 9 studies — no high-quality reviews
120 mcg (100% DV)
3.4× RDA — above typical dose 199 studies (A:1, B:55)
75 mcg (100% DV)
1.7× RDA — within safe limits 3 studies — no high-quality reviews
72 mg (2% DV)
Market median: 4002.0mg (1 products) 21 studies (A:0, B:2)
150 mcg
Market median: 3.0mg (58 products) 3 studies — no high-quality reviews
10 mcg
Market median: 0.5mg (6 products) 1 studies (A:0, B:1)
2 mg
Market median: 108.0mg (8 products) 9 studies (A:0, B:4)
250 mcg
Market median: 10.0mg (105 products) 2 studies (A:0, B:1)

Other Ingredients

Microcrystalline Methyl {Cellulose} Hydroxypropyl Cellulose Garlic Magnesium Stearate Molasses Extract PABA Alpha Lipoic Acid Beet Rice Bran extract Hypromellose Triacetin Titanium Dioxide Talc Carnauba Wax
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

With HeadacheFree, you take just two tablets a day.

INSTRUCTIONS: As a dietary supplement, take two tablets daily or as directed by your healthcare professional.

Warnings & Precautions

WARNING: Accidental overdose of iron-containing products is a leading cause of fatal poisoning of children under 6. In case of accidental overdose, call a doctor or poison control center immediately.

Formulation Notes

~ Contains no known allergens

Physician-formulated with added B2 and magnesium for natural headache prevention

HeadacheFree combines 400mg of riboflavin (vitamin B2) and 400 mg of magnesium with a comlpete, food-based multivitamin to provide a drug-free alternative to aid in the prevention and management of headaches.

~ No starch, wheat, gluten, or soy ~ No dairy, animal by-products or stearic acid ~ No salt, sugar, artificial flavoring/coloring ~ No digestible plastic or heavy metals

Additional Information

As a board-certified neurologist specializing in the diagnosis and treatment of headache, I have always prided myself on taking my patients' concerns seriously. All headache sufferers want to regain control of their lives.

Based on clinical trials, best results are realized after 60-90 days of consecutive use.

Complete Multivitamin

Distributed by Headache Free, LLC headquartered in Warwick, RI 02886

~ Maximum health benefit, minimum cost

Until now, patients wanting to manage their headaches - without the use of prescription drugs - had to take as many as 15 pills a day to get all of the important daily vitamins and minerals, along with the recommended amounts of riboflavin (B2) and magnesium for headache prevention.

~ Complete multivitamin and headache preventive supplement in one ~ Developed by a board-certified neurologist ~ Clinically proven headache preventive ingredients

Because the goal with HeadacheFree is the same as it is in my practice - headache relief in as natural a way as possible. {signature} Gary A. L'Europa, MD U.S. Board-certified in Neurology and Headache Management

HeadacheFree is made using a blend of food-based, natural, and best-grade synthetic ingredients to allow optimal nutrient absorption from the smallest possible dosage.

Metadata

Product Details

DSLD Entry Date2014-06-25
Product TypeOther Combinations
FormTablet or Pill
BrandHeadache Free
DSLD ID34179
Data Updated2026-04-11
Research

Research Evidence

337
Research Sources
54
Avg Quality
161
Meta Analysis
68
Systematic Review
51
Rct
48
Clinical Trial
2
Other
2
Regulatory Source
1
Narrative Review
1
Cochrane Review
1
Guideline
1
Openfda Safety
A Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less
Meta Analysis The Cochrane database of systematic reviews 2011 PubMed DOI
A Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection
Meta Analysis The Cochrane database of systematic reviews 2011 PubMed DOI
A Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis
Meta Analysis BMJ (Clinical research ed.) 2011 PubMed DOI
A Fortification of staple foods with vitamin A for vitamin A deficiency
Systematic Review The Cochrane database of systematic reviews 2019 PubMed DOI
A Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age
Narrative Review The Cochrane database of systematic reviews 2016 PubMed DOI
A Vitamin A and fish oils for preventing the progression of retinitis pigmentosa
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
A Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Journal of sport and health science 2023 PubMed DOI
A Food fortification with multiple micronutrients: impact on health outcomes in general population
Meta Analysis The Cochrane database of systematic reviews 2019 PubMed DOI
A Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age
Meta Analysis The Cochrane database of systematic reviews 2024 PubMed DOI
View all evidence for Vitamin A →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.