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The Big One Plus without Iron

product on market Capsule Metabolic Maintenance Safety: 97/100
97/100

This product looks safe

  • Niacin: 100mg is 2.9× the Tolerable Upper Intake Level (35mg)
  • Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)
  • 70% of ingredients have research evidence
D Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula contains essential fat-soluble and water-soluble vitamins that support immune function, bone health, and cellular protection. There is strong research evidence supporting the roles of vitamins A, C, D3, E, and K in maintaining general physiological homeostasis. The ingredient profile is associated with a high safety score.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 100mg is 2.9× the Tolerable Upper Intake Level (35mg)

Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for The Big One Plus without Iron
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
90
Servings
Multi-Vitamin and Mineral (MVM)
Product Type
70%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Vitamin A
2400 mcg RAE (267% DV)
Vitamin C
125 mg (139% DV)
50 mcg (250% DV)
3.3× RDA — above typical dose (UL: 0.1 mg) 608 studies (A:16, B:251)
67 mg (447% DV)
4.5× RDA — above typical dose (UL: 1000 mg) 179 studies (A:3, B:90)
100 mcg (83% DV)
Within RDA (0.8× RDA) 275 studies (A:9, B:175)
25 mg (2083% DV)
20.8× RDA — above typical dose 76 studies (A:0, B:33)
25 mg (1923% DV)
19.2× RDA — above typical dose 13 studies (A:0, B:1)
100 mg NE (625% DV)
Exceeds UL by 2.9× (UL: 35 mg) 196 studies (A:5, B:63)
25 mg (1471% DV)
19.2× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
667 mcg DFE (167% DV)
Exceeds UL by 667.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
100 mcg (4167% DV)
41.7× RDA — above typical dose 139 studies (A:1, B:44)
200 mcg (667% DV)
6.7× RDA — above typical dose 27 studies (A:0, B:11)
100 mg (2000% DV)
20.0× RDA — above typical dose 2 studies — no high-quality reviews
100 mcg (67% DV)
Within RDA (0.7× RDA) 245 studies (A:4, B:133)
15 mg (136% DV)
1.4× RDA — within safe limits 263 studies (A:6, B:134)
100 mcg (182% DV)
1.8× RDA — within safe limits 173 studies (A:0, B:67)
1 mg (111% DV)
1.1× RDA — within safe limits 37 studies (A:0, B:11)
5 mg (217% DV)
2.2× RDA — within safe limits 9 studies — no high-quality reviews
100 mcg (286% DV)
2.9× RDA — within safe limits 199 studies (A:1, B:55)
50 mcg (111% DV)
1.1× RDA — within safe limits 3 studies — no high-quality reviews
25 mg
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews
1 mg
Market median: 3.0mg (58 products) 3 studies — no high-quality reviews
50 mcg
Market median: 0.5mg (6 products) 1 studies (A:0, B:1)

Other Ingredients

Vegetarian Cellulose Capsule
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Info

Product Information

Directions for Use

Directions: One (1) capsule daily with a meal, or as directed by a healthcare professional.

Best consumed within 120 days after opening.

Warnings & Precautions

Physician monitoring of vitamin D level recommended.

Keep tightly closed in a cool, dry place, out of the reach of children.

Vitamin E is derived from soy oil.

Formulation Notes

Egg free Gluten free Free of nuts Dairy free

Manufactured in a GMP Compliant Facility

Multivitamin

Additional Information

Keep tightly closed in a cool, dry place, out of the reach of children.

Moisture sensitive formula.

Metadata

Product Details

UPC / SKU8 38287 00523 0
DSLD Entry Date2022-09-22
Product TypeMulti-Vitamin and Mineral (MVM)
FormCapsule
BrandMetabolic Maintenance
DSLD ID274130
Data Updated2026-04-11
Research

Research Evidence

566
Research Sources
56
Avg Quality
240
Meta Analysis
100
Clinical Trial
74
Systematic Review
71
Guideline
58
Rct
11
Cochrane Review
4
Regulatory Source
2
Other
2
Narrative Review
1
Observational
1
Openfda Safety
A Systematic review and meta-analysis of intravenous iron therapy for patients with heart failure and iron deficiency
Meta Analysis Nature medicine 2025 PubMed DOI
A Intermittent iron supplementation for reducing anaemia and its associated impairments in adolescent and adult menstruating women
Meta Analysis The Cochrane database of systematic reviews 2019 PubMed DOI
A Oral or parenteral iron supplementation to reduce deferral, iron deficiency and/or anaemia in blood donors
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Serum or plasma ferritin concentration as an index of iron deficiency and overload
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
A Non-invasive diagnostic tests for Helicobacter pylori infection
Meta Analysis The Cochrane database of systematic reviews 2018 PubMed DOI
A Hypoxia-inducible factor stabilisers for the anaemia of chronic kidney disease
Meta Analysis The Cochrane database of systematic reviews 2022 PubMed DOI
A Wheat flour fortification with iron and other micronutrients for reducing anaemia and improving iron status in populations
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
A Fortification of condiments and seasonings with iron for preventing anaemia and improving health
Meta Analysis The Cochrane database of systematic reviews 2023 PubMed DOI
A Screening and Supplementation for Iron Deficiency and Iron Deficiency Anemia During Pregnancy: US Preventive Services Task Force Recommendation Statement.
Guideline JAMA 2024 PubMed DOI
A Psychiatric and cognitive outcomes of iron supplementation in non-anemic children, adolescents, and menstruating adults: A meta-analysis and systematic review
Meta Analysis Neuroscience and biobehavioral reviews 2025 PubMed DOI
View all evidence for Iron →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.