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The Big One without Iron

product on market Capsule Metabolic Maintenance Safety: 97/100
97/100

This product looks safe

  • Niacin: 100mg is 2.9× the Tolerable Upper Intake Level (35mg)
  • Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)
  • 70% of ingredients have research evidence
D Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula contains essential vitamins A, C, D3, E, and K, which are supported by strong evidence for maintaining immune function and bone health. These nutrients play critical roles in cellular protection and coagulation. The profile maintains a high safety score, though overall evidence coverage for the specific blend is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 100mg is 2.9× the Tolerable Upper Intake Level (35mg)

Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for The Big One without Iron
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
90
Servings
Multi-Vitamin and Mineral (MVM)
Product Type
70%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Vitamin A
2400 mcg RAE (267% DV)
Vitamin C
125 mg (139% DV)
25 mcg (125% DV)
1.7× RDA — within safe limits 608 studies (A:16, B:251)
67 mg (447% DV)
4.5× RDA — above typical dose (UL: 1000 mg) 179 studies (A:3, B:90)
100 mcg (83% DV)
Within RDA (0.8× RDA) 275 studies (A:9, B:175)
25 mg (2083% DV)
20.8× RDA — above typical dose 76 studies (A:0, B:33)
25 mg (1923% DV)
19.2× RDA — above typical dose 13 studies (A:0, B:1)
100 mg NE (625% DV)
Exceeds UL by 2.9× (UL: 35 mg) 196 studies (A:5, B:63)
25 mg (1471% DV)
19.2× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
667 mcg DFE (167% DV)
Exceeds UL by 667.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
100 mcg (4167% DV)
41.7× RDA — above typical dose 139 studies (A:1, B:44)
200 mcg (667% DV)
6.7× RDA — above typical dose 27 studies (A:0, B:11)
100 mg (2000% DV)
20.0× RDA — above typical dose 2 studies — no high-quality reviews
100 mcg (67% DV)
Within RDA (0.7× RDA) 245 studies (A:4, B:133)
15 mg (136% DV)
1.4× RDA — within safe limits 263 studies (A:6, B:134)
100 mcg (182% DV)
1.8× RDA — within safe limits 173 studies (A:0, B:67)
1 mg (111% DV)
1.1× RDA — within safe limits 37 studies (A:0, B:11)
5 mg (217% DV)
2.2× RDA — within safe limits 9 studies — no high-quality reviews
100 mcg (286% DV)
2.9× RDA — within safe limits 199 studies (A:1, B:55)
50 mcg (111% DV)
1.1× RDA — within safe limits 3 studies — no high-quality reviews
25 mg
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews
1 mg
Market median: 3.0mg (58 products) 3 studies — no high-quality reviews
50 mcg
Market median: 0.5mg (6 products) 1 studies (A:0, B:1)

Other Ingredients

Vegetarian Cellulose Capsule
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Info

Product Information

Directions for Use

Directions: One (1) capsule daily with a meal, or as directed by a healthcare professional.

Best consumed within 120 days after opening.

Warnings & Precautions

Keep tightly closed in a cool, dry place, out of the reach of children.

Vitamin E is derived from soy oil.

Formulation Notes

Egg free Gluten free Free of nuts Dairy free

Manufactured in a GMP Compliant Facility

Multivitamin

Additional Information

Keep tightly closed in a cool, dry place, out of the reach of children.

Moisture sensitive formula.

Metadata

Product Details

UPC / SKU8 38287 00520 9
DSLD Entry Date2022-09-22
Product TypeMulti-Vitamin and Mineral (MVM)
FormCapsule
BrandMetabolic Maintenance
DSLD ID274129
Data Updated2026-04-11
Research

Research Evidence

566
Research Sources
56
Avg Quality
240
Meta Analysis
100
Clinical Trial
74
Systematic Review
71
Guideline
58
Rct
11
Cochrane Review
4
Regulatory Source
2
Other
2
Narrative Review
1
Observational
1
Openfda Safety
A Systematic review and meta-analysis of intravenous iron therapy for patients with heart failure and iron deficiency
Meta Analysis Nature medicine 2025 PubMed DOI
A Intermittent iron supplementation for reducing anaemia and its associated impairments in adolescent and adult menstruating women
Meta Analysis The Cochrane database of systematic reviews 2019 PubMed DOI
A Oral or parenteral iron supplementation to reduce deferral, iron deficiency and/or anaemia in blood donors
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Serum or plasma ferritin concentration as an index of iron deficiency and overload
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
A Non-invasive diagnostic tests for Helicobacter pylori infection
Meta Analysis The Cochrane database of systematic reviews 2018 PubMed DOI
A Hypoxia-inducible factor stabilisers for the anaemia of chronic kidney disease
Meta Analysis The Cochrane database of systematic reviews 2022 PubMed DOI
A Wheat flour fortification with iron and other micronutrients for reducing anaemia and improving iron status in populations
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
A Fortification of condiments and seasonings with iron for preventing anaemia and improving health
Meta Analysis The Cochrane database of systematic reviews 2023 PubMed DOI
A Screening and Supplementation for Iron Deficiency and Iron Deficiency Anemia During Pregnancy: US Preventive Services Task Force Recommendation Statement.
Guideline JAMA 2024 PubMed DOI
A Psychiatric and cognitive outcomes of iron supplementation in non-anemic children, adolescents, and menstruating adults: A meta-analysis and systematic review
Meta Analysis Neuroscience and biobehavioral reviews 2025 PubMed DOI
View all evidence for Iron →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.