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PlusOne

product on market Other (e.g. tea bag) Metagenics Safety: 99/100
99/100

This product looks safe

  • Folate: 1665mg is 1665.0× the Tolerable Upper Intake Level (1.0mg)
  • 67% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This profile includes vitamins A and C, which have strong evidence for supporting immune function and antioxidant activity. The remaining components are basic macronutrients with standard nutritional roles. Overall, the evidence coverage for these specific ingredients is limited within this formulation.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 1665mg is 1665.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for PlusOne
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Packet(s)
Serving Size
30
Servings
Other Combinations
Product Type
67%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calories
25 Calorie(s)
Total Fat
3 Gram(s) (4% DV)
Cholesterol
5 mg (2% DV)
Vitamin A
1650 mcg (183% DV)
Vitamin C
250 mg (278% DV)
25 mcg (125% DV)
1.7× RDA — within safe limits 608 studies (A:16, B:251)
100.3 mg (669% DV)
6.7× RDA — above typical dose (UL: 1000 mg) 179 studies (A:3, B:90)
90 mcg (75% DV)
Within RDA (0.8× RDA) 275 studies (A:9, B:175)
3.4 mg (283% DV)
2.8× RDA — within safe limits 76 studies (A:0, B:33)
3.4 mg (262% DV)
2.6× RDA — within safe limits 13 studies (A:0, B:1)
35 mg (219% DV)
2.5× RDA — within safe limits 196 studies (A:5, B:63)
20 mg (1176% DV)
15.4× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
1665 mcg DFE (416% DV)
Exceeds UL by 1665.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
800 mcg (33333% DV)
333.3× RDA — above typical dose 139 studies (A:1, B:44)
300 mcg (1000% DV)
10.0× RDA — above typical dose 27 studies (A:0, B:11)
20 mg (400% DV)
4.0× RDA — above typical dose 2 studies — no high-quality reviews
450 mg (82% DV)
Within RDA (0.8× RDA) 38 studies (A:1, B:7)
Iron
30 mg (167% DV)
176 mcg (117% DV)
1.2× RDA — within safe limits 245 studies (A:4, B:133)
25 mg (227% DV)
2.3× RDA — within safe limits 263 studies (A:6, B:134)
200 mcg (364% DV)
3.6× RDA — above typical dose (UL: 0.4 mg) 173 studies (A:0, B:67)
2 mg (222% DV)
2.2× RDA — within safe limits 37 studies (A:0, B:11)
2 mg (87% DV)
Within RDA (0.9× RDA) 9 studies — no high-quality reviews
200 mcg (571% DV)
5.7× RDA — above typical dose 199 studies (A:1, B:55)
25 mcg (56% DV)
Within RDA (0.6× RDA) 3 studies — no high-quality reviews
Market median: 750.0mg (447 products) 393 studies (A:18, B:204)
Market median: 750.0mg (447 products) 393 studies (A:18, B:204)
500 mg
Market median: 500.0mg (861 products) 61 studies (A:4, B:13)
6 mg
Market median: 10.0mg (105 products) 2 studies (A:0, B:1)
2 mg
Market median: 4.0mg (32 products)

Other Ingredients

PlusOne Prenatal Multi Capsule L-Carnitine Capsule Choline Capsule OmegaGenics Neuro 1000 Softgel OmegaGenics EPA-DHA 720 Softgel
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take one packet daily or as directed by your healthcare practitioner.

Warnings & Precautions

Warning: Excess vitamin A intake may increase the risk of birth defects. Pregnant women and women who may become pregnant should not exceed 3,000 mcg of preformed vitamin A (retinyl palmitate) per day. Caution: Consult your healthcare practitioner if pregnant, nursing, or taking other nutritional supplements or medications.

Contains: Fish (anchovy, sardine, and mackerel).

Warning: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of the reach of children. In case of accidental overdose, call a doctor or poison control center immediately.

Formulation Notes

Targeted support from preconception through nursing PlusOne Daily Prenatal packs provide comprehensive supplements to nutritionally support women, featuring vitamins, minerals, and phytonutrients, from preconception through nursing. This science-based combination features targeted nutrition in a convenient once-daily packet.

PlusOne Daily prenatal packs provide: Prenatal mutivitamin support: A science-based combination of vitamins and minerals, incorporating 1 mg of methylfolate (1,665 mcg DFE) and antioxidants (vitamins E,C, and beta-carotene from mixed carotenoids) that reflect the latest research in prenatal nutrition Cardiovascular health and general health support: OmegaGenics EPA-DHA 720 and OmegaGenics Neuro 1000 feature high-quality omega-3 fatty acids Fetal brain development support: Choline, an essential nutrient, is provided for additional support based on the latest research Free fatty acid metabolism support: L-carnitine plays a role in metabolic health and is required for the breakdown of fats and glucose into energy General health support: A select evidence-based combination of products featuring vitamins, minerals and nutrients to support general wellness

Products included are non-GMO and gluten-free.

Targeted support from preconception through nursing

Additional Information

Metagenics created PlusOne in partnership with board-certified experts Leslie Stone, MD, IFM-CP and Emily Rydbom, CN, BCHM, CNP, who apply nearly 50 years of combined obstetrics, nutrition, and functional medicine experience to help support women in reaching their nutrition and pregnancy goals. PlusOne supplies specialized nutritional support for you, when you're adding a plus one. Each packet contains: 2 PlusOne Prenatal Multi capsules (light brown with speckles), 1 L-Carnitine capsule (white), 2 Choline capsules (green), 1 OmegaGenics EPA-DHA 720 softgel (yellow), and 1 OmegaGenics EPA-DHA Neuro 1000 softgel (yellow, etched).

Storage: Keep in a cool, dry place.

Daily prenatal packs

Metadata

Product Details

UPC / SKU7 55571 95334 6
DSLD Entry Date2020-04-23
Product TypeOther Combinations
FormOther (e.g. tea bag)
BrandMetagenics
DSLD ID216819
Data Updated2026-04-11
Research

Research Evidence

337
Research Sources
54
Avg Quality
161
Meta Analysis
68
Systematic Review
51
Rct
48
Clinical Trial
2
Other
2
Regulatory Source
1
Narrative Review
1
Cochrane Review
1
Guideline
1
Openfda Safety
A Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less
Meta Analysis The Cochrane database of systematic reviews 2011 PubMed DOI
A Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection
Meta Analysis The Cochrane database of systematic reviews 2011 PubMed DOI
A Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis
Meta Analysis BMJ (Clinical research ed.) 2011 PubMed DOI
A Fortification of staple foods with vitamin A for vitamin A deficiency
Systematic Review The Cochrane database of systematic reviews 2019 PubMed DOI
A Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age
Narrative Review The Cochrane database of systematic reviews 2016 PubMed DOI
A Vitamin A and fish oils for preventing the progression of retinitis pigmentosa
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
A Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Journal of sport and health science 2023 PubMed DOI
A Food fortification with multiple micronutrients: impact on health outcomes in general population
Meta Analysis The Cochrane database of systematic reviews 2019 PubMed DOI
A Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age
Meta Analysis The Cochrane database of systematic reviews 2024 PubMed DOI
View all evidence for Vitamin A →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.