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System-Six

product on market Softgel Capsule Irwin Naturals Safety: 97/100
97/100

This product looks safe

  • Fish Oil: 3053mg is 1.0× the Tolerable Upper Intake Level (3000mg)
  • White Tea extract: 600mg is 1.5× the Tolerable Upper Intake Level (400mg)
  • 65% of ingredients have research evidence
D Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

The formula contains B vitamins and antioxidants, which have strong evidence for supporting cellular energy metabolism and protecting against oxidative stress. These ingredients are well-studied for their roles in general physiological function. The evidence coverage for this specific blend is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Fish Oil: 3053mg is 1.0× the Tolerable Upper Intake Level (3000mg)

White Tea extract: 600mg is 1.5× the Tolerable Upper Intake Level (400mg)

Label

Product Label

Label for System-Six
Open Full PDF View on NIH DSLD →
Details

Label Data

6 Liquid Softgel(s)
Serving Size
16
Servings
Other Combinations
Product Type
65%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Vitamin C
40 mg (67% DV)
10 IU (33% DV)
Within RDA (0.4× RDA) 179 studies (A:3, B:90)
1 mg (67% DV)
Within RDA (0.8× RDA) 76 studies (A:0, B:33)
1 mg (59% DV)
Within RDA (0.8× RDA) 13 studies (A:0, B:1)
14 mg (70% DV)
Within RDA (1.0× RDA) 196 studies (A:5, B:63)
4 mcg (67% DV)
1.7× RDA — within safe limits 139 studies (A:1, B:44)
60 mg (600% DV)
12.0× RDA — above typical dose 2 studies — no high-quality reviews
34 mcg (49% DV)
Within RDA (0.6× RDA) 173 studies (A:0, B:67)
200 mcg (167% DV)
5.7× RDA — above typical dose 199 studies (A:1, B:55)
3053 mg
Exceeds UL by 1.0× (UL: 3000 mg) 393 studies (A:18, B:204)
Market median: 600.0mg (321 products) 5 studies — no high-quality reviews
Exceeds UL by 1.5× (UL: 400 mg) 49 studies (A:1, B:19)
Market median: 260.0mg (249 products) 158 studies (A:4, B:61)
Market median: 300.0mg (122 products) 22 studies (A:0, B:7)
Market median: 983.0mg (16 products) 7 studies (A:0, B:1)
200 mg
Market median: 500.0mg (861 products) 61 studies (A:4, B:13)
100 mg
Market median: 500.0mg (223 products) 24 studies (A:0, B:1)
60 mg
Within RDA (0.1× RDA) 38 studies (A:1, B:7)
60 mg
Market median: 550.0mg (217 products) 29 studies (A:0, B:5)
Cayenne powder
40 mg
Market median: 250.0mg (337 products) 127 studies (A:1, B:41)
Market median: 495.0mg (70 products)
Mate (Yerba Mate) extract
40 mg
Market median: 200.0mg (107 products)
15 mg
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews
BioPerine Complex
6 mg

Other Ingredients

Gelatin purified Water Glycerin Soy Lecithin Beeswax Annatto Turmeric Titanium Dioxide St. John's Bread Sodium Copper Chlorophyllin
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Notice: For best results we recommend limiting the consumption of additional caffeine while using this product (e.g. less than three 8 ounce cups of coffee per day).

Full Disclosure Ingredient Panel DIRECTIONS: (Adult) Take six (6) Liquid Soft-Gels per day with meals. May be taken all at one time or in divided doses. If caffeine keeps you up at night, do not take this product in the evening since it contains natural caffeine.

Warnings & Precautions

Usage Warnings: Do not use if safety seal is broken. This product contains niacin and may cause a temporary warming tingling sensation. This product contains caffeine and may affect blood pressure and/or heart conditions.

Check with your doctor before using this product if you are using medication or have any medical conditions, including heart disease and/or high blood pressure. Do not use if you may become pregnant, are pregnant or nursing.

Do not exceed recommended daily intake.

Not intended for use by persons under 18. KEEP OUT OF REACH OF CHILDREN.

WARNING: (State of California Prop 65) This product contains a chemical known to the State of California to cause birth defects or other reproductive harm.

Contains: Fish (anchovy, sardine), Soy

Formulation Notes

This product contains niacin and may cause a temporary warming tingling sensation. This product contains caffeine and may affect blood pressure and/or heart conditions.

ONE: Thermogenisis- A combination of Green and White Tea extract, plus Advantra Z supply powerful nutrients to enhance thermogenesis (heat production) and help burn calories. TWO: Energy-Natural caffeine plus the botanicals Yerba Mate, Guarana and Spirulina help you feel energized. THREE: Mood-Standardized Rhodiola extract is included in this formula to support brain health. FOUR: Metabolism- A combination of B vitamins help convert food into energy and assist in the breakdown of carbs, fats and proteins. FIVE: Carbohydrate Support-Chromium supports the breakdown of carbohydrates into glucose and helps to maintain healthy blood sugar levels already within a normal range. SIX: Antioxidants-Vitamins C and E plus other nutrients with antioxidant activity help to protect cell health and offer nutritional support for the body.

Contains: Fish (anchovy, sardine), Soy

No preservatives added.

Additional Information

Diet & Exercise program available online at www.IrwinNaturals.com/deplan

What makes us different: Liquid Soft-Gels - The nutrients in these easy-to-swallow Liquid Soft-Gels are released fast. Other forms of delivery can contain binders and fillers that may cause stomach upset and offer no nutritional value. Advanced Liquid Soft- Gels provide an optimum delivery system.

We employ compliance testing to ensure purity and potency.

QUALITY TESTED GUARANTEED PASS

Global Responsibility - Over the years we have donated to organizations that support the environment and the health of our children.

System -Six, when combined with a low-calorie diet and exercise program, delivers powerful weight loss support to help you meet your goals.

4614-LAB-05/15 IN037383 Ver. 5

Store in a cool, dry place.

Powerful Weight Loss Support Metabolism Boosters & Carb Metabolizers

Complete Six-in-One Formula for Enhanced Metabolism, Mood & Energy Support

QUESTIONS: Call Consumer Affairs 1-800-297-3273 Weekdays 8:00 AM to 5:00 PM (PST)

To join our Wellness Club and receive tips on how to improve your health, please visit us at www.IrwinNaturals.com/wellness1

Metadata

Product Details

UPC / SKU7 10363 26247 1
DSLD Entry Date2016-03-24
Product TypeOther Combinations
FormSoftgel Capsule
DSLD ID57706
Data Updated2026-04-11
Research

Research Evidence

371
Research Sources
54
Avg Quality
148
Meta Analysis
82
Systematic Review
71
Rct
62
Clinical Trial
2
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Other
1
Openfda Safety
A Vitamin C supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Vitamin C supplementation for the primary prevention of cardiovascular disease
Systematic Review The Cochrane database of systematic reviews 2017 PubMed DOI
A Vitamin C for preventing and treating the common cold
Meta Analysis The Cochrane database of systematic reviews 2013 PubMed DOI
A Vitamin C for preventing and treating pneumonia
Meta Analysis The Cochrane database of systematic reviews 2013 PubMed DOI
A Vitamin E supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Vitamin C supplementation for prevention and treatment of pneumonia
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
A Vitamin C supplementation for prevention and treatment of pneumonia
Systematic Review The Cochrane database of systematic reviews 2021 PubMed DOI
A Nutritional interventions for preventing and treating pressure ulcers
Meta Analysis The Cochrane database of systematic reviews 2024 PubMed DOI
A Does Vitamin C Supplementation Provide a Protective Effect in Periodontal Health? A Systematic Review and Meta-Analysis
Meta Analysis International journal of molecular sciences 2024 PubMed DOI
A Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study
Meta Analysis BMC medicine 2021 PubMed DOI
View all evidence for Vitamin C →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.