System-Six

product on market Softgel Capsule Irwin Naturals 🟢 Safety: 97/100
Brand: Irwin Naturals
🟢 97/100

This product looks safe

  • Fish Oil: 3053mg is 1.0× the Tolerable Upper Intake Level (3000mg)
  • White Tea extract: 600mg is 1.5× the Tolerable Upper Intake Level (400mg)
  • 65% of ingredients have research evidence
D Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Fish Oil: 3053mg is 1.0× the Tolerable Upper Intake Level (3000mg)
⚠️ White Tea extract: 600mg is 1.5× the Tolerable Upper Intake Level (400mg)

Label Data

6 Liquid Softgel(s) Serving Size
16 Servings
Other Combinations Product Type
65% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin C
40 mg (67% DV)
10 IU (33% DV)
✅ Within RDA (0.4× RDA of 15 mg) 📚 177 studies (Tier A: 3, B: 90)
RDA 15mg This product: 6.7mg UL 1000mg
1 mg (67% DV)
✅ Within RDA (0.8× RDA of 1.2 mg) 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 1mg
1 mg (59% DV)
✅ Within RDA (0.8× RDA of 1.3 mg) 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 1mg
14 mg (70% DV)
✅ Within RDA (1.0× RDA of 14 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 14mg UL 35mg
4 mcg (67% DV)
✅ 1.7× RDA — within safe limits 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.004mg
60 mg (600% DV)
📊 12.0× RDA — above typical dose 📚 1 studies — no high-quality reviews
RDA 5mg This product: 60mg
34 mcg (49% DV)
✅ Within RDA (0.6× RDA of 0.055 mg) 📚 172 studies (Tier A: 0, B: 67)
RDA 0.055mg This product: 0.034mg UL 0.4mg
200 mcg (167% DV)
📊 5.7× RDA — above typical dose 📚 197 studies (Tier A: 1, B: 55)
RDA 0.035mg This product: 0.2mg
3053 mg
⚠️ Exceeds Tolerable Upper Intake Level by 1.0× (UL: 3000 mg) 📚 388 studies (Tier A: 18, B: 204)
This product: 3053mg UL 3000mg
670 mg
📊 Market median: 600.0mg (321 products) 📚 5 studies — no high-quality reviews
This product: 670mg
600 mg
⚠️ Exceeds Tolerable Upper Intake Level by 1.5× (UL: 400 mg) 📚 43 studies (Tier A: 1, B: 19)
This product: 600mg UL 400mg
375 mg
📊 Market median: 260.0mg (249 products) 📚 156 studies (Tier A: 4, B: 61)
This product: 375mg
340 mg
📊 Market median: 300.0mg (122 products) 📚 22 studies (Tier A: 0, B: 7)
This product: 340mg
200 mg
📊 Market median: 983.0mg (16 products) 📚 7 studies (Tier A: 0, B: 1)
This product: 200mg
200 mg
📊 Market median: 500.0mg (861 products) 📚 60 studies (Tier A: 4, B: 13)
This product: 200mg
100 mg
📊 Market median: 500.0mg (223 products) 📚 22 studies (Tier A: 0, B: 1)
This product: 100mg
60 mg
✅ Within RDA (0.1× RDA of 550 mg) 📚 36 studies (Tier A: 1, B: 7)
RDA 550mg This product: 60mg UL 3500mg
60 mg
📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)
This product: 60mg
Cayenne powder
40 mg
40 mg
📊 Market median: 250.0mg (337 products) 📚 125 studies (Tier A: 1, B: 41)
This product: 40mg
40 mg
📊 Market median: 495.0mg (70 products)
Median 495.0mg This product: 40mg
Mate (Yerba Mate) extract
40 mg
40 mg
📊 Market median: 200.0mg (107 products)
Median 200.0mg This product: 40mg
15 mg
📊 Market median: 496.0mg (192 products) 📚 20 studies — no high-quality reviews
This product: 15mg
BioPerine Complex
6 mg

Other Ingredients

Gelatin purified Water Glycerin Soy Lecithin Beeswax Annatto Turmeric Titanium Dioxide St. John's Bread Sodium Copper Chlorophyllin

Label Claims — Verification

❓ Nutrient
❓ All Other
❓ Structure/Function
All Other (99% of products) Structure/Function (83% of products) Nutrient (54% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Notice: For best results we recommend limiting the consumption of additional caffeine while using this product (e.g. less than three 8 ounce cups of coffee per day).

Full Disclosure Ingredient Panel DIRECTIONS: (Adult) Take six (6) Liquid Soft-Gels per day with meals. May be taken all at one time or in divided doses. If caffeine keeps you up at night, do not take this product in the evening since it contains natural caffeine.

⚠️ Warnings & Precautions

Usage Warnings: Do not use if safety seal is broken. This product contains niacin and may cause a temporary warming tingling sensation. This product contains caffeine and may affect blood pressure and/or heart conditions.

Check with your doctor before using this product if you are using medication or have any medical conditions, including heart disease and/or high blood pressure. Do not use if you may become pregnant, are pregnant or nursing.

Do not exceed recommended daily intake.

Not intended for use by persons under 18. KEEP OUT OF REACH OF CHILDREN.

WARNING: (State of California Prop 65) This product contains a chemical known to the State of California to cause birth defects or other reproductive harm.

Contains: Fish (anchovy, sardine), Soy

🧪 Formulation Notes

This product contains niacin and may cause a temporary warming tingling sensation. This product contains caffeine and may affect blood pressure and/or heart conditions.

ONE: Thermogenisis- A combination of Green and White Tea extract, plus Advantra Z supply powerful nutrients to enhance thermogenesis (heat production) and help burn calories. TWO: Energy-Natural caffeine plus the botanicals Yerba Mate, Guarana and Spirulina help you feel energized. THREE: Mood-Standardized Rhodiola extract is included in this formula to support brain health. FOUR: Metabolism- A combination of B vitamins help convert food into energy and assist in the breakdown of carbs, fats and proteins. FIVE: Carbohydrate Support-Chromium supports the breakdown of carbohydrates into glucose and helps to maintain healthy blood sugar levels already within a normal range. SIX: Antioxidants-Vitamins C and E plus other nutrients with antioxidant activity help to protect cell health and offer nutritional support for the body.

Contains: Fish (anchovy, sardine), Soy

No preservatives added.

Additional Information

Diet & Exercise program available online at www.IrwinNaturals.com/deplan

What makes us different: Liquid Soft-Gels - The nutrients in these easy-to-swallow Liquid Soft-Gels are released fast. Other forms of delivery can contain binders and fillers that may cause stomach upset and offer no nutritional value. Advanced Liquid Soft- Gels provide an optimum delivery system.

We employ compliance testing to ensure purity and potency.

QUALITY TESTED GUARANTEED PASS

Global Responsibility - Over the years we have donated to organizations that support the environment and the health of our children.

System -Six, when combined with a low-calorie diet and exercise program, delivers powerful weight loss support to help you meet your goals.

4614-LAB-05/15 IN037383 Ver. 5

Store in a cool, dry place.

Powerful Weight Loss Support Metabolism Boosters & Carb Metabolizers

Complete Six-in-One Formula for Enhanced Metabolism, Mood & Energy Support

QUESTIONS: Call Consumer Affairs 1-800-297-3273 Weekdays 8:00 AM to 5:00 PM (PST)

To join our Wellness Club and receive tips on how to improve your health, please visit us at www.IrwinNaturals.com/wellness1

Product Details

UPC / SKU 7 10363 26247 1
DSLD Entry Date 2016-03-24
Product Type Other Combinations
Form Softgel Capsule
Brand Irwin Naturals
DSLD ID 57706
Data Updated 2026-04-11

Research Evidence

371 Research Sources
54 Avg Quality Score
148 Meta Analysis
82 Systematic Review
71 Rct
62 Clinical Trial
2 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Other
1 Openfda Safety
A Vitamin C supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015
PubMed DOI Cochrane
A Vitamin C supplementation for the primary prevention of cardiovascular disease
Systematic Review The Cochrane database of systematic reviews 2017
PubMed DOI Cochrane
A Vitamin C for preventing and treating the common cold
Meta Analysis The Cochrane database of systematic reviews 2013
PubMed DOI Cochrane
A Vitamin C for preventing and treating pneumonia
Meta Analysis The Cochrane database of systematic reviews 2013
PubMed DOI Cochrane
A Vitamin E supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015
PubMed DOI
A Vitamin C supplementation for prevention and treatment of pneumonia
Meta Analysis The Cochrane database of systematic reviews 2020
PubMed DOI Cochrane
A Vitamin C supplementation for prevention and treatment of pneumonia
Systematic Review The Cochrane database of systematic reviews 2021
PubMed DOI Cochrane
A Nutritional interventions for preventing and treating pressure ulcers
Meta Analysis The Cochrane database of systematic reviews 2024
PubMed DOI
A Does Vitamin C Supplementation Provide a Protective Effect in Periodontal Health? A Systematic Review and Meta-Analysis
Meta Analysis International journal of molecular sciences 2024
PubMed DOI
A Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study
Meta Analysis BMC medicine 2021
PubMed DOI
View all evidence for Vitamin C →

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