🟢 98/100

This product looks safe

  • Niacin: 164mg is 4.7× the Tolerable Upper Intake Level (35mg)
  • Folate: 1360mg is 1360.0× the Tolerable Upper Intake Level (1.0mg)
  • 46% of ingredients have research evidence
D Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 164mg is 4.7× the Tolerable Upper Intake Level (35mg)
⚠️ Folate: 1360mg is 1360.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Tablet(s) Serving Size
22 Servings
Other Combinations Product Type
46% Evidence Coverage

Supplement Facts — Evidence Check

Calories
15 Calorie(s)
Total Carbohydrate
1 Gram(s) (1% DV)
Vitamin C
200 mg (222% DV)
100 mg (6667% DV)
📊 83.3× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 100mg
50 mg (2941% DV)
📊 38.5× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 50mg
164 mg (1025% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 4.7× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 164mg UL 35mg
100 mg (5882% DV)
📊 76.9× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 100mg UL 100mg
1360 mcg DFE (340% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 1360.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 1360mg UL 1.0mg
400 mcg (167% DV)
📊 166.7× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.4mg
80 mcg (267% DV)
✅ 2.7× RDA — within safe limits 📚 26 studies (Tier A: 0, B: 11)
RDA 0.03mg This product: 0.08mg
100 mg (2000% DV)
📊 20.0× RDA — above typical dose 📚 1 studies — no high-quality reviews
RDA 5mg This product: 100mg
200 mg (48% DV)
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 200mg
10 mg (91% DV)
✅ Within RDA (0.9× RDA of 11 mg) 📚 258 studies (Tier A: 6, B: 134)
RDA 11mg This product: 10mg UL 40mg
5 mg (217% DV)
✅ 2.2× RDA — within safe limits 📚 8 studies — no high-quality reviews
RDA 2.3mg This product: 5mg UL 11mg
Sodium
5 mg (1% DV)
L-Pyroglutamic Acid
600 mg
500 mg
📊 Market median: 420.0mg (227 products)
Median 420.0mg This product: 500mg
📊 Market median: 500.0mg (861 products) 📚 60 studies (Tier A: 4, B: 13)
This product: 500mg
Gotu Kola Whole Plant Extract
250 mg
📊 Market median: 100.0mg (108 products)
Median 100.0mg This product: 200mg
📊 Market median: 500.0mg (223 products) 📚 22 studies (Tier A: 0, B: 1)
This product: 200mg
DMAE
160 mg
📊 Market median: 120.0mg (440 products) 📚 187 studies (Tier A: 1, B: 71)
This product: 120mg
📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)
This product: 110mg
📊 Market median: 200.0mg (198 products) 📚 6 studies — no high-quality reviews
This product: 100mg
100 mg
📊 Market median: 500.0mg (180 products) 📚 5 studies (Tier A: 0, B: 1)
This product: 100mg
DL-Phenylalanine
100 mg
GABA
100 mg
L-Phenylalanine
100 mg
📊 6.7× RDA — above typical dose (UL: 1000 mg) 📚 177 studies (Tier A: 3, B: 90)
RDA 15mg This product: 100mg UL 1000mg
📊 Market median: 450.0mg (502 products) 📚 28 studies (Tier A: 0, B: 8)
This product: 100mg
100 mg
📊 Market median: 450.0mg (254 products) 📚 240 studies (Tier A: 0, B: 100)
This product: 100mg
📊 Market median: 100.0mg (120 products)
Median 100.0mg This product: 100mg
Eleuthero root extract
60 mg
Vinpocetine
30 mg
2 mg
📊 Market median: 3.0mg (58 products) 📚 2 studies — no high-quality reviews
This product: 2mg UL 20mg
200 mcg
📊 Market median: 0.15mg (41 products)
Median 0.15mg This product: 0.2mg

Other Ingredients

silicified Microcrystalline Cellulose Silica Hydroxypropyl Methylcellulose Magnesium Stearate Stearic Acid

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (85% of products) Nutrient (48% of products) No Claim (1% of products)

Target Groups

Adult (18 - 50 Years) Women (not pregnant or lactating)

Product Information

📋 Directions for Use

Suggested Use: 1 to 4 tablets daily with a meal.

⚠️ Warnings & Precautions

Contains soy.

Note: Niacin may cause temporary flushing, tingling, skin reddening, and sensations of heat, especially if taken on an empty stomach. This is a natural and harmless reaction.

Warning: For adult use only. Contains phenylalanine and tyrosine. Not to be used by phenylketonurics, women who are pregnant, may become pregnant, breastfeeding, or with antidepressant drugs containing MAO or SSR inhibitors.

Not to be used by phenylketonurics, women who are pregnant, may become pregnant, breastfeeding, or with antidepressant drugs containing MAO or SSR inhibitors.

If you have chronic high blood pressure consult your health care professional before using this product.

Do not use this product: Within 7 days before or after surgery; or after any physical injury or trauma; or if you are taking warfarin (Coumadin), aspirin, NSAIDs, or any other anticoagulant or antiplatelet aggregation drug; or if you have a history of bleeding, high or low blood pressure, epilepsy, stroke or heart disease.

Discontinue use and notify your physician immediately if any unusual bleeding or symptoms occur. Signs and symptoms of bleeding include: pain, swelling or discomfort, prolonged bleeding from cuts, increased menstrual flow or vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or dark brown urine, red or tar black stools, headache, dizziness, or weakness.

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

🧪 Formulation Notes

Bio Align

Higher Mind With Phosphatidylserine

Product Details

UPC / SKU 0 21078 00016 7
DSLD Entry Date 2022-11-22
Product Type Other Combinations
Form Tablet or Pill
DSLD ID 274666
Data Updated 2026-04-11

Research Evidence

22 Research Sources
49 Avg Quality Score
8 Rct
4 Meta Analysis
4 Clinical Trial
3 Systematic Review
1 Cochrane Review
1 Regulatory Source
B Effect of vitamin B2, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis
Systematic Review BMJ open 2024
B Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis
Meta Analysis Nutritional neuroscience 2022
B Supplementary vitamin E, selenium, cysteine and riboflavin for preventing kwashiorkor in preschool children in developing countries
Systematic Review The Cochrane database of systematic reviews 2010
B Riboflavin supplements for blood pressure lowering in adults.
Cochrane Review The Cochrane database of systematic reviews
B Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2022
C Prophylaxis of migraine headaches with riboflavin: A systematic review
Systematic Review Journal of clinical pharmacy and therapeutics 2017
C Medium-dose riboflavin as a prophylactic agent in children with migraine: a preliminary placebo-controlled, randomised, double-blind, cross-over trial
Rct Cephalalgia : an international journal of headache 2010
C The efficacy of 2 different phakic intraocular lens implant in keratoconus as an isolated procedure or combined with collagen crosslinking and intra-stromal corneal ring segments: a systematic review and meta-analysis
Meta Analysis International ophthalmology 2023
C Epithelium-off photochemical corneal collagen cross-linkage using riboflavin and ultraviolet a for keratoconus and keratectasia: a systematic review and meta-analysis
Meta Analysis The ocular surface 2014
C Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial
Rct The journal of headache and pain 2015
View all evidence for Riboflavin →

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