🟢 98/100

This product looks safe

  • Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)
  • Folate: 680mg is 680.0× the Tolerable Upper Intake Level (1.0mg)
  • 54% of ingredients have research evidence
D Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)
⚠️ Folate: 680mg is 680.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

336 Gram(s) Serving Size
8 Servings
Other Combinations Product Type
54% Evidence Coverage

Supplement Facts — Evidence Check

Calories
1250 Calorie(s)
Total Fat
4.5 Gram(s) (6% DV)
Cholesterol
110 mg (37% DV)
Total Carbohydrates
252 Gram(s) (92% DV)
Protein
50 Gram(s) (100% DV)
Vitamin A
750 mcg (83% DV)
Vitamin C
60 mg (67% DV)
5 mcg (25% DV)
✅ Within RDA (0.3× RDA of 0.015 mg) 📚 604 studies (Tier A: 16, B: 251)
RDA 0.015mg This product: 0.005mg UL 0.1mg
20 mg (133% DV)
✅ 1.3× RDA — within safe limits 📚 177 studies (Tier A: 3, B: 90)
RDA 15mg This product: 20mg UL 1000mg
4.8 mg (400% DV)
📊 4.0× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 4.8mg
4 mg (308% DV)
📊 3.1× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 4mg
50 mg (313% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 1.4× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 50mg UL 35mg
5 mg (294% DV)
📊 3.8× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 5mg UL 100mg
680 mcg DFE (170% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 680.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 680mg UL 1.0mg
10 mcg (417% DV)
📊 4.2× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.01mg
300 mcg (1000% DV)
📊 10.0× RDA — above typical dose 📚 26 studies (Tier A: 0, B: 11)
RDA 0.03mg This product: 0.3mg
25 mg (500% DV)
📊 5.0× RDA — above typical dose 📚 1 studies — no high-quality reviews
RDA 5mg This product: 25mg
250 mg (45% DV)
✅ Within RDA (0.5× RDA of 550 mg) 📚 36 studies (Tier A: 1, B: 7)
RDA 550mg This product: 250mg UL 3500mg
Calcium
600 mg (46% DV)
Iron
8 mg (44% DV)
590 mg (47% DV)
✅ Within RDA (0.8× RDA of 700 mg) 📚 12 studies (Tier A: 0, B: 3)
RDA 700mg This product: 590mg UL 4000mg
53 mcg (35% DV)
✅ Within RDA (0.4× RDA of 0.15 mg) 📚 243 studies (Tier A: 4, B: 133)
RDA 0.15mg This product: 0.053mg UL 1.1mg
140 mg (33% DV)
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 140mg
15 mg (136% DV)
✅ 1.4× RDA — within safe limits 📚 258 studies (Tier A: 6, B: 134)
RDA 11mg This product: 15mg UL 40mg
70 mcg (127% DV)
✅ 1.3× RDA — within safe limits 📚 172 studies (Tier A: 0, B: 67)
RDA 0.055mg This product: 0.07mg UL 0.4mg
1 mg (111% DV)
✅ 1.1× RDA — within safe limits 📚 36 studies (Tier A: 0, B: 11)
RDA 0.9mg This product: 1mg UL 10mg
2 mg (87% DV)
✅ Within RDA (0.9× RDA of 2.3 mg) 📚 8 studies — no high-quality reviews
RDA 2.3mg This product: 2mg UL 11mg
120 mcg (343% DV)
📊 3.4× RDA — above typical dose 📚 197 studies (Tier A: 1, B: 55)
RDA 0.035mg This product: 0.12mg
75 mcg (167% DV)
✅ 1.7× RDA — within safe limits 📚 2 studies — no high-quality reviews
RDA 0.045mg This product: 0.075mg UL 2mg
Sodium
570 mg (25% DV)
Potassium
1430 mg (30% DV)
📊 Market median: 5.0mg (298 products) 📚 701 studies (Tier A: 5, B: 123)
This product: 3mg
500 mg
📊 Market median: 420.0mg (227 products)
Median 420.0mg This product: 500mg
250 mg
📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)
This product: 250mg
5 mg
📊 Market median: 500.0mg (9 products)
This product: 5mg

Other Ingredients

Maltodextrin Protein Blend Cocoa Natural and Artificial flavor Medium Chain Triglyceride Lecithin Acesulfame Potassium Sucralose

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (98% of products) Structure/Function (93% of products) Nutrient (20% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

333 grams about 2 heaping scoops serious mass protein powder 24 fl oz cold water, milk or other beverage 30-45 seconds blend until dissolved

Tips: New users may find it beneficial to begin with 1/2 of a serving daily for the first week and then gradually increase to 1 serving a day.

Suggested Use: For healthy adults, consume enough protein to meet your daily protein requirements with a combination of high protein foods and protein supplements throughout the day as part of a balanced diet and exercise program.

⚠️ Warnings & Precautions

Contains: Egg, milk, soy

🧪 Formulation Notes

Why Serious Mass? Each serving is packed with 1,250 calories to support a calorie surplus for weight and muscle building. 50 grams of protein to support muscle building and recovery. 252 grams of carbohydrates to support fueling of intense workouts and aid in replenishment of glycogen stores. 3 grams of creatine monohydrate to support performance. 25 vitamins and minerals plus glutamine.

Strength Training Supports Performance Supports Weight Gain Goals

Optimum Nutrition has been trusted to provide the highest quality in post-workout recovery, pre-workout energy, and on-the-go sports nutrition for over 30 years and in 90+ countries. After careful supplier selection, each ingredient is tested to assure exceptional purity, potency and composition. We hold ourselves to the highest production standards, all so you can unlock your body's full potential.

Authentic Optimum Nutrition Product Optimumnutrition.com/authentic

Informed choice is a quality assurance program for sports nutrition products. The program certifies that nutritional supplements that bear the Informed Choice logo are regularly tested for banned substances by the world class sports anti-doping lab, LGC Limited.

Supports muscle building & weight gain goals Helps boost calorie intake Helps build and maintain muscle Helps fuel intense workouts

Chocolate naturally & Artificially Flavored

Serious Mass is designed to provide serious calories, protein and carbohydrates - making this a convenient way to get extra calories throughout your day.

Additional Information

To find out more about the science and ingredients behind our products, visit Optimumnutrition.com.

Informed Choice We test, you trust

Manufactured in the USA This product contains ingredients of international and domestic origin

See supplement facts for sodium and cholesterol content When taken in addition to normal calorie intake and regular weight resistance training

Check out optimumnutrition.com for recipes and training tips.

Store in a cool, dry place.

Serving scoop included, but may settle to the bottom during shipping

Contents sold by weight not volume. Some settling will occur.

Product Details

UPC / SKU 7 48927 02299 5
DSLD Entry Date 2021-10-22
Product Type Other Combinations
Form Powder
DSLD ID 260023
Data Updated 2026-04-11

Research Evidence

739 Research Sources
47 Avg Quality Score
472 Clinical Trial
139 Meta Analysis
74 Systematic Review
47 Rct
2 Regulatory Source
1 Cochrane Review
1 Guideline
1 Openfda Safety
A Association of Age, Antipsychotic Medication, and Symptom Severity in Schizophrenia With Proton Magnetic Resonance Spectroscopy Brain Glutamate Level: A Mega-analysis of Individual Participant-Level Data
Meta Analysis JAMA psychiatry 2021
A HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysis
Meta Analysis The Cochrane database of systematic reviews 2014
A Cordyceps sinensis (a traditional Chinese medicine) for treating chronic kidney disease
Meta Analysis The Cochrane database of systematic reviews 2014
B Greater Choline-Containing Compounds and Myo-inositol in Treatment-Resistant Versus Responsive Schizophrenia: A 1H-Magnetic Resonance Spectroscopy Meta-analysis
Meta Analysis Biological psychiatry. Cognitive neuroscience and neuroimaging 2024
B Comparison of statins for secondary prevention in patients with ischemic stroke or transient ischemic attack: a systematic review and network meta-analysis
Systematic Review BMC medicine 2019
B Efficacy of Creatine Supplementation Combined with Resistance Training on Muscle Strength and Muscle Mass in Older Females: A Systematic Review and Meta-Analysis
Meta Analysis Nutrients 2021
B The Effects of Creatine Supplementation on Upper- and Lower-Body Strength and Power: A Systematic Review and Meta-Analysis
Meta Analysis Nutrients 2025
B Meta-analysis of the efficacy and safety of Finerenone in diabetic kidney disease
Meta Analysis Medicine 2026
B Creatine and creatine analogues in hypertension and cardiovascular disease
Meta Analysis The Cochrane database of systematic reviews 2011
B HMG CoA reductase inhibitors (statins) for dialysis patients
Meta Analysis The Cochrane database of systematic reviews 2013
View all evidence for Creatine →

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