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The Big One+

product on market Capsule Metabolic Maintenance Safety: 99/100
99/100

This product looks safe

  • Niacin: 100mg is 2.9× the Tolerable Upper Intake Level (35mg)
  • 70% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

The profile contains essential fat-soluble and water-soluble vitamins that support immune function and cellular health. There is strong research evidence for the roles of vitamins A, C, D3, E, and K1 in maintaining systemic physiological processes. The formulation maintains a high safety score, indicating a low risk of adverse effects at standard dosages.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 100mg is 2.9× the Tolerable Upper Intake Level (35mg)

Label

Product Label

Label for The Big One+
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
Multi-Vitamin and Mineral (MVM)
Product Type
70%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Vitamin A
8000 IU (160% DV)
Vitamin C
150 mg (250% DV)
2000 IU (500% DV)
3.3× RDA — above typical dose (UL: 0.1 mg) 608 studies (A:16, B:251)
100 IU (333% DV)
4.5× RDA — above typical dose (UL: 1000 mg) 179 studies (A:3, B:90)
100 mcg (125% DV)
Within RDA (0.8× RDA) 275 studies (A:9, B:175)
25 mg (1667% DV)
20.8× RDA — above typical dose 76 studies (A:0, B:33)
25 mg (1471% DV)
19.2× RDA — above typical dose 13 studies (A:0, B:1)
100 mg (500% DV)
Exceeds UL by 2.9× (UL: 35 mg) 196 studies (A:5, B:63)
25 mg (1250% DV)
19.2× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
400 mcg (100% DV)
Within RDA (1.0× RDA) 226 studies (A:10, B:105)
100 mcg (1667% DV)
41.7× RDA — above typical dose 139 studies (A:1, B:44)
200 mcg (67% DV)
6.7× RDA — above typical dose 27 studies (A:0, B:11)
100 mg (1000% DV)
20.0× RDA — above typical dose 2 studies — no high-quality reviews
100 mcg (67% DV)
Within RDA (0.7× RDA) 245 studies (A:4, B:133)
15 mg (100% DV)
1.4× RDA — within safe limits 263 studies (A:6, B:134)
100 mcg (143% DV)
1.8× RDA — within safe limits 173 studies (A:0, B:67)
1 mg (50% DV)
1.1× RDA — within safe limits 37 studies (A:0, B:11)
5 mg (250% DV)
2.2× RDA — within safe limits 9 studies — no high-quality reviews
100 mcg (83% DV)
2.9× RDA — within safe limits 199 studies (A:1, B:55)
50 mcg (67% DV)
1.1× RDA — within safe limits 3 studies — no high-quality reviews
25 mg
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews
1 mg
Market median: 3.0mg (58 products) 3 studies — no high-quality reviews
50 mcg
Market median: 0.5mg (6 products) 1 studies (A:0, B:1)

Other Ingredients

vegetarian capsule
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

DIRECTIONS: One (1) capsule daily with a meal as a dietary supplement, or as directed by a healthcare professional.

Warnings & Precautions

Keep tightly closed in a cool, dry place, out of the reach of children.

Physician monitoring of Vitamin D level recommended.

Formulation Notes

Gluten and Excipient Free.

2000 IU Vitamin D without Iron

The Big One(TM)+ contains 2000 IU of Vitamin D-3 for added immune and bone support, a more bioavailable form of beta carotene, and methylated forms of B-12 and Folate.

2000 IU Vitamin D without Iron

Additional Information

Keep tightly closed in a cool, dry place, out of the reach of children.

Manufactured in a GMP Certified Facility

523008A EXP 2/14

ESSENTIALS

Vitamin E is derived from soy oil.

V-07

Metadata

Product Details

UPC / SKU8 38287 00523 0
DSLD Entry Date2013-08-23
Product TypeMulti-Vitamin and Mineral (MVM)
FormCapsule
BrandMetabolic Maintenance
DSLD ID25125
Data Updated2026-04-11
Research

Research Evidence

337
Research Sources
54
Avg Quality
161
Meta Analysis
68
Systematic Review
51
Rct
48
Clinical Trial
2
Other
2
Regulatory Source
1
Narrative Review
1
Cochrane Review
1
Guideline
1
Openfda Safety
A Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less
Meta Analysis The Cochrane database of systematic reviews 2011 PubMed DOI
A Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection
Meta Analysis The Cochrane database of systematic reviews 2011 PubMed DOI
A Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis
Meta Analysis BMJ (Clinical research ed.) 2011 PubMed DOI
A Fortification of staple foods with vitamin A for vitamin A deficiency
Systematic Review The Cochrane database of systematic reviews 2019 PubMed DOI
A Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age
Narrative Review The Cochrane database of systematic reviews 2016 PubMed DOI
A Vitamin A and fish oils for preventing the progression of retinitis pigmentosa
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
A Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Journal of sport and health science 2023 PubMed DOI
A Food fortification with multiple micronutrients: impact on health outcomes in general population
Meta Analysis The Cochrane database of systematic reviews 2019 PubMed DOI
A Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age
Meta Analysis The Cochrane database of systematic reviews 2024 PubMed DOI
View all evidence for Vitamin A →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.