Wellness Essentials by Metagenics — Ingredients, Evidence & Safety

🟢 89/100

This product is generally safe

Folate: 665mg is 665.0× the Tolerable Upper Intake Level (1.0mg)
Contains proprietary blend — exact ingredient amounts not disclosed
66% of ingredients have research evidence

C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Folate: 665mg is 665.0× the Tolerable Upper Intake Level (1.0mg)

ℹ️ Contains proprietary blend — exact ingredient amounts not disclosed

Label Data

1 Packet(s) Serving Size

30 Servings

Other Combinations Product Type

66% Evidence Coverage

Supplement Facts — Evidence Check

Calories

20 Calorie(s)

Total Fat

2 Gram(s) (3% DV)

Cholesterol

5 mg (2% DV)

Vitamin A

1500 mcg (167% DV)

Vitamin C

60 mg (67% DV)

Vitamin D

37.5 mcg (188% DV)

✅ 2.5× RDA — within safe limits 📚 604 studies (Tier A: 16, B: 251)

RDA 0.015mg This product: 0.0375mg UL 0.1mg

Vitamin E

33.5 mg (223% DV)

✅ 2.2× RDA — within safe limits 📚 177 studies (Tier A: 3, B: 90)

RDA 15mg This product: 33.5mg UL 1000mg

Vitamin K

60 mcg (50% DV)

✅ Within RDA (0.5× RDA of 0.12 mg) 📚 273 studies (Tier A: 9, B: 175)

RDA 0.12mg This product: 0.06mg

Thiamine

12.5 mg (1042% DV)

📊 10.4× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)

RDA 1.2mg This product: 12.5mg

Riboflavin

7.5 mg (577% DV)

📊 5.8× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)

RDA 1.3mg This product: 7.5mg

Niacin

25 mg (156% DV)

✅ 1.8× RDA — within safe limits 📚 193 studies (Tier A: 5, B: 63)

RDA 14mg This product: 25mg UL 35mg

Vitamin B6

12.5 mg (735% DV)

📊 9.6× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 12.5mg UL 100mg

Folate

665 mcg DFE (166% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 665.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 665mg UL 1.0mg

Vitamin B12

100 mcg (4167% DV)

📊 41.7× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 0.1mg

Biotin

250 mcg (833% DV)

📊 8.3× RDA — above typical dose 📚 26 studies (Tier A: 0, B: 11)

RDA 0.03mg This product: 0.25mg

Pantothenic Acid

37.5 mg (750% DV)

📊 7.5× RDA — above typical dose 📚 1 studies — no high-quality reviews

RDA 5mg This product: 37.5mg

Choline

12.5 mg (2% DV)

📊 Market median: 125.0mg (294 products) 📚 36 studies (Tier A: 1, B: 7)

RDA 550mg This product: 12.5mg UL 3500mg

Iodine

75 mcg (50% DV)

✅ Within RDA (0.5× RDA of 0.15 mg) 📚 243 studies (Tier A: 4, B: 133)

RDA 0.15mg This product: 0.075mg UL 1.1mg

Magnesium

20 mg (5% DV)

📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)

This product: 20mg

Zinc

7.5 mg (68% DV)

✅ Within RDA (0.7× RDA of 11 mg) 📚 258 studies (Tier A: 6, B: 134)

RDA 11mg This product: 7.5mg UL 40mg

Selenium

50 mcg (91% DV)

✅ Within RDA (0.9× RDA of 0.055 mg) 📚 172 studies (Tier A: 0, B: 67)

RDA 0.055mg This product: 0.05mg UL 0.4mg

Copper

0.5 mg (56% DV)

✅ Within RDA (0.6× RDA of 0.9 mg) 📚 36 studies (Tier A: 0, B: 11)

RDA 0.9mg This product: 0.5mg UL 10mg

Manganese

0.25 mg (11% DV)

✅ Within RDA (0.1× RDA of 2.3 mg) 📚 8 studies — no high-quality reviews

RDA 2.3mg This product: 0.25mg UL 11mg

Chromium

100 mcg (286% DV)

✅ 2.9× RDA — within safe limits 📚 197 studies (Tier A: 1, B: 55)

RDA 0.035mg This product: 0.1mg

Molybdenum

25 mcg (56% DV)

✅ Within RDA (0.6× RDA of 0.045 mg) 📚 2 studies — no high-quality reviews

RDA 0.045mg This product: 0.025mg UL 2mg

Marine Lipid concentrate

2 Gram(s)

Proprietary Phytonutrient Blend

200 mg

Myo-Inositol

12.5 mg

📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)

This product: 12.5mg

Resveratrol

5 mg

📊 Market median: 167.0mg (311 products) 📚 182 studies (Tier A: 0, B: 65)

This product: 5mg

Lutein

3 mg

📊 Market median: 10.0mg (105 products) 📚 1 studies (Tier A: 0, B: 1)

This product: 3mg

Lycopene

3 mg

📊 Market median: 10.0mg (35 products) 📚 5 studies (Tier A: 0, B: 2)

This product: 3mg

Zeaxanthin

1 mg

📊 Market median: 4.0mg (32 products)

This product: 1mg

Other Ingredients

PhytoMulti OmegaGenics EPA-DHA 500 D3 1000

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (76% of products) Nutrient (58% of products)

Target Groups

Adult (18 - 50 Years) Women (not pregnant or lactating) Gluten Free

Product Information

📋 Directions for Use

Directions: Take one packet daily or as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

Warning: Excess vitamin A intake may be toxic and may increase the risk of birth defects. Pregnant women and women who may become pregnant should not exceed 3,000 mcg of preformed vitamin A (retinyl acetate) per day. Caution: Do not use if pregnant or nursing. Consult your healthcare practitioner if taking other nutritional supplements or medications.

Keep out of the reach of children.

Contains: Fish (anchovy, sardine, and mackerel).

🧪 Formulation Notes

Targeted nutrition for overall wellness Wellness Essentials is formulated to support your nutritional needs to help you stay active and vital and maintain general health.

Each once-daily packet provides: Multifaceted health support: PhytoMulti is the “smart multi” with essential nutrients and a proprietary blend of 13 concentrated extracts and phytonutrients to help support cellular health and overall wellness. Immune health support: D3 1000 features 25 mcg (1,000 IU) of vitamin D3 per tablet—the most bioactive form of supplemental vitamin D. Cardiovascular health support, immune system health support, and general wellness support: OmegaGenics EPA-DHA 500 is a quality-guaranteed omega-3 fatty acid formula manufactured and third-party tested to ensure safety and potency.

The wellness essentials difference Overall wellness support Targeted health support Convenient and easy

Products included are non-GMO and gluten-free.

Wellness Essentials helps provide Advanced Nutritional Support for: Joint health Heart health Brain health Eye health Immune system support Liver health Cellular Health General health

Additional Information

The Metagenics Difference Metagenics is a professional nutraceutical company that formulates, manufactures, and continually evaluates nutritional products in clinical practice. Each Wellness Essentials formula represents years of collective research to deliver optimized foundation nutrition and targeted health support.

GF Certified Gluten-free

Each packet contains: 1 PhytoMulti tablet (green), 2 OmegaGenics EPA-DHA 500 softgels (golden yellow), and 1 D3 1000 tablet (white).

Storage: Keep in a cool, dry place.

Please recycle

Practitioner exclusive

Product Details

UPC / SKU 7 55571 92953 2

DSLD Entry Date 2020-03-24

Product Type Other Combinations

Form Other (e.g. tea bag)

Brand Metagenics

DSLD ID 216514

Data Updated 2026-04-11

Research Evidence

337 Research Sources

54 Avg Quality Score

161 Meta Analysis

68 Systematic Review

51 Rct

48 Clinical Trial

2 Other

2 Regulatory Source

1 Narrative Review

1 Cochrane Review

1 Guideline

1 Openfda Safety

A Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age

Meta Analysis The Cochrane database of systematic reviews 2017

PubMed DOI Cochrane

A Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less

Meta Analysis The Cochrane database of systematic reviews 2011

PubMed DOI Cochrane

A Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection

Meta Analysis The Cochrane database of systematic reviews 2011

PubMed DOI Cochrane

A Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis

Meta Analysis BMJ (Clinical research ed.) 2011

PubMed DOI

A Fortification of staple foods with vitamin A for vitamin A deficiency

Systematic Review The Cochrane database of systematic reviews 2019

PubMed DOI Cochrane

A Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age

Narrative Review The Cochrane database of systematic reviews 2016

PubMed DOI Cochrane

A Vitamin A and fish oils for preventing the progression of retinitis pigmentosa

Meta Analysis The Cochrane database of systematic reviews 2020

PubMed DOI

A Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Journal of sport and health science 2023

PubMed DOI

A Food fortification with multiple micronutrients: impact on health outcomes in general population

Meta Analysis The Cochrane database of systematic reviews 2019

PubMed DOI

A Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age

Meta Analysis The Cochrane database of systematic reviews 2024

PubMed DOI

View all evidence for Vitamin A →