One Daily Active
99/100
This product looks safe
- Niacin: 40mg is 1.1× the Tolerable Upper Intake Level (35mg)
- 64% of ingredients have research evidence
C
Label Compliance Grade
Product Label
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Safety Alerts
⚠️ Niacin: 40mg is 1.1× the Tolerable Upper Intake Level (35mg)
Label Data
1 Tablet(s)
Serving Size
Botanical with Nutrients
Product Type
64%
Evidence Coverage
Supplement Facts — Evidence Check
Vitamin A
5000 IU
(100% DV)
Vitamin C
120 mg
(200% DV)
400 IU
(100% DV)
✅ Within RDA (0.7× RDA of 0.015 mg)
📚 604 studies (Tier A: 16, B: 251)
60 IU
(200% DV)
✅ 2.7× RDA — within safe limits
📚 177 studies (Tier A: 3, B: 90)
25 mcg
(31% DV)
✅ Within RDA (0.2× RDA of 0.12 mg)
📚 273 studies (Tier A: 9, B: 175)
4.5 mg
(300% DV)
📊 3.8× RDA — above typical dose
📚 76 studies (Tier A: 0, B: 33)
5.1 mg
(300% DV)
📊 3.9× RDA — above typical dose
📚 12 studies (Tier A: 0, B: 1)
40 mg
(200% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 1.1× (UL: 35 mg)
📚 193 studies (Tier A: 5, B: 63)
6 mg
(300% DV)
📊 4.6× RDA — above typical dose (UL: 100 mg)
📚 113 studies (Tier A: 3, B: 35)
400 mcg
(100% DV)
✅ Within RDA (1.0× RDA of 0.4 mg)
📚 225 studies (Tier A: 10, B: 105)
18 mcg
(300% DV)
📊 7.5× RDA — above typical dose
📚 138 studies (Tier A: 1, B: 44)
40 mcg
(13% DV)
✅ 1.3× RDA — within safe limits
📚 26 studies (Tier A: 0, B: 11)
10 mg
(100% DV)
✅ 2.0× RDA — within safe limits
📚 1 studies — no high-quality reviews
Calcium
110 mg
(11% DV)
Iron
9 mg
(50% DV)
48 mg
(4% DV)
✅ Within RDA (0.1× RDA of 700 mg)
📚 12 studies (Tier A: 0, B: 3)
40 mg
(10% DV)
📊 Market median: 4002.0mg (1 products)
📚 20 studies (Tier A: 0, B: 2)
15 mg
(100% DV)
✅ 1.4× RDA — within safe limits
📚 258 studies (Tier A: 6, B: 134)
45 mcg
(64% DV)
✅ Within RDA (0.8× RDA of 0.055 mg)
📚 172 studies (Tier A: 0, B: 67)
2 mg
(100% DV)
✅ 2.2× RDA — within safe limits
📚 36 studies (Tier A: 0, B: 11)
2 mg
(100% DV)
✅ Within RDA (0.9× RDA of 2.3 mg)
📚 8 studies — no high-quality reviews
100 mcg
(83% DV)
✅ 2.9× RDA — within safe limits
📚 197 studies (Tier A: 1, B: 55)
25 mcg
(33% DV)
✅ Within RDA (0.6× RDA of 0.045 mg)
📚 2 studies — no high-quality reviews
180 mg
(5% DV)
📊 Market median: 4002.0mg (1 products)
📚 20 studies (Tier A: 0, B: 2)
Potassium
200 mg
(5% DV)
Nickel
5 mcg
Tin
10 mcg
6 mg
📊 Market median: 108.0mg (8 products)
📚 9 studies (Tier A: 0, B: 4)
10 mcg
📊 Market median: 0.5mg (6 products)
📚 1 studies (Tier A: 0, B: 1)
150 mcg
📊 Market median: 3.0mg (58 products)
📚 2 studies — no high-quality reviews
55 mg
📊 Market median: 450.0mg (390 products)
📚 155 studies (Tier A: 0, B: 63)
Other Ingredients
Cellulose
Starch
Croscarmellose Sodium
Stearic Acid
Silicon Dioxide
Magnesium Stearate
Titanium Dioxide
Artificial Colors
Label Claims — Verification
❓
Nutrient
❓
All Other
❓
Structure/Function
All Other (99% of products)
Structure/Function (76% of products)
Nutrient (58% of products)
Target Groups
Adult (18 - 50 Years)
Product Information
📋 Directions for Use
DIRECTIONS: As a dietary supplement, adults take one (1) tablet daily with any meal, or as directed by a health care provider. Do not exceed recommended dosage.
⚠️ Warnings & Precautions
Keep out of reach of children.
Do not use if product appears to be tampered with or seal is broken.
Warning: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of reach of children. In case of accidental overdose, call a doctor or poison control center immediately.
🧪 Formulation Notes
No Added Sugar, Salt, Yeast, Preservatives, Artificial Flavors.
Additional Information
Store at room temperature.
Unconditionally guaranteed for purity, freshness and label potency.
MADE IN USA
1205
Product Details
UPC / SKU
7 40985 22656 8
DSLD Entry Date
2012-07-25
Product Type
Botanical with Nutrients
Form
Tablet or Pill
Brand
21st Century
DSLD ID
11548
Data Updated
2026-04-11
Research Evidence
337
Research Sources
54
Avg Quality Score
161
Meta Analysis
68
Systematic Review
51
Rct
48
Clinical Trial
2
Other
2
Regulatory Source
1
Narrative Review
1
Cochrane Review
1
Guideline
1
Openfda Safety
A
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A
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A
Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection
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A
Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials
A
Food fortification with multiple micronutrients: impact on health outcomes in general population
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