🟢 99/100

This product looks safe

  • Niacin: 100mg is 2.9× the Tolerable Upper Intake Level (35mg)
  • 60% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 100mg is 2.9× the Tolerable Upper Intake Level (35mg)

Label Data

2 Tablet(s) Serving Size
15 Servings
Other Combinations Product Type
60% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin A
4500 mcg (500% DV)
Vitamin C
1000 mg (1111% DV)
25 mcg (125% DV)
✅ 1.7× RDA — within safe limits 📚 604 studies (Tier A: 16, B: 251)
RDA 0.015mg This product: 0.025mg UL 0.1mg
124.5 mg (830% DV)
📊 8.3× RDA — above typical dose (UL: 1000 mg) 📚 177 studies (Tier A: 3, B: 90)
RDA 15mg This product: 124.5mg UL 1000mg
50 mcg (42% DV)
✅ Within RDA (0.4× RDA of 0.12 mg) 📚 273 studies (Tier A: 9, B: 175)
RDA 0.12mg This product: 0.05mg
30 mg (2500% DV)
📊 25.0× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 30mg
34 mg (2615% DV)
📊 26.2× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 34mg
100 mg (625% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 2.9× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 100mg UL 35mg
40 mg (2353% DV)
📊 30.8× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 40mg UL 100mg
400 mcg (100% DV)
✅ Within RDA (1.0× RDA of 0.4 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 0.4mg UL 1.0mg
200 mcg (8333% DV)
📊 83.3× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.2mg
300 mcg (1000% DV)
📊 10.0× RDA — above typical dose 📚 26 studies (Tier A: 0, B: 11)
RDA 0.03mg This product: 0.3mg
100 mg (2000% DV)
📊 20.0× RDA — above typical dose 📚 1 studies — no high-quality reviews
RDA 5mg This product: 100mg
100 mg (18% DV)
✅ Within RDA (0.2× RDA of 550 mg) 📚 36 studies (Tier A: 1, B: 7)
RDA 550mg This product: 100mg UL 3500mg
Calcium
200 mg (16% DV)
150 mcg (100% DV)
✅ Within RDA (1.0× RDA of 0.15 mg) 📚 243 studies (Tier A: 4, B: 133)
RDA 0.15mg This product: 0.15mg UL 1.1mg
200 mg (47% DV)
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 200mg
15 mg (136% DV)
✅ 1.4× RDA — within safe limits 📚 258 studies (Tier A: 6, B: 134)
RDA 11mg This product: 15mg UL 40mg
150 mcg (273% DV)
✅ 2.7× RDA — within safe limits 📚 172 studies (Tier A: 0, B: 67)
RDA 0.055mg This product: 0.15mg UL 0.4mg
1.5 mg (167% DV)
✅ 1.7× RDA — within safe limits 📚 36 studies (Tier A: 0, B: 11)
RDA 0.9mg This product: 1.5mg UL 10mg
2 mg (87% DV)
✅ Within RDA (0.9× RDA of 2.3 mg) 📚 8 studies — no high-quality reviews
RDA 2.3mg This product: 2mg UL 11mg
200 mcg (571% DV)
📊 5.7× RDA — above typical dose 📚 197 studies (Tier A: 1, B: 55)
RDA 0.035mg This product: 0.2mg
25 mcg (56% DV)
✅ Within RDA (0.6× RDA of 0.045 mg) 📚 2 studies — no high-quality reviews
RDA 0.045mg This product: 0.025mg UL 2mg
Potassium
30 mg (2% DV)
SuperFood Complex
908 mg
Herbal Extracts
700 mg
Co-Nutrients
440.3 mg
400 mg
📊 Market median: 500.0mg (283 products) 📚 173 studies (Tier A: 0, B: 62)
This product: 400mg
Minerals
29 mg
Digestive Aids/Enzymes
27 mg

Other Ingredients

Silicon Dioxide Croscarmellose Sodium Stearic Acid Cellulose L-Leucine

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (76% of products) Nutrient (58% of products)

Target Groups

Vegan Vegetarian Women (not pregnant or lactating) Adult Female (18 - 50 Years) Menopause Seniors/Mature (>50 Years) - Women ONLY Gluten Free Dairy Free

Product Information

📋 Directions for Use

Suggested Use: Two tablets, twice daily, with or between meals.

⚠️ Warnings & Precautions

Caution: Keep all supplements out of children's reach.

Not intended for use during pregnancy.

🧪 Formulation Notes

Non GMO

Vegan

Gluten Free

Organic Ingredients

100% Purity & Potency Guarantee

Menopause multi

16,200 mg of whole food value

Helps reduce hot flashes, mood swings

More than a multiple, ProFema is a complete nutritional system for women in their transitional years. It provides perfect potencies of vitamins and minerals, an energy packed superfood complex, adaptogens and superior herbs, and specific menopausal support nutrients.

Supports: Immune function Bone health Healthy stress response Helps calm: Hot flashes Mood swings Associated menopausal discomfort

Does Not Contain: Gluten, wheat, milk, tree nuts, peanuts, soy, eggs, fish, shellfish

Additional Information

15 days supply

Please Recycle

Made in USA

Storage: Keep closed in a cool, dry place.

90 Day Money Back Guarantee

Product Details

UPC / SKU 6 59670 01603 5
DSLD Entry Date 2021-08-23
Product Type Other Combinations
Form Tablet or Pill
Brand Pure Essence
DSLD ID 253199
Data Updated 2026-04-11

Research Evidence

337 Research Sources
54 Avg Quality Score
161 Meta Analysis
68 Systematic Review
51 Rct
48 Clinical Trial
2 Other
2 Regulatory Source
1 Narrative Review
1 Cochrane Review
1 Guideline
1 Openfda Safety
A Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age
Meta Analysis The Cochrane database of systematic reviews 2017
A Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less
Meta Analysis The Cochrane database of systematic reviews 2011
A Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection
Meta Analysis The Cochrane database of systematic reviews 2011
A Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis
Meta Analysis BMJ (Clinical research ed.) 2011
A Fortification of staple foods with vitamin A for vitamin A deficiency
Systematic Review The Cochrane database of systematic reviews 2019
A Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age
Narrative Review The Cochrane database of systematic reviews 2016
A Vitamin A and fish oils for preventing the progression of retinitis pigmentosa
Meta Analysis The Cochrane database of systematic reviews 2020
A Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Journal of sport and health science 2023
A Food fortification with multiple micronutrients: impact on health outcomes in general population
Meta Analysis The Cochrane database of systematic reviews 2019
A Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age
Meta Analysis The Cochrane database of systematic reviews 2024
View all evidence for Vitamin A →

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